Phorbol esters modulate spontaneous and Ca2+-evoked transmitter release via acting on both Munc13 and protein kinase C

Journal of Neuroscience

Volumn 28, Issue 33, 2008, Pages 8257-8267

  Lou, Xuelin ^a,d   Korogod, Natalya ^b,e   Brose, Nils ^c   Schneggenburger, Ralf ^a,b  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b EPFL   (Switzerland)

^c MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Diacylglycerol; Organotypic culture; Readily releasable pool; Release probability; Second messenger; Synapse

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; CALCIUM ION; PHORBOL DIBUTYRATE; PHOSPHATIDYLCHOLINE; PROTEIN KINASE C; PROTEIN MUNC 13 1; REGULATOR PROTEIN; UNCLASSIFIED DRUG; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; CALCIUM; INDOLE DERIVATIVE; NERVE PROTEIN; PHORBOL ESTER; RO 31-8220; UNC13A PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EVOKED RESPONSE; EXCITATORY POSTSYNAPTIC POTENTIAL; KNOCKOUT MOUSE; LONG TERM POTENTIATION; MOUSE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; RAT; SYNAPSE VESICLE; SYNAPTIC TRANSMISSION; TISSUE CULTURE; ANIMAL; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; ENZYMOLOGY; GENETICS; METABOLISM; MOUSE MUTANT; ORGAN CULTURE TECHNIQUE; SECRETION; SYNAPTOSOME; WISTAR RAT;

ANIMALS; CALCIUM; DRUG SYNERGISM; EXCITATORY POSTSYNAPTIC POTENTIALS; INDOLES; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; NEUROTRANSMITTER AGENTS; ORGAN CULTURE TECHNIQUES; PHORBOL ESTERS; PRESYNAPTIC TERMINALS; PROTEIN KINASE C; RATS; RATS, WISTAR;

EID: 51149097917     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0550-08.2008     Document Type: Article

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