Hybrid silicon/silicone (polydimethylsiloxane) microsystem for cell culture

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

Volumn , Issue , 2006, Pages 2490-2493

  Christen, Jennifer Blain ^a   Andreou, Andreas G ^a  

^a Johns Hopkins University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMEDICAL ENGINEERING; CELL CULTURE; FLUIDIC DEVICES; POLYDIMETHYLSILOXANE; SILICON; SILICONES; TEMPERATURE SENSORS;

ELECTRONIC RIBBON CABLES; FLUIDIC CHANNELS; HYBRID MICROSYSTEMS; MICROINCUBATORS;

MICROSYSTEMS;

BIOMATERIAL; DIMETICONE; NYLON; POLY(DIMETHYLSILOXANE) POLYAMIDE COPOLYMER; POLY(DIMETHYLSILOXANE)-POLYAMIDE COPOLYMER; SILICON;

ARTICLE; CHEMISTRY; CULTURE TECHNIQUE; ELECTRONICS; EQUIPMENT; EQUIPMENT DESIGN; EQUIPMENT FAILURE; FLOW CYTOMETRY; MATERIALS TESTING; METHODOLOGY; MICROFLUIDIC ANALYSIS; TISSUE ENGINEERING;

BIOCOMPATIBLE MATERIALS; CELL CULTURE TECHNIQUES; DIMETHYLPOLYSILOXANES; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; FLOW CYTOMETRY; MATERIALS TESTING; MICROFLUIDIC ANALYTICAL TECHNIQUES; MINIATURIZATION; NYLONS; SILICON; TISSUE ENGINEERING;

EID: 34047142856     PISSN: 05891019     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/IEMBS.2006.260375     Document Type: Conference Paper

References (16)

1. R. Langer and D. A. Tirrell, "Designing materials for biology and medicine," Nature, vol. 428, pp. 487-492, April 2004.
2. Y. Xia and G. Whitesides, "Soft lithography," Angewandte Chemie International Edition, vol. 37, no. 5, pp. 550-575, Dec. 1998.
3. N. Li, A. Tourovskaia, and A. Folch, "Biology on a chip: Microfabrication for study of the behavior of cultured cells," Critical Review in Biomedical Engineering, vol. 31, no. 5 and 6, pp. 423-488, 2003.
4. N. Cohen, "The development of spontaneous beating activity in cultured heart cells: From cells to networks," Ph.D. dissertation, Israel Institute of Technology, Kislev, 5761, Haifa, Israel, December 2000.
5. W. Gu, X. Zhu, N. Futai, B. Cho, and S. Takayama, "Computerized microfluidic cell culture using elastomeric channels and braille displays," Proceedings of the National Academy of Sciences, vol. 10, no. 45, pp. 15861-15866, 2004.
6. P. Hung, P. Lee, P. Sabounchi, N. Aghdam, R. Lin, and L. Lee, "A novel high aspect ratio microfluidic design to provide a stable and uniform microenvironment for cell growth in a high throughput mammalian cell culture array," Lab on a Chip, vol. 5, no. 44-48, pp. 44-48, 2005.
7. M. Adams, S. Quake, and A. Scherer, "On-chip absorption and fluorescence spectroscopy with polydimethylsiloxane (PDMS) microfluidic flow channels," 2nd. Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, vol. 1, no. 1, pp. 369-373, May 2002.
8. G. Walker, H. Zeringue, and D. Beebe, "Microenvironment design considerations for cellular scale studies," Lab on a Chip, vol. 4, pp. 91-97, 2004.
9. J. Blain Christen and A. Andreou, "Integration of silicon CMOS with with multilayer silicone (PDMS) fluidics into a Micro-Incubator for cell culture studies," Transactions on Circuits and Systems Part I: Regular Papers: Special Issue Life Science Systems and Applications, (submitted).
10. M. Shin, K. Matsuda, O. Ishii, H. Terai, M. Kaazemput-Mofrad, J. Borenstein, M. Detmar, and J. Vacanti, "Endothelialized networks with vascular geometry in microfabricated poly(dimethylsiloxane)," Biomedical Microdevices, vol. 6, no. 4, pp. 269-278, 2004.
11. M. Hutzler and P. Fromherz, "Silicon chip with capacitors and transistors for interfacing organotypic brain slice of rat hippocampus," European Journal of Neuroscience, vol. 19, pp. 2231-2238, 2004.
12. Y. Liu, E. Smela, N. Nelson, and P. Abshire, "Cell-Lab on a chip: A CMOS-based microsystem for culturing and monitoring cells," IEEE EMBS. San Francisco CA, USA: IEEE, September 1-5 2004.
13. B. Debusschere and G. Kovacs, "Portable cell-based biosensor system using integrated CMOS cell-cartridges," Biosensors and Bioelectronics, vol. 16, pp. 543-556, 2001.
14. J. Blain Christen and A. Andreou, "CMOS heater array for incubation environment cellular study," Proceedings of the 48th Midwest Symposium on Circuits and Systems, August 2005.
15. J. Blain Christen, C. Davis, M. Li, and A. Andreou, "Design, double sided post-processing, and packaging of CMOS compatible BioMEMS device arrays," IEEE International Symposium on Circuits and Systems, 2002, vol. 1, pp. 665-668, May 2002.
16. E. Culurciello and A. Andreou, "3D integrated senseors in silicon-on-sapphire CMOS," Proceedings of the 2006 IEEE International Symposium on Circuits and Systems, 2006.