Bcl-2 genes and growth factors in the pathology of ischaemic acute renal failure

Immunology and Cell Biology

Volumn 77, Issue 3, 1999, Pages 279-286

  Gobe G ^a   Zhang, X J ^a   Cuttle, L ^a   Pat, B ^a   Willgoss, D ^a   Hancock, J ^a   Barnard, R ^b   Endre, Z ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

Acute renal failure; Apoptosis; Bcl 2 genes; Growth factors; Ischaemia; Necrosis; Reperfusion

Indexed keywords

GROWTH FACTOR; PROTEIN BCL 2;

APOPTOSIS; CELL SURVIVAL; CONFERENCE PAPER; GENE EXPRESSION; HUMAN; HUMAN TISSUE; KIDNEY FAILURE; KIDNEY ISCHEMIA; OXIDATIVE STRESS; PATHOPHYSIOLOGY; REPERFUSION INJURY;

ANIMALS; APOPTOSIS; EPIDERMAL GROWTH FACTOR; GENES, BCL-2; GROWTH SUBSTANCES; HUMANS; INSULIN-LIKE GROWTH FACTOR I; ISCHEMIA; KIDNEY; KIDNEY FAILURE, ACUTE; NECROSIS; NEPHRONS; REPERFUSION INJURY;

EID: 0033045687     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1711.1999.00826.x     Document Type: Conference Paper

References (72)

1. 1 Walker NI, Harmon BV, Gobé GC, Kerr JFR. Patterns of cell death. Meth. Achiev. Exp. Pathol. 1988; 13: 18-54.
2. 2 Kerr JFR, Gobé G, Winterford C, Harmon B. Anatomical methods in cell death. In: Schwartz LM, Osborne BA (eds). Methods in cell biology (46): Cell death. San Diego: Academic Press, 1995; 1-27.
3. 3 Racusen L. The histopathology of acute renal failure. In: Ronco C, Bellomo R (eds). Critical care nephrology. The Hague: Kluwer Academic Publishers, 1998; 623-30.
4. 4 Gobé GC, Axelsen RA, Searle JW. Cellular events in experimental unilateral ischemic renal atrophy, and in regeneration after contralateral nephrectomy. Lab. Invest. 1990; 63: 770-9.
5. 5 Schumer M, Colombel M, Sawczuk I et al. Morphological, biochemical and molecular parameters distinguish the mode of cell death following severe ischemia from the cell deaths associated with ischemia-reperfusion injury. Am. J. Pathol. 1992; 140: 831-8.
6. 6 Bonventre J. Mechanisms of ischemic acute renal failure. Kidney Int. 1993; 43: 160-178.
7. 7 Nouwen EJ, Verstrepen WA, Buyssens N, Zhu MQ. de Broe ME. Hyperplasia, hypertrophy, and phenotypic alterations in the distal nephron after acute proximal tubular injury in the rat. Lab. Invest. 1994; 70: 479-93.
8. 8 Gobé GC, Buttyan R, Wyburn K, Etheridge MR, Smith PJ. Clusterin expression and apoptosis in tissue remodeling associated with renal regeneration. Kidney Int. 1995; 47: 411-20.
9. 9 Basile D, Liapis H, Hammerman M. Expression of bcl-2 and bax in regenerating rat renal tubules following ischemic injury. Am. J. Physiol. 1997; 272: F640-7.
10. 10 Racusen L, Fivush B, Li YL, Solez K. Dissociation of tubular cell detachment and tubular cell death in clinical and experimental 'acute tubular necrosis'. Lab. Invest. 1991; 64: 546-54.
11. 11 Shanley P, Brezis M, Spokes K, Silva P, Epstein F, Rosen S. Hypoxic injury in the proximal tubule of the isolated perfused rat kidney. Kidney Int. 1986; 29: 1021-32.
12. 12 Brezis M, Shanley P, Silva P et al. Disparate mechanisms for hypoxic injury in different nephron segments. Studies in the isolated perfused rat kidney. J. Clin. Invest. 1985; 76: 1796-806.
13. 13 Buttyan R, Gobé G. Apoptosis in the mammalian kidney: Incidence, effectors, and molecular control in normal and disease states. In: Kaufmann SH (ed.). Advances in Pharmacology (41). Apoptosis: Pharmacological implications and therapeutic opportunities. San Diego: Academic Press, 1997; 369-81.
14. 14 Gobé GC, Axelsen RA. Genesis of renal tubular atrophy in experimental hydronephrosis. Role of apoptosis. Lab. Invest. 1987; 56; 273-81.
15. 15 Savill J. Apoptosis and the kidney. J. Am. Soc. Nephrol. 1994; 5: 12-21.
16. 16 Bortner CD, Oldenburg N, Cidlowski J. The role of DNA fragmentation in apoptosis. Trend Cell Biol. 1995; 5: 21-6.
17. 17 Gavrieli Y, Sherman Y, Ben-Sasson S. Identification of programmed cell death in situ via specific labeling of DNA fragmentation. J Cell Biol. 1992; 119: 493-501.
18. 18 Ansari B, Coates P, Greenstein B, Hall P. In situ end labelling detects DNA strand breaks in apoptosis and other physiological and pathological slates. J. Pathol. 1993; 170: 1-8.
19. 19 Zager RA, Fuerstenberg SM, Myerson D, Torok-Storb B. An evaluation of antioxidant effects on recovery from postischemic acute renal failure. J. Am. Soc. Nephrol. 1994; 4: 1588-97.
20. 20 Beeri R, Symon Z, Brezis M et al. Rapid DNA fragmentation from hypoxia along the thick ascending limb of rat kidneys. Kidney Int. 1995; 47: 1806-10.
21. 21 Kadkhodace M, Gobé G, Willgoss D, Endre Z. DNA fragmentation reduced by anti-oxidants following ischemia reperfusion in the isolated rat kidney. Nephrology 1998; 4: 163-75.
22. 22 Grasl-Kraup B, Ruttkay-Nedeeky B, Koudelka H et al. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note. Hepatology 1995; 21: 1465-8.
23. 23 Elkind MM. Repair processes in radiation biology. Radiat. Res. 1984; 100: 425-49.
24. 24 O'Connor A, Nishigori C, Yarosh D et al. DNA double strand breaks in epidermal cells cause immune suppression in vivo and cytokine production in vitro. J. Immunol. 1996; 157: 271-8.
25. 25 Nelms BE, Maser RS, MacKay JF, Lagally MG, Petrini J. In situ visualization of DNA double-strand break repair in human fibroblasts. Science 1988; 280; 590-2.
26. 26 Tsujimoto Y, Cossman J, Jaffe E, Croce C. Involvement of the bcl-2 gene in human follicular lymphoma. Science 1985; 228: 1440-3.
27. 27 Vaux D, Cory S, Adams J. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 1988; 335: 440-2.
28. 28 Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990; 348: 334-6.
29. 29 Oltvai Z, Korsmeyer S. Checkpoints of dueling dimers foil death wishes. Cell 1994; 79: 189-92.
30. 30 Gajewski T, Thompson CB. Apoptosis meets signal transduction: Elimination of a BAD influence. Cell 1996; 87: 589-92.
31. 31 Rao L, White E. Bcl-2 and the ICE family of apoptotic regulators: Making a connection. Curr. Opin. Genet. Dev. 1997; 7: 52-8.
32. 32 Yin C, Oltvai Z, Korsmeyer SJ, Heterodimerisation with Bax is required for Bcl-2 to repress cell death. Curr. Top. Microbiol. Immunol. 1995; 194: 331-8.
33. 33 Yin C, Knudson CM, Korsmeyer SJ, Van Dyke T. Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature 1997; 385: 637-40.
34. 34 Oltvai Z, Milliman C, Korsmeyer S. Bcl-2 hetrodimerisation with a conserved homolog Bax that accelerated programmed cell death in vivo. Cell 1993; 74: 609-19.
35. 35 Le Brun D, Warnke R, Cleary M. Expression of bcl-2 in fetal tissues suggests a role in morphogenesis. Am. J. Pathol. 1993; 142: 743-53.
36. 36 Chandler D, el Naggar AK, Brisbay S, Redline RW, McDonnell TJ. Apoptosis and expression of the bcl-2 proto-oncogene in the fetal and adult human kidney. Hum. Pathol. 1994; 25: 789-96.
37. 37 Kamada S, Shimono A, Shinto Y et al. Bcl-2 deficiency in mice leads to pleiotropic abnormalities: Accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine. Cancer Res. 1995; 55: 354-9.
38. 38 Sorenson CM, Rogers SA, Korsmeyer SJ, Hammerman MR. Fulminant metanephric apoptosis and abnormal kidney development in bcl-2 deficient mice. Am. J. Physiol. 1995; 268: F73-81.
39. 39 Sorenson C, Padanilam B, Hammerman M. Abnormal postpartum renal development and cystogenesis in the bcl-2 (-/-) mouse. Am. J. Physiol. 1996; 271: F184-93.
40. 40 Knudson CM, Tung KS, Tourtellotte WG, Brown GA, Korsmeyer SJ. Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 1995; 270: 96-9.
41. L is the major bcl-x mRNA form expressed during murine development and its product localises to mitochondria. Development 1994; 120: 3033-42.
42. 42 Boise LH, Gonzalez-Garcia M, Postema C et al. Bcl-X, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 1993; 74: 597-606.
43. 43 Winyard P, Nauta J, Lirenman DS et al. Deregulation of cell survival in cystic and dysplastic renal development. Kidney Int. 1996; 49: 135-46.
44. 44 Buttke T, Sandstrom P. Oxidative stress as a mediator of apoptosis. Immunol. Today 1994; 15: 7-10.
45. 45 Jacobson M, Raff M. Programmed cell death and Bcl-2 protection in very low oxygen. Nature 1995; 374: 814-16.
46. 46 Korsmeyer SJ, Yin X-M, Oltvai Z, Veis-Novack D, Linette G. Reactive oxygen species and the regulation of cell death by the bcl-2 gene family. Biochim. Biophys. Acta 1995; 1271: 63-6.
47. L. Nature 1995; 374: 811-13.
48. 48 Muschel RJ, Bernhard EJ, Garza L, McKenna WG, Koch CJ. Induction of apoptosis at different oxygen tensions: Evidence that oxygen radicals do not mediate apoptotic signaling. Cancer Res. 1995; 55: 995-8.
49. 49 Hockenbery D, Oltvai Z, Yin X-M, Milliman C, Korsmeyer S. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 1993; 75: 241-51.
50. 50 Katoh S, Mitsui Y, Kitani K, Suzuki T. The rescuing effect of nerve growth factor is the result of up-regulation of bcl-2 in hyperoxia-induced apoptosis of a subclone of pheochromocytoma cells PC12h. Neurosci. Lett. 1997; 232: 71-4.
51. 51 Hammerman MR, Miller SB. Therapeutic use of growth factors in renal failure. J. Am. Soc. Nephrol. 1996; 5: 1-11.
52. 52 Hirschberg R. Biologically active peptides in acute renal failure: Recent clinical trials. Nephrol. Dial. Transplant. 1997; 12: 1563-6.
53. 53 Ong AC, Fine LG. Tubular derived cytokines and human renal disease. Nephrol. Dial. Transplant. 1994; 9: 471-3.
54. 54 Nouwen EJ, Verstrepen WA, de Broe ME. Epidermal growth factor in acute renal failure. Ren. Fail. 1994; 16: 49-60.
55. 55 Taira T, Yoshimura A, Iizuka K et al. Expression of epidermal growth factor and its receptor in rabbits with ischemic acute renal failure. Virchows Arch. 1996; 427: 583-8.
56. 56 Safirstein R. Gene expression in nephrotoxic and ischemic acute renal failure. J. Am. Soc. Nephrol. 1993; 4: 1387-95.
57. 57 Walton G, Buttyan R, Olsson C, Hensle T, Sawezuk I, Expression of renal growth factors during experimental hydronephrosis. J. Urol. 1993; 148: 510-17.
58. 58 Lin J, Cybulsky AV, Goodyer PR, Fine RN, Kaskel FJ. Insulin-like growth factor-1 enhances epidermal growth factor receptor activation and renal tubular cell regeneration in postischemic acute renal failure. J. Lab. Clin. Med. 1995; 125: 724-33.
59. 59 Fervenza C, Tsao T, Rabkin R. Response of the intrarenal insulin-like growth factor-1 axis to acute ischemic injury and treatment with growth hormone and epidermal growth factor. Kidney Int. 1996; 49: 344-54.
60. 60 Ding H, Qing DP, Kopple JD. IGF-1 resistance in chronic renal failure: current evidence and possible mechanisms. Kidney Int. 1997; 62: S45-7
61. 61 Matejka GL, Jennische E. IGF-1 binding and IGF-I mRNA expression in the post-ischemic regenerating rat kidney. Kidney Int. 1992; 42: 1113-23.
62. 62 Evan A, Henry D, Connors B, Summerlin P, Lee WH. Analysis of insulin-like growth factors IGF-I and -II, type II IGF receptor and IGF-binding protein-2 mRNA and peptide levels in normal and nephrectomised rat kidney. Kidney Int. 1995; 48: 1517-29.
63. 63 Miller S, Martin D, Kissane D, Hammerman M. Hepatocyte growth factor accelerates recovery from acute ischaemic renal injury in rats. Am. J. Physiol. 1994; 266: F129-34.
64. 64 Taylor R, Beveridge D, Nakamura T, Fuller P. Hepatocyte growth factor gene expression after massive small bowel resection: lack of stimulation in lung and liver. Exp. Clin. Endocrinol. Diabetes 1995; 103: 58-62.
65. 65 Basile D, Rovak J, Martin D, Hammerman M. Increased transforming growth factor-beta 1 expression in regenerating rat renal tubules following ischemic injury. Am. J. Physiol. 1996; 270: F500-9.
66. 66 Border W, Noble N. TGF-β in kidney fibrosis. A target for gene therapy. Kidney Int. 1997; 51: 1388-96.
67. 67 Núñez G, London L, Hockenbery D, Alexander M, McKearn J, Korsmeyer S. Deregulated bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. J. Immunol. 1990; 144: 3602-10.
68. 68 Xie K, Huang S, Wang Y et al. Bcl-2 protects cells from cytokine-induced nitric-oxide-dependent apoptosis. Cancer Immunol. Immunother. 1996; 43: 109-15.
69. 69 Fine L, Norman J, Ong A. Cell-cell cross-talk in the pathogenesis of renal interstitial fibrosis. Kidney Int. 1995; 47: S48-50.
70. 70 Ong AC, Jowett TP, Firth JD, Burton S, Karet FE, Fine LG. An endothelin-1 mediated autocrine growth loop involved in human renal tubular regeneration. Kidney Int. 1995; 48: 390-401.
71. 71 Linette G, Li Y, Roth K, Korsmeyer S. Cross talk between cell death and cell cycle progression: Bcl-2 regulates NFAT-mediated activation. Proc. Natl. Acad. Sci. USA 1996; 93: 9545-52.
72. 72 Humes HD, Liu S. Cellular and molecular basis of renal repair in acute renal failure. J. Lab. Clin. Med. 1994; 124: 749-54.