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Volumn 68, Issue 4, 2008, Pages 371-380

A rationalized set of default postulates that permit a coherent description of the immune system amenable to computer modeling

Author keywords

[No Author keywords available]

Indexed keywords

ALGORITHM; ANALYTICAL RESEARCH; COMPUTER MODEL; CONCEPTUAL FRAMEWORK; DATA MINING; IMMUNE SYSTEM; MATHEMATICS; POSTULATE; PRIORITY JOURNAL; REVIEW; SIMULATION; THEORY;

EID: 51349153460     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2008.02158.x     Document Type: Review
Times cited : (19)

References (41)
  • 1
    • 84919844116 scopus 로고    scopus 로고
    • Timmis, J., Flower, D.R., eds. New York: Springer
    • Timmis J, Flower DR, eds. In Silico Immunology. New York : Springer, 2007.
    • (2007) In Silico Immunology.
  • 2
    • 33947288974 scopus 로고    scopus 로고
    • Quantitative modeling of immune responses
    • Cohn M, Mata J. Quantitative modeling of immune responses. Immunol Rev 2007 216 : 5 8.
    • (2007) Immunol Rev , vol.216 , pp. 5-8
    • Cohn, M.1    Mata, J.2
  • 3
    • 51349107893 scopus 로고    scopus 로고
    • Artificial Immune Systems
    • Castro, L.N.D., Zuben, F.J.V., Knidel, H., eds. In: Santos, Brazil: Springer
    • Castro LND, Zuben FJV, Knidel H, eds. Artificial Immune Systems. In : Proceedings of the 6th International Conference, ICARIS, 2007. Santos, Brazil : Springer, 2007 : 438.
    • (2007) Proceedings of the 6th International Conference, ICARIS, 2007.
  • 4
    • 26044472477 scopus 로고    scopus 로고
    • A general account of selection: Biology, immunology and behavior
    • Hull DL, Langman RE, Glenn SS. A general account of selection: biology, immunology and behavior. Behav Brain Sci 2001 245 : 11 28.
    • (2001) Behav Brain Sci , vol.245 , pp. 11-28
    • Hull, D.L.1    Langman, R.E.2    Glenn, S.S.3
  • 5
    • 37049242573 scopus 로고
    • Immunological specificity: An alternative to the classical concept
    • Talmage DW. Immunological specificity: an alternative to the classical concept. Science 1959 129 : 1643 8.
    • (1959) Science , vol.129 , pp. 1643-8
    • Talmage, D.W.1
  • 6
    • 10644222102 scopus 로고    scopus 로고
    • Degeneracy, mimicry and crossreactivity in immune recognition
    • Cohn M. Degeneracy, mimicry and crossreactivity in immune recognition. Mol Immunol 2005 42 : 651 5.
    • (2005) Mol Immunol , vol.42 , pp. 651-5
    • Cohn, M.1
  • 7
    • 42249105265 scopus 로고    scopus 로고
    • An in depth analysis of the concept of "polyspecificity" assumed to characterize TCR/BCR recognition
    • Cohn M. An in depth analysis of the concept of " polyspecificity" assumed to characterize TCR/BCR recognition. Immunol Res 2008 40 : 128 47.
    • (2008) Immunol Res , vol.40 , pp. 128-47
    • Cohn, M.1
  • 8
    • 0034521774 scopus 로고    scopus 로고
    • The specificity of immunological reactions
    • Langman RE. The specificity of immunological reactions. Mol Immunol 2000 37 : 555 61.
    • (2000) Mol Immunol , vol.37 , pp. 555-61
    • Langman, R.E.1
  • 9
    • 0000376001 scopus 로고
    • The Protecton: The evolutionarily selected unit of humoral immunity
    • Cohn M, Langman RE. The Protecton: the evolutionarily selected unit of humoral immunity. Immunol Rev 1990 115 : 1 131.
    • (1990) Immunol Rev , vol.115 , pp. 1-131
    • Cohn, M.1    Langman, R.E.2
  • 10
    • 0031277398 scopus 로고    scopus 로고
    • A new concept of immune specificity emerges from a consideration of the Self-Nonself discrimination
    • Cohn M. A new concept of immune specificity emerges from a consideration of the Self-Nonself discrimination. Cell Immunol 1997 181 : 103 8.
    • (1997) Cell Immunol , vol.181 , pp. 103-8
    • Cohn, M.1
  • 11
    • 26044481694 scopus 로고    scopus 로고
    • What are the commonalities governing the behavior of humoral immune recognitive repertoires?
    • Cohn M. What are the commonalities governing the behavior of humoral immune recognitive repertoires? Dev Comp Immunol 2006 30 : 19 42.
    • (2006) Dev Comp Immunol , vol.30 , pp. 19-42
    • Cohn, M.1
  • 12
    • 0023640093 scopus 로고
    • The self-nonself discrimination is not regulated by suppression
    • Langman RE. The self-nonself discrimination is not regulated by suppression. Cell Immunol 1987 108 : 214 9.
    • (1987) Cell Immunol , vol.108 , pp. 214-9
    • Langman, R.E.1
  • 13
    • 2342663126 scopus 로고    scopus 로고
    • Whither T-suppressors: If they didn't exist would we have to invent them?
    • Cohn M. Whither T-suppressors: if they didn't exist would we have to invent them? Cell Immunol 2004 227 : 81 92.
    • (2004) Cell Immunol , vol.227 , pp. 81-92
    • Cohn, M.1
  • 14
    • 0036796380 scopus 로고    scopus 로고
    • A computerized model for the self-nonself discrimination at the level of the T-helper (Th-genesis). I. the origin of "primer" effector T-helpers
    • Cohn M, Langman RE, Mata J. A computerized model for the self-nonself discrimination at the level of the T-helper (Th-genesis). I. The origin of "primer" effector T-helpers. Int Immunol 2002 14 : 1105 12.
    • (2002) Int Immunol , vol.14 , pp. 1105-12
    • Cohn, M.1    Langman, R.E.2    Mata, J.3
  • 15
    • 0037406492 scopus 로고    scopus 로고
    • A computerized model for the self-nonself discrimination at the level of the T-helper (Th genesis) II. the behavior of the system upon encounter with nonself antigens
    • Langman RE, Mata JJ, Cohn M. A computerized model for the self-nonself discrimination at the level of the T-helper (Th genesis) II. The behavior of the system upon encounter with nonself antigens. Int Immunol 2003 15 : 593 609.
    • (2003) Int Immunol , vol.15 , pp. 593-609
    • Langman, R.E.1    Mata, J.J.2    Cohn, M.3
  • 16
    • 0026020374 scopus 로고
    • Has immunoglobulin come to a sticky end?
    • Langman RE, Cohn M. Has immunoglobulin come to a sticky end? Scand J Immunol 1991 33 : 99 109.
    • (1991) Scand J Immunol , vol.33 , pp. 99-109
    • Langman, R.E.1    Cohn, M.2
  • 17
    • 0031454188 scopus 로고    scopus 로고
    • Some thoughts on the response to antigens that are effector T-helper independent ("thymus-independence")
    • Cohn M. Some thoughts on the response to antigens that are effector T-helper independent ("thymus-independence"). Scan J Immunol 1997 46 : 565 71.
    • (1997) Scan J Immunol , vol.46 , pp. 565-71
    • Cohn, M.1
  • 18
    • 18244394284 scopus 로고    scopus 로고
    • A biological context for the Self-Nonself discrimination and the regulation of effector class by the immune system
    • Cohn M. A biological context for the Self-Nonself discrimination and the regulation of effector class by the immune system. Immunol Res 2005 31 : 133 50.
    • (2005) Immunol Res , vol.31 , pp. 133-50
    • Cohn, M.1
  • 19
    • 0033524482 scopus 로고    scopus 로고
    • A two-step, two-signal model for the primary activation of precursor helper T cells
    • Bretscher PA. A two-step, two-signal model for the primary activation of precursor helper T cells. Proc Natl Acad Sci U S A 1999 96 : 185 90.
    • (1999) Proc Natl Acad Sci U S a , vol.96 , pp. 185-90
    • Bretscher, P.A.1
  • 20
    • 0029838754 scopus 로고    scopus 로고
    • Immunity to viruses in B cell-deficient mice: Influence of antibodies on virus persistence and on T cell memory
    • Brundler M-A, Aichele P, Bachmann M. Immunity to viruses in B cell-deficient mice: influence of antibodies on virus persistence and on T cell memory. Eur J Immunol 1996 26 : 2257 62.
    • (1996) Eur J Immunol , vol.26 , pp. 2257-62
    • Brundler, M.-A.1    Aichele, P.2    Bachmann, M.3
  • 21
    • 0033857977 scopus 로고    scopus 로고
    • Relapsing and remitting experimental autoimmune encephalomyelitis in B cell deficient mice
    • Dittel BN, Urbania TH, Janeway CAJ. Relapsing and remitting experimental autoimmune encephalomyelitis in B cell deficient mice. J Autoimmun 2000 14 : 311 8.
    • (2000) J Autoimmun , vol.14 , pp. 311-8
    • Dittel, B.N.1    Urbania, T.H.2    Janeway, C.A.J.3
  • 22
    • 21344459077 scopus 로고    scopus 로고
    • The common sense of the Self-Nonself discrimination
    • Cohn M. The common sense of the Self-Nonself discrimination. Springer Semin Immunopathol 2005 27 : 3 17.
    • (2005) Springer Semin Immunopathol , vol.27 , pp. 3-17
    • Cohn, M.1
  • 23
    • 36248951719 scopus 로고    scopus 로고
    • Conceptualizing the Self-Nonself discrimination by the vertebrate immune system
    • In: Timmis, J., Flower, D., eds. New York: Springer
    • Cohn M. Conceptualizing the Self-Nonself discrimination by the vertebrate immune system. In : Timmis J, Flower D, eds. In Silico Immunology. New York : Springer, 2007 : 375 98.
    • (2007) In Silico Immunology. , pp. 375-98
    • Cohn, M.1
  • 24
    • 0345671747 scopus 로고
    • Class switch recombination is IgG1 specific on active and inactive IgH loci of IgG1-secreting B-cell blasts
    • Radbruch A, Muller W, Rajewsky K. Class switch recombination is IgG1 specific on active and inactive IgH loci of IgG1-secreting B-cell blasts. PNAS 1986 83 : 3954 7.
    • (1986) PNAS , vol.83 , pp. 3954-7
    • Radbruch, A.1    Muller, W.2    Rajewsky, K.3
  • 25
    • 0028201732 scopus 로고
    • Tolerance, danger and the extended family
    • Matzinger P. Tolerance, danger and the extended family. Annu Rev Immunol 1994 12 : 991 1045.
    • (1994) Annu Rev Immunol , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 26
    • 0026791975 scopus 로고
    • The immune system evolved to discriminate infectious nonself from noninfectious self
    • Janeway CA. The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol Today 1992 13 : 11 6.
    • (1992) Immunol Today , vol.13 , pp. 11-6
    • Janeway, C.A.1
  • 27
    • 0030050118 scopus 로고    scopus 로고
    • Immunology taught by viruses
    • Zinkernagel RM. Immunology taught by viruses. Science 1996 271 : 172 8.
    • (1996) Science , vol.271 , pp. 172-8
    • Zinkernagel, R.M.1
  • 28
    • 0033179679 scopus 로고    scopus 로고
    • On the role of feedback in promoting conflicting goals of the adaptive immune system
    • Segel LA, Bar-Or RL. On the role of feedback in promoting conflicting goals of the adaptive immune system. J Immunol 1999 163 : 1342 9.
    • (1999) J Immunol , vol.163 , pp. 1342-9
    • Segel, L.A.1    Bar-Or, R.L.2
  • 29
    • 0034519112 scopus 로고    scopus 로고
    • Immune system protects integrity of tissues
    • Dembic Z. Immune system protects integrity of tissues. Mol Immunol 2000 37 : 563 9.
    • (2000) Mol Immunol , vol.37 , pp. 563-9
    • Dembic, Z.1
  • 30
    • 3242678124 scopus 로고    scopus 로고
    • Response to Cohn: The immune system rejects the harmful, protects the useful and neglects the rest of microorganisms
    • Dembic Z. Response to Cohn: the immune system rejects the harmful, protects the useful and neglects the rest of microorganisms. Scand J Immunol 2004 60 : 3 5.
    • (2004) Scand J Immunol , vol.60 , pp. 3-5
    • Dembic, Z.1
  • 31
    • 3242700716 scopus 로고    scopus 로고
    • Second response to Cohn: Does the immune system reject the harmful, protect the useful and neglect the rest?
    • Dembic Z. Second response to Cohn: does the immune system reject the harmful, protect the useful and neglect the rest? Scand J Immunol 2004 60 : 8.
    • (2004) Scand J Immunol , vol.60 , pp. 8
    • Dembic, Z.1
  • 32
    • 0029800638 scopus 로고    scopus 로고
    • Do we need integrity?
    • Dembic Z. Do we need integrity? Scand J Immunol 1996 44 : 549 50.
    • (1996) Scand J Immunol , vol.44 , pp. 549-50
    • Dembic, Z.1
  • 33
    • 0031456694 scopus 로고    scopus 로고
    • Morphostasis: An evolving perspective
    • Cunliffe J. Morphostasis: an evolving perspective. Med Hypotheses 1997 49 : 449 59.
    • (1997) Med Hypotheses , vol.49 , pp. 449-59
    • Cunliffe, J.1
  • 34
    • 33747063794 scopus 로고    scopus 로고
    • Tissue homeostasis and immunity-more on models
    • Cunliffe J. Tissue homeostasis and immunity-more on models. Scand J Immunol 2006 64 : 172 6.
    • (2006) Scand J Immunol , vol.64 , pp. 172-6
    • Cunliffe, J.1
  • 35
    • 36248996934 scopus 로고    scopus 로고
    • Intentional pathogen killing-or denial of substrate?
    • Cunliffe J. Intentional pathogen killing-or denial of substrate? Scand J Immunol 2007 66 : 604 9.
    • (2007) Scand J Immunol , vol.66 , pp. 604-9
    • Cunliffe, J.1
  • 36
    • 33846990935 scopus 로고    scopus 로고
    • Friendly and dangerous signals: Is the tissue in control?
    • Matzinger P. Friendly and dangerous signals: is the tissue in control? Nat Immunol 2007 8 : 11 3.
    • (2007) Nat Immunol , vol.8 , pp. 11-3
    • Matzinger, P.1
  • 37
    • 34548125310 scopus 로고    scopus 로고
    • H-17 differentiation: Of mice and men
    • H-17 differentiation: of mice and men. Nat Immunol 2007 8 : 903 5.
    • (2007) Nat Immunol , vol.8 , pp. 903-5
    • Laurence, A.1    O'Shea, J.J.2
  • 38
    • 0001935674 scopus 로고
    • The ground rules determining any solution to the problem of the self/nonself discrimination
    • In: Matzinger, P., Flajnik, M., Rammensee, H-G, Stockinger, G., Rolink, T., Nicklin, L., eds. Basle, Switzerland: Editiones (Roche)
    • Cohn M. The ground rules determining any solution to the problem of the self/nonself discrimination. In : Matzinger P, Flajnik M, Rammensee H-G, Stockinger G, Rolink T, Nicklin L, eds. The Tolerance Workshop, Proceedings of the EMBO Workshop on Tolerance. Basle, Switzerland : Editiones (Roche), 1987 : 3 35.
    • (1987) The Tolerance Workshop, Proceedings of the EMBO Workshop on Tolerance. , pp. 3-35
    • Cohn, M.1
  • 40
    • 0023216961 scopus 로고
    • The E-T (elephant-tadpole) paradox necessitates the concept of a unit of B-cell function: The Protecton
    • Langman RE, Cohn M. The E-T (elephant-tadpole) paradox necessitates the concept of a unit of B-cell function: The Protecton. Mol Immunol 1987 24 : 675 97.
    • (1987) Mol Immunol , vol.24 , pp. 675-97
    • Langman, R.E.1    Cohn, M.2
  • 41
    • 0026461967 scopus 로고
    • Molecular economy and antibody function: The evolution of a Protecton
    • Langman RE. Molecular economy and antibody function: the evolution of a Protecton. Int J Clin Lab Res 1992 22 : 63 8.
    • (1992) Int J Clin Lab Res , vol.22 , pp. 63-8
    • Langman, R.E.1


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