Nitric oxide signaling in colon cancer chemoprevention

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 555, Issue 1-2 SPEC. ISS., 2004, Pages 107-119

  Rao, Chinthalapally V ^a,b  

^a AMERICAN HEALTH FOUNDATION   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Colon cancer; Cyclooxygenase 2; Inducible nitric oxide synthase; Peroxynitrite; Tumor progression chemoprevention

Indexed keywords

1,4 PHENYLENEBIS(1,2 ETHANEDIYL)BISISOTHIOUREA; ACETYLSALICYLIC ACID 3 (NITROXYMETHYL)PHENYL ESTER; ACETYLSALICYLIC ACID DERIVATIVE; AMIDE; AMINOGUANIDINE; CYCLOOXYGENASE 2; FLURBIPROFEN 4 NITROXYBUTYL ESTER; IBUPROFEN DERIVATIVE; INDOMETACIN DERIVATIVE; INDUCIBLE NITRIC OXIDE SYNTHASE; N 6 (1 IMINOETHYL)LYSINE; N 6 (1 IMINOETHYL)LYSINE TETRAZOLE AMIDE; N [(1,3 BENZODIOXOL 5 YL)METHYL] 1 [2 (1H IMIDAZOL 1YL)PYRIMIDIN 4 YL] 4 (METHOXYCARBONYL)PIPERAZIN 2 ACETAMIDE; N METHYLARGININE; NCX 1102; NCX 2210; NCX 2219; NCX 530; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE INHIBITOR; NITROGEN OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; REACTIVE NITROGEN SPECIES; SULINDAC; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

CHEMOPROPHYLAXIS; COLON CANCER; COLON CARCINOGENESIS; CORRELATION ANALYSIS; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ANTICARCINOGENIC AGENTS; APOPTOSIS; CHEMOPREVENTION; COLONIC NEOPLASMS; HUMANS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; SIGNAL TRANSDUCTION;

EID: 5144230475     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2004.05.022     Document Type: Review

References (114)

1. S. Moncada, R.M. Palmer, and E.A. Higgs Nitric oxide: physiology, pathophysiology, and pharmacology Pharmacol. Rev. 43 1991 109 142
2. W.K. Alderton, C.E. Cooper, and R.G. Knowles Nitric oxide synthases: structure, function and inhibition Biochem. J. 357 2001 593 615
3. K.D. Kroncke, K. Fehsel, and V. Kolb-Bachofen Inducible nitric oxide synthase in human diseases Clin. Exp. Immunol. 113 1998 147 156
4. C. Nathan, and Q.W. Xie Nitric oxide synthases: roles, tolls, and controls Cell 78 1994 915 918
5. U. Forstermann, and H. Kleinert Nitric oxide synthase: expression and expressional control of the three isoforms Naunyn-Schmiedebergs Arch. Pharmakol. 352 1995 351 364
6. L.J. Ignarro Introduction and overview L.J. Ignarro Nitric Oxide: Biology and Pathobiology 2000 Academic Press San Diego, CA 3 19
7. M. Jaiswal, N.F. LaRusso, and G.J. Gores Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to carcinogenesis Am. J. Physiol. Gastrointest. Liver Physiol. 281 2001 G626 G634
8. C.V. Rao, and B.S. Reddy NSAIDs and chemoprevention Curr. Cancer Drug Targets 4 2004 29 43
9. D.A. Wink, Y. Vodovotz, J. Laval, F. Laval, M.W. Dewhirst, and J.B. Mitchell The multifaceted roles of nitric oxide in cancer Carcinogenesis 19 1998 711 721
10. S.P. Hussain, L.J. Hofseth, and C.C. Harris Radical causes of cancer Nat. Rev. Cancer 3 2003 276 285
11. S.J. Middleton, M. Shorthouse, and J.O. Hunter Increased nitric oxide synthesis in ulcerative colitis Lancet 341 1993 465
12. S. Ambs, W.G. Merriam, W.P. Bennett, E. Felley-Bosco, M.O. Ogunfusika, S.M. Oser, S. Klein, P.G. Shields, T.R. Billiar, and C.C. Harris Frequent nitric oxide synthase-2 expression in human colon adenomas: Implication for tumor angiogenesis and colon cancer progression Cancer Res. 58 1998 334 341
13. F. Cianchi, C. Cortesini, O. Fantappie, and L. Messerini Inducible nitric oxide synthase expression in human colorectal cancer Am. J. Pathol. 162 2003 793
14. P.K. Lala, and C. Chekraborty Role of nitric oxide in carcinogenesis and tumor progression Lancet Oncol. 3 2001 149 152
15. C.V. Rao, T. Kawamori, R. Hamid, B. Simi, B. Gambrell, and B.S. Reddy Chemoprevention of colon cancer by iNOS specific and non-specific inhibitors: a safer colon cancer chemopreventive strategy Proc. Am. Assoc. Cancer Res. 39 1998 197
16. M. Takahashi, K. Fukuda, T. Ohata, T. Sugimura, and K. Wakabayashi Increased expression of inducible and endothelial constitutive nitric oxide synthases in rat colon tumors induced by azoxymethane Cancer Res. 57 1997 1233 1237
17. B. Brune, A. von Knethen, and K.B. Sandau Nitric oxide (NO): an effector of apoptosis Cell Death Differ. 6 1999 969 975
18. S. Tamir, S. Burney, and S. Tannenbaum DNA damage by nitric oxide Chem. Res. Toxicol. 9 1996 821 827
19. M. Jaiswal, N. LaRusso, L. Burgart, and G. Gores Inflammatory cytokines induce DNA damage and inhibit DNA repair in colonic carcinoma cells by a nitric oxide-dependent mechanism Cancer Res. 60 2000 184 189
20. R.H. Liu, and J.H. Hotchkiss Potential genotoxicity of chronically elevated nitric oxide: a review Mutat. Res. 339 1995 73 89
21. L. Chazotte-Aubert, P. Hainaut, and H. Ohshima Nitric oxide nitrates tyrosine residues of tumor suppressor p53 protein in MCF-7 cells Biochem. Biophy. Res. Commun. 267 2000 609 613
22. K. Forrester, S. Ambs, S.E. Lupold, R.B. Kapust, E.A. Spillare, W.C. Weinberg, E. Felley-Bosco, X.W. Wang, D.A. Geller, E. Tzeng, T.M. Billiar, and C.C. Harris Nitric oxide-induced p53 accumulation and regulation of iNOS expression by wildtype p53 Proc. Natl. Acad. Sci. U.S.A. 93 1996 2442 2447
23. D.A. Wink, K.S. Kasprzak, C.M. Maragosd, R.R. Elespru, M. Misra, T.M. Dunams, T.A. Cebula, W.N. Koch, A.W. Andrews, J.S. Aleen, and L.K. Keefer DNA deaminating ability and genotoxicity of nitric oxide and its progenitors Science 254 1991 1001 1103
24. S. Ambs, M.O. Ogunfusika, W.G. Merriam, W.P. Bennett, T.M. Billiar, and C.C. Harris Up-regulation of iNOS expression in cancer-prone p53 knockout mice Proc. Natl. Acad. Sci. U.S.A. 95 1998 8823 8828
25. J. Li, T.R. Billiar, R.V. Talanian, and Y.M. Kim Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation Biochem. Biophys. Res. Commun. 240 1997 419 424
26. A.J. Marrogi, W.D. Travis, J.A. Welsh, M.A. Khan, H. Rahim, H. Tazelaar, P. Pairolero, V. Trastek, J. Jett, N.E. Caporaso, L.A. Liotta, and C.C. Harris Nitric oxide synthase, cyclooxygenase 2, and vascular endothelial growth factor in the angiogenesis of non-small cell lung carcinoma Clin. Cancer Res. 6 2000 4739 4744
27. L.L. Thomsen, F.G. Lawton, R.G. Knowles, J.E. Beesley, V. Riveros-Moreno, and S. Moncada Nitric oxide synthase activity in human gynecological cancer Cancer Res. 54 1994 1352 1354
28. L.L. Thomsen, D.W. Miles, L. Happerfield, L.G. Bobrow, R.G. Knowles, and S. Moncada Nitric oxide synthase activity in human breast cancer Br. J. Cancer 72 1995 41 44
29. P. Uotila, E. Valve, P. Martikainen, M. Nevalainen, M. Nurmi, and P. Harkonen Increased expression of cyclooxygenase-2 and nitric oxide synthase-2 in human prostate cancer Urol. Res. 29 2001 23 28
30. T. Klotz, W. Bloch, C. Volberg, U. Engelmann, and K. Addicks Selective expression of inducible nitric oxide synthase in human prostate carcinoma Cancer (Philadelphia, PA) 82 1998 1897 1903
31. O. Gallo, E. Masini, L. Morbidelli, A. Franchi, I. Fini-Storchi, W.A. Vergari, and M. Ziche Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer J. Natl. Cancer Inst. (Bethesda) 90 1998 587 596
32. K.T. Wilson, S. Fu, K.S. Ramanujam, and S.J. Meltzer Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas Cancer Res. 58 1998 2929 2934
33. S. Ekmekcioglu, J. Ellerhorst, C.M. Smid, V.G. Prieto, M. Munsell, A.C. Buzaid, and E.A. Grimm Inducible nitric oxide synthase and nitrotyrosine in human metastatic melanoma tumors correlate with poor survival Clin. Cancer Res. 6 2000 4768 4775
34. T. Goto, K. Haruma, Y. Kitadai, M. Ito, M. Yoshihara, K. Sumii, N. Hayakawa, and G. Kajiyama Enhanced expression of inducible nitric oxide synthase and nitrotyrosine in gastric mucosa of gastric cancer patients Clin. Cancer Res. 5 1999 1411 1415
35. C.S. Cobbs, J.E. Brenmen, K.D. Aldape, D.S. Bredt, and M.A. Israel Expression of nitric oxide synthase in human central nervous system tumors Cancer Res. 55 1995 727 730
36. K.J. Baek, B.A. Theil, S. Lucas, and D.J. Stuehr Macrophage nitric oxide synthase subunits: purification, characterization and role of prosthetic groups and substrates in regulating their association into dimeric enzyme J. Biol. Chem. 268 1993 21120 21129
37. M.A. Tayeh, and M.A. Marle Macrophage oxidation of l-arginine to NO, nitrite and nitrate: tetrahydrobiopterin is required as co-factor J. Biol. Chem. 264 1989 19654 19658
38. M.A. Marletta Nitric oxide synthase: aspects concerning structure and catalysis Cell 78 1994 927 930
39. T. Michel, and O. Ferron Nitric oxide and nitric oxide synthases J. Clin. Invest. 100 1997 2146 2152
40. D.A. Geller, A.K. Nussler, M. DiSilvio, C.J. Lowenstein, R.A. Shapiro, M.D. Simmons, and T.M. Billiar Cytokines, endotoxin and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes Proc. Natl. Acad. Sci. U.S.A. 90 1992 522 526
41. M. Jaiswal, N.F. LaRusso, and G.J. Gores Cholangiocarcinoma and pro-inflammatory cytokines Cancer Alert 1 2000 141 144
42. C. Nathan, and Q-W. Xie Regulation of biosynthesis of nitric oxide J. Biol. Chem. 269 1994 13725 13728
43. G.R. Starke, I.M. Kerr, B.R. Williams, R.H. Silverman, and R.D. Schreiber How cells respond to interferons Annu. Rev. Biochem. 67 1998 227 264
44. B.S. Taylor, L.H. Alarcon, and T.M. Billiar Inducible nitric oxide synthase in the liver: regulation and function Biochemistry 63 1998 766 781
45. B.G. Bentz, R.L. Simmons, G.K. Halnes, and J.A. Radosevich The yin and yang of nitric oxide: reflections on physiology and pathophysiology of nitric oxide Head Neck 22 2000 71 83
46. M.G. Davies, G.J. Fulton, and P.O. Hagen Clinical biology of nitric oxide Br. J. Surg. 82 1995 1598 1610
47. C. Nathan, and J.B. Hibbs Role of nitric oxide synthesis in macrophage antimicrobial activity Curr. Opin. Immunol. 3 1991 70 85
48. S.J. Green, C.A. Nacy, and M.S. Meltzer Cytokine-induced synthesis of nitrogen oxides in macrophages: a protective host response to Leishmania and other intracellular pathogens J. Leukoc. Biol. 50 1991 91 103
49. B.S. Taylor, M.E. de Vera, R.W. Ganster, Q. Wang, R.A. Shapiro, S.M. Morris, T.M. Billiar, and D.A. Geller Multiple NF-κB enhances elements regulate cytokine induction in human inducible nitric oxide synthase gene J. Biol. Chem. 273 1998 15148 15156
50. D.A. Wink, M.B. Grisham, J.B. Mitchell, and P.C. Ford Direct and indirect effects of nitric oxide in chemical reactions relevant to biology Methods Enzymol. 268 1996 12 31
51. T. Nguyen, D. Brunson, C.L. Crespi, B.W. Penman, J.S. Wishnok, and S.R. Tannenbaum DNA damage and mutation in human cells exposed to nitric oxide in vivo Proc. Natl. Acad. Sci. U.S.A. 89 1992 3030 3034
52. S.R. Tannenbaum, S. Tamir, T. Walker, DNA damage and cytotoxicity of nitric oxide, in: R.N. Loepsky, C.J. Michejda (Eds.), Nitrosoamines and Related Nitroso-Compound Chemistry and Biochemistry, Am. Chem. Soc., Washington, DC, ASA Symp. Ser. 553 (1994) 120-135.
53. C. Szabo, and H. Ohshima DNA damage induced by peroxynitrite: subsequent biological effects Nitric Oxide 1 1997 373 385
54. R. Radi, M. Rodriguez, L. Castro, and R. Telleri Inhibition of mitochondrial electron transport by peroxynitrite Arch. Biochem. Biophys. 308 1994 89 95
55. M. Lepoivre, J.M. Flaman, P. Bobe, G. Lemaire, and Y. Henry Quenching of tyrosyl free radical of ribonucleotide reductase by nitric oxide J. Biol. Chem. 269 1994 21891 21897
56. G. Weiss, B. Goossen, W. Doppler, D. Fuchs, K. Pantopoulos, G. Warner-Femayer, H. Wachter, and M.W. Hentze Translational regulation via iron-responsive elements by nitric oxide/nitric oxide synthase pathway EMBO J. 12 1993 3651 3657
57. V.M. Darley-Usman, N. Hogg, V.J. O'Leary, M.T. Wilson, and S. Moncada The simultaneous generation of superoxide and nitric oxide can initiate lipid peroxidation in human low density lipoprotein Free Radic. Res. Commun. 17 1992 9 20
58. C.M. Padgett, and A.R. Whorton Cellular responses to nitric oxide: role of protein S-thiolation/dethiolation Arch. Biochem. Biophys. 358 1998 232 242
59. T.T. Rohn, and M.T. Quinn Inhibition of peroxynitrite-mediated inhibition of tyrosine nitration by a novel pyrolopyrimidine antioxidant Eur. J. Pharmacol. 353 1998 329 336
60. M. Tsujii, and R.N. DuBois Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase-2 Cell 8 1995 493 499
61. M.M. Taketo Cyclooxygenase-2 inhibitors in tumorigenesis (part I) J. Natl. Cancer Inst. 90 1998 1529 1534
62. B.S. Reddy, Y. Hirsoe, R. Lubet, V.E. Steele, G.J. Kelloff, S. Paulson, K. Seibert, and C.V. Rao Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis Cancer Res. 60 2000 293 298
63. G. Steinbach, P.M. Lynch, and R.K.S. Phillips The effect of celecoxib, s-cyclooxygenase-2 inhibitor, in familial adenomatous polyposis N. Engl. J. Med. 342 1946 2000
64. P.J. Morin, B. Vogelstein, and K.W. Kinzler Apoptosis and APC in colorectal tumorigenesis Proc. Natl. Acad. Sci. U.S.A. 93 1996 7950 7955
65. Y. Sun, X.M. Tang, E. Half, M.T. Kuo, and F.A. Sinicrope Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent pathway in human colon cancer cells Cancer Res. 62 2002 6323 6328
66. D. Salvemini, T.P. Misko, J.L. Masferrer, K. Seibert, M.G. Currie, and P. Needleman Nitric oxide activates cyclooxygenase enzymes Proc. Natl. Acad. Sci. U.S.A. 90 1993 7240
67. T. Tetsuka, D.D. Iken, B.W. Miler, Z. Guan, and L.D. Baier Morrison, Nitric oxide amplifies interleukin 1-induced cyclooxygenase-2 expression in rat mesangial cells J. Clin. Invest. 97 1996 2051 2055
68. J.M. Mei, N.G. Hord, D.F. Winterstein, S.P. Donald, and J.M. Phang Expression of prostaglandin endoperoxide H synthase-2 induced by nitric oxide in conditionally immortalized murine colonic epithelial cells FASEB J. 14 2000 1188 1192
69. L.J. Marnett, T.L. Wright, B.C. Crews, S.R. Tannenbaum, and J.D. Morrow Regulation of prostaglandin biosynthesis by nitric oxide is revealed by targeted deletion of inducible nitric oxide synthase J. Biol. Chem. 275 2000 13421 13427
70. D. Salvemini, S.L. Settle, J.L. Masferrer, K. Seibert, M.G. Currie, and P. Needleman Regulation of prostaglandin production by nitric oxide: an in vivo analysis Br. J. Pharmacol. 114 1995 1171 1178
71. L.J. Marnett, S.W. Rowlinson, D.C. Goodwin, A.S. Kalgutkar, and C.A. Lanzo Arachidonic acid oxygenation by COX-1 and COX-2 J. Biol. Chem. 274 1999 22903 22906
72. V.B. O'Donell, B. Coles, M.J. Lewis, B.C. Crews, L.J. Marnett, and B.A. Freeman Catalytic consumption of nitric oxide by prostaglandin H synthase regulates platelet function J. Biol. Chem. 275 2000 38239 38243
73. C.V. Rao, C. Indranie, B. Simi, P.T. Manning, J.R. Connor, and B.S. Reddy Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase inhibitor Cancer Res. 62 2002 165 170
74. C.V. Rao, T. Kawamori, R. Hamid, and B.S. Reddy Chemoprevention of colonic aberrant crypt foci by an inducible nitric oxide synthase-selective inhibitor Carcinogenesis 20 1999 641 644
75. C.V. Rao, I. Cooma, M.V. Swamy, B. Simi, and B.S. Reddy Modulation of inducible nitric oxide synthase and cyclooxygenase activities by curcumin during different stages of experimental colon carcinogenesis Proc. Am. Assoc. Cancer Res. 39 2001 3084
76. Y. Liu, G.L. Borchert, and J.M. Phang PEA3, an Ets transcription factor, mediates the induction of cyclooxygenase-2 by nitric oxide in colorectal cancer cells J. Biol. Chem. 279 2004 18694 18700
77. J.F. Petit, M. Nicaise, M. Lepoivre, A. Guissani, and G. Lemaire Protection by glutathione against the antiproliferative effects of nitric oxide Biochem. Phamacol. 52 1996 205 210
78. L.M. Li, R.G. Kilbourn, and J. Adams Role of nitric oxide in lysis of tumor cells by cytokine-activated endothelial cells Cancer Res. 51 1991 2531
79. Q. Shi, Q. Xiong, B. Wang, X. Le, N.A. Khan, and K. Xie Influence of nitric oxide synthase II gene disruption on tumor growth and metastasis Cancer Res. 60 2000 2579
80. L. Liu, and J.S. Stamler NO: an inhibitor of cell death Cell Death Differ. 6 1999 937 942
81. J.B. Mannick, X.Q. Miao, and J.S. Stamler Nitric oxide inhibits Fas-induced apoptosis J. Biol. Chem. 272 1997 24125 24130
82. O. Salvucci, M. Carsana, I. Bersani, G. Tragni, and A. Anichini Antiapoptotic role of endogenous nitric oxide in human melanoma cells Cancer Res. 61 2001 318 323
83. S. Ambs, S.P. Hussain, and C.C. Harris Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression FASEB J. 11 1997 443 448
84. N. Schneiderhan, A. Budde, Y. Zhang, and B. Brune Nitric oxide induces phosphorylation of p53 and impairs nuclear export Oncogene 22 2003 2857 2862
85. G. Melino, B. Bernassola, R.A. Knight, M.T. Corasniti, G. Nistico, and A. Finazzi-Agro S-nitrosylation regulates apoptosis Nature 388 1997 432 437
86. L. Rossig, B. Fichtlscherer, K. Breitschopf, J. Haendeler, A.M. Zeiher, A. Mulsch, and S. Dimmeler Nitric oxide inhibits caspase-3 by S-nitrosation in vivo J. Biol. Chem. 274 1999 6823 6828
87. P.J. Moos, K. Edes, and Fitzpatrick Inactivation of wild-type p53 tumor suppressor by electrophilic prostaglandins Proc. Natl. Acad. Sci. U.S.A. 97 2000 9215 9219
88. M.S. Swamy, C.R. Herzog, and C.V. Rao Inhibition of COX-2 in colon cancer cell lines by celecoxib increases the nuclear localization of active p53 Cancer Res. 63 2003 5239 5242
89. M. Yoshida, T. Akaike, S. Goto, W. Takahashi, A. Inadome, M. Yono, H. Seshita, H. Maeda, and S. Ueda Effect of nitric oxide scavenger carboxy-PTIO on endothelium dependent vasorelaxation of various blood vessels from rabbits Life Sci. 62 1998 203 211
90. G.E. Arteel, K. Briviba, and H. Seis Function of thioredoxin reductase as a peroxynitrite reductase using selenocysteine or ebselen Chem. Res. Toxicol. 12 1999 264 269
91. K.M. Faulkner, S.I. Liochev, and I. Fridovich Stable Mn(II)-porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo J. Biol. Chem. 269 1994 23471 23476
92. A. Gulati, A. Bavre, and A.P. Sen Pharmacology of hemoglobin therapeutics J. Lab. Clin. Med. 133 1999 112 119
93. M.Y. Chang, H.I. Huang, M.R. Fenton, and D. Fong In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventing natural product with anti-inflammatory properties Biochem. Pharmacol. 55 1998 1955 1962
94. K.R. Thomas, D.A. Geller, T.M. Billiar, M.G. Davies, B.R. Pitt, R.L. Simmons, and D.K. Nakayama Antisense oligonucleotide to inducible nitric oxide synthases inhibits nitric oxide synthesis in rat pulmonary artery smooth muscle cells in culture Surgery 114 1993 272 277
95. P. Vallance, and J. Leper Blocking NO synthesis: how, where and why? Nat. Rev. Drug Discov. 1 2002 939 945
96. J.A. Crowell, V.E. Steele, and J.R.F. Sigman Is inducible nitric oxide synthase a target for chemoprevention? Mol. Cancer Therap. 2 2003 815 823
97. D.C. Jenkins, I.G. Charles, L.L. Thomsen, D.W. Moss, L.S. Holmes, A.S. Baylis, P. Rhodes, K. Westmore, P.C. Emson, and S. Moncada Roles of nitric oxide in tumor growth Proc. Natl. Acad. Sci. U.S.A. 92 1995 4392 4396
98. L.L. Thomson, J.M. Scott, P. Topley, R.G. Knowles, A.J. Keerie, and A.J. Frend Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor Cancer Res. 57 1997 3300 3305
99. G.J. Southan, and C. Szabo Selective pharmacological inhibition of distinct nitric oxide synthase isoforms Biochem. Pharmacol. 51 1996 383 388
100. 6-(1- iminoethyl)lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor, J. Med. Chem. 45 (2002) 1638-1644.
101. K. MacMillan, M. Adler, and D.S. Auld Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry Proc. Natl. Acad. Sci. U.S.A. 97 2000 1506 1510
102. E. Blasko, C.B. Glaser, J.J. Devlin, and W. Xia Mechanistic studies with potent and selective inducible nitric-oxide synthase dimerization inhibitors J. Biol. Chem. 277 2002 295 301
103. min mice model Proc. Am. Assoc. Cancer Res. 43 2002 670
104. S. Cottrell, D. Bicknell, L. Kaklamanis, and W.F. Bodmer Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas Lancet 340 1992 626 630
105. L. Li, R.G. Kilbourn, J. Adams, and I.J. Fidler Role of nitric oxide in lysis of tumor cells by cytokine-activated endothelial cells Cancer Res. 51 1991 2531 2535
106. K. Xie, S. Huang, Z. Dong, S-H. Juang, M. Gutman, Q. Xie, C. Nathan, and I.J. Fidler Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells J. Exp. Med. 181 1995 1333 1343
107. S-H. Juang, K. Xie, L. Xu, Q. Shi, Y. Wang, J. Yoneda, and I.J. Fidler Suppression of tumorigenicity and metastasis of human renal carcinoma cells by infection with retroviral vectors harboring the murine inducible nitric oxide synthase gene Hum. Gene Ther. 9 1998 845 854
108. D.A. Wink, I. Hanbauer, M.C. Krishna, W. DeGraff, J. Gamson, and J.B. Mitchell Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species Proc. Natl. Acad. Sci. U.S.A. 90 1993 9813 9817
109. E. Pipili-Synetos, E. Sakkoula, G. Haralabopoulos, P. Andriopoulou, P. Peristeris, and M.E. Maragoudakis Evidence that nitric oxide is an endogenous antiangiogenic mediator Br. J. Pharmacol. 11 1994 894 902
110. G. Magrinat, S.N. Mason, P.J. Shami, and J.B. Weinberg Nitric oxide modulation of human leukemia cell differentiation and gene expression Blood 80 1992 1880 1884
111. J.E. Albina, and J.S. Reichner Role of nitric oxide in mediation of macrophage cytotoxicity and apoptosis Cancer Metastasis Rev. 17 1998 39 53
112. Y. Yoshie, and H. Ohshima Nitric oxide synergistically enhances DNA strand breakage induced by polyhydroxyaromatic compounds, but inhibits that induced by the Fenton reaction Arch. Biochem. Biophys. 342 1997 13 21
113. B. Rigas, and J.L. Williams NO-releasing NSAIDs and colon cancer chemoprevention: a promising novel approach Int. J. Oncol. 20 2002 885 890
114. C.V. Rao, B. Simi, I. Cooma, B. Rigas, L. Kopelovich, and B.S. Reddy Chemoprevention of colonic aberrant crypt foci by nitric oxide (NO)-releasing NSAIDs Front. Cancer Prev. Res. 1 2002 D321