Increased expression of adrenomedullin 2/intermedin in rat hearts with congestive heart failure

European Journal of Heart Failure

Volumn 10, Issue 9, 2008, Pages 840-849

  Hirose, Takuo ^a   Totsune, Kazuhito ^a,b   Mori, Nobuyoshi ^c   Morimoto, Ryo ^c   Hashimoto, Masahiro ^a   Nakashige, Yukiko ^a   Metoki, Hirohito ^a,c   Asayama, Kei ^b   Kikuya, Masahiro ^a   Ohkubo, Takayoshi ^a,b   Hashimoto, Junichiro ^a,b   Sasano, Hironobu ^c   Kohzuki, Masahiro ^c   Takahashi, Kazuhiro ^a,b   Imai, Yutaka ^a,b  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Adrenomedullin; Adrenomedullin 2 Intermedin; Heart failure; Immunohistochemistry; RT PCR

Indexed keywords

ADRENOMEDULLIN; ADRENOMEDULLIN 2; INTERMEDIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; HEART INFARCTION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADRENOMEDULLIN; ANALYSIS OF VARIANCE; ANIMALS; GENE EXPRESSION; HEART FAILURE; IMMUNOENZYME TECHNIQUES; MALE; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 51349169372     PISSN: 13889842     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejheart.2008.06.020     Document Type: Article

References (30)

1. Roh J., Chang C.L., Bhalla C., Klein C., and Hsu S.Y. Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes. J Biol Chem 279 (2004) 7264-7274
2. Takei Y., Inoue K., Ogoshi M., Kawahara T., Bannai H., and Miyano S. Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator. FEBS Lett 556 (2004) 53-58
3. Takei Y., Hyodo S., Katafuchi T., and Minamino N. Novel fish-derived adrenomedullin in mammals: structure and possible function. Peptides 25 (2004) 1643-1656
4. Chang C.L., Roh J., and Hsu S.Y. Intermedin, a novel calcitonin family peptide that exists in teleosts as well as in mammals: a comparison with other calcitonin/intermedin family peptides in vertebrates. Peptides 25 (2004) 1633-1642
5. Poyner D.R., Sexton P.M., Marshall I., et al. International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol Rev 54 (2002) 233-246
6. Morimoto R., Satoh F., Murakami O., et al. Expression of adrenomedullin2/intermedin in human brain, heart, and kidney. Peptides 28 (2007) 1095-1103
7. McLatchie L.M., Fraser N.J., Main M.J., et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 393 (1998) 333-339
8. Pan C.S., Yang J.H., Cai D.Y., et al. Cardiovascular effects of newly discovered peptide intermedin/adrenomedullin 2. Peptides 26 (2005) 1640-1646
9. Dong F., Taylor M.M., Samson W.K., and Ren J. Intermedin(adrenomedullin-2) enhances cardiac contractile function via a protein kinase C- and protein kinase A-dependent pathway in murine ventricular myocytes. J Appl Physiol 101 (2006) 778-784
10. Kandilci H.B., Gumusel B., Wasserman A., Witriol N., and Lippton H. Intermedin/adrenomedullin-2 dilates the rat pulmonary vascular bed: dependence on CGRP receptors and nitric oxide release. Peptides 27 (2006) 1390-1396
11. Fujisawa Y., Nagae Y., Miyatake A., et al. Renal effects of a new member of adrenomedullin family, adrenomedullin2 in rats. Eur J Pharmacol 497 (2004) 75-80
12. Hinson J.P., Kapas S., and Smith D.M. Adrenomedullin, a multifunctional regulatory peptide. Endocr Rev 21 (2000) 138-167
13. Hamid S.A., and Baxter G.F. Adrenomedullin: regulator of systemic and cardiac homeostasis in acute myocardial infarction. Pharmacol Ther 105 (2005) 95-112
14. Ishimatsu T., Ono H., Minami J., and Matsuoka H. Pathophysiologic and therapeutic implications of adrenomedullin in cardiovascular disorders. Pharmacol Ther 111 (2006) 909-927
15. Zhang P.L., Mackenzie H.S., Totsune K., Troy J.L., and Brenner B.M. Renal effects of high-dose natriuretic peptide receptor blockade in rats with congestive heart failure. Circ Res 77 (1995) 1240-1245
16. Nakayama T., Hirose T., Totsune K., et al. Increased gene expression of urotensin II-related peptide in the hearts of rats with congestive heart failure. Peptides 29 (2008) 801-808
17. Totsune K., Mackenzie H.S., Totsune H., Troy J.L., Lytton J., and Brenner B.M. Upregulation of atrial natriuretic peptide gene expression in remnant kidney of rats with reduced renal mass. J Am Soc Nephrol 9 (1998) 1613-1619
18. Totsune K., Takahashi K., Mackenzie H.S., et al. Increased gene expression of adrenomedullin and adrenomedullin-receptor complexes, receptor-activity modifying protein (RAMP)2 and calcitonin-receptor-like receptor (CRLR) in the hearts of rats with congestive heart failure. Clin Sci (Lond) 99 (2000) 541-546
19. Totsune K., Takahashi K., Mackenzie H.S., et al. Adrenomedullin and its receptor complexes in remnant kidneys of rats with renal mass ablation: decreased expression of calcitonin receptor-like receptor and receptor-activity modifying protein-3. Peptides 22 (2001) 1933-1937
20. Takahashi K., Kikuchi K., Maruyama Y., et al. Immunocytochemical localization of adrenomedullin 2/intermedin-like immunoreactivity in human hypothalamus, heart and kidney. Peptides 27 (2006) 1383-1389
21. Romppanen H., Marttila M., Magga J., et al. Adrenomedullin gene expression in the rat heart is stimulated by acute pressure overload: blunted effect in expresimental hypertension. Endocrinology 138 (1997) 2636-2639
22. Cueille C., Pidoux E., de Vernejoul M.C., Ventura-Clapier R., and Garel J.M. Increased myocardial expression of RAMP1 and RAMP3 in rats with chronic heart failure. Biochem Biophys Res Commun 294 (2002) 340-346
23. Øie E., Vinge L.E., Andersen G.O., et al. RAMP2 and RAMP3 mRNA levels are increased in failing rat cardiomyocytes and associated with increased responsiveness to adrenomedullin. J Mol Cell Cardiol 38 (2005) 145-151
24. Hagner S., Stahl U., Knoblauch B., McGregor G.P., and Lang R.E. Calcitonin receptor-like receptor: identification and distribution in human peripheral tissues. Cell Tissue Res 310 (2002) 41-50
25. Kato J., Yin H., Agata J., Yoshida H., Chao L., and Chao J. Adrenomedullin gene delivery attenuates myocardial infarction and apoptosis after ischemia and reperfusion. Am J Physiol 285 (2003) H1506-H1514
26. Fischer J.A., Muff R., and Born W. Functional relevance of G-protein-coupled-receptor-associated proteins, exemplified by receptor-activity-modifying proteins (RAMPs). Biochem Soc Trans 30 (2002) 455-460
27. Yang J.H., Qi Y.X., Jia Y.X., et al. Protective effect of intermedin/adrenomedullin-2 on ischemia/reperfusion injury in isolated rat hearts. Peptides 26 (2005) 501-507
28. Jia Y.X., Yang J.H., Pan C.S., et al. Intermedin 1-53 protects the heart against isoproterenol-induced ischemic injury in rats. Eur J Pharmacol 549 (2006) 117-123
29. Taylor M.M., Bagley S.L., and Samson W.K. Intermedin/Adrenomedullin-2 inhibits growth hormone release from cultured, primary anterior pituitary cells. Endocrinology 147 (2006) 859-864
30. Nakamura Y., Shimatsu A., Murabe H., Mizuta H., Ihara C., and Nakao K. Calcitonin gene-related peptide as a GH secretagogue in human and rat pituitary somatotrophs. Brain Res 807 (1998) 203-207