A computerized model for the self-non-self discrimination at the level of the Th (Th genesis). I. The origin of 'primer' effector Th cells

International Immunology

Volumn 14, Issue 10, 2002, Pages 1105-1112

  Cohn, Melvin ^a   Langman, Rodney E ^a   Mata, James J ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

Computer simulation; Origin of effector Th; Self non self discrimination; Tolerance; Two signal model

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; CELL ACTIVITY; CELL SELECTION; COMPUTER MODEL; COMPUTER SIMULATION; CONTROLLED STUDY; EFFECTOR CELL; FETUS DEVELOPMENT; HELPER CELL; IMMUNE RESPONSE; IMMUNE SYSTEM; LYMPHOCYTE FUNCTION; PRIORITY JOURNAL;

EID: 0036796380     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/dxf078     Document Type: Article

References (6)

1. Langman, R, E., ed. 2000. Self-non-self discrimination revisited. Semin. Immunol. 12:344.
2. Langman, R. E. and Cohn, M. 2000. A minimal model for the self-non-self discrimination: a return to the basics. Semin. Immunol. 13:189.
3. Langman, R. E. and Cohn, M. 1987. The E-T (elephant-tadpole) paradox necessitates the concept of a unit of B-cell function: the Protecton. Mol. Immunol. 24:675.
4. Cohn, M. and Langman, R. E. 1990. The Protecton: the evolutionarily selected unit of humoral immunity, Immunol. Rev. 115:1.
5. Cohn, M. 1997. A new concept of immune specificity emerges from a consideration of the self-non-self discrimination. Cell. Immunol. 181:103.
6. Langman, R. E. 2001. The specificity of immunological reactions. Mol. Immunol. 37:555.