Roller compaction, granulation and capsule product dissolution of drug formulations containing a lactose or mannitol filler, starch, and talc

AAPS PharmSciTech

Volumn 9, Issue 2, 2008, Pages 597-604

  Chang, Chialu Kevin ^a,b   Alvarez Nunez, Fernando A ^a,b   Rinella Jr , Joseph V ^a,c   Magnusson, Lars Erik ^a,d   Sueda, Katsuhiko ^a,c  

^a PFIZER INC   (United States)

^b AMGEN INC   (United States)

^c GLAXOSMITHKLINE   (United States)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

Compaction; Flowability; Granulation; Particlesize; Ribbon; Starch

Indexed keywords

DRUG; GELATIN; LACTOSE; MAGNESIUM STEARATE; MANNITOL; MANNOGEM EZ; STARCH; TALC; UNCLASSIFIED DRUG; EXCIPIENT; STEARIC ACID; STEARIC ACID DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG CAPSULE; DRUG FORMULATION; DRUG GRANULATION; DRUG GRANULE; DRUG SOLUBILITY; DRUG STORAGE; PARTICLE SIZE; STORAGE TEMPERATURE; TENSILE STRENGTH; CHEMICAL MODEL; CHEMISTRY; DRUG STABILITY; FLOW KINETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMIDITY; METHODOLOGY; MICROCAPSULE; PHARMACEUTICS; POWDER; SOLUBILITY; TEMPERATURE; TIME;

CAPSULES; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG COMPOUNDING; DRUG STABILITY; EXCIPIENTS; GELATIN; HUMIDITY; LACTOSE; MANNITOL; MODELS, CHEMICAL; PARTICLE SIZE; POWDERS; RHEOLOGY; SOLUBILITY; STARCH; STEARIC ACIDS; TALC; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; TENSILE STRENGTH; TIME FACTORS;

EID: 51449104993     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-008-9088-y     Document Type: Article

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