TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes

BMC Medical Genetics

Volumn 9, Issue , 2008, Pages

  Mahurkar, Swapna ^a   Bhaskar, Seema ^a   Nageshwar, Nageshwar D ^b   Prakash, Swami ^a   Venkat, Venkat G ^b   Singh, Shivaram ^c   Thomas, Varghese ^d   Chandak, Giriraj Ratan ^a  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^b ASIAN INSTITUTE OF GASTROENTEROLOGY   (India)

^c SCB MEDICAL COLLEGE   (India)

^d GOVERNMENT MEDICAL COLLEGE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN B; SERINE PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR KAZAL TYPE 1; TRANSCRIPTION FACTOR 7 LIKE 2; CARRIER PROTEIN; SPINK1 PROTEIN, HUMAN; T CELL FACTOR 4; T CELL FACTOR PROTEIN;

ARTICLE; CASE CONTROL STUDY; CHRONIC PANCREATITIS; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE PREDISPOSITION; ETHNIC DIFFERENCE; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; PREDICTION; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; TROPICAL CALCIFIC PANCREATITIS; ALLELE; CALCINOSIS; ETHNIC GROUP; ETHNOLOGY; GENETIC PREDISPOSITION; GENETICS; INDIA; MUTATION;

ALLELES; CALCINOSIS; CARRIER PROTEINS; CATHEPSIN B; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; ETHNIC GROUPS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INDIA; MALE; MUTATION; PANCREATITIS, CHRONIC; POLYMORPHISM, SINGLE NUCLEOTIDE; TCF TRANSCRIPTION FACTORS;

EID: 51349120973     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-9-80     Document Type: Article

References (33)

1. Barman KK Premalatha G Mohan V Tropical chronic pancreatitis Postgrad Med J 2003, 79:606-15 10.1136/pmj.79.937.606 14654569
2. Reddy DN Tropical pancreatitis. The Indian Experience Proceedings of the 8th World Congress of the International Gastro-Surgical Club, 15-18 April Strasbourg, France 1998:249-253
3. Mohan V Snehalatha C Ramachandran A Jayashree R Viswanathan M Pancreatic beta cell function in tropical pancreatic diabetes Metabolism 1983, 32:1091-92 10.1016/0026-0495(83)90053-7 6358777
4. Mohan V Ramachandran A Vijay Kumar G Snehalatha C Viswanathan M Insulin resistance in fibrocalculous (tropical) pancreatic diabetes Horm Metab Res 1988, 20(12):746-48 3220451
5. Mehrotra RN Bhatia E Choudhury G Beta cell function and insulin sensitivity in tropical calcific pancreatitis from North India Metabolism 1997, 46(4):441-44 10.1016/S0026-0495(97)90063-9 9109851
6. Bank S Marks IN Vinik AI Clinical and hormonal aspects of pancreatic diabetes Am J Gastroenterol 1975, 64(1):13-22 808121
7. Mohan R Rajendran B Mohan V Ramachandran A Viswanathan M Kohner EM Retinopathy in tropical pancreatic diabetes Diabetes Care 1987, 10(4):532-533 3622214
8. Ramachandran A Mohan V Kumaravel TS Velmurugendran CU Snehalatha C Chinnikrishnudu M Viswanathan M Peripheral neuropathy in tropical pancreatic diabetes Acta Diabetol Lat 1986, 23(2):135-140 10.1007/ BF02624673 3751448
9. Yajnik CS Shelgikar KM Naik SS Kanitkar SV Orskov H Alberti KG Hockaday TD The ketosis resistance in Fibrocalculous Pancreatic Diabetes 1. Clinical observations and endocrine metabolic measurements during oral glucose tolerance test Diab Res Clin Pract 1992, 15:145-56 10.1016/ 0168-8227(92)90019-N
10. Mohan V Mohan R Susheela L Snehalatha C Bharani G Mahajan VK Ramachandran A Viswanathan M Kohner EM Tropical pancreatic diabetes in South India: Heterogeneity in clinical and biochemical profile Diabetologia 1985, 28:229-32 10.1007/BF00282238 4018450
11. Chandak GR Idris MM Reddy DN Bhaskar S Sriram PV Singh L Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis J Med Genet 2002, 39(5):347-51 1735106 12011155 10.1136/jmg.39.5.347
12. Bhatia E Choudhuri G Sikora SS Landt O Kage A Becker M Witt H Tropical calcific pancreatitis: Strong association with SPINK1 trypsin inhibitor mutations Gastroenterology 2002, 123:1020-5 10.1053/gast.2002.36028 12360463
13. Hassan Z Mohan V Ali L Allotey R Barakat K Faruque MO Deepa R McDermott MF Jackson AE Cassell P Curtis D Gelding SV Vijayaravaghan S Gyr N Whitcomb DC Khan AK Hitman GA SPINK1 is a susceptibility gene for fibrocalculous pancreatic diabetes in subjects from the Indian subcontinent Am J Hum Genet 2002, 71:964-8 378551 12187509 10.1086/342731
14. Rossi L Pfutzer RH Parvin S Ali L Sattar S Kahn AK Gyr N Whitcomb DC SPINK1/PSTI mutations are associated with tropical pancreatitis in Bangladesh. A preliminary report Pancreatology 2001, 1:242-5 10.1159/ 000055818 12120202
15. Schneider A Suman A Rossi L Barmada MM Beglinger C Parvin S Sattar S Ali L Khan AK Gyr N Whitcomb DC SPINK1/PSTI mutations are associated with tropical pancreatitis and type II diabetes mellitus in Bangladesh Gastroenterology 2002, 123:1026-30 10.1053/gast.2002.36059 12360464
16. Bhatia E Durie P Zielenski J Lam D Sikora SS Choudhuri G Tsui LC Mutations in the cystic fibrosis transmembrane regulator gene in patients with tropical calcific pancreatitis Am J Gastroenterol 2000, 95:3658-59 10.1111/j.1572-0241.2000.03400.x 11151920
17. Mahurkar S Idris MM Reddy DN Bhaskar S Rao GV Thomas V Singh L Chandak GR Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis Gut 2006, 55(9):1270-75 10.1136/gut.2005.087403 16492714
18. Rosendahl J Witt H Szmola R Bhatia E Ozsvari B Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis Nat Genet 2008, 40(1):78-82 10.1038/ng.2007.44 18059268
19. Grant SF Thorleifsson G Reynisdottir I Benediktsson R Manolescu A Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes Nat Genet 2006, 38:320-23 10.1038/ng1732 16415884
20. Chandak GR Janipalli CS Bhaskar S Kulkarni SR Mohankrishna P Hattersley AT Frayling TM Yajnik CS Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population Diabetologia 2007, 50:63-67 10.1007/s00125-006-0502-2 17093941
21. Bodhini D Radha V Dhar M Narayani N Mohan V The rs12255372(G/T) and rs7903146(C/T) polymorphisms of the TCF7L2 gene are associated with type 2 diabetes mellitus in Asian Indians Metabolism 2007, 56(9):1174-78 10.1016/j.metabol.2007.04.012 17697858
22. Cauchi S Meyre D Dina C Choquet H Samson C Gallina S Balkau B Charpentier G Pattou F Stetsyuk V Scharfmann R Staels B Fruhbeck G Froguel P Transcription factor TCF7L2 genetic study in French population Diabetes 2006, 55:2903-08 10.2337/db06-0474 17003360
23. Groves CJ Zeggini E Minton J Frayling TM Weedon MN Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk Diabetes 2006, 55(9):2640-44 10.2337/db06-0355 16936215
24. Scott LJ Bonnycastle LL Willer CJ Sprau AG Jackson AU Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample Diabetes 2006, 55:2649-53 10.2337/db06-0341 16936217
25. Weedon MN The importance of TCF7L2 Diabet Med 2007, 24:1062-66 10.1111/ j.1464-5491.2007.02258.x 17888129
26. Yi F Brubaker PL Jin T TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta J Biol Chem 2005, 280(2):1457-64 10.1074/jbc.M411487200 15525634
27. Qu H Polychronakos C The TCF7L2 locus and type 1 diabetes BMC Med Genet 2007, 8:51 1978206 17683561 10.1186/1471-2350-8-51
28. WHO Study Group Report on Diabetes Mellitus WHO technical report series 727 Geneva: WHO 1985
29. Schaid DJ Rowland CM Tines DE Jacobson RM Poland GA Score tests for association between traits and haplotypes when linkage phase is ambiguous Am J Hum Genet 2002, 70(2):425-34 384917 11791212 10.1086/ 338688
30. 2 tests Biometrics 1954, 10:417-451 10.2307/3001616
31. Wilkin TJ The accelerator hypothesis: Weight gain as the missing link between type I and type II diabetes Diabetologia 2001, 44(7):914-22 10.1007/s001250100548 11508279
32. Field SF Howson JM Smyth DJ Walker NM Dunger DB Todd JA Analysis of the type 2 diabetes gene, TCF7L2, in 13,795 type 1 diabetes cases and control subjects Diabetologia 2007, 50(1):212-13 2151139 17063324 10.1007/s00125-006-0506-y
33. Zhang C Qi L Hunter DJ Meigs JB Manson JE van Dam RM Hu FB Variant of Transcription Factor 7-Like 2 (TCF7L2) Gene and the Risk of Type 2 Diabetes in Large Cohorts of U.S. Women and Men Diabetes 2006, 55:2645-48 10.2337/db06-0643 16936216