A high-throughput bioreactor system for simulating physiological environments

IEEE Transactions on Industrial Electronics

Volumn 55, Issue 9, 2008, Pages 3273-3280

  Mazzei, Daniele ^a   Vozzi, Federico ^a,b   Cisternino, Antonio ^a   Vozzi, Giovanni ^a   Ahluwalia, Arti ^a,b  

^a UNIVERSITY OF PISA   (Italy)

^b INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

Author keywords

Bioreactor; Cell culture; High throughput; Mimic physiological environments

Indexed keywords

BIOCONVERSION; BIOREACTORS; CELL CULTURE; CHEMICAL REACTORS; COMPUTER NETWORKS; EMBEDDED SYSTEMS; EXPERIMENTS; INDUSTRIAL CHEMICALS; INTEGRATED CIRCUITS; MIXING; THROUGHPUT; TISSUE ENGINEERING;

BIOREACTOR; HIGH THROUGHPUT; HIGH THROUGHPUTS; MIMIC PHYSIOLOGICAL ENVIRONMENTS;

CONTROL SYSTEMS;

EID: 51449097483     PISSN: 02780046     EISSN: None     Source Type: Journal    
DOI: 10.1109/TIE.2008.928122     Document Type: Conference Paper

References (38)

1. J. J. Burbaum and N. H. Sigal, "New technologies for high-throughput screening," Curr. Opin. Chem. Biol., vol. 1, no. 1, pp. 72-78, Jun. 1997.
2. P. J. Hung and P. J. Lee, "Continuous perfusion microfluidic cell culture array for high-throughput cell-based assays," Biotechnol. Bioeng., vol. 89, no. 1, pp. 1-8, Dec. 3, 2004.
3. S. K. Tingley, "High-throughput cell culture: A real-world evaluation," Innov. Pharm. Technol., pp. 54-58, Feb. 2006.
4. Y. Martina and P. Vermette, "Bioreactors for tissue mass culture: Design, characterization, and recent advances," Biomaterials, vol. 26, no. 35, pp. 7481-7503, Dec. 2005. Review.
5. M. J. Jaasma, N. A. Plunkett, and F. J. O'Brien, "Design and validation of a dynamic flow perfusion bioreactor for use with compliant tissue engineering scaffolds," J. Biotechnol., vol. 133, no. 4, pp. 490-496, Feb. 29, 2008.
6. K. Dumont, J. Yperman, and P. R. Verdonck, "Design of a new pulsatile bioreactor for tissue engineered aortic heart valve formation," Artif. Organs, vol. 26, no. 8, pp. 710-714, Aug. 2002.
7. F. Anton, K. Suck, and S. Diederichs, "Design and characterization of a rotating bed system bioreactor for tissue engineering applications," Biotechnol. Prog., vol. 24, no. 1, pp. 140-147, Jan./Feb. 2008.
8. M. Ingram, G. B. Techy, and R. Saroufeem, "Three dimensional growth patterns of various human tumor cell lines in simulated microgravity of a NASA bioreactor," In Vitro Cell. Dev. Biol., Anim., vol. 33, no. 6, pp. 459-466, Jun. 1997.
9. E. M. Darling and K. A. Athanasiou, "Axticular cartilage bioreactors and bioprocesses," Tissue Eng., vol. 9, no. 1, pp. 9-26, 2003.
10. B. J. Kane, M. J. Zinner, M. L. Yarmush, and M. Toner, "Liver-specific functional studies in a microfluidic array of primary Mammalian hepatocytes," Anal. Chem., vol. 78, no. 13, pp. 4291-4298, Jun. 2006.
11. A. Sin, G. T. Baxter, and M. L. Shuler, "Animal on a chip: A microscale cell culture analog device for evaluating toxicological and pharmacological profiles," in Proc. SPIE - Microfluidics and BioMEMS Sep. 2001, vol. 4560, pp. 98-101.
12. F. Vozzi, J. M. Heinrich, A. Bader, and A. D. Ahluwalia, "Connected culture of Murine Hepatocytes and HUVEC in a multi-compartmental bioreactor," Tissue Eng., submitted for publication.
13. A. Ahluwalia, G. Vozzi et al., "Bioreattori bi-e tridimensionali high-throughput sensorizzati e/o dotati da sistemi di filtrazione e di trasduzione ed attuazione," Patent N PI2006A000121, Nov. 8, 2006.
14. A. Ahluwalia, G. Vozzi, and F. Vozzi, "Bioreattore per lo studio degli effetti sulle attività cellulari di stimoli imposti," Patent N PI2004A000046, Jun. 2004.
15. G. B. West and J. H. Brown, Eds., Scaling in Biology. NewYork: Oxford Univ. Press, 2000.
16. G. B. West, J. H. Brown, and B. J. Enquist, "A general model for the origin of allometric scaling laws in biology," Science, vol. 276, no. 5309, pp. 122-126, Apr. 1997.
17. Y. C. Fung et al., Biomechanics of the Circulation. New York: Springer-Verlag, 1997.
18. R. L. Fournier, Basic Transport Phenomena in Biomedical Engineering Book. New York: Taylor & Francis, 1999.
19. B. Capaldo, A. Gastaldelli et al., "Splanchnic and leg substrate exchange after ingestion of a natural mixed meal in humans," Diabetes, vol. 48, no. 5, pp. 958-966, May 1999.
20. C. Meyer et al., "Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasis," Amer. J. Endocrinol. Metab., vol. 282, no. 2, pp. E419-E427, Feb. 2002.
21. A. D. Cherrington, M. C. Moore et al., "All insulin action on the liver in vivo," Biochem. Soc. Trans., vol. 35, pt. 5, pp. 1171-1174, Nov. 2007.
22. J. M. Wilkinson and A. D. Ahluwalia, "A novel multichamber bioreactor system for early stage toxicology screening," in Proc. Nanotechnol. - Towards Reducing Animal Testing, London, U.K., May 28-29, 2008, pp. 50-52.
23. 3-buffer," Biomaterials, vol. 24, no. 9, pp. 1541-1548, Apr. 2003.
24. "SteroidMicros web page," Wildfire 5282 Data Sheet. [Online]. Available: http://www.steroidmicros.com/
25. "Omega Catalogs," Kapton Insulated Flexible Heaters Data Sheet, Omega Web Catalog. [Online]. Available: http://www.omega.com
26. J. B. Christen and A. G. Andreou, "Design, fabrication, and testing of a hybrid CMOS/PDMS microsystem for cell culture and incubation," IEEE Trans. Biomed. Circuits Syst., vol. 1, no. 1, pp. 3-18, Mar. 2007.
27. J. B. Christen and A. G. Andreou, "Hybrid silicon/silicone (polydimethylsiloxane) microsystem for cell culture," in Proc. 28th IEEE Annu. Int. Conf. EMBS, Aug. 30-Sep. 3, 2006, pp. 2490-2493.
28. H. Hassan et al., "Remote laboratory architecture for the validation of industrial control applications," IEEE Trans. Ind. Electron., vol. 54, no. 6, pp. 3094-3102, Dec. 2007.
29. A. Faro, O. Mirabella, and C. Nigro, "Performance evaluation of the standard proway network for process control," IEEE Trans. Ind. Electron., vol. IE-33, no. 1, pp. 9-20, Feb. 1986.
30. D. T. Nguyen, S.-R. Oh et al., "A framework for Internet-based interaction of humans, robots, and responsive environments using agent technology," IEEE Trans. Ind. Electron., vol. 52, no. 6, pp. 1521-1529, Dec. 2005.
31. A. Cisternino, D. Colombo, G. Ennas, and D. Picciaia, "Robotics4.NET: Software body for controlling robots," Proc. Inst. Elect. Eng. - Software, vol. 152, no. 5, pp. 215-222, Oct. 2005.
32. A. Cisternino, F. Cicchi, and D. Mazzei, μTNetOS: Operating System Generation for Micro-Controllers, 2007. submitted for publication.
33. M. A. Henson and D. E. Seborg, "Adaptive nonlinear control of a pH neutralization process," IEEE Trans. Control Syst. Technol., vol. 2, no. 3, pp. 169-182, Aug. 1994.
34. E. Boerger and R. Staerk, Abstract State Machines - A Method for High-Level System Design and Analysis. New York: Springer-Verlag, 2003.
35. V. Gervasi and D. Mazzei, "Using abstract state machines in modeling biological systems," in Proc. GNB, Pisa, Italy, 2008, pp. 79-80.
36. E. A. Jaffe, R. L. Nachman, C. G. Becker, and C. R. Minick, "Culture of human endothelial cells derived from umbilical vein. Identification by morphologic and immunologic criteria," J. Clin. Invest., vol. 52, no. 11, pp. 2745-2756, Nov. 1973.
37. J. D. Cohen, "Overview of physiology, vascular biology, and mechanisms of hypertension," J. Manag. Care Pharm., vol. 13, pp. S6-S8, Jun. 2007. (5 Suppl), Review.
38. P. O. Seglen, "Preparation of isolated rat liver cells," Methods Cell Biol., vol. 13, pp. 29-83, 1976.