Interaction of coenzyme Q10 with the intestinal drug transporter P-glycoprotein

Journal of Agricultural and Food Chemistry

Volumn 56, Issue 16, 2008, Pages 6923-6927

  Itagaki, Shirou ^a   Ochiai, Akiko ^a   Kobayashi, Masaki ^a   Sugawara, Mitsuru ^b   Hirano, Takeshi ^a   Iseki, Ken ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Caco 2; Coenzyme; Intestine; P glycoprotein; Transporter

Indexed keywords

DIGOXIN; DRUG DERIVATIVE; GLYCOPROTEIN P; QUINIDINE; RHODAMINE 123; UBIDECARENONE; UBIQUINONE; VITAMIN;

ARTICLE; CELL STRAIN CACO 2; DRUG EFFECT; DRUG INTERACTION; HUMAN; INTESTINE; METABOLISM; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

BIOLOGICAL TRANSPORT; CACO-2 CELLS; DIGOXIN; DRUG INTERACTIONS; HUMANS; INTESTINES; P-GLYCOPROTEIN; QUINIDINE; RHODAMINE 123; UBIQUINONE; VITAMINS;

EID: 51649115382     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf800992p     Document Type: Article

References (28)

1. Ernster, L.; Forsmark, P.; Nordenbrand, K. The mode of action of lipid-soluble antioxidants in biological membranes: relationship between the effects of ubiquinol and vitamin E as inhibitors of lipid peroxidation in submitochondrial particles. Biofactors 1992, 3, 241-248.
2. Forsmark, P.; Aberg, F.; Norling, B.; Nordenbrand, K.; Dallner, G.; Ernster, L. Inhibition of lipid peroxidation by ubiquinol in submitochondrial particles in the absence of vitamin E. FEBS Lett. 1991, 285, 39-43.
3. Stocker, R.; Bowry, V. W.; Frei, B. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc. Natl. Acad. Sci. U.S.A. 1991, 88, 1646-1650.
4. Kalen, A.; Appelkvist, E. L.; Dallner, G. Age-related changes in the lipid compositions of rat and human tissues. Lipids 1989, 24, 579-584.
5. Overvad, K.; Diamant, B.; Holm, L.; Holmer, G.; Mortensen, S. A.; Stender, S. Coenzyme Q10 in health and disease. Eur. J. Clin. Nutr. 1999, 53, 764-770.
6. Langsjoen, P. H.; Langsjoen, A. M. Overview of the use of CoQ10 in cardiovascular disease. Biofactors 1999, 9, 273-284.
7. Greenberg, S.; Frishman, W. H. Co-enzyme Q10: a new drug for cardiovascular disease. J. Clin. Pharmacol. 1990, 30, 596-608.
8. Hodgson, J. M.; Watts, G. F.; Playford, D. A.; Burke, V.; Croft, K. D. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur. J. Clin. Nutr. 2002, 56, 1137-1142.
9. Roffe, L.; Schmidt, K.; Ernst, E. Efficacy of coenzyme Q10 for improved tolerability of cancer treatments: a systematic review. J. Clin. Oncol. 2004, 22, 4418-4424.
10. Hauss, D. J.; Fogal, S. E.; Ficorilli, J. V.; Price, C. A.; Roy, T.; Jayaraj, A. A.; Keirns, J. J. Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly water-soluble LTB4 inhibitor. J. Pharm. Sci. 1998, 87, 164-169.
11. Erkko, P.; Granlund, H.; Nuutinen, M.; Reitamo, S. Comparison of cyclosporin A pharmacokinetics of a new microemulsion formulation and standard oral preparation in patients with psoriasis. Br. J. Dermatol 1997, 136, 82-88.
12. Ochiai, A.; Itagaki, S.; Kurokawa, T.; Kobayashi, M.; Hirano, T.; Iseki, K. Improvement in intestinal coenzyme q10 absorption by food intake. Yakugaku Zasshi 2007, 127, 1251-1254.
13. Terao, T.; Hisanaga, E.; Sai, Y.; Tamai, I.; Tsuji, A. Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier. J. Pharm. Pharmacol. 1996, 48, 1083-1089.
14. Tamai, I.; Saheki, A.; Saitoh, R.; Sai, Y.; Yamada, I.; Tsuji, A. Nonlinear intestinal absorption of 5-hydroxytryptamine receptor antagonist caused by absorptive and secretory transporters. J. Pharmacol. Exp. Ther. 1997, 283, 108-115.
15. Suzuki, H.; Sugiyama, Y. Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine. Eur. J. Pharm. Sci 2000, 12, 3-12.
16. Elbling, L.; Berger, W.; Weiss, R. M.; Printz, D.; Fritsch, G.; Micksche, M. A novel bioassay for P-glycoprotein functionality using cytochalasin D. Cytometry 1998, 31, 187-198.
17. Hidalgo, I. J.; Raub, T. J.; Borchardt, R. T. Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 1989, 96, 736-749.
18. Itagaki, S.; Kobayashi, Y.; Otsuka, Y.; Kubo, S.; Kobayashi, M.; Hirano, T.; Iseki, K. Food-drug interaction between ferulic acid and nateglinide involving the fluorescein/H+ cotransport system. J. Agric. Food Chem. 2005, 53, 2499-2502.
19. Saito, Y.; Itagaki, S.; Otsuka, Y.; Kobayashi, Y.; Okumura, H.; Kobayashi, M.; Hirano, T.; Iseki, K. Substrate specificity of the nateglinide/H(+) cotransport system for phenolic acids. J. Agric. Food Chem. 2005, 53, 6100-6104.
20. Peters, W. H.; Roelofs, H. M. Biochemical characterization of resistance to mitoxantrone and adriamycin in Caco-2 human colon adenocarcinoma cells: a possible role for glutathione S-transferases. Cancer Res. 1992, 52, 1886-1890.
21. Yoo, H. H.; Lee, M.; Chung, H. J.; Lee, S. K.; Kim, D. H. Effects of diosmin, a flavonoid glycoside in citrus fruits, on P-glycoprotein-mediated drug efflux in human intestinal Caco-2 cells. J. Agric. Food Chem. 2007, 55, 7620-7625.
22. Goto, Y.; Itagaki, S.; Umeda, S.; Kobayashi, M.; Hirano, T.; Iseki, K.; Tadano, K. Transepithelial transport of telmisartan in caco-2 monolayers. Biol. Pharm. Bull. 2005, 28, 2235-2239.
23. Kimoto, E.; Seki, S.; Itagaki, S.; Matsuura, M.; Kobayashi, M.; Hirano, T.; Goto, Y.; Tadano, K.; Iseki, K. Efflux transport of N-monodesethylamiodarone by the human intestinal cell-line Caco-2 cells. Drug Metab. Pharmacokinet. 2007, 22, 307-312.
24. Lowry, O. H.; Rosebrough, N. J.; Farr, A. L.; Randall, R. J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 1951, 193, 265-275.
25. Terlouw, S.; Masereeuw, R.; vandenBroek, P. H.; Notenboom, S.; Russel, F. G. M. Role of multidrug resistance protein 2 (MRP2) in glutathione-bimane efflux from Caco-2 and rat renal proximal tubule cells. Br. J. Pharmacol. 2001, 134, 931-938.
26. Catalioto, R. M.; Triolo, A.; Giuliani, S.; Altamura, M.; Evangelista, S.; Maggi, C. A. Increased paracellular absorption by bile salts and P-glycoprotein stimulated efflux of otilonium bromide in Caco-2 cells monolayers as a model of intestinal arrier. J. Pharm. Sci., in press.
27. Korjamo, T.; Mönkkönen, J.; Uusitalo, J.; Turpeinen, M.; Pelkonen, O.; Honkakoski, P. Metabolic and efflux properties of Caco-2 cells stably transfected with nuclear receptors. Pharm. Res. 2006, 23, 1991-2001.
28. Tanigawara, Y.; Okamura, N.; Hirai, M.; Yasuhara, M.; Ueda, K.; Kioka, N.; Romano, T.; Hori, R. Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1). J. Pharmacol. Exp. Ther. 1992, 263, 840-845.