-
1
-
-
0030820394
-
Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p
-
Amos CI, Bali D, Thiel TJ, Anderson JP, Gourley I, Frazier ML, Lynch PM, et al. (1997) Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p. Cancer Res 57:3653-3656
-
(1997)
Cancer Res
, vol.57
, pp. 3653-3656
-
-
Amos, C.I.1
Bali, D.2
Thiel, T.J.3
Anderson, J.P.4
Gourley, I.5
Frazier, M.L.6
Lynch, P.M.7
-
2
-
-
0037068461
-
Loss of the LKB1 tumor suppressor provokes intestinal polyposis but resistance to transformation
-
Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NS, Loda M, et al. (2002) Loss of the LKB1 tumor suppressor provokes intestinal polyposis but resistance to transformation. Nature 419:162-167
-
(2002)
Nature
, vol.419
, pp. 162-167
-
-
Bardeesy, N.1
Sinha, M.2
Hezel, A.F.3
Signoretti, S.4
Hathaway, N.A.5
Sharpless, N.S.6
Loda, M.7
-
3
-
-
15444350943
-
Increased risk for cancer in patients with the Peutz-Jeghers syndrome
-
Boardman LA, Thibodeau SN, Schaid DJ, Lindor NM, McDonnell SK, Burgart LJ, Ahlquist DA, et al. (1998) Increased risk for cancer in patients with the Peutz-Jeghers syndrome. Ann Intern Med 128:896-899
-
(1998)
Ann Intern Med
, vol.128
, pp. 896-899
-
-
Boardman, L.A.1
Thibodeau, S.N.2
Schaid, D.J.3
Lindor, N.M.4
McDonnell, S.K.5
Burgart, L.J.6
Ahlquist, D.A.7
-
4
-
-
0034141636
-
LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo
-
Collins SP, Reoma JL, Gamm DM, Uhler MD (2000) LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo. Biochem J 345:673-680
-
(2000)
Biochem J
, vol.345
, pp. 673-680
-
-
Collins, S.P.1
Reoma, J.L.2
Gamm, D.M.3
Uhler, M.D.4
-
5
-
-
0025903863
-
Extrachromosomal amplification of the epidermal growth factor receptor gene in a human colon carcinoma cell line
-
Dolf G, Meyn RE, Curley D, Prather N, Story MD, Boman BM, Siciliano MJ, et al. (1991) Extrachromosomal amplification of the epidermal growth factor receptor gene in a human colon carcinoma cell line. Genes Chromosomes Cancer 3:48-54
-
(1991)
Genes Chromosomes Cancer
, vol.3
, pp. 48-54
-
-
Dolf, G.1
Meyn, R.E.2
Curley, D.3
Prather, N.4
Story, M.D.5
Boman, B.M.6
Siciliano, M.J.7
-
6
-
-
0029021758
-
Eicosanoids and the gastrointestinal tract
-
Eberhart CE, DuBois RN (1995) Eicosanoids and the gastrointestinal tract. Gastroenterology 109:285-301
-
(1995)
Gastroenterology
, vol.109
, pp. 285-301
-
-
Eberhart, C.E.1
DuBois, R.N.2
-
7
-
-
0035142924
-
Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome
-
Entius MM, Keller JJ, Westerman AM, van Rees BP, van Velthuysen ML, de Goeij AF, Wilson JH, et al. (2001) Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome. J Clin Pathol 54:126-131
-
(2001)
J Clin Pathol
, vol.54
, pp. 126-131
-
-
Entius, M.M.1
Keller, J.J.2
Westerman, A.M.3
Van Rees, B.P.4
Van Velthuysen, M.L.5
De Goeij, A.F.6
Wilson, J.H.7
-
8
-
-
0024238366
-
Peutz-Jeghers syndrome: A clinicopathologic survey of the "Harrisburg family" with a 49-year follow-up
-
Foley TR, McGarrity TJ, Abt AR (1988) Peutz-Jeghers syndrome: a clinicopathologic survey of the "Harrisburg family" with a 49-year follow-up. Gastroenterology 95:1535-1540
-
(1988)
Gastroenterology
, vol.95
, pp. 1535-1540
-
-
Foley, T.R.1
McGarrity, T.J.2
Abt, A.R.3
-
9
-
-
0023192463
-
Increased risk of cancer in the Peutz-Jeghers syndrome
-
Giardiello FM, Welsh SB, Hamilton SR (1987) Increased risk of cancer in the Peutz-Jeghers syndrome. N Engl J Med 316:1511-1513
-
(1987)
N Engl J Med
, vol.316
, pp. 1511-1513
-
-
Giardiello, F.M.1
Welsh, S.B.2
Hamilton, S.R.3
-
10
-
-
0032495530
-
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome
-
Hemminki A, Markie D, Tomlinson I, Avizienyte E, Roth S, Loukola A, Bignell G, et al. (1998) A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 391:184-187
-
(1998)
Nature
, vol.391
, pp. 184-187
-
-
Hemminki, A.1
Markie, D.2
Tomlinson, I.3
Avizienyte, E.4
Roth, S.5
Loukola, A.6
Bignell, G.7
-
11
-
-
0031012344
-
Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis
-
Hemminki A, Tomlinson I, Markie D, Jarvinen H, Sistonen P, Bjorkqvist AM, Knuutila S, et al. (1997) Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis. Nature Genet 15:87-90
-
(1997)
Nature Genet
, vol.15
, pp. 87-90
-
-
Hemminki, A.1
Tomlinson, I.2
Markie, D.3
Jarvinen, H.4
Sistonen, P.5
Bjorkqvist, A.M.6
Knuutila, S.7
-
12
-
-
0000152019
-
Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits
-
Jeghers H, McKusick VA, Katz KH (1949) Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits. N Engl J Med 241:992-1036
-
(1949)
N Engl J Med
, vol.241
, pp. 992-1036
-
-
Jeghers, H.1
McKusick, V.A.2
Katz, K.H.3
-
13
-
-
0031974516
-
Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase
-
Jenne DE, Reimann H, Nezu J, Freidel W, Loff S, Jeschke R, Muller O, et al. (1998) Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nature Genet 18:38-43
-
(1998)
Nature Genet
, vol.18
, pp. 38-43
-
-
Jenne, D.E.1
Reimann, H.2
Nezu, J.3
Freidel, W.4
Loff, S.5
Jeschke, R.6
Muller, O.7
-
14
-
-
0034964446
-
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death
-
Karuman P, Gozani O, Odze RD, Zhou XC, Zhu H, Shaw R, Brien TP, et al. (2001) The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. Mol Cell 7:1307-1319
-
(2001)
Mol Cell
, vol.7
, pp. 1307-1319
-
-
Karuman, P.1
Gozani, O.2
Odze, R.D.3
Zhou, X.C.4
Zhu, H.5
Shaw, R.6
Brien, T.P.7
-
15
-
-
0035980097
-
LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest
-
Marignani PA, Kanai F, Carpenter CL (2001) LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest. J Biol Chem 276:32415-32418
-
(2001)
J Biol Chem
, vol.276
, pp. 32415-32418
-
-
Marignani, P.A.1
Kanai, F.2
Carpenter, C.L.3
-
16
-
-
0037343907
-
Overexpression of cyclooxygenase 2 in hamartomatous polyps of Peutz-Jeghers syndrome
-
McGarrity TJ, Peiffer LP, Amos CI, Frazier ML, Ward MG, Howett MK (2003) Overexpression of cyclooxygenase 2 in hamartomatous polyps of Peutz-Jeghers syndrome. Am J Gastroenterol 98:671-678
-
(2003)
Am J Gastroenterol
, vol.98
, pp. 671-678
-
-
McGarrity, T.J.1
Peiffer, L.P.2
Amos, C.I.3
Frazier, M.L.4
Ward, M.G.5
Howett, M.K.6
-
17
-
-
17344365130
-
Peutz-Jeghers syndrome: Confirmation of linkage to chromosome 19p13.3 and identification of a potential second locus, on 19q13.4
-
Mehenni H, Blouin JL, Radhakrishna U, Bhardwaj SS, Bhardwaj K, Dixit VB, Richards KF, et al. (1997) Peutz-Jeghers syndrome: confirmation of linkage to chromosome 19p13.3 and identification of a potential second locus, on 19q13.4. Am J Hum Genet 61:1327-1334
-
(1997)
Am J Hum Genet
, vol.61
, pp. 1327-1334
-
-
Mehenni, H.1
Blouin, J.L.2
Radhakrishna, U.3
Bhardwaj, S.S.4
Bhardwaj, K.5
Dixit, V.B.6
Richards, K.F.7
-
18
-
-
0033692749
-
Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome
-
Miyaki M, Iijima T, Hosono K, Ishii R, Yasuno M, Mori T, Toi M, et al. (2000) Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome. Cancer Res 60:6311-6313
-
(2000)
Cancer Res
, vol.60
, pp. 6311-6313
-
-
Miyaki, M.1
Iijima, T.2
Hosono, K.3
Ishii, R.4
Yasuno, M.5
Mori, T.6
Toi, M.7
-
19
-
-
0037089467
-
Gastrointestinal hamartomatous polyposis in LKB1 heterozygous knockout mice
-
Miyoshi H, Nakau M, Ishikawa T, Seldin MF, Oshima M, Taketo MM (2002) Gastrointestinal hamartomatous polyposis in LKB1 heterozygous knockout mice. Cancer Res 62:2261-2266
-
(2002)
Cancer Res
, vol.62
, pp. 2261-2266
-
-
Miyoshi, H.1
Nakau, M.2
Ishikawa, T.3
Seldin, M.F.4
Oshima, M.5
Taketo, M.M.6
-
20
-
-
0033546695
-
Loss of cytoplasmic retention ability of mutant LKB1 found in Peutz-Jeghers syndrome patients
-
Nezu J, Oku A, Shimane M (1999) Loss of cytoplasmic retention ability of mutant LKB1 found in Peutz-Jeghers syndrome patients. Biochem Biophys Res Commun 261:750-755
-
(1999)
Biochem Biophys Res Commun
, vol.261
, pp. 750-755
-
-
Nezu, J.1
Oku, A.2
Shimane, M.3
-
21
-
-
17344367301
-
Peutz-Jeghers disease: Most, but not all, families are compatible with linkage to 19p13.3
-
Olschwang S, Markie D, Seal S, Neale K, Philios R, Cottrell S, Ellis I, et al. (1998) Peutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3. J Med Genet 35:42-44
-
(1998)
J Med Genet
, vol.35
, pp. 42-44
-
-
Olschwang, S.1
Markie, D.2
Seal, S.3
Neale, K.4
Philios, R.5
Cottrell, S.6
Ellis, I.7
-
23
-
-
0026078249
-
Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequence
-
Robbins J, Dilworth SM, Laskey RA, Dingwall C (1991) Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence. Cell 64:615-623
-
(1991)
Cell
, vol.64
, pp. 615-623
-
-
Robbins, J.1
Dilworth, S.M.2
Laskey, R.A.3
Dingwall, C.4
-
24
-
-
0037125996
-
Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis
-
Rossi DJ, Ylikorkala A, Korsisaari N, Salovaara R, Luukko K, Launonen V, Henkemeyer M, et al. (2002) Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis. Proc Natl Acad Sci USA 99:12327-12332
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 12327-12332
-
-
Rossi, D.J.1
Ylikorkala, A.2
Korsisaari, N.3
Salovaara, R.4
Luukko, K.5
Launonen, V.6
Henkemeyer, M.7
-
25
-
-
0033771625
-
In situ analysis of LKB1/STK11 mRNA expression in human normal tissues and tumours
-
Rowan A, Churchman M, Jefferey R, Hanby A, Poulsom R, Tomlinson I (2000) In situ analysis of LKB1/STK11 mRNA expression in human normal tissues and tumours. J Pathol 192:203-206
-
(2000)
J Pathol
, vol.192
, pp. 203-206
-
-
Rowan, A.1
Churchman, M.2
Jefferey, R.3
Hanby, A.4
Poulsom, R.5
Tomlinson, I.6
-
26
-
-
0035375261
-
Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth
-
Sapkota GP, Kieloch A, Lizcano JM, Lain S, Arthur JS, Williams MR, Morrice N, et al. (2001) Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth. J Biol Chem 276:19469-19482
-
(2001)
J Biol Chem
, vol.276
, pp. 19469-19482
-
-
Sapkota, G.P.1
Kieloch, A.2
Lizcano, J.M.3
Lain, S.4
Arthur, J.S.5
Williams, M.R.6
Morrice, N.7
-
29
-
-
0030947525
-
Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2
-
Sheng H, Shao J, Kirkland SC, Isakson P, Coffey RJ, Morow J, Beauchamp RD, et al. (1997) Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J Clin Invest 99:2254-2259
-
(1997)
J Clin Invest
, vol.99
, pp. 2254-2259
-
-
Sheng, H.1
Shao, J.2
Kirkland, S.C.3
Isakson, P.4
Coffey, R.J.5
Morow, J.6
Beauchamp, R.D.7
-
30
-
-
0030479496
-
Prostaglandin endoperoxide H synthases (cyclooxygenase)-1 and -2
-
Smith WL, Garavito M, Dewitt, DL (1996) Prostaglandin endoperoxide H synthases (cyclooxygenase)-1 and -2. J Biol Chem 271:33157-33160
-
(1996)
J Biol Chem
, vol.271
, pp. 33157-33160
-
-
Smith, W.L.1
Garavito, M.2
Dewitt, D.L.3
-
32
-
-
0037096833
-
Growth arrest by the LKB1 tumor suppressor: Induction of p21(WAF1/CIP1)
-
Tiainen M, Vaahtomeri K, Ylikorkala A, Makela TP (2002) Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1). Hum Mol Genet 11:1497-1504
-
(2002)
Hum Mol Genet
, vol.11
, pp. 1497-1504
-
-
Tiainen, M.1
Vaahtomeri, K.2
Ylikorkala, A.3
Makela, T.P.4
-
33
-
-
0033529838
-
Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest
-
Tiainen M, Ylikorkala A, Makela TP (1999) Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest. Proc Natl Acad Sci USA 96:9248-9251
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 9248-9251
-
-
Tiainen, M.1
Ylikorkala, A.2
Makela, T.P.3
-
34
-
-
0028803728
-
Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
-
Tsujii M, DuBois RN (1995) Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 83:493-501
-
(1995)
Cell
, vol.83
, pp. 493-501
-
-
Tsujii, M.1
DuBois, R.N.2
-
35
-
-
0033012429
-
Novel mutations in the LKB1/STKII gene in Dutch Peutz-Jeghers families
-
Westerman AM, Entius MM, Boor PP, Koole R, de Baar E, Offerhaus GJ, Lubinski J, et al. (1999) Novel mutations in the LKB1/STKII gene in Dutch Peutz-Jeghers families. Hum Mutat 13:476-481
-
(1999)
Hum Mutat
, vol.13
, pp. 476-481
-
-
Westerman, A.M.1
Entius, M.M.2
Boor, P.P.3
Koole, R.4
De Baar, E.5
Offerhaus, G.J.6
Lubinski, J.7
|