Allosteric modulation of the presynaptic Ca2+ sensor for vesicle fusion

Nature

Volumn 435, Issue 7041, 2005, Pages 497-501

  Lou, Xuelin ^a   Scheuss, Volker ^a   Schneggenburger, Ralf ^a,b  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; ALCOHOLS; DATA REDUCTION; ENZYMES; ESTERS; PLASTICITY;

ALLOSTERIC MODULATION; NEUROTRANSMITTER RELEASE; SYNAPTIC PLASTICITY; VESICLE FUSION;

CALCIUM;

CALCIUM ION; MUNC 13 PROTEIN; PHORBOL ESTER; PROTEIN; PROTEIN KINASE C; UNCLASSIFIED DRUG;

NEUROLOGY;

ALLOSTERISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CELL FUSION; CONTROLLED STUDY; CYTOSOL; EXCITATORY POSTSYNAPTIC POTENTIAL; NERVE CELL PLASTICITY; NERVE ENDING; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; SENSOR; SIGNAL TRANSDUCTION; SYNAPSE VESICLE;

ALLOSTERIC REGULATION; ANIMALS; BRAIN STEM; CALCIUM; CALCIUM SIGNALING; CHROMAFFIN CELLS; EXCITATORY POSTSYNAPTIC POTENTIALS; MEMBRANE FUSION; MODELS, BIOLOGICAL; NEUROTRANSMITTER AGENTS; PHORBOL 12,13-DIBUTYRATE; PRESYNAPTIC TERMINALS; RATS; SYNAPSES; SYNAPTIC TRANSMISSION;

ANIMALIA; CALYX;

EID: 19444365446     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03568     Document Type: Article

References (28)

1. Malenka, R. C., Madison, D. V. & Nicoll, R. A. Potentiation of synaptic transmission in the hippocampus by phorbol ester. Nature 321, 175-177 (1986).
2. Shapira, R., Silberberg, S. D., Ginsburg, S, & Rahamimoff, R. Activation of protein kinase C augments evoked transmitter release. Nature 325, 58-60 (1987).
3. Yawo, H. Protein kinase C potentiates transmitter release from the chick ciliary presynaptic terminal by increasing the exocytotic fusion probability. J. Physiol. (Lond.) 515, 169-180 (1999).
4. Hori, T., Takai, Y. & Takahashi, T. Presynaptic mechanism for phorbol ester-induced synaptic potentiation. J. Neurosci. 19, 7262-7267 (1999).
5. Rhee, J.-S. et al. β phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by munc13s and not by PKCs. Cell 108, 121-133 (2002).
6. Silinsky, E. M. & Searl, T. J. Phorbol esters and neurotransmitter release: More than just protein kinase C? Br. J. Pharmacol. 138, 1191-1201 (2003).
7. Chen, Y. A. & Scheller, R. H. SNARE-mediated membrane fusion. Nature Rev. Mol. Cell Biol. 2, 98-106 (2001).
8. Jahn, R., Lang, T. & Südhof, T. C. Membrane fusion. Cell 112, 519-533 (2003).
9. Bollmann, J., Sakmann, B. & Borst, J. Calcium sensitivity of glutamate release in a calyx-type terminal. Science 289, 953-957 (2000).
10. Schneggenburger, R. & Neher, E. Intracellular calcium dependence of transmitter release rates at a fast central synapse. Nature 406, 889-893 (2000).
11. Felmy, F., Neher, E. & Schneggenburger, R. Probing the intracellular calcium sensitivity of transmitter release during synaptic facilitation. Neuron 37, 801-811 (2003).
12. 2+ sensor. J. Neurosci. 21, 7928-7936 (2001).
13. Ishikawa, T., Sahara, Y. & Takahashi, T. A single packet of transmitter does not saturate postsynaptic glutamate receptors. Neuron 34, 613-621 (2002).
14. Gillis, K. D., Mößner, R. & Neher, E. Protein kinase C enhances exocytosis from chromaffin cells by increasing the size of the readily releasable pool of secretory granules. Neuron 16, 1209-1220 (1996).
15. Stevens, C. F. & Sullivan, J. M. Regulation of the readily releasable vesicle poo by protein kinase C. Neuron 21, 885-893 (1998).
16. Sakaba, T. & Neher, E. Calmodulin mediates rapid recruitment of fast-releasing synaptic vesicles at a calyx-type synapse. Neuron 32, 1119-1131 (2001).
17. Deitcher, D. L. et al. Distinct requirements for evoked and spontaneous release of neurotransmitter are revealed by mutations in the Drosophila gene neuronal-synaptobrevin. J. Neurosci. 18, 2028-2039 (1998).
18. Schoch, S. et al. SNARE function analyzed in synaptobrevin/VAMP knockout mice. Science 294, 1117-1122 (2001).
19. Washbourne, P. et al. Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis. Nature Neurosci. 5, 19-26 (2002).
20. 2+-sensitive pool of vesicles is regulated by protein kinase C in adrenal chromaffin cells. Proc. Natl Acad. Sci. USA 99, 17060-17065 (2002).
21. Monod, J., Wyman, J. & Changeux, J.-P. On the nature of allosteric transitions: A plausible model. J. Mol. Biol. 12, 88-118 (1965).
22. Li, J., Zagotta, W. N. & Lester, H. A. Cyclic nucleotide-gated channels: structural basis of ligand efficacy and allosteric modulation. Q. Rev. Biophys. 30, 177-193 (1997).
23. Zhu, H., Hille, B. & Xu, T. Sensitization of regulated exocytosis by protein kinase C. Proc. Natl Acad. Sci. USA 99, 17055-17059 (2002).
24. Stevens, C. F. & Wesseling, J. F. Augmentation is a potentiation of the exocytotic process. Neuron 22, 139-146 (1999).
25. Scanziani, M., Capogna, M., Gähwiler, B. H. & Thompson, S. M. Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine in the hippocampus. Neuron 9, 919-927 (1992).
26. 2+ entry pathway. Proc. Natl Acad. Sci. USA 101, 3609-3614 (2004).
27. Delaney, K. R. & Tank, D. W. A quantitative measurement of the dependence of short-term synaptic enhancement on presynaptic residual calcium. J. Neurosci. 14, 5885-5902 (1994).
28. 2+ and spontaneous transmitter release at the frog neuromuscular junction. J. Neurophysiol. 85, 287-294 (2001).