The endocytic adaptor protein ARH associates with motor and centrosomal proteins and is involved in centrosome assembly and cytokinesis

Molecular Biology of the Cell

Volumn 19, Issue 7, 2008, Pages 2949-2961

  Lehtonen, Sanna ^a   Shah, Mehul ^a   Nielsen, Rikke ^a   Iino, Noriaki ^a   Ryan, Jennifer J ^c   Zhou, Huilin ^a,c   Farquhar, Marilyn G ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; DYNEIN ADENOSINE TRIPHOSPHATASE; GAMMA TUBULIN; LOW DENSITY LIPOPROTEIN RECEPTOR; MOLECULAR MOTOR; PROTEIN ARH; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CENTROMERE; CENTROSOME; CONTROLLED STUDY; CYTOKINESIS; ENDOCYTOSIS; FIBROBLAST; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN LOCALIZATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL NUCLEUS; CENTROSOME; CYTOKINESIS; ENDOCYTOSIS; FIBROBLASTS; HELA CELLS; HUMANS; KINETOCHORES; MICE; PROTEIN BINDING; RATS; TUBULIN;

RATTUS;

EID: 51349123880     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E07-05-0521     Document Type: Article

References (45)

1. Blomberg-Wirschell, M., and Doxsey, S. J. (1998). Rapid isolation of centrosomes. Methods Enzymol. 298, 228-238.
2. Bornens, M., Paintrand, M., Berges, J., Marty, M. C., and Karsenti, E. (1987). Structural and chemical characterization of isolated centrosomes. Cell Motil. Cytoskelet. 8, 238-249.
3. Brett, T. J., and Traub, L. M. (2006). Molecular structures of coat and coat-associated proteins: function follows form. Curr. Opin. Cell Biol. 18, 395-406.
4. Cohen, J. C., Kimmel, M., Polanski, A., and Hobbs, H. H. (2003). Molecular mechanisms of autosomal recessive hypercholesterolemia Curr. Opin. Lipidol. 14, 121-127.
5. Delcros, J. G., Prigent, C., and Giet, R. (2006). Dynactin targets Pavarotti-KLP to the central spindle during anaphase and facilitates cytokinesis in Drosophila S2 cells. J. Cell Sci. 119, 4431-4441.
6. Doxsey, S., McCollum, D., and Theurkauf, W. (2005). Centrosomes in cellular regulation. Annu. Rev. Cell Dev. Biol. 21, 411-434.
7. Doxsey, S. (2001). Re-evaluating centrosome function. Nat. Rev. Mol. Cell Biol. 2(9), 688-698.
8. Dryková, D., Cenklová, V., Sulimenko, V., Volc, J., Dráber, P., and Binarová, P. (2003). Plant gamma-tubulin interacts with alphabeta-tubulin dimers and forms membrane-associated complexes. Plant Cell 15(2), 465-480.
9. Efimov, A. et al. (2007). Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network. Dev. Cell 12(6), 917-930.
10. Garcia, C. K. et al. (2001). Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein. Science 292, 1394-1398.
11. Gotthardt, M., Trommsdorff, M., Nevitt, M. F., Shelton, J., Richardson, J. A., Stockinger, W., Nimpf, J., and Herz, J. (2000). Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction. J. Biol. Chem. 275, 25616-25624.
12. He, G., Gupta, S., Yi, M., Michaely, P., Hobbs, H. H., and Cohen, J. C. (2002). ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2. J. Biol. Chem. 277, 44044-44049.
13. Hinchcliffe, E. H., Miller, F. J., Cham, M., Khodjakov, A., and Sluder, G. (2001). Requirement of a centrosomal activity for cell cycle progression through G1 into S phase. Science 291, 1547-1550.
14. Howell, B. J., McEwen, B. F., Canman, J. C., Hoffman, D. B., Farrar, E. M., Rieder, C. L., and Salman, E. D. (2001). Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation. J. Cell Biol. 155, 1159-1172.
15. Jones, C., Hammer, R. E., Li, W. P., Cohen, J. C., Hobbs, H. H., and Herz, J. (2003). Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia. J. Biol. Chem. 278, 29024-29030.
16. Karki, S., and Holzbaur, E.L.F. (1999). Cytoplasmic dynein and dynactin in cell division and intracellular transport. Curr. Opin. Cell Biol. 11, 45-53.
17. Keyel, P. A., Mishra, S. K., Roth, R., Heuser, J. E., Watkins, S. C., and Traub, L. M. (2006). A single common portal for clathrin-mediated endocytosis of distinct cargo governed by cargo-selective adaptors. Mol. Biol. Cell 17, 4300-4317.
18. Khodjakov, A., and Rieder, C. L. (2001). Centrosomes enhance the fidelity of cytokinesis in vertebrates and are required for cell cycle progression. J. Cell Biol. 153, 237-242.
19. Knoblich, J. A., Jan, L. Y., and Jan, Y. N. (1995). Asymmetric segregation of Numb and Prospero during cell division. Nature 377, 624-627.
20. Konopka, C. A., Schleede, J. B., Skop, A. R., and Bednarek, S. Y. (2006). Dynamin and cytokinesis. Traffic 7(3), 239-47.
21. Lehtonen, S., Lehtonen, E., Kudlicka, K., Holthöfer, H., and Farquhar, M. G. (2004) Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin. Am. J. Pathol. 165(3), 923-936.
22. Marples, D., Schroer, T. A., Ahrens, N., Taylor, A., Knepper, M. A., and Nielsen, S. (1998). Dynein and dynactin colocalize with AQP2 water channels in intracellular vesicles from kidney collecting duct. Am. J. Physiol. 274, F384-F394.
23. Maurer, M. E., and Cooper, J. A. (2006). The adaptor protein Dab2 sorts LDL receptors into coated pits independently of AP-2 and ARH. J. Cell Sci. 119, 4235-4246.
24. Mishra, S. K., Watkins, S. C., and Traub, L. M. (2002). The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery. Proc. Natl. Acad. Sci. USA 99, 16099-16104.
25. Mishra, S. K., Keyel, P. A., Edeling, M. A., Dupin, A. L., Owen, D. J., and Traub, L. M. (2005). Functional dissection of an AP-2 beta2 appendage-binding sequence within the autosomal recessive hypercholesterolemia protein. J. Biol. Chem. 280, 19270-19280.
26. Mitchison, T. J., and Kirschner, M. W. (1986). Isolation of mammalian centrosomes. Methods Enzymol. 134, 261-268.
27. Moritz, M., and Agard, D. A. (2001). Gamma-tubulin complexes and microtubule nucleation. Curr. Opin. Struct. Biol. 11, 174-181.
28. Moudjou, M., Bordes, N., Paintrand, M., and Bornens, M. (1996). Gamma-tubulin in mammalian cells: the centrosomal and the cytosolic forms. J. Cell Sci. 109, 875-887.
29. Nagai, M., Meerloo, T., Takeda, T., and Farquhar, M. G. (2003). The adaptor protein ARH escorts megalin to and through endosomes. Mol. Biol. Cell 14, 4984-4996.
30. Niswonger, M. L., and O'Halloran, T. J. (1997). A novel role for clathrin in cytokinesis. Proc. Natl. Acad. Sci. USA 94, 8575-8578.
31. Piel, M., Nordberg, J., Euteneuer, U., and Bornens, M. (2001). Centrosome-dependent exit of cytokinesis in animal cells. Science 291, 1550-1553.
32. Quintyne, N. J., and Schroer, T. A. (2002). Distinct cell cycle-dependent roles for dynactin and dynein at centrosomes. J. Cell Biol. 159, 245-254.
33. Rosse, C., L'Hoste, S., Offner, N., Picard, A., and Camonis, J. (2003). RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis. J. Biol. Chem. 278, 30597-30604.
34. Royle, S. J., Bright, N. A., and Lagnado, L. (2005). Clathrin is required for the function of the mitotic spindle. Nature 434, 1152-1157.
35. Salina, D., Bodoor, K., Eckley, D. M., Schroer, T. A., Rattner, J. B., and Burke, B. (2002). Cytoplasmic dynein as a facilitator of nuclear envelope breakdown. Cell 108, 97-107.
36. Schiebel, E. (2000). Gamma-tubulin complexes: binding to the centrosome, regulation and microtubule nucleation. Curr. Opin. Cell Biol. 12, 113-118.
37. Schroer, T. (2004). Dynactin. Annu. Rev. Cell Dev. Biol. 20, 759-779.
38. Stolt, P. C., and Bock, H. H. (2006). Modulation of lipoprotein receptor functions by intracellular adaptor proteins. Cell Signal. 18(10):1560-1571.
39. Thompson, H. M., Cao, H., Chen, J., Euteneuer, U., and McNiven, M. A. (2004). Dynamin-2 binds gamma-tubulin and participates in centrosome cohesion. Nat. Cell Biol. 6, 335-342.
40. Vallee, R. B., Williams, J. C., Varma, D., and Barnhart, L. E. (2004). Dynein: an ancient motor protein involved in multiple modes of transport. J. Neurobiol. 58, 189-200.
41. Wilund, K. R., Yi, M., Campagna, F., Arca, M., Zuliani, G., Fellin, R., Ho, Y.-K., Garcia, J. V., Hobbs, H. H., and Cohen, J. C. (2002). Molecular mechanisms of autosomal recessive hypercholesterolemia. Hum. Mol. Genet. 11, 3019-3030.
42. Young, A., Dictenberg, J. B., Purohit, A., Tuft, R., and Doxsey, S. J. (2000). Cytoplasmic dynein-mediated assembly of pericentrin and gamma tubulin onto centrosomes. Mol. Biol. Cell 11, 2047-2056.
43. Zheng, Y., Wong, M. L., Alberts, B., and Mitchison, T. (1995). Nucleation of microtubule assembly by a gamma-tubulin-containing ring complex. Nature 378, 578-583.
44. Zimmerman, W., and Doxsey, S. J. (2000). Construction of centrosomes and spindle poles by molecular motor-driven assembly of protein particles. Traffic. 1(12), 927-934.
45. Zhou, W., Ryan, J. J., and Zhou, H. (2004). Global analyses of sumolyated proteins in Saccharomyces cerevisiae. J. Biol. Chem. 279, 32262-32268.