-
1
-
-
0033382831
-
Otilonium bromide: A selective spasmolytic for the gastrointestinal tract
-
Evangelista S. 1999. Otilonium bromide: A selective spasmolytic for the gastrointestinal tract. J Int Med Res 27:207-222.
-
(1999)
J Int Med Res
, vol.27
, pp. 207-222
-
-
Evangelista, S.1
-
2
-
-
0031663620
-
Otilonium bromide in irritable bowel syndrome: A double-blind, placebo-controlled, 15-week study
-
Battaglia G, Morselli-Labate AM, Camarri E, Francavilla A, De Marco F, Mastropaolo G, Naccarato R. 1998. Otilonium bromide in irritable bowel syndrome: A double-blind, placebo-controlled, 15-week study. Aliment Pharmacol Ther 12:1003-1010.
-
(1998)
Aliment Pharmacol Ther
, vol.12
, pp. 1003-1010
-
-
Battaglia, G.1
Morselli-Labate, A.M.2
Camarri, E.3
Francavilla, A.4
De Marco, F.5
Mastropaolo, G.6
Naccarato, R.7
-
3
-
-
0036932020
-
Extended analysis of a double-blind, placebo-controlled, 15-week study with otilonium bromide in irritable bowel syndrome
-
Glende M, Morselli-Labate AM, Battaglia G, Evangelista S. 2002. Extended analysis of a double-blind, placebo-controlled, 15-week study with otilonium bromide in irritable bowel syndrome. Eur J Gastroenterol Hepatol 14:1331-1338.
-
(2002)
Eur J Gastroenterol Hepatol
, vol.14
, pp. 1331-1338
-
-
Glende, M.1
Morselli-Labate, A.M.2
Battaglia, G.3
Evangelista, S.4
-
4
-
-
0020518528
-
Octylonium bromide: A smooth muscle relaxant which interferes with calcium ions mobilisation
-
Maggi CA, Manzini S, Meli A. 1983. Octylonium bromide: A smooth muscle relaxant which interferes with calcium ions mobilisation. Arch Intern Pharmacodyn Ther 264:305-323.
-
(1983)
Arch Intern Pharmacodyn Ther
, vol.264
, pp. 305-323
-
-
Maggi, C.A.1
Manzini, S.2
Meli, A.3
-
5
-
-
0022243751
-
Regional selectivity of calcium blockers at intestinal level
-
Maggi CA, Manzini S, Meli A. 1985. Regional selectivity of calcium blockers at intestinal level. Arch Int Pharmacodyn Ther 276:202-221.
-
(1985)
Arch Int Pharmacodyn Ther
, vol.276
, pp. 202-221
-
-
Maggi, C.A.1
Manzini, S.2
Meli, A.3
-
7
-
-
0032146268
-
Receptor binding profile of otilonium bromide
-
Evangelista S, Giachetti A, Chapelain B, Neliat G, Maggi CA. 1998. Receptor binding profile of otilonium bromide. Pharmacol Res 38:111-118.
-
(1998)
Pharmacol Res
, vol.38
, pp. 111-118
-
-
Evangelista, S.1
Giachetti, A.2
Chapelain, B.3
Neliat, G.4
Maggi, C.A.5
-
9
-
-
2342484968
-
Otilonium bromide inhibits calcium entry through L-type calcium channels in human intestinal smooth muscle
-
Strege PR, Evangelista S, Lyford GL, Sarr MG, Farrugia G. 2004. Otilonium bromide inhibits calcium entry through L-type calcium channels in human intestinal smooth muscle. Neurogastroenterol Motil 16:167-173.
-
(2004)
Neurogastroenterol Motil
, vol.16
, pp. 167-173
-
-
Strege, P.R.1
Evangelista, S.2
Lyford, G.L.3
Sarr, M.G.4
Farrugia, G.5
-
10
-
-
0036900395
-
The colon-selective spasmolytic otilonium bromide inhibits muscarinic M3 receptor-coupled calcium signals in isolated human colonic crypts
-
Lindqvist S, Hernon J, Sharp P, Johns N, Addison S, Watson M, Tighe R, Greer S, Mackay J, Rhodes M, Lewis M, Stebbings W, Speakman C, Evangelista S, Johnson I, Williams M. 2002. The colon-selective spasmolytic otilonium bromide inhibits muscarinic M3 receptor-coupled calcium signals in isolated human colonic crypts. Br J Pharmacol 137:1134-1142.
-
(2002)
Br J Pharmacol
, vol.137
, pp. 1134-1142
-
-
Lindqvist, S.1
Hernon, J.2
Sharp, P.3
Johns, N.4
Addison, S.5
Watson, M.6
Tighe, R.7
Greer, S.8
Mackay, J.9
Rhodes, M.10
Lewis, M.11
Stebbings, W.12
Speakman, C.13
Evangelista, S.14
Johnson, I.15
Williams, M.16
-
11
-
-
0030794522
-
The clinical pharmacology of single doses of otilonium bromide in healthy volunteers
-
Sutton JA, Kilminster SG, Mould GP. 1997. The clinical pharmacology of single doses of otilonium bromide in healthy volunteers. Eur J Clin Pharmacol 52:365-369.
-
(1997)
Eur J Clin Pharmacol
, vol.52
, pp. 365-369
-
-
Sutton, J.A.1
Kilminster, S.G.2
Mould, G.P.3
-
12
-
-
0021236425
-
A study of the absorption of otilonium bromide following oral administration in man
-
Signorini C, Tosoni S, Ballerini R, Chinol M, Mannucci C. 1984. A study of the absorption of otilonium bromide following oral administration in man. Drugs Exp Clin Res 10:273-276.
-
(1984)
Drugs Exp Clin Res
, vol.10
, pp. 273-276
-
-
Signorini, C.1
Tosoni, S.2
Ballerini, R.3
Chinol, M.4
Mannucci, C.5
-
13
-
-
0025815653
-
Autoradiographic localization of octylonium bromide binding sites in the rat gastrointestinal tract
-
Amenta F, Baroldi P, Ferrante F, Napoleone P, Meli A. 1991. Autoradiographic localization of octylonium bromide binding sites in the rat gastrointestinal tract. Arch Int Pharmacodyn Ther 311: 5-19.
-
(1991)
Arch Int Pharmacodyn Ther
, vol.311
, pp. 5-19
-
-
Amenta, F.1
Baroldi, P.2
Ferrante, F.3
Napoleone, P.4
Meli, A.5
-
15
-
-
0344665555
-
ABC of oral bioavailability: Transporters as gate-keepers in the gut
-
Dietrich CG, Geier A, Oude Elferink RPJ. 2003. ABC of oral bioavailability: Transporters as gate-keepers in the gut. Gut 52:1788-1795.
-
(2003)
Gut
, vol.52
, pp. 1788-1795
-
-
Dietrich, C.G.1
Geier, A.2
Oude Elferink, R.P.J.3
-
16
-
-
0035286778
-
Caco-2 monolayers in experimental and theoretical predictions of drug transport
-
Artursson P, Palm K, Luthman K. 2001. Caco-2 monolayers in experimental and theoretical predictions of drug transport. Adv Drug Deliv Rev 46:27-43.
-
(2001)
Adv Drug Deliv Rev
, vol.46
, pp. 27-43
-
-
Artursson, P.1
Palm, K.2
Luthman, K.3
-
17
-
-
0021067619
-
Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture
-
Pinto M, Leon-Robine S, Appay MD, Kedinger M, Triadou N, Dussaulx E, Lacroix B, Assmann-Simon P, Haffen K, Fogh J, Zweibaum A. 1983. Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture. Biol Cell 47:323-330.
-
(1983)
Biol Cell
, vol.47
, pp. 323-330
-
-
Pinto, M.1
Leon-Robine, S.2
Appay, M.D.3
Kedinger, M.4
Triadou, N.5
Dussaulx, E.6
Lacroix, B.7
Assmann-Simon, P.8
Haffen, K.9
Fogh, J.10
Zweibaum, A.11
-
18
-
-
0022509516
-
The human colon carcinoma cell lines HT-29 and Caco-2: Two in vitro models for study of intestinal differentiation
-
Rousset M. 1986. The human colon carcinoma cell lines HT-29 and Caco-2: Two in vitro models for study of intestinal differentiation. Biochimie 68: 1035-1040.
-
(1986)
Biochimie
, vol.68
, pp. 1035-1040
-
-
Rousset, M.1
-
19
-
-
0024593744
-
Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability
-
Hidalgo IJ, Raub TJ, Borchardt RT. 1989. Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 96:736-749.
-
(1989)
Gastroenterology
, vol.96
, pp. 736-749
-
-
Hidalgo, I.J.1
Raub, T.J.2
Borchardt, R.T.3
-
20
-
-
0025804183
-
Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
-
Artursson P, Karlsson J. 1991. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem Biophys Res Commun 175:880-885.
-
(1991)
Biochem Biophys Res Commun
, vol.175
, pp. 880-885
-
-
Artursson, P.1
Karlsson, J.2
-
21
-
-
0030023536
-
Comparison between active and passive drug transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo
-
Lennernas H, Palm K, Fagerholm U, Artursson P. 1996. Comparison between active and passive drug transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo. Int J Pharm 127:103-107.
-
(1996)
Int J Pharm
, vol.127
, pp. 103-107
-
-
Lennernas, H.1
Palm, K.2
Fagerholm, U.3
Artursson, P.4
-
22
-
-
0030990079
-
In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man: Fact or myth?
-
Yee S. 1997. In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man: Fact or myth? Pharm Res 14: 763-766.
-
(1997)
Pharm Res
, vol.14
, pp. 763-766
-
-
Yee, S.1
-
23
-
-
0037108931
-
Simultaneous LC-MS/MS determination of reference pharmaceuticals as a method for the characterization of the Caco-2 cell monolayer absorption properties
-
Larger P, Altamura M, Catalioto R-M, Giuliani S, Maggi CA, Valenti C, Triolo A. 2002. Simultaneous LC-MS/MS determination of reference pharmaceuticals as a method for the characterization of the Caco-2 cell monolayer absorption properties. Anal Chem 74:5273-5281.
-
(2002)
Anal Chem
, vol.74
, pp. 5273-5281
-
-
Larger, P.1
Altamura, M.2
Catalioto, R.-M.3
Giuliani, S.4
Maggi, C.A.5
Valenti, C.6
Triolo, A.7
-
24
-
-
0021139131
-
Fluorimetric determination of critical micelle concentration avoiding interference from detergent charge
-
Chattopadhyay A, London E. 1984. Fluorimetric determination of critical micelle concentration avoiding interference from detergent charge. Anal Biochem 139:408-412.
-
(1984)
Anal Biochem
, vol.139
, pp. 408-412
-
-
Chattopadhyay, A.1
London, E.2
-
25
-
-
5744241657
-
Quaternary ammonium derivatives as spasmolytics for irritable bowel syndrome
-
Evangelista S. 2004. Quaternary ammonium derivatives as spasmolytics for irritable bowel syndrome. Curr Pharm Des 10:3561-3568.
-
(2004)
Curr Pharm Des
, vol.10
, pp. 3561-3568
-
-
Evangelista, S.1
-
26
-
-
0027180795
-
Drug absorption limited by P-glycoprotein mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers
-
Hunter J, Hirst BH, Simmons NL. 1993. Drug absorption limited by P-glycoprotein mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers. Pharm Res 10:743-749.
-
(1993)
Pharm Res
, vol.10
, pp. 743-749
-
-
Hunter, J.1
Hirst, B.H.2
Simmons, N.L.3
-
28
-
-
0029986277
-
Relevance of P-glycoprotein for the enteral absorption of cyclosporin A: In vitro-in vivo correlation
-
Fricker G, Drewe J, Huwyler J, Gutmann H, Beglinger C. 1996. Relevance of P-glycoprotein for the enteral absorption of cyclosporin A: In vitro-in vivo correlation. Br J Pharmacol 118: 1841-1847.
-
(1996)
Br J Pharmacol
, vol.118
, pp. 1841-1847
-
-
Fricker, G.1
Drewe, J.2
Huwyler, J.3
Gutmann, H.4
Beglinger, C.5
-
29
-
-
0142010611
-
P-glycoprotein increases from proximal to distal regions of human small intestine
-
Mouly S, Paine MF. 2003. P-glycoprotein increases from proximal to distal regions of human small intestine. Pharm Res 20:1595-1599.
-
(2003)
Pharm Res
, vol.20
, pp. 1595-1599
-
-
Mouly, S.1
Paine, M.F.2
-
30
-
-
4243091738
-
Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring
-
Englund G, Hallberg P, Artursson P, Michaëlsson K, Melhus H. 2004. Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring. BMC Med 2:8.
-
(2004)
BMC Med
, vol.2
, pp. 8
-
-
Englund, G.1
Hallberg, P.2
Artursson, P.3
Michaëlsson, K.4
Melhus, H.5
-
31
-
-
0035146553
-
Kinetic profiling of P-glycoprotein-mediated drug efflux in rat and human intestinal epithelia
-
Stephens RH, O'neill CA, Warhurst A, Carlson GL, Rowland M, Warhurst G. 2001. Kinetic profiling of P-glycoprotein-mediated drug efflux in rat and human intestinal epithelia. J Pharmacol Exp Ther 296:584-591.
-
(2001)
J Pharmacol Exp Ther
, vol.296
, pp. 584-591
-
-
Stephens, R.H.1
O'neill, C.A.2
Warhurst, A.3
Carlson, G.L.4
Rowland, M.5
Warhurst, G.6
-
32
-
-
0041402720
-
Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: Asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers
-
Troutman MD, Thakker DR. 2003. Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: Asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers. Pharm Res 20:1200-1209.
-
(2003)
Pharm Res
, vol.20
, pp. 1200-1209
-
-
Troutman, M.D.1
Thakker, D.R.2
-
34
-
-
0041402719
-
Rhodamine 123 requires carrier-mediated influx for its activity as a P-glycoprotein substrate in Caco-2 cells
-
Troutman MD, Thakker DR. 2003. Rhodamine 123 requires carrier-mediated influx for its activity as a P-glycoprotein substrate in Caco-2 cells. Pharm Res 20:1192-1199.
-
(2003)
Pharm Res
, vol.20
, pp. 1192-1199
-
-
Troutman, M.D.1
Thakker, D.R.2
-
35
-
-
0037203703
-
Simulated intestinal fluid as transport medium in the Caco-2 cell culture model
-
Ingels FM, Degerme S, Destexhe E, Oth M, Van den Mooter G, Augustijns P. 2002. Simulated intestinal fluid as transport medium in the Caco-2 cell culture model. Int J Pharm 232:183-192.
-
(2002)
Int J Pharm
, vol.232
, pp. 183-192
-
-
Ingels, F.M.1
Degerme, S.2
Destexhe, E.3
Oth, M.4
Van den Mooter, G.5
Augustijns, P.6
-
36
-
-
0033816196
-
Intestinal permeation enhancers
-
Aungst BJ. 2000. Intestinal permeation enhancers. J Pharm Sci 89:429-442.
-
(2000)
J Pharm Sci
, vol.89
, pp. 429-442
-
-
Aungst, B.J.1
-
37
-
-
0043212075
-
Biological, pharmaceutical, and analytical considerations with respect to the transport media used in the absorption screening system, Caco-2
-
Ingels FM, Augustijns PF. 2003. Biological, pharmaceutical, and analytical considerations with respect to the transport media used in the absorption screening system, Caco-2. J Pharm Sci 92: 1545-1558.
-
(2003)
J Pharm Sci
, vol.92
, pp. 1545-1558
-
-
Ingels, F.M.1
Augustijns, P.F.2
-
38
-
-
0030833787
-
Effects of absorption enhancers on the transport of model compounds in Caco-2 cell monolayers: Assessment by confocal laser scanning microscopy
-
Sakai M, Imai T, Ohtake H, Azuma H, Otagiri M. 1997. Effects of absorption enhancers on the transport of model compounds in Caco-2 cell monolayers: Assessment by confocal laser scanning microscopy. J Pharm Sci 86:779-785.
-
(1997)
J Pharm Sci
, vol.86
, pp. 779-785
-
-
Sakai, M.1
Imai, T.2
Ohtake, H.3
Azuma, H.4
Otagiri, M.5
-
39
-
-
0032922857
-
Effect of long term simvastatin administration as an adjunct to ursodeoxycholic acid: Evidence for a synergistic effect on biliary bile acid composition but not on serum lipids in humans
-
Lanzarotto F, Panarotto B, Sorbara R, Panteghini M, Pagani F, Sosta S, Lanzini A. 1999. Effect of long term simvastatin administration as an adjunct to ursodeoxycholic acid: Evidence for a synergistic effect on biliary bile acid composition but not on serum lipids in humans. Gut 44:552-556.
-
(1999)
Gut
, vol.44
, pp. 552-556
-
-
Lanzarotto, F.1
Panarotto, B.2
Sorbara, R.3
Panteghini, M.4
Pagani, F.5
Sosta, S.6
Lanzini, A.7
-
40
-
-
0027989292
-
Effects of lovastatin and Chenodiol on bile acid synthesis, bile lipid composition, and biliary lipid secretion in healthy human subjects
-
Hanson DS, Duane WC. 1994. Effects of lovastatin and Chenodiol on bile acid synthesis, bile lipid composition, and biliary lipid secretion in healthy human subjects. J Lipid Res 35:1462-1468.
-
(1994)
J Lipid Res
, vol.35
, pp. 1462-1468
-
-
Hanson, D.S.1
Duane, W.C.2
-
41
-
-
0037781431
-
Effect of apolipoprotein E polymorphism on bile lipid composition and the formation of cholesterol gallstone
-
Hasegawa K, Terada S, Kubota K, Itakura H, Imamura H, Ohnishi S, Aoki T, Ijichi M, Saiura A, Makuuchi M. 2003. Effect of apolipoprotein E polymorphism on bile lipid composition and the formation of cholesterol gallstone. Am J Gastroenterol 98: 1605-1609.
-
(2003)
Am J Gastroenterol
, vol.98
, pp. 1605-1609
-
-
Hasegawa, K.1
Terada, S.2
Kubota, K.3
Itakura, H.4
Imamura, H.5
Ohnishi, S.6
Aoki, T.7
Ijichi, M.8
Saiura, A.9
Makuuchi, M.10
-
42
-
-
0029799520
-
Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein
-
Balda MS, Whitney JA, Flores C, Gonzalez S, Cereijido M, Matter K. 1996. Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein. J Cell Biol 134:1031-1049.
-
(1996)
J Cell Biol
, vol.134
, pp. 1031-1049
-
-
Balda, M.S.1
Whitney, J.A.2
Flores, C.3
Gonzalez, S.4
Cereijido, M.5
Matter, K.6
-
43
-
-
0025329248
-
Epithelial transport of drugs in cell culture. II: Effect of extracellular calcium concentration on the paracellular transport of drugs of different lipophilicities across monolayers of intestinal epithelial (Caco-2) cells
-
Artursson P, Magnusson C. 1990. Epithelial transport of drugs in cell culture. II: Effect of extracellular calcium concentration on the paracellular transport of drugs of different lipophilicities across monolayers of intestinal epithelial (Caco-2) cells. J Pharm Sci 79:595-600.
-
(1990)
J Pharm Sci
, vol.79
, pp. 595-600
-
-
Artursson, P.1
Magnusson, C.2
-
44
-
-
0035181786
-
Bile acid metabolism by fresh human colonic contents: A comparison of caecal versus faecal samples
-
Thomas LA, Veysey MJ, French G, Hylemon PB, Murphy GM, Dowling RH. 2001. Bile acid metabolism by fresh human colonic contents: A comparison of caecal versus faecal samples. Gut 49:835-842.
-
(2001)
Gut
, vol.49
, pp. 835-842
-
-
Thomas, L.A.1
Veysey, M.J.2
French, G.3
Hylemon, P.B.4
Murphy, G.M.5
Dowling, R.H.6
-
45
-
-
0037360715
-
Fecal bile acid concentrations in a subpopulation of the wheat bran fiber colon polyp trial
-
Alberts DS, Einspahr JG, Earnest DL, Krutzsch MF, Lin P, Hess LM, Heddens DK, Roe DJ, Martinez ME, Salen G, Batta AK. 2003. Fecal bile acid concentrations in a subpopulation of the wheat bran fiber colon polyp trial. Cancer Epidemiol Biomarkers Prev 12:197-200.
-
(2003)
Cancer Epidemiol Biomarkers Prev
, vol.12
, pp. 197-200
-
-
Alberts, D.S.1
Einspahr, J.G.2
Earnest, D.L.3
Krutzsch, M.F.4
Lin, P.5
Hess, L.M.6
Heddens, D.K.7
Roe, D.J.8
Martinez, M.E.9
Salen, G.10
Batta, A.K.11
-
46
-
-
0025824484
-
Idiopathic bile acid malabsorption - A review of clinical presentation, diagnosis and response to treatment
-
Williams AJ, Merrick MV, Eastwood MA. 1991. Idiopathic bile acid malabsorption - A review of clinical presentation, diagnosis and response to treatment. Gut 32:1004-1006.
-
(1991)
Gut
, vol.32
, pp. 1004-1006
-
-
Williams, A.J.1
Merrick, M.V.2
Eastwood, M.A.3
|