Discovery of novel potent and selective dipeptide hepatitis C virus NS3/4A serine protease inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 18, 2008, Pages 5095-5100

  Raboisson, Pierre ^a   Lin, Tse I ^a   Kock, Herman de ^a   Vendeville, Sandrine ^a   Vreken, Wim Van de ^a   McGowan, David ^a   Tahri, Abdellah ^a   Hu, Lili ^a   Lenz, Oliver ^a   Delouvroy, Frederic ^a   Surleraux, Dominique ^a   Wigerinck, Piet ^a   Nilsson, Magnus ^b   Rosenquist, Åsa ^b   Samuelsson, Bertil ^b   Simmen, Kenneth ^a  

^a TIBOTEC BVBA   (Belgium)

^b MEDIVIR AB   (Sweden)

Author keywords

Hepatitis C; Macrocycle; NS3; Protease

Indexed keywords

CILUPREVIR; CYCLOPROPANE DERIVATIVE; MACROCYCLIC COMPOUND; N[17 [8 CHLORO 2 (4 ISOPROPYLTHIAZOL 2 YL) 7 METHOXY QUINOLIN 4 YLOXY] 2,14 DIOXO 3,15 DIAZATRICYCLO[13.3.0.0 4.6]OCTADEC 7 ENE 4 CARBONYL](1 METHYLCYCLOPROPYL)(1 METHYLCYCLOPROPYL)SULFONAMIDE; QUINOLINE; SERINE PROTEINASE INHIBITOR; SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG INHIBITION; DRUG METABOLISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TISSUE LEVEL; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ADMINISTRATION, ORAL; ANIMALS; ANTIVIRAL AGENTS; CARBAMATES; COMBINATORIAL CHEMISTRY TECHNIQUES; DOGS; LIVER; MACROCYCLIC COMPOUNDS; MOLECULAR STRUCTURE; QUINOLINES; RATS; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; THIAZOLES; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 51349136109     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.124     Document Type: Article

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