-
1
-
-
0028589270
-
Therapeutic strategies in autoimmune diseases: the search for tolerance induction
-
Bach J.F. Therapeutic strategies in autoimmune diseases: the search for tolerance induction. Transplant Proc. 26 (1994) 3188-3190
-
(1994)
Transplant Proc.
, vol.26
, pp. 3188-3190
-
-
Bach, J.F.1
-
2
-
-
0031794964
-
Problems with inducing tolerance to type 1 diabetes
-
Beales P.E. Problems with inducing tolerance to type 1 diabetes. Diabetes. Metab. Rev. 14 (1998) 257-258
-
(1998)
Diabetes. Metab. Rev.
, vol.14
, pp. 257-258
-
-
Beales, P.E.1
-
3
-
-
0031058917
-
Effect of morphine on lipopolysaccharide-induced tumor necrosis factor-alpha production in vivo: involvement of the sympathetic nervous system
-
Bencsics A., Elenkov I.J., and Vizi E.S. Effect of morphine on lipopolysaccharide-induced tumor necrosis factor-alpha production in vivo: involvement of the sympathetic nervous system. J. Neuroimmunol. 73 (1997) 1-6
-
(1997)
J. Neuroimmunol.
, vol.73
, pp. 1-6
-
-
Bencsics, A.1
Elenkov, I.J.2
Vizi, E.S.3
-
4
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
-
(1976)
Anal. Biochem.
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
5
-
-
0025241225
-
Suppressive effects of morphine pellet implants on in vivo parameters of immune function
-
Bryant H.U., and Roudebush R.E. Suppressive effects of morphine pellet implants on in vivo parameters of immune function. J. Pharmacol. Exp. Ther. 255 (1990) 410-414
-
(1990)
J. Pharmacol. Exp. Ther.
, vol.255
, pp. 410-414
-
-
Bryant, H.U.1
Roudebush, R.E.2
-
6
-
-
33747890010
-
Pain management: is opioid immunosuppression a clinical problem?
-
Budd K. Pain management: is opioid immunosuppression a clinical problem?. Biomed. Pharmacother. 60 (2006) 310-317
-
(2006)
Biomed. Pharmacother.
, vol.60
, pp. 310-317
-
-
Budd, K.1
-
7
-
-
0030995686
-
Treatment with neutralizing antibodies specific for IL-1beta prevents cyclophosphamide-induced diabetes in nonobese diabetic mice
-
Cailleau C., Diu-Hercend A., Ruuth E., Westwood R., and Carnaud C. Treatment with neutralizing antibodies specific for IL-1beta prevents cyclophosphamide-induced diabetes in nonobese diabetic mice. Diabetes 46 (1997) 937-940
-
(1997)
Diabetes
, vol.46
, pp. 937-940
-
-
Cailleau, C.1
Diu-Hercend, A.2
Ruuth, E.3
Westwood, R.4
Carnaud, C.5
-
8
-
-
0031573072
-
IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function
-
Cameron M.J., Arreaza G.A., Zucker P., Chensue S.W., Strieter R.M., Chakrabarti S., and Delovitch T.L. IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function. J. Immunol. 159 (1997) 4686-4692
-
(1997)
J. Immunol.
, vol.159
, pp. 4686-4692
-
-
Cameron, M.J.1
Arreaza, G.A.2
Zucker, P.3
Chensue, S.W.4
Strieter, R.M.5
Chakrabarti, S.6
Delovitch, T.L.7
-
10
-
-
23644437526
-
Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells
-
Gysemans C.A., Ladriere L., Callewaert H., Rasschaert J., Flamez D., Levy D.E., Matthys P., Eizirik D.L., and Mathieu C. Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells. Diabetes 54 (2005) 2396-2403
-
(2005)
Diabetes
, vol.54
, pp. 2396-2403
-
-
Gysemans, C.A.1
Ladriere, L.2
Callewaert, H.3
Rasschaert, J.4
Flamez, D.5
Levy, D.E.6
Matthys, P.7
Eizirik, D.L.8
Mathieu, C.9
-
11
-
-
0028882673
-
Suppression of insulitis in non-obese diabetic (NOD) mice by oral insulin administration is associated with selective expression of interleukin-4 and -10, transforming growth factor-beta, and prostaglandin-E
-
Hancock W.W., Polanski M., Zhang J., Blogg N., and Weiner H.L. Suppression of insulitis in non-obese diabetic (NOD) mice by oral insulin administration is associated with selective expression of interleukin-4 and -10, transforming growth factor-beta, and prostaglandin-E. Am. J. Pathol. 147 (1995) 1193-1199
-
(1995)
Am. J. Pathol.
, vol.147
, pp. 1193-1199
-
-
Hancock, W.W.1
Polanski, M.2
Zhang, J.3
Blogg, N.4
Weiner, H.L.5
-
12
-
-
0029949222
-
Regulation of cytokine production during development of autoimmune diabetes induced with multiple low doses of streptozotocin
-
Herold K.C., Vezys V., Sun Q., Viktora D., Seung E., Reiner S., and Brown D.R. Regulation of cytokine production during development of autoimmune diabetes induced with multiple low doses of streptozotocin. J. Immunol. 156 (1996) 3521-3527
-
(1996)
J. Immunol.
, vol.156
, pp. 3521-3527
-
-
Herold, K.C.1
Vezys, V.2
Sun, Q.3
Viktora, D.4
Seung, E.5
Reiner, S.6
Brown, D.R.7
-
13
-
-
0034961753
-
A transcriptional inhibitor of TNF-alpha prevents diabetes induced by multiple low-dose streptozotocin injections in mice
-
Holstad M., and Sandler S. A transcriptional inhibitor of TNF-alpha prevents diabetes induced by multiple low-dose streptozotocin injections in mice. J. Autoimmun. 16 (2001) 441-447
-
(2001)
J. Autoimmun.
, vol.16
, pp. 441-447
-
-
Holstad, M.1
Sandler, S.2
-
14
-
-
17844368647
-
Early manifestations in multiple-low-dose streptozotocin-induced diabetes in mice
-
Karabatas L.M., Pastorale C., de Bruno L.F., Maschi F., Pivetta O.H., Lombardo Y.B., Chemes H., and Basabe J.C. Early manifestations in multiple-low-dose streptozotocin-induced diabetes in mice. Pancreas 30 (2005) 318-324
-
(2005)
Pancreas
, vol.30
, pp. 318-324
-
-
Karabatas, L.M.1
Pastorale, C.2
de Bruno, L.F.3
Maschi, F.4
Pivetta, O.H.5
Lombardo, Y.B.6
Chemes, H.7
Basabe, J.C.8
-
15
-
-
9644308049
-
Prevention of type 1 diabetes: from the view point of beta cell damage
-
Kawasaki E., Abiru N., and Eguchi K. Prevention of type 1 diabetes: from the view point of beta cell damage. Diabetes. Res. Clin. Pract. 66 (2004) S27-S32
-
(2004)
Diabetes. Res. Clin. Pract.
, vol.66
-
-
Kawasaki, E.1
Abiru, N.2
Eguchi, K.3
-
16
-
-
0028168812
-
Immune intervention in type I diabetes mellitus-current clinical and experimental approaches
-
Kolb H. Immune intervention in type I diabetes mellitus-current clinical and experimental approaches. Exp. Clin. Endocrinol. 102 (1994) 269-272
-
(1994)
Exp. Clin. Endocrinol.
, vol.102
, pp. 269-272
-
-
Kolb, H.1
-
17
-
-
0028970418
-
The mu1, mu2, delta, kappa opioid receptor binding profiles of methadone stereoisomers and morphine
-
Kristensen K., Christensen C.B., and Christrup L.L. The mu1, mu2, delta, kappa opioid receptor binding profiles of methadone stereoisomers and morphine. Life. Sci. 56 (1995) 45-50
-
(1995)
Life. Sci.
, vol.56
, pp. 45-50
-
-
Kristensen, K.1
Christensen, C.B.2
Christrup, L.L.3
-
18
-
-
0041820127
-
Critical roles of tumor necrosis factor-related apoptosis-inducing ligand in type 1 diabetes
-
Lamhamedi-Cherradi S.E., Zheng S., Tisch R.M., and Chen Y.H. Critical roles of tumor necrosis factor-related apoptosis-inducing ligand in type 1 diabetes. Diabetes 52 (2003) 2274-2278
-
(2003)
Diabetes
, vol.52
, pp. 2274-2278
-
-
Lamhamedi-Cherradi, S.E.1
Zheng, S.2
Tisch, R.M.3
Chen, Y.H.4
-
19
-
-
77957179147
-
The effect of methadone on the immune status of B6C3F1 mice
-
Levier D.G., Brown R.D., Musgrove D.L., Butterworth L.F., Mccay J.A., White K.L., Fuchs B.A., Harris L.S., and Munson A.E. The effect of methadone on the immune status of B6C3F1 mice. Fundam. Appl. Toxicol. 24 (1995) 275-284
-
(1995)
Fundam. Appl. Toxicol.
, vol.24
, pp. 275-284
-
-
Levier, D.G.1
Brown, R.D.2
Musgrove, D.L.3
Butterworth, L.F.4
Mccay, J.A.5
White, K.L.6
Fuchs, B.A.7
Harris, L.S.8
Munson, A.E.9
-
20
-
-
0036138197
-
Methadone enhances human immunodeficiency virus infection of human immune cells
-
Li Y., Wang X., Tian S., Guo C.J., Douglas S.D., and Ho W.Z. Methadone enhances human immunodeficiency virus infection of human immune cells. J. Infect. Dis. 185 (2002) 118-122
-
(2002)
J. Infect. Dis.
, vol.185
, pp. 118-122
-
-
Li, Y.1
Wang, X.2
Tian, S.3
Guo, C.J.4
Douglas, S.D.5
Ho, W.Z.6
-
21
-
-
0017179001
-
Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus
-
Like A.A., and Rossini A.A. Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. Science 193 (1976) 415-417
-
(1976)
Science
, vol.193
, pp. 415-417
-
-
Like, A.A.1
Rossini, A.A.2
-
22
-
-
0036179356
-
Nicotine reduces the incidence of type I diabetes in mice
-
Mabley J.G., Pacher P., Southan G.J., Salzman A.L., and Szabo C. Nicotine reduces the incidence of type I diabetes in mice. J. Pharmacol. Exp. Ther. 300 (2002) 876-881
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.300
, pp. 876-881
-
-
Mabley, J.G.1
Pacher, P.2
Southan, G.J.3
Salzman, A.L.4
Szabo, C.5
-
23
-
-
0037972010
-
Inosine protects against the development of diabetes in multiple-low-dose streptozotocin and nonobese diabetic mouse models of type 1 diabetes
-
Mabley J.G., Rabinovitch A., Suarez-Pinzon W., Hasko G., Pacher P., Power R., Southan G., Salzman A., and Szabo C. Inosine protects against the development of diabetes in multiple-low-dose streptozotocin and nonobese diabetic mouse models of type 1 diabetes. Mol. Med. 9 (2003) 96-104
-
(2003)
Mol. Med.
, vol.9
, pp. 96-104
-
-
Mabley, J.G.1
Rabinovitch, A.2
Suarez-Pinzon, W.3
Hasko, G.4
Pacher, P.5
Power, R.6
Southan, G.7
Salzman, A.8
Szabo, C.9
-
24
-
-
0036381752
-
Down-regulation of multiple low dose streptozotocin-induced diabetes by mycophenolate mofetil
-
Maksimovic-Ivanic D., Trajkovic V., Miljkovic D.J., Mostarica S.M., and Stosic-Grujicic S. Down-regulation of multiple low dose streptozotocin-induced diabetes by mycophenolate mofetil. Clin. Exp. Immunol. 129 (2002) 214-223
-
(2002)
Clin. Exp. Immunol.
, vol.129
, pp. 214-223
-
-
Maksimovic-Ivanic, D.1
Trajkovic, V.2
Miljkovic, D.J.3
Mostarica, S.M.4
Stosic-Grujicic, S.5
-
25
-
-
0035314027
-
Opioids, opioid receptors, and the immune response
-
McCarthy L., Wetzel M., Sliker J.K., Eisenstein T.K., and Rogers T.J. Opioids, opioid receptors, and the immune response. Drug Alcohol Depend. 62 (2001) 111-123
-
(2001)
Drug Alcohol Depend.
, vol.62
, pp. 111-123
-
-
McCarthy, L.1
Wetzel, M.2
Sliker, J.K.3
Eisenstein, T.K.4
Rogers, T.J.5
-
26
-
-
0020629924
-
Opiate receptors on lymphocytes and platelets in man
-
Mehrishi J.N., and Mills I.H. Opiate receptors on lymphocytes and platelets in man. Clin. Immunol. Immunopathol. 27 (1983) 240-249
-
(1983)
Clin. Immunol. Immunopathol.
, vol.27
, pp. 240-249
-
-
Mehrishi, J.N.1
Mills, I.H.2
-
27
-
-
0030064460
-
Beta-cell apoptosis is responsible for the development of IDDM in the multiple low-dose streptozotocin model
-
O'Brien B.A., Harmon B.V., Cameron D.P., and Allan D.J. Beta-cell apoptosis is responsible for the development of IDDM in the multiple low-dose streptozotocin model. J. Pathol. 178 (1996) 176-181
-
(1996)
J. Pathol.
, vol.178
, pp. 176-181
-
-
O'Brien, B.A.1
Harmon, B.V.2
Cameron, D.P.3
Allan, D.J.4
-
28
-
-
0034003084
-
Multiple low-dose and single high-dose treatments with streptozotocin do not generate nitric oxide
-
Papaccio G., Pisanti F.A., Latronico M.V., Ammendola E., and Galdieri M. Multiple low-dose and single high-dose treatments with streptozotocin do not generate nitric oxide. J. Cell. Biochem. 77 (2000) 82-91
-
(2000)
J. Cell. Biochem.
, vol.77
, pp. 82-91
-
-
Papaccio, G.1
Pisanti, F.A.2
Latronico, M.V.3
Ammendola, E.4
Galdieri, M.5
-
29
-
-
0028222756
-
Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse
-
Pennline K.J., Roque-Gaffney E., and Monahan M. Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse. Clin. Immunol. Immunopathol. 71 (1994) 169-175
-
(1994)
Clin. Immunol. Immunopathol.
, vol.71
, pp. 169-175
-
-
Pennline, K.J.1
Roque-Gaffney, E.2
Monahan, M.3
-
30
-
-
0023779707
-
Destruction of rat islet cell monolayers by cytokines. Synergistic interactions of interferon-gamma, tumor necrosis factor, lymphotoxin, and interleukin 1
-
Pukel C., Baquerizo H., and Rabinovitch A. Destruction of rat islet cell monolayers by cytokines. Synergistic interactions of interferon-gamma, tumor necrosis factor, lymphotoxin, and interleukin 1. Diabetes 37 (1988) 133-136
-
(1988)
Diabetes
, vol.37
, pp. 133-136
-
-
Pukel, C.1
Baquerizo, H.2
Rabinovitch, A.3
-
31
-
-
0031871335
-
An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus
-
Rabinovitch A. An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus. Diabetes. Metab. Rev. 14 (1998) 129-151
-
(1998)
Diabetes. Metab. Rev.
, vol.14
, pp. 129-151
-
-
Rabinovitch, A.1
-
32
-
-
0032523104
-
Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus
-
Rabinovitch A., and Suarez-Pinzon W.L. Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus. Biochem. Pharmacol. 55 (1998) 1139-1149
-
(1998)
Biochem. Pharmacol.
, vol.55
, pp. 1139-1149
-
-
Rabinovitch, A.1
Suarez-Pinzon, W.L.2
-
33
-
-
17144404203
-
Animal models of diabetes mellitus
-
Rees D.A., and Alcolado J.C. Animal models of diabetes mellitus. Diabet. Med. 22 (2005) 359-370
-
(2005)
Diabet. Med.
, vol.22
, pp. 359-370
-
-
Rees, D.A.1
Alcolado, J.C.2
-
34
-
-
0018074911
-
Complete protection from low-dose streptozotocin-induced diabetes in mice
-
Rossini A.A., Williams R.M., Appel M.C., and Like A.A. Complete protection from low-dose streptozotocin-induced diabetes in mice. Nature 276 (1978) 182-184
-
(1978)
Nature
, vol.276
, pp. 182-184
-
-
Rossini, A.A.1
Williams, R.M.2
Appel, M.C.3
Like, A.A.4
-
35
-
-
0032582829
-
MU-opioid receptor-knockout mice: role of mu-opioid receptor in morphine mediated immune functions
-
Roy S., Barke R.A., and Loh H.H. MU-opioid receptor-knockout mice: role of mu-opioid receptor in morphine mediated immune functions. Mol. Brain. Res. 61 (1998) 190-194
-
(1998)
Mol. Brain. Res.
, vol.61
, pp. 190-194
-
-
Roy, S.1
Barke, R.A.2
Loh, H.H.3
-
36
-
-
0034905665
-
Morphine directs T cells toward T (H2) differentiation
-
Roy S., Balasubramanian S., Sumandeep S., Charboneau R., Wang J., Melnyk D., Beilman G.J., Vatassery R., and Barke R.A. Morphine directs T cells toward T (H2) differentiation. Surgery 130 (2001) 304-309
-
(2001)
Surgery
, vol.130
, pp. 304-309
-
-
Roy, S.1
Balasubramanian, S.2
Sumandeep, S.3
Charboneau, R.4
Wang, J.5
Melnyk, D.6
Beilman, G.J.7
Vatassery, R.8
Barke, R.A.9
-
37
-
-
1642493592
-
Chronic morphine treatment differentiates T helper cells to Th2 effector cells by modulating transcription factors GATA 3 and T-bet
-
Roy S., Wang J., Gupta S., Charboneau R., Loh H.H., and Barke R.A. Chronic morphine treatment differentiates T helper cells to Th2 effector cells by modulating transcription factors GATA 3 and T-bet. J. Neuroimmunol. 147 (2004) 78-81
-
(2004)
J. Neuroimmunol.
, vol.147
, pp. 78-81
-
-
Roy, S.1
Wang, J.2
Gupta, S.3
Charboneau, R.4
Loh, H.H.5
Barke, R.A.6
-
38
-
-
27744456909
-
Morphine induces CD4+T cell IL-4 expression through an adenylyl cyclase mechanism independent of the protein kinase A pathway
-
Roy S., Wang J., Charboneau R., Loh H.H., and Barke R.A. Morphine induces CD4+T cell IL-4 expression through an adenylyl cyclase mechanism independent of the protein kinase A pathway. J. Immunol. 175 (2005) 6361-6367
-
(2005)
J. Immunol.
, vol.175
, pp. 6361-6367
-
-
Roy, S.1
Wang, J.2
Charboneau, R.3
Loh, H.H.4
Barke, R.A.5
-
39
-
-
34548858217
-
Simvastatin protects against multiple low-dose streptozotocin-induced type 1 diabetes in CD-1 mice and recurrence of disease in nonobese diabetic mice
-
Rydgren T., Vaarala O., and Sandler S. Simvastatin protects against multiple low-dose streptozotocin-induced type 1 diabetes in CD-1 mice and recurrence of disease in nonobese diabetic mice. J. Pharmacol. Exp. Ther. 323 (2007) 180-185
-
(2007)
J. Pharmacol. Exp. Ther.
, vol.323
, pp. 180-185
-
-
Rydgren, T.1
Vaarala, O.2
Sandler, S.3
-
40
-
-
0031710593
-
Endogenous opioids modulate allograft rejection time in mice: possible relation with Th1/Th2 cytokines
-
Sacerdote P., Di San Secondo V.E., Sirchia G., Manfredi B., and Panerai A.E. Endogenous opioids modulate allograft rejection time in mice: possible relation with Th1/Th2 cytokines. Clin. Exp. Immunol. 113 (1998) 465-469
-
(1998)
Clin. Exp. Immunol.
, vol.113
, pp. 465-469
-
-
Sacerdote, P.1
Di San Secondo, V.E.2
Sirchia, G.3
Manfredi, B.4
Panerai, A.E.5
-
41
-
-
0034654402
-
The opioid antagonist naloxone induces a shift from type 2 to type 1 cytokine pattern in BALB/cJ mice
-
Sacerdote P., Manfredi B., Gaspani L., and Panerai A.E. The opioid antagonist naloxone induces a shift from type 2 to type 1 cytokine pattern in BALB/cJ mice. Blood 95 (2000) 2031-2036
-
(2000)
Blood
, vol.95
, pp. 2031-2036
-
-
Sacerdote, P.1
Manfredi, B.2
Gaspani, L.3
Panerai, A.E.4
-
42
-
-
0035692747
-
Approaches to type 1 diabetes prevention by intervention in cytokine immunoregulatory circuits
-
Suarez-Pinzon W.L., and Rabinovitch A. Approaches to type 1 diabetes prevention by intervention in cytokine immunoregulatory circuits. Int. J. Exp. Diabetes Res. 2 (2001) 3-17
-
(2001)
Int. J. Exp. Diabetes Res.
, vol.2
, pp. 3-17
-
-
Suarez-Pinzon, W.L.1
Rabinovitch, A.2
-
43
-
-
0033894567
-
COX-2 inhibition prevents insulin-dependent diabetes in low-dose streptozotocin-treated mice
-
Tabatabaie T., Waldon A.M., Jacob J.M., Floyd R.A., and Kotake Y. COX-2 inhibition prevents insulin-dependent diabetes in low-dose streptozotocin-treated mice. Biochem. Biophys. Res. Commun. 273 (2000) 699-704
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.273
, pp. 699-704
-
-
Tabatabaie, T.1
Waldon, A.M.2
Jacob, J.M.3
Floyd, R.A.4
Kotake, Y.5
-
45
-
-
0141509934
-
Morphine negatively regulates interferon-gamma promoter activity in activated murine T cells through two distinct cyclic AMP-dependent pathways
-
Wang J., Barke R.A., Charboneau R., Loh H.H., and Roy S. Morphine negatively regulates interferon-gamma promoter activity in activated murine T cells through two distinct cyclic AMP-dependent pathways. J. Biol. Chem. 278 (2003) 37622-37631
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 37622-37631
-
-
Wang, J.1
Barke, R.A.2
Charboneau, R.3
Loh, H.H.4
Roy, S.5
-
46
-
-
1642273986
-
The novel anti-inflammatory compound, lisofylline, prevents diabetes in multiple low-dose streptozotocin-treated mice
-
Yang Z., Chen M., Fialkow L.B., Ellett J.D., Wu R., and Nadler J.L. The novel anti-inflammatory compound, lisofylline, prevents diabetes in multiple low-dose streptozotocin-treated mice. Pancreas 26 (2003) 99-104
-
(2003)
Pancreas
, vol.26
, pp. 99-104
-
-
Yang, Z.1
Chen, M.2
Fialkow, L.B.3
Ellett, J.D.4
Wu, R.5
Nadler, J.L.6
-
47
-
-
0020565744
-
Naltrexone modulates tumor response in mice with neuroblastoma
-
Zagon I.S., and McLaughlin P.J. Naltrexone modulates tumor response in mice with neuroblastoma. Science 12 (1983) 671-673
-
(1983)
Science
, vol.12
, pp. 671-673
-
-
Zagon, I.S.1
McLaughlin, P.J.2
|