Roller compaction and tableting of microcrystalline cellulose/drug mixtures

International Journal of Pharmaceutics

Volumn 161, Issue 2, 1998, Pages 215-224

  Inghelbrecht, Sabine ^a   Remon, Jean Paul ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Granule; Ibuprofen; Microcrystalline cellulose; Roller compaction; Tabelt

Indexed keywords

AVICEL CE 15; AVICEL PH 302; IBUPROFEN; MICROCRYSTALLINE CELLULOSE; UNCLASSIFIED DRUG;

ARTICLE; CRUSHING STRENGTH; DISSOLUTION; DRUG GRANULE; DRUG QUALITY; DRUG RELEASE; IN VITRO STUDY; INSTRUMENT; PARTICLE SIZE; PRIORITY JOURNAL; TABLET MANUFACTURE; TECHNIQUE;

EID: 0032559531     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)00356-6     Document Type: Article

References (12)

1. Falzone A.M., Peck G.G., McCabe G.P. Effects of changes in roller compactor parameters on granulations produced by compaction. Drug Dev. Ind. Pharm. 18:1992;469-489.
2. Inghelbrecht S., Remon J.P., Fernandes de Aguiar P., Walczak B., Massart D.L., Van De Velde F., De Baets P., Vermeersch H., De Backer P. Instrumentation of a roll compactor and the evaluation of the parameter settings by neural networks. Int. J. Pharm. 148:1997;103-115.
3. Kochhar S.K., Rubinstein M.H., Barnes D. The effects of slugging and recompression on pharmaceutical excipients. Int. J. Pharm. 155:1995;35-43.
4. Li, J.H., 1990. The sintering of ibuprofen, PhD Dissertation, Perdue University, West Lafayette, IN.
5. ™. Drug Dev. Ind. Pharm. 16:1990;1491-1503.
6. Malkowska M.L., Khan K.A. Effect of recompression on the properties of tablets prepared by dry granulation. Drug Dev. Ind. Pharm. 9:1983;331-347.
7. McKenna A., McCafferty F. Effect of particle size on the compaction mechanism and tensile strength of tablets. J. Pharm. Pharmacol. 34:1982;347-351.
8. Nesic M., Cvetkovic N., Polic D. Contribution to the knowledge of the consolidation mechanism of a ibuprofen/polyvinylpyrolidone system. Acta Pharm. Yugosl. 40:1990;545-555.
9. Remon J.P., Schwartz J.B. Effect of raw materials and processing on the quality of granules prepared from microcrystalline cellulose-lactose mixtures. Drug Dev. Ind. Pharm. 13:1987;1-14.
10. Roberts R.J., Rowe R.C. The effect of the relationship between punch velocity and particle size on the compaction behaviour of materials with varying deformation mechanism. J. Pharm. Pharmacol. 38:1986;567-571.
11. Roberts R.J., Rowe R.C. Brittle/ductile behavior in pharmaceutical materials used in tableting. Int. J. Pharm. 36:1987;205-209.
12. Sheskey P.J., Dasbach P. Evaluation of various polymers as dry binders in the preparation of an immediate-release tablet formulation by roller compaction. Pharm. Tech. 19:1995;98-112.