Correlation analysis between the expression of P21WAF1/CIP1, P16 proteins and human glioma

Clinical and Experimental Medicine

Volumn 8, Issue 3, 2008, Pages 151-157

  Song, Tao ^a   Wu, Jun ^a   Fang, Fang ^a   Chen, Fanghua ^a   Huo, Lei ^a   Zhang, Mingyu ^a   Wu, Lei ^a   Zhai, Zhiyong ^a   Yang, Liang ^a   Fang, Jiesheng ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Correlation; Glioma; Immunohistochemistry; P16; P21WAF1 CIP1; RT PCR

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; PROTEIN P16;

ARTICLE; ASTROCYTE; CANCER GRADING; CONTROLLED STUDY; CORRELATION ANALYSIS; GLIOMA; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BASE SEQUENCE; BRAIN NEOPLASMS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA PRIMERS; GLIOMA; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASM PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 51749117358     PISSN: 15918890     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10238-008-0172-0     Document Type: Article

References (23)

1. A.B. Lassman 2004 Molecular biology of gliomas Curr Neurol Neurosci Rep 4 228 233
2. L. Frederick X.Y. Wang G. Eley C.D. James 2000 Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas Cancer Res 60 1383 1387
3. S.M. Ranuncolo M. Varela A. Morandi 2004 Prognostic value of Mdm2, p53 and p16 in patients with astrocytomas J Neuro-Oncol 68 113 121
4. A.B. Chakravarti M.A. Delaney E. Noll 2001 Prognostic and pathologic significance of quantitative protein expression profiling in human gliomas Clin Cancer Res 7 2387 2395
5. J.N. Rich C. Hans B. Jones 2005 Gene expression profiling and genetic markers in glioblastoma survival Cancer Res 65 4051 4058
6. A. Dobra B. Jones C. Hans 2004 Sparse graphical models for exploring gene expression data J Multivariate Anal 90 196 212
7. M. Khalid N. Yagi T. Hiura S. Shibata 1998 Immunohistochemical analysis of p53 and p21 in human primary glioblastomas in relation to proliferative potential and apoptosis Brain Tumor Pathol 15 89 94
8. T.-J. Wang M.-S. Huang C.-Y. Hong 2001 Comparisons of tumor suppressor p53, p21, and p16 gene therapy effects on glioblastoma tumorigenicity in situ Biochem Biophys Res Commun 287 173 180
9. P. Ghaneh W. Greenhalf M. Humphreys 2001 Adenovirus-mediated transfer of p53 and p16(INK4a) results in pancreatic cancer regression in vitro and in vivo Gene Ther 8 199 208
10. K.S. Hung C.Y. Hong J. Lee 2000 Expression of p16(INK4A) induces dominant suppression of glioblastoma growth in situ through necrosis and cell cycle arrest Biochem Biophys Res Commun 269 718 725
11. Kleihues P, Cavanee W (2000)Pathology and genetics of tumours of the nervous system. International Agency for Research on Cancer, Lyon, France
12. Y. Jiang C. Sui F. Meng 2007 The relationship of the expression Canceration 17 311 313
13. Y.K. Jeon K. Park C.K. Park 2007 Chromosome 1p and 19q status and p53 and p16 expression patterns as prognostic indicators of oligodendroglial tumors: a clinicopathological study using fluorescence in situ hybridization Neuropathology 27 10 20
14. M.W. Gross A. Kraus K. Nashwan 2005 Expression of p53 and p21 in primary glioblastomas Strahlenther Onkol 181 164 171
15. B. Gerlach A.H. Harder T.J.M. Hulsebos 2002 Radiosensitivity and TP53, EGFR amplification and LOH 10 analysis of primary glioma cell cultures Strahlenther Onkol 178 491 496
16. M. Preusser C. Haberler J.A. Hainfellner 2006 Malignant glioma: neuropathology and neurobiology Wien Med Wochenschr 156 332 337
17. M. Sanson J. Thillet K. Hoang-Xuan 2004 Molecular changes in gliomas Curr Opin Oncol 16 607 613
18. J.R. Nevins 2001 The Rb/E2F pathway and cancer Hum Mol Genet 10 699 703
19. G.S. Kapoor D.M. O'Rourke 2003 Mitogenic signaling cascades in glial tumors Neurosurgery 52 1425 1434
20. D.R. Alessi S.R. James C.P. Downes 1997 Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha Curr Biol 7 261 269
21. P. Korkolopoulou K. Kouzelis P. Christodoulou 1998 Expression of retinoblastoma gene product and p21 (WAF1/Cip1) protein in gliomas: correlations with proliferation markers, p53 expression and survival Acta Neuropathol 95 617 624
22. A. Besson V.W. Yong 2000 Involvement of p21Waf1/Cip1 in protein kinase C alpha-induced cell cycle progression Mol Cell Biol 20 4580 4590
23. D. Hilton M. Penney B. Evans 2002 Evaluation of molecular markers in low-grade diffuse astrocytomas Am J Surg Path 26 472 478