The genes and enzymes involved in the biosynthesis of thiamin and thiamin diphosphate in yeasts

Cellular and Molecular Biology Letters

Volumn 13, Issue 2, 2008, Pages 271-282

  Kowalska, E W A ^a   Kozik, Andrzej ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

Pyrimidine; Saccharomyces cerevisiae; THI genes; Thiamin biosynthesis; Thiamin diphosphate; Thiazole

Indexed keywords

DNA; ENZYME; MESSENGER RNA; ORGANOPHOSPHATE; PHOSPHOTRANSFERASE; REACTIVE OXYGEN METABOLITE; SYNTHETASE; THIAMIN DIPHOSPHATE; THIAMIN DIPHOSPHOKINASE; THIAMINE; THIAMINE DERIVATIVE; THIAZOLE SYNTHASE; UNCLASSIFIED DRUG; COCARBOXYLASE; SACCHAROMYCES CEREVISIAE PROTEIN;

BACTERIUM; BIOSYNTHESIS; CATALYSIS; CELL ORGANELLE; CELL PROTECTION; DEPHOSPHORYLATION; DIETARY INTAKE; DNA REPAIR; ENVIRONMENT; ENZYME STRUCTURE; GENE; GENE EXPRESSION REGULATION; GENETIC REGULATION; GENETICS; ILLUMINATION; KNOWLEDGE; NONHUMAN; PROTEIN STRUCTURE; RNA STRUCTURE; SHORT SURVEY; ULTRAVIOLET RADIATION; VITAMIN INTAKE; YEAST; CHEMISTRY; ENZYMOLOGY; FUNGAL GENE; METABOLISM; REVIEW; SACCHAROMYCES CEREVISIAE;

ANIMALIA; SACCHAROMYCES CEREVISIAE;

GENES, FUNGAL; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; THIAMINE; THIAMINE PYROPHOSPHATE;

EID: 51549105375     PISSN: 14258153     EISSN: 16891392     Source Type: Journal    
DOI: 10.2478/s11658-007-0055-5     Document Type: Short Survey

References (28)

1. 1, aneurin). in: Hanbuch der Vitamine, Urban & Schwarzenberg, München, Vien, Baltimore, 1987, 240-258.
2. Hohmann, S. and Meacock, P.A. Thiamin metabolism and thiamin diphosphate-dependent enzymes in the yeast Saccharomyces cerevisiae: genetic regulation. Biochim. Biophys. Acta 1385 (1998) 201-219.
3. Nosaka, K. Recent progress in understanding thiamin biosynthesis and its genetic regulation in Saccharomyces cerevisiae. Appl. Microbiol. Biotechnol. 72 (2006) 30-40.
4. Lai, E.C. RNA sensors and riboswitches: self-regulating messages. Curr. Biol. 13 (2003) 285-291.
5. Bettendorff, L. A non-cofactor role of thiamine derivatives in excitable cells? Arch. Physiol. Biochem. 104 (1996) 745-751.
6. Lakaye, B., Wirtzfeld, B., Wins, P., Grisar, T. and Bettendorff, L. Thiamine triphosphate, a new signal required for optimal growth of Escherichia coli during amino acid starvation. J. Biol. Chem. 279 (2004) 17142-17147.
7. Machado, C.R., Praekelt, U.M., Costa de Oliveira, R.L., Barbosa, A.C.C., Byrne, K.L., Meacock, P.A. and Menck, C.F.M. Dual role for yeast THI4 gene in thiamine biosynthesis and DNA damage tolerance. J. Mol. Biol. 273 (1997) 114-121.
8. Medina-Silva, R., Barros, M.P., Galhardo, R.S., Netto, L.S., Colepicolo, P. and Menck, C.F. Heat stress promotes mitochondrial instability and oxidative responses in yeast deficient in thiazole biosynthesis. Res. Microbiol. 157 (2005) 275-281.
9. Ahn, I-P., Kim, S. and Lee, Y-H. Vitamin B1 functions as an activator of plant disease resistance. Plant Physiol. 138 (2005) 1505-1515.
10. Begley, T., Downs, D., Ealick S., McLafferty, F., Van Loon, D., Taylor, S., Campobasso, N., Chiu, J., Kinsland, C., Reddick, J. and Xi, J. Thiamin biosynthesis in prokaryotes. Arch. Microbiol. 171 (1999) 293-300.
11. Chatterjee, A., Jurgenson, C.T., Schroeder, F.C., Ealick, S.E. and Begley, T.P. Biosynthesis of thiamin thiazole in eukaryotes: conversion of NAD to an advanced intermediate. J. Am. Chem. Soc. 14 (2007) 2914-2922.
12. Nosaka, K., Nishimura, H., Kawasaki, Y., Tsujihara, T. and Iwashima, A. Isolation and characterization of the THI6 gene encoding a bifunctional thiamin-phosphate pyrophosphorylase/hydroxyethylthiazole kinase from Saccharomyces cerevisiae. J. Biol. Chem. 269 (1994) 30510-3-516.
13. Zeidler, J., Sayer, B.G. and Spenser, I.D. Biosynthesis of vitamin B1 in yeast. Derivation of the pyrimidine unit from pyridoxine and histidine. Intermediacy of urocanic acid. J. Am. Chem. Soc. 125 (2003) 13094-13105.
14. Kawasaki, Y., Onozuka, M., Mizote, T. and Nosaka, K. Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae. Curr. Genet. 47 (2005) 156-162.
15. Nosaka, K., Kaneko, Y., Nishimura, H. and Iwashima, A. Isolation and characterization of a thiamin pyrophosphokinase gene, THI80, from Saccharomyces cerevisiae. J. Biol. Chem. 268 (1993) 17440-17447.
16. Enjo, F., Nosaka, K., Ogata, M., Iwashima, A. and Nishimura, H. Isolation and characterization of a thiamin transport gene, THI10, from Saccharomyces cerevisiae. J. Biol. Chem. 272 (1997) 19165-19170.
17. Jurgenson, C.T., Chatterjee, A., Begley, T.P. and Ealick, S.E. Structural insights into the function of the thiamine biosynthetic enzyme Thi4 from Saccharomyces cerevisiae. Biochemistry 45 (2006) 11061-11070.
18. Faou, P. and Tropschug, M. Neurospora crassa CyPBP37: a cytosolic stress protein that is able to replace yeast Thi4p function in the synthesis of vitamin B1. J. Mol. Biol. 344 (2004) 1147-1157.
19. Wightman, R. and Meacock, P.A. The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine. Microbiology 149 (2003) 1447-1460.
20. Haas, A.L., Laun, N.P. and Begley, T.P. Thi20, a remarkable enzyme from Saccharomyces cerevisiae with dual thiamin biosynthetic and degradation activities. Bioorg. Chem. 33 (2005) 338-344.
21. Llorente, B., Fairhead, C. and Dujon, B. Genetic redundancy and gene fusion in the genome of the baker's yeast Saccharomyces cerevisiae: functional characterization of a three-member gene family involved in the thiamine biosynthetic pathway. Mol. Microbiol. 32 (1999) 1140-1152.
22. Nosaka, K., Kaneko, Y., Nishimura, H. and Iwashima, A. A possible role for acid phosphatase with thiamin-binding activity encoded by PHO3 in yeast. FEMS Microbiol. Lett. 51 (1989) 55-59.
23. Marobbio, C.M., Vozza, A., Harding, M., Bissaccia, F., Palmieri, F. and Walker, J.E. Identification and reconstitution of the yeast mitochondrial transporter for thiamine pyrophosphate. EMBO J. 21 (2002) 5653-5661.
24. Nosaka, K., Onozuka, M., Konno, H., Kawasaki, Y., Nishimura H., Sano, M. and Akaji, K. Genetic regulation mediated by thiamin pyrophosphate-binding motif in Saccharomyces cerevisiae. Mol. Microbiol. 58 (2005) 467-479.
25. Mojzita D. and Hohmann, S. Pdc2 coordinates expression of the THI regulon in the yeast Saccharomyces cerevisiae. Mol. Gen. Genomics 276 (2006) 147-161.
26. Baker, L.J., Dorocke, J.A., Harris, R.A. and Timm, D.E. The crystal structure of yeast thiamin pyrophosphokinase. Structure 9 (2001) 539-546.
27. Voskoboyev, A.I. and Ostrovsky, Y.M. Thiamin pyrophosphokinase: structure, properties, and role in thiamin metabolism. Ann. N. Y. Acad. Sci. 378 (1982) 161-176.
28. Kawasaki, Y. Copurification of hydroxyethylthiazole kinase and thiaminephosphate pyrophosphorylase of Saccharomyces cerevisiae: characterization of hydroxyethylthiazole kinase as a bifunctional enzyme in the thiamine biosynthetic pathway. J. Bacteriol. 175 (1993) 5153-5158.