Cryptococcus neoformans inhibits nitric oxide synthesis caused by CpG-oligodeoxynucleotide-stimulated macrophages in a fashion independent of capsular polysaccharides

Microbiology and Immunology

Volumn 52, Issue 3, 2008, Pages 171-179

  Xiao, Gang ^a,e   Miyazato, Akiko ^b   Inden, Ken ^b   Nakamura, Kiwamu ^b   Shiratori, Kohei ^a   Nakagawa, Kiyotaka ^a   Miyazawa, Teruo ^a   Suzuki, Kazuo ^c   Kaku, Mitsuo ^a,b,d   Kawakami, Kazuyoshi ^a,d  

^a TOHOKU UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c CHIBA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d TOHOKU UNIVERSITY HOSPITAL   (Japan)

^e SUN YAT SEN UNIVERSITY   (China)

Author keywords

CpG ODN; Cryptococcus neoformans; Macrophages; Nitric oxide

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; NITRIC OXIDE; POLYSACCHARIDE; PYROXYLIN; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; CPG OLIGONUCLEOTIDE; CPG-OLIGONUCLEOTIDE; OLIGODEOXYRIBONUCLEOTIDE;

ARTICLE; BACTERIAL STRAIN; CELL STRAIN HEK293; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; HEAT TREATMENT; HUMAN; HUMAN CELL; LUNG ALVEOLUS MACROPHAGE; MACROPHAGE; MALE; NONHUMAN; NUCLEOTIDE METABOLISM; ANIMAL; CELL LINE; DRUG ANTAGONISM; GENETICS; IMMUNOLOGY; MOUSE;

FILOBASIDIELLA NEOFORMANS;

ANIMALS; CELL LINE; CRYPTOCOCCUS NEOFORMANS; HUMANS; INTERFERON TYPE II; MACROPHAGES, ALVEOLAR; MICE; NITRIC OXIDE; OLIGODEOXYRIBONUCLEOTIDES; POLYSACCHARIDES;

EID: 51449106376     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2008.00019.x     Document Type: Article

References (36)

1. Stevens D.A. (1990) Fungal infections in AIDS patients. Br J Clin Pract Suppl 71: 11-22.
2. Robinson P.A., Bauer M., Leal M.A., Evans S.G., Holtom P.D., Diamond D.A., Leedom, J.M., Larsen, R.A. (1999) Early mycological treatment failure in AIDS-associated cryptococcal meningitis. Clin Infect Dis 28: 82-92.
3. Lim T.S., Murphy J.W. (1980) Transfer of immunity to cryptococcosis by T-enriched splenic lymphocytes from Cryptococcus neoformans-sensitized mice. Infect Immun 30: 5-11.
4. Koguchi Y., Kawakami K. (2002) Cryptococcal infection and Th1-Th2 cytokine balance. Int Rev Immunol 21: 423-38.
5. Decken K., Köhler G., Palmer-Lehmann K.,Wunderlin A., Mattner F., Magram J., Gately, M.K., Alber, G. (1998) Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans. Infect Immun 66: 4994-5000.
6. Kawakami K., Koguchi Y., Qureshi M.H., Kinjo Y., Yara S.,Miyazato A., Kurimoto,M., Takeda, K., Akira, S., Saito, A. (2000) Reduced host resistance and Th1 response to Cryptococcus neoformans in interleukin-18 deficient mice. FEMS Microbiol Lett 186: 121-6.
7. Kawakami K., Koguchi Y., Qureshi M.H., Miyazato A., Yara S., Kinjo Y., Iwakura, Y., Takeda, K., Akira, S., Kurimoto, M., Saito, A. (2000) IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-gamma production by NK cells. J Immunol 165: 941-7.
8. Rayhane N., Lortholary O., Fitting C., Callebert J., Huerre M., Dromer F., Cavaillon, J.M. (1999) Enhanced sensitivity of tumor necrosis factor/lymphotoxin-beta-deficient mice to Cryptococcus neoformans infection despite increased levels of nitrite/nitrate, interferon-gamma, and interleukin-12. J Infect Dis 180: 1637-47.
9. Yuan R.R., Casadevall A., Oh J., Scharff M.D. (1997) T cells cooperate with passive antibody to modify Cryptococcus neoformans infection in mice. Proc Natl Acad Sci USA 94: 2483-8.
10. Feldmesser M., Tucker S., Casadevall A. (2001) Intracellular parasitism of macrophages by Cryptococcus neoformans. Trends Microbiol 9: 273-8.
11. MacMicking J., Xie Q.W., Nathan C. (1997) Nitric oxide and macrophage function. Annu Rev Immunol 15: 323-50.
12. Aguirre K.M., Gibson G.W. (2000) Differing requirement for inducible nitric oxide synthesis activity in clearance of primary Cryptococcus neoformans infection. Med Mycol 38: 343-53.
13. Lovchik J.A., Lyons C.R., Lipscomb M.F. (1995) A role for gamma interferon-induced nitric oxide in pulmonary clearance of Cryptococcus neoformans. Am J Respir Cell Mol Biol 13: 116-24.
14. Tohyama M., Kawakami K., Futenma M., Saito A. (1996) Enhancing effect of oxygen radical scavengers on murine macrophage anticryptococcal activity through production of nitric oxide. Clin Exp Immunol 103: 436-41.
15. Monari C., Bistoni F., Casadevall A., Pericolini E., Pietrella D., Kozel T.R., Vecchiarelli, A. (2005) Glucuronoxylomannan, a microbial compound, regulates expression of costimulatory molecules and production of cytokines in macrophages. J Infect Dis 191: 127-37.
16. Monari C., Bistoni F., Vecchiarelli A. (2006) Glucuronoxylomannan exhibits potent immunosuppressive properties. FEMS Yeast Res 6: 537-42.
17. Vecchiarelli A., Retini C., Pietrella D., Monari C., Tascini C., Beccari, Kozel, T.R. (1995) Downregulation by cryptococcal polysaccharide of tumor necrosis factor alpha and interleukin-1 beta secretion from human monocytes. Infect Immun 63: 2919-23.
18. Vecchiarelli A., Pietrella D., Lupo P., Bistoni F., McFadden D.C., Casadevall A. (2003) The polysaccharide capsule of Cryptococcus neoformans interferes with human dendritic cell maturation and activation. J Leukoc Biol 74: 370-8.
19. Kawakami K., Zhang T., Qureshi M.H., Saito A. (1997) Cryptococcus neoformans inhibits nitric oxide production by murine peritoneal macrophages stimulated with interferon-gamma and lipopolysaccharide. Cell Immunol 180: 47-54.
20. Kawakami K., Qureshi M.H., Koguchi Y., Nakajima K., Saito A. (1999) Differential effect of Cryptococcus neoformans on the production of IL-12p40 and IL-10 by murine macrophages stimulated with lipopolysaccharide and gamma interferon. FEMS Microbiol Lett 175: 87-94.
21. Krieg A.M., Yi A.K., Matson S.,Wakdschmidt T.J., Bishop G.A., Teasdale R., Koretzky, G.A., Klinman, D.M. (1995) CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374: 546-9.
22. Krieg A.M. (2002) CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 20: 709-60.
23. Jakob T.,Walker P.S., Krieg A.M., Udey M.C., Vogel J.C. (1998) Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: a role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA. J Immunol 161: 3042-9.
24. Sparwasser T., Koch E.S., Vabulas R.M., Heeg K., Lipford G.B., Ellwart J.W.,Wagner, H. (1998) Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur J Immunol 28: 2045-54.
25. Henmi H., Takeuchi O., Kawai T., Kaisho T., Sato S., Sanjo H., Matsumoto, M., Hoshino, K.,Wagner, H., Takeda, K., Akira, S. (2000) A toll-like receptor recognizes bacterial DNA. Nature 408: 740-5.
26. Edwards L.,Williams A.E., Krieg A.M., Rae A.J., Snelgrove R.J., Hussell T. (2005) Stimulation via Toll-like receptor 9 reduces Cryptococcus neoformans-induced pulmonary inflammation in an IL-12-dependent manner. Eur J Immunol 35: 273-81.
27. Miyagi K., Kawakami K., Kinjo Y., Uezu K., Kinjo T., Nakamura K., Saito, A. (2005) CpG oligodeoxynucleotides promote the host protective response against infection with Cryptococcus neoformans through induction of interferon-gamma production by CD4+ T cells. Clin Exp Immunol 140: 220-9.
28. Yasuoka A., Kohno S., Yamada H., Kaku K., Koga H. (1994) Influence of molecular sizes of Cryptococcus neoformans capsular polysaccharide on phagocytosis. Microbiol Immunol 38: 851-6.
29. Stuehr D.J., Nathan C.F. (1989) Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J ExpMed 169: 1543-55.
30. Kawakami K., Tohyama M., Qifeng X., Saito A. (1997) Expression of cytokines and inducible nitric oxide synthase mRNA in the lungs of mice infected with Cryptococcus neoformans: effects of interleukin-12. Infect Immun 65: 1307-12.
31. Villas-Boas M.H., Egge H., Pohlentz G., Hartmann R., Barreto-Bergter R. (1994) Structural determination of N-2′-hydroxyoctadecenoyl-1-O- beta-D-glucopyranosyl-9-methyl-4,8-sphingadienine from species of Aspergillus. Chem Phys Lipids 70: 11-9.
32. Folch J., Less M., Tacker T.R. (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226: 467-509.
33. Chuang T.H., Lee J., Kline L., Mathison J.C., Ulevitch R.J. (2002) Toll-like receptor 9 mediates CpG-DNA signaling. J Leukoc Biol 71: 538-44.
34. Takeda K., Kaisho T., Akira S. (2003) Toll-like receptors. Annu Rev Immunol 21: 335-76.
35. Honda K., Ohba Y., Yanai H., Negishi H., Mizutani T., Takaoka A., Taya, C., Taniguchi, T. (2005) Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 434: 1035-40.
36. Latz E., Schoenemeyer A., Visintin A., Fitzgerald K.A., Monks B.G., Knetter C.F., Lien, E., Nilsen, N.J., Espevik, T., Golenbock, D.T. (2004) TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat Immunol 5: 190-8.