Novel contrast mechanisms at 3 tesla and 7 tesla

Seminars in Musculoskeletal Radiology

Volumn 12, Issue 3, 2008, Pages 266-280

  Regatte, Ravinder R ^a,b   Schweitzer, Mark E ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NYU HOSPITAL FOR JOINT DISEASES   (United States)

Author keywords

CEST; dGEMRIC; Osteoarthritis; Sodium MR; T1p; T2

Indexed keywords

CONTRAST MEDIUM; GADOLINIUM; GADOLINIUM PENTETATE; SODIUM;

7 TESLA MAGNETIC RESONANCE IMAGING; ARTICULAR CARTILAGE; BIOCHEMISTRY; BONE STRUCTURE; CONTRAST ENHANCEMENT; DIAGNOSTIC IMAGING; DIFFUSION WEIGHTED IMAGING; DRUG MONITORING; EARLY DIAGNOSIS; MORPHOMETRICS; MUSCULOSKELETAL DISEASE; MUSCULOSKELETAL SYSTEM; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEOARTHRITIS; QUANTITATIVE DIAGNOSIS; REVIEW; SENSITIVITY AND SPECIFICITY; THREE DIMENSIONAL TESLA RESONANCE MAGNETIC IMAGING;

CARTILAGE, ARTICULAR; CONTRAST MEDIA; HUMANS; IMAGE ENHANCEMENT; IMAGING, THREE-DIMENSIONAL; MAGNETIC RESONANCE IMAGING; MAGNETICS; MUSCULOSKELETAL DISEASES; SENSITIVITY AND SPECIFICITY;

EID: 51649127568     PISSN: 10897860     EISSN: 1098898X     Source Type: Journal    
DOI: 10.1055/s-0028-1083109     Document Type: Review

References (151)

1. Felson DT. Clinical practice. Osteoarthritis of the knee. N Engl J Med 2006;354:841-848
2. Felson DT, Niu J, Guermazi A, et al. Correlation of the development of knee pain with enlarging bone marrow lesions on magnetic resonance imaging. Arthritis Rheum 2007;56:2986-2992
3. Felson DT, Kim YJ. The futility of current approaches to chondroprotection. Arthritis Rheum 2007;56:1378-1383
4. Felson DT. Risk factors for osteoarthritis: understanding joint vulnerability. Clin Orthop Relat Res 2004:S16-S21
5. Brandt HJ, Ma KD. Osteoarthritis: Diagnosis and Medical/Surgical Management. Philadelphia, Pa: WB Saunders; 1992
6. Sharma L, Song J, Felson DT, Cahue S, Shamiyeh E, Dunlop DD. The role of knee alignment in disease progression and functional decline in knee osteoarthritis. JAMA 2001;286:188-195
7. Sharma L, Chang A. Overweight: advancing our understanding of its impact on the knee and the hip. Ann Rheum Dis 2007;66:141-142
8. Sharma L. Nonpharmacologic management of osteoarthritis. Curr Opin Rheumatol 2002;14:603-607
9. Sharma L. Local factors in osteoarthritis. Curr Opin Rheumatol 2001;13:441-446
10. Nevitt MC, Sharma L. OMERACT workshop radiography session 1. Osteoarthritis Cartilage 2006;14(suppl A):A4-A9
11. Buckland-Wright JC, Ward RJ, Peterfy C, Mojcik CF, Leff RL. Reproducibility of the semiflexed (metatarsophalangeal) radiographic knee position and automated measurements of medial tibiofemoral joint space width in a multicenter clinical trial of knee osteoarthritis. J Rheumatol 2004;31:1588-1597
12. Le Graverand MP, Mazzuca S, Lassere M, Guermazi A, Pickering E, Brandt K, et al. Assessment of the radioanatomic positioning of the osteoarthritic knee in serial radiographs: comparison of three acquisition techniques. Osteoarthritis Cartilage 2006;14(suppl A):A37-A43
13. Peterfy C, Kothari M. Imaging osteoarthritis: magnetic resonance imaging versus X-ray. Curr Rheumatol Rep 2006;8:16-21
14. Gale DR, Chaisson CE, Totterman SM, Schwartz RK, Gale ME, Felson D. Meniscal subluxation: association with osteoarthritis and joint space narrowing. Osteoarthritis Cartilage 1999;7:526-532
15. Hunter DJ, Zhang YQ, Tu X, et al. Change in joint space width: hyaline articular cartilage loss or alteration in meniscus? Arthritis Rheum 2006;54:2488-2495
16. 2- as a measure of cartilage degradation. Magn Reson Med 1996;36:665-673
17. 2--enhanced MR imaging. Radiology 1997; 205:551-558
18. Mosher TJ, Dardzinski BJ, Smith MB. Human articular cartilage: influence of aging and early symptomatic degeneration on the spatial variation of T2 - preliminary findings at 3 T. Radiology 2000;214:259-266
19. Reddy R, Insko EK, Noyszewski EA, Dandora R, Kneeland JB, Leigh JS. Sodium MRI of human articular cartilage in vivo. Magn Reson Med 1998;39:697-701
20. Regatte RR, Akella SV, Wheaton AJ, et al. 3D-T1rho-relaxation mapping of articular cartilage: in vivo assessment of early degenerative changes in symptomatic osteoarthritic subjects. Acad Radiol 2004;11:741-749
21. Regatte RR, Akella SV, Borthakur A, Kneeland JB, Reddy R. In vivo proton MR three-dimensional T1rho mapping of human articular cartilage: initial experience. Radiology 2003;229:269-274
22. Li X, Benjamin Ma C, Link TM, et al. In vivo T(1rho) and T(2) mapping of articular cartilage in osteoarthritis of the knee using 3 T MRI. Osteoarthritis Cartilage 2007;15:789-797
23. Li X, Han ET, Busse RF, Majumdar S. In vivo T(1rho) mapping in cartilage using 3D magnetization-prepared angle-modulated partitioned k-space spoiled gradient echo snapshots (3D MAPSS). Magn Reson Med 2008;59:298-307
24. Li X, Han ET, Ma CB, Link TM, Newitt DC, Majumdar S. In vivo 3T spiral imaging based multi-slice T(1rho) mapping of knee cartilage in osteoarthritis. Magn Reson Med 2005;54:929-936
25. Pakin SK, Cavalcanti C, La Rocca R, Schweitzer ME, Regatte RR. Ultra-high-field MRI of knee joint at 7.0T: preliminary experience. Acad Radiol 2006;13:1135-1142
26. Pakin SK, Xu J, Schweitzer ME, Regatte RR. Rapid 3D-T1rho mapping of the knee joint at 3.0T with parallel imaging. Magn Reson Med 2006;56:563-571
27. Pakin SK, Schweitzer ME, Regatte RR. 3D-T1rho quantitation of patellar cartilage at 3.0T. J Magn Reson Imaging 2006;24:1357-1363
28. Gold GE, Hargreaves BA, Reeder SB, et al. Balanced SSFP imaging of the musculoskeletal system. J Magn Reson Imaging 2007;25:270-278
29. Gold GE, Busse RF, Beehler C, et al. Isotropic MRI of the knee with 3D fast spin-echo extended echo-train acquisition (XETA): initial experience. AJR Am J Roentgenol 2007;188:1287-1293
30. Gold GE, Reeder SB, Yu H, et al. Articular cartilage of the knee: rapid three-dimensional MR imaging at 3.0 T with IDEAL balanced steady-state free precession - initial experience. Radiology 2006;240:546-551
31. Gold GE, Han E, Stainsby J, Wright G, Brittain J, Beaulieu C. Musculoskeletal MRI at 3.0 T: relaxation times and image contrast. AJR Am J Roentgenol 2004;183:343-351
32. Gold GE. Dynamic and functional imaging of the musculoskeletal system. Semin Musculoskelet Radiol 2003;7:245-248
33. Dardzinski BJ, Mosher TJ, Li SZ, VanSlyke MA, Smith MB. Spatial variation of T2 in human articular cartilage. Radiology 1997;205:546-550
34. David-Vaudey E, Ghosh S, Ries M, Majumdar S. T2 relaxation time measurements in osteoarthritis. Magn Reson Imaging 2004;22:673-682
35. Eckstein F, Mosher T, Hunter D. Imaging of knee osteoarthritis: data beyond the beauty. Curr Opin Rheumatol 2007;19:435-443
36. Eckstein F, Burstein D, Link TM. Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis. NMR Biomed 2006;19:822-854
37. Eckstein F, Ateshian G, Burgkart R, et al. Proposal for a nomenclature for magnetic resonance imaging based measures of articular cartilage in osteoarthritis. Osteoarthritis Cartilage 2006;14:974-983
38. Eckstein F, Hudelmaier M, Wirth W, et al. Double echo steady state magnetic resonance imaging of knee articular cartilage at 3 Tesla: a pilot study for the Osteoarthritis Initiative. Ann Rheum Dis 2006;65:433-441
39. Eckstein F, Hudelmaier M, Putz R. The effects of exercise on human articular cartilage. J Anat 2006;208:491-512
40. Eckstein F, Kunz M, Schutzer M, et al. Two year longitudinal change and test-retest-precision of knee cartilage morphology in a pilot study for the osteoarthritis initiative. Osteoarthritis Cartilage 2007;15:1326-1332
41. Ling W, Regatte RR, Schweitzer ME, Jerschow A. Characterization of bovine patellar cartilage by NMR. NMR Biomed 2008;21(3):289-295
42. Ling W, Regatte RR, Navon G, Jerschow A. Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST). Proc Natl Acad Sci U S A 2008;105(7):2266-2270
43. Link TM, Sell CA, Masi JN, et al. 3.0 vs 1.5T MRI in the detection of focal cartilage pathology - ROC analysis in an experimental model. Osteoarthritis Cartilage 2006;14(1):63-70
44. Link TM, Stahl R, Woertler K. Cartilage imaging: motivation, techniques, current and future significance. Eur Radiol 2007;17:1135-1146
45. Wheaton AJ, Borthakur A, Kneeland JB, Regatte RR, Akella SV, Reddy R. In vivo quantification of T1rho using a multislice spin-lock pulse sequence. Magn Reson Med 2004;52:1453-1458
46. Wheaton AJ, Borthakur A, Charagundla SR, Reddy R. Pulse sequence for multislice T1rho-weighted MRI. Magn Reson Med 2004;51:362-369
47. Wheaton AJ, Borthakur A, Dodge GR, Kneeland JB, Schumacher HR, Reddy R. Sodium magnetic resonance imaging of proteoglycan depletion in an in vivo model of osteoarthritis. Acad Radiol 2004;11:21-28
48. Wheaton AJ, Borthakur A, Shapiro EM, et al. Proteoglycan loss in human knee cartilage: quantitation with sodium MR imaging - feasibility study. Radiology 2004;231:900-905
49. Witschey WR II, Borthakur A, Elliott MA, et al. Artifacts in T1 rho-weighted imaging: compensation for B(1) and B(0) field imperfections. J Magn Reson 2007;186:75-85
50. Witschey WR, Borthakur A, Elliott MA, et al. Compensation for spin-lock artifacts using an off-resonance rotary echo in T1rho off-weighted imaging. Magn Reson Med 2007;57:2-7
51. McKenzie CA, Williams A, Prasad PV, Burstein D. Three-dimensional delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5T and 3.0T. J Magn Reson Imaging 2006;24:928-933
52. Wang L, Schweitzer ME, Padua A, Regatte RR. Rapid 3D-T(1) mapping of cartilage with variable flip angle and parallel imaging at 3.0T. J Magn Reson Imaging 2008;27:154-161
53. Reeder SB, McKenzie CA, Pineda AR, et al. Water-fat separation with IDEAL gradient-echo imaging. J Magn Reson Imaging 2007;25:644-652
54. Reeder SB, Pelc NJ, Alley MT, Gold GE. Rapid MR imaging of articular cartilage with steady-state free precession and multipoint fat-water separation. AJR Am J Roentgenol 2003;180:357-362
55. Shapiro EM, Borthakur A, Gougoutas A, Reddy R. 23Na MRI accurately measures fixed charge density in articular cartilage. Magn Reson Med 2002;47:284-291
56. Mlynarik V, Szomolanyi P, Toffanin R, Vittur F, Trattnig S. Transverse relaxation mechanisms in articular cartilage. J Magn Reson 2004;169:300-307
57. Mlynarik V, Sulzbacher I, Bittsansky M, Fuiko R, Trattnig S. Investigation of apparent diffusion constant as an indicator of early degenerative disease in articular cartilage. J Magn Reson Imaging 2003;17:440-444
58. Mlynarik V, Degrassi A, Toffanin R, Vittur F, Cova M, Pozzi-Mucelli RS. Investigation of laminar appearance of articular cartilage by means of magnetic resonance microscopy. Magn Reson Imaging 1996;14:435-442
59. Xia Y, Farquhar T, Burton-Wurster N, Lust G. Origin of cartilage laminae in MRI. J Magn Reson Imaging 1997;7:887-894
60. Xia Y. Relaxation anisotropy in cartilage by NMR microscopy (μMRI) at 14-μm resolution. Magn Reson Med 1998;39:941-949
61. Xia Y, Moody JB, Alhadlaq H. Orientational dependence of T2 relaxation in articular cartilage: A microscopic MRI (microMRI) study. Magn Reson Med 2002;48:460-469
62. Xia Y, Moody JB, Alhadlaq H, Hu J. Imaging the physical and morphological properties of a multi-zone young articular cartilage at microscopic resolution. J Magn Reson Imaging 2003;17:365-374
63. Bloch F, Hansen WW, Packard M. Nuclear induction. Phys Rev 1946;69:127
64. Blumenkrantz G, Li X, Han ET, et al. A feasibility study of in vivo T1rho imaging of the intervertebral disc. Magn Reson Imaging 2006;24:1001-1007
65. Burstein D. MRI for development of disease-modifying osteoarthritis drugs. NMR Biomed 2006;19:669-680
66. Burstein D, Bashir A, Gray ML. MRI techniques in early stages of cartilage disease. Invest Radiol 2000;35:622-638
67. Kimelman T, Vu A, Storey P, McKenzie C, Burstein D, Prasad P. Three-dimensional T1 mapping for dGEMRIC at 3.0 T using the Look Locker method. Invest Radiol 2006;41:198-203
68. Roos EM, Dahlberg L. Positive effects of moderate exercise on glycosaminoglycan content in knee cartilage: a four-month, randomized, controlled trial in patients at risk of osteoarthritis. Arthritis Rheum 2005;52:3507-3514
69. Williams A, Mikulis B, Krishnan N, Gray M, McKenzie C, Burstein D. Suitability of T(1Gd) as the dGEMRIC index at 1.5T and 3.0T. Magn Reson Med 2007;58:830-834
70. Williams A, Sharma L, McKenzie CA, Prasad PV, Burstein D. Delayed gadolinium-enhanced magnetic resonance imaging of cartilage in knee osteoarthritis: findings at different radiographic stages of disease and relationship to malalignment. Arthritis Rheum 2005;52:3528-3535
71. Lammentausta E, Silvast TS, Narvainen J, Jurvelin JS, Nieminen MT, Grohn OHT. T2, Carr-Purcell T2 and T1rho of fat and water as surrogate markers of trabecular bone structure. Phys Med Biol 2008;53:543-555
72. Lammentausta E, Kiviranta P, Toyras J, et al. Quantitative MRI of parallel changes of articular cartilage and underlying trabecular bone in degeneration. Osteoarthritis Cartilage 2007;15:1149-1157
73. Lammentausta E, Kiviranta P, Nissi MJ, et al. T2 relaxation time and delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) of human patellar cartilage at 1.5 T and 9.4 T: relationships with tissue mechanical properties. J Orthop Res 2006;24:366-374
74. Recht MP, Resnick D. MR imaging of articular cartilage: current status and future directions. AJR Am J Roentgenol 1994;163:283-290
75. Recht MP, Piraino DW, Paletta GA, Schils JP, Belhobek GH. Accuracy of fat-suppressed three-dimensional spoiled gradient-echo FLASH MR imaging in the detection of patellofemoral articular cartilage abnormalities. Radiology 1996;198:209-212
76. Recht MP, Resnick D. Magnetic resonance imaging of articular cartilage: an overview. [Review] [69 refs]Top Magn Reson Imaging 1998;9:328-336
77. Huber M, Trattnig S, Lintner F. Anatomy, biochemistry, and physiology of articular cartilage. Invest Radiol 2000;35:573-580
78. Huster D, Schiller J, Arnold K. Dynamics of collagen in articular cartilage studied by solid-state NMR methods. Methods Mol Med 2004;101:303-318
79. Hodgeson RJ, Carpenter TA, Hall LD. Articular Cartilage and Osteoarthritis. New York: Raven; 1991
80. Venn M, Maroudas A. Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage. I. Chemical composition. Ann Rheum Dis 1977;36:121-129
81. Carney SL, Muir H. The structure and function of cartilage proteoglycans. Physiol Rev 1988;68:858-910
82. Mankin HJ, Brandt KD. Biochemistry and metabolism of articular cartilage in osteoarthritis. In: Moskowitz RW, Howell DS, Goldberg VM, Mankin HJ, eds. Osteoarthritis: Diagnosis and Medical/Surgical Management. Philadelphia, Pa: WB Saunders; 1992:109-154
83. Roughley PJ, Lee ER. Cartilage proteoglycans: structure and potential functions. Microsc Res Tech 1994;28:385-397
84. Moskowitz RW, Howell DS, Goldberg VM, Mankin HJ. Osteoarthritis: Diagnosis and Medical/Surgical Management. Philadelphia, Pa: WB Saunders; 1992:761
85. Xia Y, Farquhar T, Burton-Wurster N, Ray E, Jelinski LW. Diffusion and relaxation mapping of cartilage-bone plugs and excised disks using microscopic magnetic resonance imaging. Magn Reson Med 1994;31:273-282
86. Mosher TJ. Musculoskeletal imaging at 3T: current techniques and future applications. Magn Reson Imaging Clin N Am 2006;14:63-76
87. Mosher TJ, Smith HE, Collins C, et al. Change in knee cartilage T2 at MR imaging after running: a feasibility study. Radiology 2005;234:245-249
88. Mosher TJ, Dardzinski BJ. Cartilage MRI T2 relaxation time mapping: overview and applications. Semin Musculoskelet Radiol 2004;8:355-368
89. Eckstein F, Gavazzeni A, Sittek H, et al. Determination of knee joint cartilage thickness using three- dimensional magnetic resonance chondro-crassometry (3D MR-CCM). Magn Reson Med 1996;36:256-265
90. Eckstein F, Sittek H, Gavazzeni A, et al. Magnetic resonance chondro-crassometry (MR CCM): a method for accurate determination of articular cartilage thickness. Magn Reson Med 1996;35:89-96
91. Eckstein F, Schnier M, Haubner M, et al. Accuracy of cartilage volume and thickness measurements with magnetic resonance imaging. Clin Orthop Relat Res 1998:137-148
92. Eckstein F, Adam C, Sittek H, et al. Non-invasive determination of cartilage thickness throughout joint surfaces using magnetic resonance imaging. J Biomech 1997;30:285-289
93. Eckstein F, Englmeier KH. Quantitative image analysis: software systems in drug development trials. Drug Discov Today 2003;8:922-923
94. Eckstein F, Buck RJ, Wyman BT, et al. Quantitative imaging of cartilage morphology at 3.0 Tesla in the presence of gadopentetate dimeglumine (Gd-DTPA). Magn Reson Med 2007;58:402-406
95. Eckstein F, Kunz M, Hudelmaier M, et al. Impact of coil design on the contrast-to-noise ratio, precision, and consistency of quantitative cartilage morphometry at 3 Tesla: a pilot study for the Osteoarthritis Initiative. Magn Reson Med 2007;57:448-454
96. Waterton JC, Solloway S, Foster JE, et al. Diurnal variation in the femoral articular cartilage of the knee in young adult humans. Magn Reson Med 2000;43:126-132
97. Otterness IG, Eckstein F. Women have thinner cartilage and smaller joint surfaces than men after adjustment for body height and weight. Osteoarthritis Cartilage 2007;15:666-672
98. Wang Y, Ding C, Wluka AE, et al. Factors affecting progression of knee cartilage defects in normal subjects over 2 years. Rheumatology 2006;45:79-84
99. Borthakur A, Mellon E, Niyogi S, Witschey W, Kneeland JB, Reddy R. Sodium and T1rho MRI for molecular and diagnostic imaging of articular cartilage. NMR Biomed 2006;19:781-821
100. Gold GE, McCauley TR, Gray ML, Disler DG. What's new in cartilage?. Radiographics 2003;23:1227-1242
101. Gold GE, Burstein D, Dardzinski B, Lang P, Boada F, Mosher T. MRI of articular cartilage in OA: novel pulse sequences and compositional/functional markers. Osteoarthritis Cartilage 2006;14(suppl A):A76-A86
102. Tiderius C, Hori M, Williams A, et al. dGEMRIC as a function of BMI. Osteoarthritis Cartilage 2006;14:1091-1097
103. Bashir A, Gray ML, Hartke J, Burstein D. Nondestructive imaging of human cartilage glycosaminoglycan concentration by MRI. Magn Reson Med 1999;41:857-865
104. Burstein D, Velyvis J, Scott KT, et al. Protocol issues for delayed Gd(DTPA)2-enhanced MRI (dGEMRIC) for clinical evaluation of articular cartilage. Magn Reson Med 2001;45:36-41
105. Todd DJ, Kagan A, Chibnik LB, Kay J. Cutaneous changes of nephrogenic systemic fibrosis: predictor of early mortality and association with gadolinium exposure. [see comment]. Arthritis Rheum 2007;56:3433-3441
106. Ersoy H, Rybicki FJ. Biochemical safety profiles of gadolinium-based extracellular contrast agents and nephrogenic systemic fibrosis. J Magn Reson Imaging 2007;26:1190-1197
107. Shapiro EM, Borthakur A, Kaufman JH, Leigh JS, Reddy R. Water distribution patterns inside bovine articular cartilage as visualized by 1H magnetic resonance imaging. Osteoarthritis Cartilage 2001;9:533-538
108. Lusse S, Claassen H, Gehrke T, et al. Evaluation of water content by spatially resolved transverse relaxation times of human articular cartilage. Magn Reson Imaging 2000;18:423-430
109. Lehner KB, Rechl HP, Gmeinwieser JK, Heuck AF, Lukas HP, Kohl HP. Structure, function, and degeneration of bovine hyaline cartilage: assessment with MR imaging in vitro. Radiology 1989;170:495-499
110. Nieminen MT, Rieppo J, Toyras J, et al. T2 relaxation reveals spatial collagen architecture in articular cartilage: a comparative quantitative MRI and polarized light microscopic study. Magn Reson Med 2001;46:487-493
111. Nieminen MT, Toyras J, Laasanen MS, Silvennoinen J, Helminen HJ, Jurvelin JS. Prediction of biomechanical properties of articular cartilage with quantitative magnetic resonance imaging. J Biomech 2004;37:321-328
112. Nieminen MT, Toyras J, Rieppo J, et al. Quantitative MR microscopy of enzymatically degraded articular cartilage. Magn Reson Med 2000;43:676-681
113. Goodwin DW, Zhu H, Dunn JF. In vitro MR imaging of hyaline cartilage: correlation with scanning electron microscopy. AJR Am J Roentgenol 2000;174:405-409
114. Dunn TC, Lu Y, Jin H, Ries MD, Majumdar S. T2 relaxation time of cartilage at MR imaging: comparison with severity of knee osteoarthritis. Radiology 2004;232:592-598
115. Glaser C, Horng A, Mendlik T, et al. T2 relaxation time in patellar cartilage - global and regional reproducibility at 1.5 Tesla and 3 Tesla. Rofo 2007;179:146-152
116. Glaser C, Mendlik T, Dinges J, et al. Global and regional reproducibility of T2 relaxation time measurements in human patellar cartilage. Magn Reson Med 2006;56:527-534
117. Mosher TJ, Liu Y, Yang QX, et al. Age dependency of cartilage magnetic resonance imaging T2 relaxation times in asymptomatic women. Arthritis Rheum 2004;50:2820-2828
118. Gold GE, Hargreaves BA, Stevens KJ, Beaulieu CF. Advanced magnetic resonance imaging of articular cartilage. Orthop Clin North Am 2006;37:331-347vi
119. Nieminen MT, Menezes NM, Williams A, Burstein D. T2 of articular cartilage in the presence of Gd-DTPA2. Magn Reson Med 2004;51:1147-1152
120. Regatte RR, Akella SV, Borthakur A, Kneeland JB, Reddy R. Proteoglycan depletion-induced changes in transverse relaxation maps of cartilage: comparison of T2 and T1rho. Acad Radiol 2002;9:1388-1394
121. Filidoro L, Dietrich O, Weber J, et al. High-resolution diffusion tensor imaging of human patellar cartilage: feasibility and preliminary findings. Magn Reson Med 2005;53:993-998
122. Deng X, Farley M, Nieminen MT, Gray M, Burstein D. Diffusion tensor imaging of native and degenerated human articular cartilage. Magn Reson Imaging 2007;25:168-171
123. Miller KL, Hargreaves BA, Gold GE, Pauly JM. Steady-state diffusion-weighted imaging of in vivo knee cartilage. Magn Reson Med 2004;51:394-398
124. Glaser C. New techniques for cartilage imaging: T2 relaxation time and diffusion-weighted MR imaging. Radiol Clin North Am 2005;43:641-653
125. Redfield AG. Nuclear magnetic resonance saturation and rotary saturation in solids. Phys Rev 1955;98:1787
126. Santyr GE, Henkelman RM, Bronskill MJ. Spin locking for magnetic resonance imaging with application to human breast. Magn Reson Med 1989;12:25-37
127. Santyr GE, Fairbanks EJ, Kelcz F, Sorenson JA. Off-resonance spin locking for MR imaging. Magn Reson Med 1994;32:43-51
128. Akella SV, Regatte RR, Gougoutas AJ, Borthakur A, Shapiro EM, Kneeland JB, et al. Proteoglycan-induced changes in T1rho-relaxation of articular cartilage at 4T. 2001;46(3):419-423
129. Regatte RR, Akella SV, Lonner JH, Kneeland JB, Reddy R. T1rho relaxation mapping in human osteoarthritis (OA) cartilage: comparison of T1rho with T2. J Magn Reson Imaging 2006;23:547-553
130. Hilal SK, Maudsley AA, Ra JB, et al. In vivo NMR imaging of sodium-23 in the human head. J Comput Assist Tomogr 1985;9:1-7
131. Maudsley AA, Hilal SK. Biological aspects of sodium-23 imaging. Br Med Bull 1984;40:165-166
132. Garner WH, Hilal SK, Lee SW, Spector A. Sodium-23 magnetic resonance imaging of the eye and lens. Proc Natl Acad Sci U S A 1986;83:1901-1905
133. Ra JB, Hilal SK, Oh CH, Mun IK. In vivo magnetic resonance imaging of sodium in the human body. Magn Reson Med 1988;7:11-22
134. Springer CS. Biological systems: spin-3/2 nuclei. In: Grant DM, Harris RK, eds. Encyclopedia of Nuclear Magnetic Resonance. New York: John Wiley; 1996:940-951
135. Reddy R, Li SC, Noyszewski EA, Kneeland JB, Leigh JS. In vivo sodium multiple quantum spectroscopy of human articular cartilage. Magn Reson Med 1997;38:207-214
136. Reddy R, Shinnar M, Wang Z, Leigh JS. Multiple-quantum filters of spin-3/2 with pulses of arbitrary flip angle. J Magn Reson B 1994;104:148-152
137. Ling W, Regatte RR, Schweitzer ME, Jerschow A. Behavior of ordered sodium in enzymatically depleted cartilage tissue. Magn Reson Med 2006;56:1151-1155
138. Navon G, Werrmann JG, Maron R, Cohen SM. 31P NMR and triple quantum filtered 23Na NMR studies of the effects of inhibition of Na+/H+ exchange on intracellular sodium and pH in working and ischemic hearts. Magn Reson Med 1994;32:556-564
139. Wheaton AJ, Casey FL, Gougoutas AJ, et al. Correlation of T1rho with fixed charge density in cartilage. J Magn Reson Imaging 2004;20:519-525
140. 23Na MRI and MRS. J Magn Reson 2000;142:24-31
141. Borthakur A, Mellon E, Niyogi S, Witschey W, Kneeland JB, Reddy R. Sodium and T1rho MRI for molecular and diagnostic imaging of articular cartilage. NMR Biomed 2006;19:781-821
142. Borthakur A, Shapiro EM, Beers J, Kudchodkar S, Kneeland JB, Reddy R. Sensitivity of MRI to proteoglycan depletion in cartilage: comparison of sodium and proton MRI. Osteoarthritis Cartilage 2000;8:288-293
143. Guivel-Scharen V, Sinnwell T, Wolff SD, Balaban RS. Detection of proton chemical exchange between metabolites and water in biological tissues. J Magn Reson 1998;133:36-45
144. Ward KM, Aletras AH, Balaban RS. A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST). J Magn Reson 2000;143:79-87
145. Ward KM, Balaban RS. Determination of pH using water protons and chemical exchange dependent saturation transfer (CEST). Magn Reson Med 2000;44:799-802
146. Zhou J, Lal B, Wilson DA, Laterra J, van Zijl PC. Amide proton transfer (APT) contrast for imaging of brain tumors. Magn Reson Med 2003;50:1120-1126
147. Zhou J, Wilson DA, Sun PZ, Klaus JA, Van Zijl PC. Quantitative description of proton exchange processes between water and endogenous and exogenous agents for WEX, CEST, and APT experiments. Magn Reson Med 2004;51:945-952
148. Zhou J, Payen JF, Wilson DA, Traystman RJ, van Zijl PC. Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI. Nat Med 2003;9:1085-1090
149. Henkelman RM, Stanisz GJ, Graham SJ. Magnetization transfer in MRI: a review. NMR Biomed 2001;14:57-64
150. Henkelman RM, Huang X, Xiang QS, Stanisz GJ, Swanson SD, Bronskill MJ. Quantitative interpretation of magnetization transfer. Magn Reson Med 1993;29:759-766
151. Wolff SD, Balaban RS. Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo. Magn Reson Med 1989;10:135-144