SPINK1/PSTI Mutations Are Associated with Tropical Pancreatitis in Bangladesh: A Preliminary Report

Pancreatology

Volumn 1, Issue 3, 2001, Pages 242-245

  Rossi, Livio ^a   Pfützer, Roland H ^f   Parvin, Shahana ^b   Ali, Liaquat ^b   Sattar, Soheli ^b   Kahn, A K Azad ^b   Gyr, Niklaus ^c   Whitcomb, David C ^d,e  

^a LUZERNER KANTONSSPITAL   (Switzerland)

^b Bangladesh Institute of Research and Rehabilitation in Diabetes Endocrine and Metabolic Disorders   (Bangladesh)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e UNIVERSITY OF PITTSBURGH   (United States)

^f NONE

Author keywords

Kazal type 1; Mutation; Pancreatic secretory trypsin inhibitor; Pancreatitis; Serine protease inhibitor; Tropical pancreatitis

Indexed keywords

SERINE PROTEINASE INHIBITOR;

ADULT; ARTICLE; BANGLADESH; CALCINOSIS; FEMALE; GENETICS; HUMAN; MALE; MUTATION; PANCREATITIS; TROPIC CLIMATE;

ADULT; BANGLADESH; CALCINOSIS; FEMALE; HUMANS; MALE; MUTATION; PANCREATITIS; SERINE PROTEINASE INHIBITORS; TROPICAL CLIMATE;

EID: 0035554065     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1159/000055818     Document Type: Article

References (15)

1. Azad Khan AK, Ali L: Tropical calcifi pancreatitis and fibrocalculus pancreatic diabetes in Bangladesh. J Gastroenterol Hepatol 1997;12: S48-S52.
2. Rossi L, Whitcomb DC, Ehrlich GD, Gorry MC, Parvin S, Sattar S, Ali L, Azad Khan AK, Gyr N: Lack of R117H mutation in the cationic trypsinogen gene in patients with tropical pancreatitis from Bangladesh. Pancreas 1998; 17:278-280.
3. Antonarakis SE, the Nomenclature Working Group: Recommendations for a nomenclature system for human gene mutations. Hum Mutat 1998;11:1-3.
4. Whitcomb DC, Gorry MC, Preston RA, Furey W, Sossenheimer MJ, Ulrich CD, Martin SP, Gates LK Jr, Amann ST, Toskes PP, Liddle R, McGrath K, Uomo G, Post JC, Ehrlich GD: Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet 1996;14:141-145.
5. Witt H, Luck W, Hennies HC, Classen M, Kage A, Lass U, Landt O, Becker M: Mutations in the gene encoding the serine protease inhibitor, Kazal type I are associated with chronic pancreatitis. Nat Genet 2000;25:213-216.
6. Pfützer RH, Barmada MM, Brunskill APJ, Finch R, Hart PS, Neoptolemos J, Furey WF, Whitcomb DC: SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis. Gastroenterology 2000;119:615-623.
7. Hariharan M: Clinical features of tropical calcific pancreatitis; in Kumar N, Acharya S (eds): Tropical Calcific Pancreatitis. Thiruvananthapuram, Kerala, Roussel Scientific Institute, 1994, pp 29-34.
8. Rinderknecht H: Pancreatic secretory enzymes; in Go VLW, DiMagno EP, Gardner JD, Lebenthal E, Reber HA, Scheele GA (eds): The Pancreas: Biology, Pathobiology, and Disease. New York, Raven Press, 1993, pp 219-251.
9. Whitcomb DC: Early trypsinogen activation in acute pancreatitis. Gastroenterology 1999;116: 770-772.
10. Whitcomb DC: Hereditary pancreatitis: New insights into acute and chronic pancreatitis. Gut 1999;45:317-322.
11. Whitcomb DC: Genetic predispositions to acute and chronic pancreatitis. Med Clin North Am 2000;84:531-547, vii.
12. Gorry MC, Gabbaizedeh D, Furey W, Gates LK Jr, Preston RA, Aston CE, Zhang Y, Ulrich C, Ehrlich GD, Whitcomb DC: Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis. Gastroenterology 1997;113:1063-1068.
13. Colomb E, Guy O, Deprez P, Michel R, Figarella C: The two human trypsinogens: Catalytic properties of the corresponding trypsins. Biochim Biophys Acta 1978;525:186-193.
14. Chen JM, Mercier B, Audrezet MP, Ferec C: Mutational analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene in hereditary and sporadic chronic pancreatitis (letter). J Med Genet 2000;37:67-69.
15. Owyang C, Levitt M: Chronic pancreatitis; in Yamada T (ed): Textbook of Gastroenterology. Philadelphia, Lippincott, 1991, vol 2, pp 1874-1893.