An in depth analysis of the concept of "polyspecificity" assumed to characterize TCR/BCR recognition

Immunologic Research

Volumn 40, Issue 2, 2008, Pages 128-147

  Cohn, Melvin ^a,b  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

Author keywords

Alloreactivity; Allorestriction; BCR; Degeneracy; Restrictive recognition; Self nonself discrimination; Specificity; TCR

Indexed keywords

B LYMPHOCYTE RECEPTOR; CARBOHYDRATE; EPITOPE; LIPID; NUCLEIC ACID; PEPTIDE; STEROID; T LYMPHOCYTE RECEPTOR; ANTIGEN; LIGAND; LYMPHOCYTE ANTIGEN RECEPTOR;

ALLELE; ALLOIMMUNITY; ANTIBODY COMBINING SITE; BIOLOGICAL MODEL; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR DYNAMICS; PRIORITY JOURNAL; REVIEW; ANIMAL; BINDING SITE; CHEMISTRY; CROSS REACTION; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; T LYMPHOCYTE;

ANIMALS; ANTIGENS; BINDING SITES; BINDING SITES, ANTIBODY; CROSS REACTIONS; EPITOPES; HUMANS; LIGANDS; MODELS, IMMUNOLOGICAL; RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, ANTIGEN, T-CELL; SELF TOLERANCE; T-LYMPHOCYTES;

EID: 42249105265     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12026-007-8003-z     Document Type: Review

References (56)

1. Wucherpfennig KW, Allen PM, Celada F, et al. Polyspecificity of T cell and B cell receptor recognition. Sem Immunol 2007;19:216-224.
2. Matzinger P, Bevan MJ. Hypothesis. Why do so many lymphocytes respond to major histocompatibility antigens? Cellular Immunol 1977;29:1-5.
3. Langman RE, Cohn M. The Standard Model of T-cell receptor function: a critical reassessment. Scand J Immunol 1999;49:570-7.
4. Cohn M. The Tritope model of restrictive recognition by the TCR. Trends Immunol 2003;24:127-31.
5. Cohn M. Distinguishing the Tritope from the interaction antigen models. Trends Immunol 2004;25:8-9.
6. Cohn M. The Tritope Model for restrictive recognition of antigen by T-cells: I. What assumptions about structure are needed to explain function? Mol Immunol 2005;42:1419-43.
7. Cohn M. The Tritope Model for restrictive recognition of antigen by T-cells: II. Implications for ontogeny, evolution and physiology. Mol Immunol 2007;in press.
8. Garboczi DN, Ghosh P, Utz U, et al. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 1996;384:134-41.
9. Garcia KD, Degano M, Stanfield RL. An alpha-beta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science 1996;274:209-19.
10. Langman RE. The specificity of immunological reactions. Mol Immunol 2000;37:555-61.
11. Cohn M. A new concept of immune specificity emerges from a consideration of the self-nonself discrimination. Cell Immunol 1997;181:103-8.
12. Cohn M. At the feet of the Master: the search for universalities. Divining the evolutionary selection pressures that resulted in an immune system. Cytogenet Cell Genet 1998;80:54-60.
13. Cohn M. The immune system: a weapon of mass destruction invented by evolution to even the odds during the war of the DNAs. Immunol Revs 2002;185:24-38.
14. Landsteiner K. The specificity of serological reactions. Cambridge: Harvard University Press; 1945.
15. Lederberg J. Genes and antibodies. Science 1959;129:1649-53.
16. Talmage DW. Immunological specificity: an alternative to the classical concept. Science 1959;129:1643-48.
17. Cohn M. Logic of the self-nonself discrimination: principles and history. In: Cambrosio A, Moulin A, editors. Dialogues with selves historical issues and contemporary debates in immunology. France: Editions Elsevier; 2001. p. 53-85.
18. Langman RE, Cohn M. The E-T (elephant-tadpole) paradox necessitates the concept of a unit of B-cell function: the Protecton. Mol Immunol 1987;24:675-97.
19. Cohn M, Langman RE. The Protecton: the evolutionarily selected unit of humoral immunity. Immunol Rev 1990;115:1-131.
20. Cohn M. What are the commonalities governing the behavior of humoral immune recognitive repertoires? Dev Comp Immunol 2006;30:19-42.
21. Cohn M. Degeneracy, mimicry and crossreactivity in immune recognition. Mol Immunol 2005;42:651-5.
22. Cohn M. Conceptualizing the self-nonself discrimination by the vertebrate immune system. In: Timmis J, Flower D, editors. In silico immunology. New York: Springer; 2007. p. 375-98.
23. Cohn M. A biological context for the self-nonself discrimination and the regulation of effector class by the immune system. Immunol Res 2005;31:133-50.
24. Cohn M. The common sense of the self-nonself discrimination. Springer Semin Immunopathol 2005;27:3-17.
25. Cohn M. The self-nonself discrimination: reconstructing a cabbage from sauerkraut. Res Immunol 1992;143:323-34.
26. Bevan M. Killer cells reactive to altered-self antigens can also be alloreactive. Proc Natl Acad Sci USA 1977;74:2094-8.
27. Hunig TR, Bevan MJ. Antigen recognition by cloned cytotoxic T lymphocytes follows rules predicted by the altered-self hypothesis. J Exp Med 1982;155:111-25.
28. Bevan MJ. High determinant density may explain the phenomenon of alloreactivity. Imunol Today 1984;5:128-30.
29. Nikolich-Zugich J. High specificity, not degeneracy, allows T cell alloresponses. Nat Immunol 2007;8:335-7.
30. Felix NJ, Donermeyer DL, Horvath S, et al. Alloreactive T cells respond specifically to multiple distinct peptide-MHC complexes. Nat Immunol 2007;8:388-97.
31. Müllbacher A, Lobigs M, Kos FJ, et al. Alloreactive cytotoxic T-cell function, peptide nonspecific. Scand J Immunol 1999;49:563-9.
32. Rubin B, Gouaillard C, Weideranders G, et al. The IE allogeneic response of T cells from C57B1/6 mice is associated with genes of the TCRa locus. Scand J Immunol 1993;37:388-97.
33. Ewijk WV, Ron Y, Monaco J, et al. Compartmentalization of MHC Class II gene expression in transgenic mice. Cell 1988;53:357-70.
34. Viret C, Janeway CA. Functional and phenotypic evidence for presentation of E alpha 52-68 structurally related self-peptide(s) in I-E alpha-deficient mice. J Immunol 2000;164:4627-34.
35. LaFuse WP, Savariravan S, McCormick JF, et al. Identification of 1-E alpha genes in H-2 recombinant mouse strains by F1 complementation. Transplantation 1987;43:297-301.
36. Zy-Tmg E, Chu C, Carswell C, et al. The minimal polymorphism of Class II E alpha chains is not due to the functional neutrality of mutations. Genetics 1994;40:9-20.
37. Chen C, Eisen HN, Kranz DM. A model T-cell receptor system for studying memory T-cell development. Microbes Infect 2003;5:233-40.
38. Sha WC, Nelson CA, Newberry RD, et al. Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature 1988;336:73-6.
39. Capone M, Curnow J, Bouvier G, et al. T cell development in TCR-αβ transgenic mice. J Immunol 1995;154:5165-72.
40. Dao T, Blander JM, Sant'Angelo DB. Recognition of a specific self-peptide: self-MHC Class II complex is critical for positive selection of thymocytes expressing the D10-TCR. J Immunol 2003;170:48-54.
41. Huseby ES, White J, Crawford F, et al. How the T cell repertoire becomes peptide and MHC specific. Cell 2005;122:247-60.
42. Huseby ES, Crawford F, White J, et al. Negative selection imparts peptide specificity to the mature T cell repertoire. PNAS 2003;100:11565-70.
43. Percus JK, Percus OE, Perelson AS. Predicting the size of the T-cell receptor and antibody combining region from consideration of efficient self-nonself discrimination. Proc Natl Acad Sci USA 1993;90:1691-5.
44. De Boer RJ, Perelson AS. How diverse should the immune system be? Proc R Soc Scan 1993;B252:171-5.
45. Nemazee D. Antigen receptor "capacity" and the sensitivity of self-tolerance. Immunol Today 1996;17:25-9.
46. Notkins AL. Polyreactivity of antibody molecules. Trends Immunol 2004;25:174-9.
47. Tiegs SL, Russell DM, Nemazee D. Receptor editing in self-reactive bone marrow B cells. J Exp Med 1993;177:1009-20.
48. Lang J, Jackson M, Teyton L, et al. B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen. J Exp Med 1996;184:1685-97.
49. Radic MZ, Erikson J, Litwin S, et al. B lymphocytes may escape tolerance by revising their antigen receptors. J Exp Med 1993;177:1165-73.
50. Gay D, Saunders T, Camper S, et al. Receptor editing: an approach by autoreactive B cells to escape tolerance. J Exp Med 1993;177:999-1008.
51. Nemazee D, Weigert M. Revising B cell receptors. J Exp Med 2000;191:1881-94.
52. Matsuda F, Ishii K, Bourvagnet P, et al. The complete nucleotide sequence of the human heavy chain variable region locus. J Exp Med 1998;188:2151-62.
53. Zachau HG. The immunoglobulin kappa gene families of human and mouse: a cottage industry approach. Biol Chem 2000;381:951-4.
54. Cohn M, Langman RE, editors. Haplotype and isotype exclusion: How and Why? Semin Immunol 2002;14:247.
55. Garcia KC, Degano M, Pease LR, et al. Structural basis of plasticity in T cell receptor recognition of a Self Peptide-MHC antigen. Science 1998;279:1166-72.
56. Mazza C, Malissen B. What guides MHC-restricted TCR recognition? Sem Immunol 2007;19(4):225-35.