Reduced retinal function in amyloid precursor protein-over-expressing transgenic mice via attenuating glutamate-N-methyl-D-aspartate receptor signaling

Journal of Neurochemistry

Volumn 107, Issue 1, 2008, Pages 279-290

  Shimazawa, Masamitsu ^a   Inokuchi, Yuta ^a   Okuno, Takashi ^b   Nakajima, Yoshihiro ^c   Sakaguchi, Gaku ^c   Kato, Akira ^c   Oku, Hidehiro ^b   Sugiyama, Tetsuya ^b   Kudo, Takashi ^d   Ikeda, Tsunehiko ^b   Takeda, Masatoshi ^d   Hara, Hideaki ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b OSAKA MEDICAL COLLEGE   (Japan)

^c SHIONOGI AND CO LTD   (Japan)

^d OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Amyloid ; Electroretinogram; N methyl D aspartate; Retinal ganglion cell death; Transgenic mice; Visual evoked potential

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; CALMODULIN DEPENDENT PROTEIN KINASE 2A; GAMMA SECRETASE INHIBITOR; N [N (3,5 DIFLUOROPHENACETYL) ALANYL] S PHENYLGLYCINE TERT BUTYL ESTER; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; PRESENILIN 1; PROTEIN KINASE (CALCIUM,CALMODULIN); UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ELECTRORETINOGRAM; ENZYME LINKED IMMUNOSORBENT ASSAY; EVOKED VISUAL RESPONSE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NERVE CELL; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RETINA; RETINA INJURY; SIGNAL TRANSDUCTION; VISION;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; DOWN-REGULATION; ENZYME INHIBITORS; EVOKED POTENTIALS, VISUAL; GLUTAMIC ACID; HUMANS; MICE; MICE, TRANSGENIC; NERVE DEGENERATION; PEPTIDE FRAGMENTS; PHOTOTRANSDUCTION; PRESENILIN-1; RECEPTORS, N-METHYL-D-ASPARTATE; RETINAL DISEASES; RETINAL GANGLION CELLS; SIGNAL TRANSDUCTION;

MUS; MUS MUSCULUS;

EID: 51849086808     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05606.x     Document Type: Article

References (45)

1. Arendt T., Bruckner M. K., Gertz H. J. Marcova L. (1998) Cortical distribution of neurofibrillary tangles in Alzheimer's disease matches the pattern of neurons that retain their capacity of plastic remodelling in the adult brain. Neuroscience 83, 991 1002.
2. Barelli H., Lebeau A., Vizzavona J. et al. (1997) Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid beta peptides: their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiopathy cases. Mol. Med. 3, 695 707.
3. Bayer A. U., Ferrari F. Erb C. (2002) High occurrence rate of glaucoma among patients with Alzheimer's disease. Eur. Neurol. 47, 165 168.
4. Billings L. M., Oddo S., Green K. N., McGaugh J. L. LaFerla F. M. (2005) Intraneuronal Aβ causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron 45, 675 688.
5. Bonne C., Muller A. Villain M. (1998) Free radicals in retinal ischemia. Gen. Pharmacol. 30, 275 280.
6. Chin J. H., Ma L., MacTavish D. Jhamandas J. H. (2007) Amyloid β protein modulates glutamate-mediated neurotransmission in the rat basal forebrain: involvement of presynaptic neuronal nicotinic acetylcholine and metabotropic glutamate receptors. J. Neurosci. 27, 9262 9269.
7. Chui D. H., Dobo E., Makifuchi T. et al. (2001) Apoptotic neurons in Alzheimer's disease frequently show intracellular Aβ42 labeling. J. Alzheimers. Dis. 3, 231 239.
8. Colbran R. J. (2004) Targeting of calcium/calmodulin-dependent protein kinase II. Biochem. J. 378, 1 16.
9. Comery T. A., Martone R. L., Aschmies S. et al. (2005) Acute γ-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease. J. Neurosci. 25, 8898 8902.
10. Dentchev T., Milam A. H., Lee V. M., Trojanowski J. Q. Dunaief J. L. (2003) Amyloid-β is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas. Mol. Vision 9, 184 190.
11. Dreyer E. B. (1998) A proposed role for excitotoxicity in glaucoma. J. Glaucoma 7, 62 67.
12. Dreyer E. B., Zurakowski D., Schumer R. A., Podos S. M. Lipton S. A. (1996) Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma. Arch. Ophthalmol. 114, 299 305.
13. 2+/calmodulin-dependent protein kinase II and protein kinase C by glutamate in cultured rat hippocampal neurons. J. Biol. Chem. 267, 22527 22533.
14. 2+/ calmodulin-dependent protein kinase II. J. Biol. Chem. 268, 7863 7867.
15. Goto Y., Niidome T., Akaike A., Kihara T. Sugimoto H. (2006) Amyloid β-peptide preconditioning reduces glutamate-induced neurotoxicity by promoting endocytosis of NMDA receptor. Biochem. Biophys. Res. Commun. 351, 259 265.
16. Gray C. W. Patel A. J. (1995) Neurodegeneration mediated by glutamate and β-amyloid peptide: a comparison and possible interaction. Brain Res. 691, 169 179.
17. Guo L., Salt T. E., Luong V. et al. (2007) Targeting amyloid-β in glaucoma treatment. Proc. Natl Acad. Sci. USA 104, 13444 13449.
18. Hara H., Oh-hashi K., Yoneda S., Shimazawa M., Inatani M., Tanihara H. Kiuchi K. (2006) Elevated neprilysin activity in vitreous of patients with proliferative diabetic retinopathy. Mol. Vision 12, 977 982.
19. Harkany T., Abraham I., Timmerman W. et al. (2000) β-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis. Eur. J. Neurosci. 12, 2735 2745.
20. Hasegawa K., Yamaguchi I., Omata S., Gejyo F. Naiki H. (1999) Interaction between Aβ (1-42) and Aβ (1-40) in Alzheimer's β-amyloid fibril formation in vitro. Biochemistry 38, 15514 15521.
21. Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S., Yang F. Cole G. (1996) Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice. Science 274, 99 102.
22. Jackson G. R. Owsley C. (2003) Visual dysfunction, neurodegenerative diseases, and aging. Neurol. Clin. 21, 709 728.
23. Johnson L. V., Leitner W. P., Rivest A. J., Staples M. K., Radeke M. J. Anderson D. H. (2002) The Alzheimer's Aβ-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration. Proc. Natl Acad. Sci. USA 99, 11830 11835.
24. Koh J. Y., Yang L. L. Cotman C. W. (1990) β-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage. Brain Res. 533, 315 320.
25. Lanz T. A., Himes C. S., Pallante G., Adams L., Yamazaki S., Amore B. Merchant K. M. (2003) The γ-secretase inhibitor N-[N-(3,5- difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester reduces Aβ levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice. J. Pharmacol. Exp. Ther. 305, 864 871.
26. Masliah E., Alford M., Mallory M., Rockenstein E., Moechars D. Van Leuven F. (2000) Abnormal glutamate transport function in mutant amyloid precursor protein transgenic mice. Exp. Neurol. 163, 381 387.
27. McKinnon S. J., Lehman D. M., Kerrigan-Baumrind L. A. et al. (2002) Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension. Invest. Ophthalmol. Vis. Sci. 43, 1077 1087.
28. Merrill M. A., Chen Y., Strack S. Hell J. W. (2005) Activity-driven postsynaptic translocation of CaMKII. Trends Pharmacol. Sci. 26, 645 653.
29. Nakagami Y. Oda T. (2002) Glutamate exacerbates amyloid β1-42-induced impairment of long-term potentiation in rat hippocampal slices. Jpn. J. Pharmacol. 88, 223 226.
30. Nakano Y., Kondoh G., Kudo T., Imaizumi K., Kato M., Miyazaki J. I., Tohyama M., Takeda J. Takeda M. (1999) Accumulation of murine amyloidβ42 in a gene-dosage-dependent manner in PS1 'knock-in' mice. Eur. J. Neurosci. 11, 2577 2581.
31. Neufeld A. H. (1999) Nitric oxide: a potential mediator of retinal ganglion cell damage in glaucoma. Surv. Ophthalmol. 43 (Suppl. 1 S129 S135.
32. Qiu Z. Gruol D. L. (2003) Interleukin-6, β-amyloid peptide and NMDA interactions in rat cortical neurons. J. Neuroimmunol. 139, 51 57.
33. Shimazawa M., Inokuchi Y., Ito Y., Murata H., Aihara M., Miura M., Araie M. Hara H. (2007a) Involvement of ER stress in retinal cell death. Mol. Vision 13, 578 587.
34. Shimazawa M., Ito Y., Inokuchi Y. Hara H. (2007b) Involvement of double-stranded RNA-dependent protein kinase in ER stress-induced retinal neuron damage. Invest. Ophthalmol. Vis. Sci. 48, 3729 3736.
35. Snyder E. M., Nong Y., Almeida C. G. et al. (2005) Regulation of NMDA receptor trafficking by amyloid-β. Nat. Neurosci. 8, 1051 1058.
36. Suemori S., Shimazawa M., Kawase K., Satoh M., Nagase H., Yamamoto T. Hara H. (2006) Metallothionein, an endogenous antioxidant, protects against retinal neuron damage in mice. Invest. Ophthalmol. Vis. Sci. 47, 3975 3982.
37. Venkitaramani D. V., Chin J., Netzer W. J., Gouras G. K., Lesne S., Malinow R., Lombroso P. J. (2007) β-amyloid modulation of synaptic transmission and plasticity. J. Neurosci. 27, 11832 11837.
38. Viswanathan S., Frishman L. J. Robson J. G. (2000) The uniform field and pattern ERG in macaques with experimental glaucoma: removal of spiking activity. Invest. Ophthalmol. Vis. Sci. 41, 2797 2810.
39. Viswanathan S., Frishman L. J., Robson J. G. Walters J. W. (2001) The photopic negative response of the flash electroretinogram in primary open angle glaucoma. Invest. Ophthalmol. Vis. Sci. 42, 514 522.
40. Walsh D. T., Montero R. M., Bresciani L. G. et al. (2002) Amyloid-β peptide is toxic to neurons in vivo via indirect mechanisms. Neurobiol. Dis. 10, 20 27.
41. Walsh D. T., Bresciani L., Saunders D., Manca M. F., Jen A., Gentleman S. M. Jen L. S. (2005) Amyloid β peptide causes chronic glial cell activation and neuro-degeneration after intravitreal injection. Neuropathol. Appl. Neurobiol. 31, 491 502.
42. Wang Q., Rowan M. J. Anwyl R. (2004) β-amyloid-mediated inhibition of NMDA receptor-dependent long-term potentiation induction involves activation of microglia and stimulation of inducible nitric oxide synthase and superoxide. J. Neurosci. 24, 6049 6056.
43. Wirths O., Multhaup G., Czech C., Blanchard V., Moussaoui S., Tremp G., Pradier L., Beyreuther K. Bayer T. A. (2001) Intraneuronal Aβ accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice. Neurosci. Lett. 306, 116 120.
44. Yamamoto R., Yoneda S. Hara H. (2004) Neuroprotective effects of β-secretase inhibitors against rat retinal ganglion cell death. Neurosci. Lett. 370, 61 64.
45. (1-42) and tau in patients with retinal diseases. Jpn. J. Ophthalmol. 49, 106 108.