Synthesis and pharmacological evaluation of bis-3-(3,4-dichlorophenyl)acrylamide derivatives as glycogen phosphorylase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 18, 2008, Pages 8627-8634

  Onda, Kenichi ^a   Shiraki, Ryota ^a   Yonetoku, Yasuhiro ^a   Momose, Kazuhiro ^a   Katayama, Naoko ^a   Orita, Masaya ^a   Yamaguchi, Tomohiko ^a   Ohta, Mitsuaki ^a   Tsukamoto, Shin ichi ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Bis 3 (3,4 dichlorophenyl)acrylamide; Glycogen phosphorylase; High throughput screening (HTS); Type 2 diabetes; X ray crystallographic study

Indexed keywords

ACRYLAMIDE DERIVATIVE; GLYCOGEN PHOSPHORYLASE; N,N' PENTANE 1,5 DIYLBIS[3 (3,4 DICHLOROPHENYL)ACRYLAMIDE]; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; HIGH THROUGHPUT SCREENING; HUMAN; X RAY CRYSTALLOGRAPHY;

ACRYLAMIDES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DICHLOROPHEN; ENZYME INHIBITORS; GLYCOGEN PHOSPHORYLASE, LIVER FORM; HUMANS; HYDROPHOBICITY; HYPOGLYCEMIC AGENTS; SOLVENTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 51449085578     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.08.010     Document Type: Article

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