Alternate arrangement of PpL B3 domain and SpA D domain creates synergistic double-site binding to VH3 and Vκ regions of Fab

DNA and Cell Biology

Volumn 27, Issue 8, 2008, Pages 423-431

  Jiang, Shaohua H ^a   Wang, Jufang F ^b   Xu, Rong ^a   Liu, Yanjun J ^c   Wang, Xiaoning N ^b   Cao, Jie ^a   Zhao, Ping ^a   Shen, Yijun J ^c   Yang, Tong ^c   Yang, Hua ^a   Jia, Jiaan A ^a   Chen, Qiuli L ^a   Pan, Wei ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

^c Shanghai Fudan Zhangjiang Bio pharmaceutical Co Ltd   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN M; PROTEIN PPL; PROTEIN SPA; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; IMMUNOGLOBULIN KAPPA CHAIN; L PROTEIN, PEPTOCOCCUS MAGNUS; L-PROTEIN, PEPTOCOCCUS MAGNUS; STAPHYLOCOCCUS PROTEIN A;

ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; COMPUTER MODEL; CONTROLLED STUDY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; ANTIBODY COMBINING SITE; CHEMISTRY; COMPUTER SIMULATION; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; WESTERN BLOTTING;

FINEGOLDIA MAGNA;

BACTERIAL PROTEINS; BINDING SITES, ANTIBODY; BLOTTING, WESTERN; COMPUTER SIMULATION; DNA-BINDING PROTEINS; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STAPHYLOCOCCAL PROTEIN A;

EID: 51649123560     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/dna.2007.0708     Document Type: Article

References (28)

1. Björck, L., and Kronvall, G. (1984). Purification and some properties of streptococcal protein G, a novel IgG-binding reagent. J Immunol 133, 969-974.
2. Eigenbrot, C., Randal, M., Presta, L., Carter, P., and Kossiakoff, A.A. (1993). X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling. J Mol Biol 229, 969-995.
3. Goodyear, C.S., Narita, M., and Silverman, G.J. (2004). In vivo VL-targeted activation-induced apoptotic supraclonal deletion by a microbial B cell toxin. J Immunol 172, 2870-2877.
4. Goodyear, C.S., and Silverman, G.J. (2005). B cell superantigens: a microbe's answer to innate-like B cells and natural antibodies. Springer Semin Immunopathol 26, 463-484.
5. Graille, M., Stura, E.A., Corper, A.L., Sutton, B.J., Taussig, M.J., Charbonnier, J.B., and Silverman, G.J. (2000). Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: structural basis for recognition of B-cell receptors and superantigen activity. Proc Natl Acad Sci USA 97, 5399-5404.
6. Graille, M., Stura, E.A., Housden, N.G., Beckingham, J.A., Bottomley, S.P., Beale, D., Taussig, M.J., Sutton, B.J., Gore, M.G., and Charbonnier, J.B. (2001). Complex between Finegoldia magna protein L and a human antibody reveals structural convergence in the interaction modes of Fab binding proteins. Structure 9, 679-687.
7. Guss, B., Eliasson, M., Olsson, A., Uhlén, M., Frej, A.K., Jörnvall, H., Flock, J.I., and Lindberg, M. (1986). Structure of the IgG-binding regions of streptococcal protein G. EMBO J 5, 1567-1575.
8. 2ε protein A interactions. Scand J Immunol 13, 343-352.
9. 2 fragment of human IgG. Scand J Immunol 12, 23-31.
10. Jansson, B., Uhlén, M., and Nygren, P.A. (1998). All individual domains of staphylococcal protein A show Fab binding. FEMS Immunol Med Microbiol 20, 69-78.
11. Kastern, W., Holst, E., Nielsen, E., Sjöbring, U., and Björck, L. (1990). Protein L, a bacterial immunoglobulin-binding protein and possible virulence determinant. Infect Immun 58, 1217-1222.
12. Kihlberg, B.M., Sjöbring, U., Kastern, W., and Björck, L. (1992). Protein LG: a hybrid molecule with unique immunoglobulin binding properties. J Biol Chem 267, 25583-25588.
13. Menez, R., Housden, N.G., Harrison, S., Jolivet-Reynaud, C., Gore, M.G., and Stura, E.A. (2005). Different crystal packing in Fab-protein L semi-disordered peptide complex. Acta Crystallogr D 61, 744-749.
14. Murdoch, D.A., and Shah, H.N. (1999). "Reclassification of Peptostreptococcus magnus (Prevot 1933) Holdeman and Moore 1972 as Finegoldia magna comb. nov. and Peptostreptococcus micros (Prevot 1933) Smith 1957 as Micromonas micros comb. nov." Anaerobe 5, 555-559.
15. Nilson, B.H.K., Solomon, A., Björck, L., and Akerström, B. (1992). Protein L from Finegoldia magna binds to the kappa light chain variable domain. J Biol Chem 267, 2234-2239.
16. Romagnani, S., Giudizi, M.G., del. Prete, G., Maggi, E., Biagiotti, R., Almerigogna, F., and Ricci, M. (1982). Demonstration on protein A of two distinct immunoglobulin-binding sites and their role in the mitogenic activity of Staphylococcus aureus Cowan I on human B cells. J Immunol 129, 596-602.
17. Röthlisberger, D., Honegger, A., and Plückthun, A. (2005). Domain interactions in the Fab fragment: a comparative evaluation of the single-chain Fv and Fab format engineered with variable domains of different stability. J Mol Biol 347, 773-789.
18. Sasso, E.H., Silverman, G.J., and Mannik, M. (1989). Human IgM molecules that bind staphylococcal protein A contain VHIII H chains. J Immunol 142, 2778-2783.
19. Sasso, E.H., Silverman, G.J., and Mannik, M. (1991). Human IgA and IgG F(ab′)2 that bind to staphylococcal protein A belong to the VHIII subgroup. J Immunol 147, 1877-1883.
20. Schier, R., Marks, J.D., Wolf, E.J., Apell, G., Wong, C., McCartney, J.E., Bookman, M.A., Huston, J.S., Houston, L.L., and Weiner, L.M. (1995). In vitro and in vivo characterization of a human anti-c-erbB-2 single-chain Fv isolated from a filamentous phage antibody library. Immunotechnology 1, 73-81.
21. Sjödahl, J. (1977). Repetitive sequences in protein A from Staphylococcus aureus. Arrangement of five regions within the protein, four being highly homologous and Fc-binding. Eur J Biochem 73, 343-351.
22. Stone, G.C., Sjöbring, U., Björck, L., Sjöquist, J., Barber, C.V., and Nardella, F.A. (1989). The Fc binding site for streptococcal protein G is in the Cγ2-Cγ3 interface region of IgG and is related to the sites that bind staphylococcal protein A and human rheumatoid factors. J Immunol 143, 565-570.
23. Svensson, H.G., Hoogenboom, H.R., and Sjöbring, U. (1998). Protein LA, a novel hybrid protein with unique single-chain Fv antibody- and Fab-binding properties. Eur J Biochem 258, 890-896.
24. Uhlén, M., Guss, B., Nilsson, B., Gatenbeck, S., Philipson, L., and Lindberg, M. (1984). Complete sequence of the staphylococcal gene encoding protein A. A gene evolved through multiple duplications. J Biol Chem 259, 1695-1702.
25. VandenBrink, E.N., Bril, W.S., Turenhout, E.A., Zuurveld, M., Bovenschen, N., Peters, M., Yee, T.T., Mertens, K., Lewis, D.A., Ortel, T.L., Lollar, P., Scandella, D., and Voorberg, J. (2001). Multiple VH genes are used to assemble human antibodies directed toward the A3-C1 domains of factor VIII. Blood 97, 966-972.
26. Wikström, M., Forsén, S., and Drakenberg, T. (1996). Backbone dynamics of a domain of protein L which binds to immunoglobulin light chains. Eur J Biochem 235, 543-548.
27. Xu, R., Shen, Y.J., Deng, S.H., Cai, C.X., Chen, Q.L., Jia, J.A., Wang, J.H., Pan, X., and Pan, W. (2005). Affinity selection of randomly-rearranged molecular library of mono Ig-binding domains of protein A and protein L. Prog Biochem Biophys 32, 535-543.
28. Zdanov, A., Li, Y., Bundle, D.R., Deng, S.J., MacKenzie, C.R., Narang, S.A., Young, N.M., and Cygler, M. (1994). Structure of a single-chain antibody variable domain (Fv) fragment complexed with a carbohydrate antigen at 1.7-A resolution. Proc Natl Acad Sci USA 91, 6423-6427.