Released fraction and total size of a pool of immediately available transmitter quanta at a calyx synapse

Neuron

Volumn 23, Issue 2, 1999, Pages 399-409

  Schneggenburger, Ralf ^a   Meyer, Alexander C ^a   Neher, Erwin ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; NEUROTRANSMITTER;

ANIMAL TISSUE; ARTICLE; BRAIN STEM; CALCIUM TRANSPORT; DEPLETION; FREQUENCY ANALYSIS; NEUROTRANSMITTER RELEASE; NONHUMAN; PHOTOLYSIS; POSTSYNAPTIC POTENTIAL; PRESYNAPTIC POTENTIAL; PRIORITY JOURNAL; RAT; SYNAPSE; SYNAPSE VESICLE;

EID: 0033152473     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)80789-8     Document Type: Article

References (55)

1. Augustine, G.J., Charlton, M.P., and Smith, S.J. (1985). Calcium entry and transmitter release at voltage-clamped nerve terminals of squid. J. Physiol. 369, 163-181.
2. Barnes-Davies, M., and Forsythe, I.D. (1995). Pre-and postsynaptic glutamate receptors at a giant excitatory synapse in rat auditory brainstem slices. J. Physiol. 488, 387-406.
3. Borst, J.G.G., and Sakmann, B. (1996). Calcium influx and transmitter release in a fast CNS synapse. Nature 383, 431-434.
4. Borst, J.G.G., and Sakmann, B. (1999). Effect of changes in action potential shape on calcium currents and transmitter release in a calyx-type synapse of the rat auditory brainstem. Phil. Trans. R. Soc. Lond. B 354, 355-363.
5. Borst, J.G.G., Helmchen, F., and Sakmann, B. (1995). Pre- and post-synaptic whole-cell recordings in the medial nucleus of the trapezoid body of the rat. J. Physiol. 489, 825-840.
6. Caicedo, A., and Eybalin, M. (1999). Glutamate receptor phenotypes in the auditory brainstem and mid-brain of the developing rat. Eur. J. Neurosci. 11, 51-74.
7. Chuhma, N., and Ohmori, H. (1998). Postnatal development of phase-locked high-fidelity synaptic transmission in the medial nucleus of the trapezoid body of the rat. J. Neurosci. 18, 512-520.
8. Church, P.J., and Stanley, E.F. (1996). Single L-type calcium channel conductance with physiological levels of calcium in chick ciliary ganglion neurons. J. Physiol. 496, 59-68.
9. Delaney, K.R., and Zucker, R.S. (1990). Calcium released by photolysis of DM-nitrophen stimulates transmitter release at squid giant synapse. J. Physiol. 426, 473-498.
10. Diamond, J.S., and Jahr, C.E. (1995). Asynchronous release of synaptic vesicles determines the time course of the AMPA receptor-mediated EPSC. Neuron 15, 1097-1107.
11. Dittman, J.S., and Regehr, W.G. (1998). Calcium dependence and recovery kinetics of presynaptic depression at the climbing fiber to Purkinje cell synapse. J. Neurosci. 18, 6147-6162.
12. Dobrunz, L.E., Huang, E.P., and Stevens, C.F. (1997). Very short-term plasticity in hippocampal synapses. Proc. Natl. Acad. Sci. USA 94, 14843-14847.
13. Dodge, F.A., and Rahamimoff, R. (1967). Co-operative action ofcalcium ions in transmitter release at the neuromuscular junction. J. Physiol. 193, 419-432.
14. Elmquist, D., and Quastel, D.M.J. (1965). A quantitative study of end-plate potentials in isolated human muscle. J. Physiol. 178, 505-529.
15. Forsythe, I.D. (1994). Direct patch recording from identified presynaptic terminals mediating glutamatergic EPSCs in the rat CNS, in vitro. J. Physiol. 479, 381-387.
16. Forsythe, I.D., Tsujimoto, T., Barnes-Davies, M., Cuttle, M.F., andTakahashi, T. (1998). Inactivation of presynaptic calcium current contributes to synaptic depression at a fast central synapse. Neuron 20, 797-807.
17. Frankenhaeuser, B. (1957). The effect of calcium on the myelinated nerve fibre. J. Physiol. 137, 245-260.
18. 2+-permeability of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron 15, 193-204.
19. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260, 3440-3450.
20. Heidelberger, R. (1998). Adenosine triphosphate and the late steps in calcium-dependent exocytosis at a ribbon synapse. J. Gen. Physiol. 111, 225-241.
21. Heidelberger, R., Heinemann, C., Neher, E., and Matthews, G. (1994). Calcium dependence of the rate of exocytosis in a synaptic terminal. Nature 371, 513-515.
22. +. Biophys. J. 67, 2546-2557.
23. Helmchen, F., Borst, J.G.G., and Sakmann, B. (1997). Calcium dynamics associated with a single action potential in a CNS presynaptic terminal. Biophys. J. 72, 1458-1471.
24. 2+-triggered exocytosis in presynaptic terminals. Neuron 17, 501-512.
25. b receptor-mediated modulation of presynaptic currents and excitatory transmission at a fast central synapse. J. Neurophysiol. 80, 1571-1576.
26. Jonas, P., Major, G., and Sakmann, B. (1993). Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. J. Physiol. 472, 615-663.
27. 2+ and short-term synaptic plasticity. Nature 371, 603-606.
28. Kaplan, J.H., and Ellis-Davies, G.C.R. (1988). Photolabile chelators for the rapid photorelease of divalent cations. Proc. Natl. Acad. Sci. USA 85, 6571-6575.
29. Katz, B. (1969). The Release of Neural Transmitter Substances (Liverpool, United Kingdom: University Press).
30. Kemp, J.A., Foster, A.C., Leeson, P.D., Priestley, T., Tridgett, R., Iversen, L.L., and Woodruff, G.N. (1988). 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex. Proc. Natl. Acad. Sei. USA 85, 6547- 6550.
31. Korn, H., Triller, A., Mallet, A., and Faber, D.S. (1981). Fluctuating responses at a central synapse: N of binomial fit predicts number of stained presynaptic boutons. Science 213, 898-901.
32. Kusano, K., and Landau, E.M. (1975). Depression and recovery of transmission at the squid giant synapse. J. Physiol. 245, 13-22.
33. Lenn, N.J., and Reese, T.S. (1966). The fine structure of nerve endings in the nucleus of the trapezoid body and the ventral cochlear nucleus. Am. J. Anat. 118, 375-390.
34. Martell, A.E., and Smith, R.M. (1974). Critical Stability Constants, Volume 1 (New York: Plenum Press).
35. Neher, E. (1995). The use of fura-2 for estimating Ca buffers and Ca fluxes. Neuropharmacology 34, 1423-1442.
36. 2+-microdomains: New tools for understanding their roles in neurotransmitter release. Neuron 20, 389-399.
37. Otis, T., Zhang, S., and Trussell, L.O. (1996). Direct measurement of AMPA receptor desensitization induced by glutamatergic synaptic transmission. J. Neurosci. 16, 7496-7504.
38. Partin, K.M., Patneau, D.K., and Mayer, M.L. (1994). Cyclothiazide differentially modulates desensitization of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor splice variants. Mol. Pharmacol. 46, 129-138.
39. 2+ channels mediate transmitter release with a similar cooperativity at rat hippocampal autapses. J. Neurosci. 18, 2849-2855.
40. Reyes, A., Lujan, R., Rozov, A., Burnashev, N., Somogyi, P., and Sakmann, B. (1998). Target-cell-specific facilitation and depression in neocortical circuits. Nat. Neurosci. 1, 279-285.
41. Rosenmund, C., and Stevens, C.F. (1996). Definition of the readilyreleasable pool of vesicles at hippocampal synapses. Neuron 16, 1197-1207.
42. Ryugo, D.K., Wu, M.M., and Pongstaporn, T. (1996). Activity-related features of synapse morphology: A study of endbulbs of Held. J.Comp. Neurol. 365, 141-158.
43. Silver, R.A., Momiyama, A., and Cull-Candy, S.G. (1998). Locus of frequency-dependent depression identified with multiple-probability fluctuation analysis at rat climbing fibre-Purkinje cell synapses. J. Physiol. 570, 881-902.
44. Stevens, C.F., and Wesseling, J.F. (1998). Activity-dependent modulation of the rate at which synaptic vesicles become available to undergo exocytosis. Neuron 27, 415-424.
45. Takahashi, T., Forsythe, I.D., Tsujimoto, T., Barnes-Davies, M., and Onodera, K. (1996). Presynaptic calcium current modulation by a metabotropic glutamate receptor. Science 274, 594-597.
46. b receptor. J. Neurosci. 18, 3138-3146.
47. 2+ receptor controls the final steps in peptide secretion from pituitary melanotrophs. Neuron 11, 93-104.
48. Trussell, L.O., Zhang, S., and Raman, I.M. (1993). Desensitization of AMPA receptors upon multiquantal neurotransmitter release. Neuron 10, 1185-1196.
49. von Gersdorff, H., Schneggenburger, R., Weis, S., and Neher, E. (1997). Presynaptic depression at a calyx synapse: The small contribution of metabotropic glutamate receptors. J. Neurosci. 17, 8137-8146.
50. Wang, L.-Y., and Kaczmarek, L.K. (1998). High-frequency firing helpsreplenish the readily releasable pool of synaptic vesicles. Nature 394, 384-388.
51. Wu, L.G., Westenbroek, R.E., Borst, J.G.G., Catterall, W.A., and Sakmann, B. (1999). Calcium channel types with distinct presynaptic localization couple differentially to transmitter release in single calyx-type synapses. J. Neurosci. 19, 726-736.
52. 2+ clearance in the cytosol of adrenal chromaffin cells. Biophys. J. 73, 532-545.
53. Yamada, K.A., and Tang, C.-M. (1993). Benzothiazides inhibit rapid glutamate receptor desensitization and enhance glutamatergic synaptic currents. J. Neurosci. 13, 3904-3915.
54. Zucker, R.S. (1973). Changes in the statistics of transmitter release during facilitation. J. Physiol. 229, 787-810.
55. Zucker, R.S. (1996). Exocytosis: A molecular and physiological perspective. Neuron 17, 1049-1055.