The role of the glutamatergic system in posttraumatic stress disorder

CNS Spectrums

Volumn 13, Issue 7, 2008, Pages 585-591

  Nair, Jyotsna ^a,b   Ajit, Sarbjot Singh ^c  

^a Burrell Behavioral Health   (United States)

^b University of Missouri   (United States)

^c Community Counseling Center ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN RELEASING FACTOR; GLUTAMIC ACID; HYDROCORTISONE; LAMOTRIGINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ALERTNESS; ANXIETY DISORDER; AVOIDANCE BEHAVIOR; DISEASE SEVERITY; HORMONE RELEASE; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; NEGATIVE FEEDBACK; NONHUMAN; PATHOPHYSIOLOGY; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SYMPTOM; VICTIM;

EID: 51049124685     PISSN: 10928529     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1092852900016862     Document Type: Review

References (38)

1. Diagnostic and Statistical Manual of Mental Disorders. 4th ed, text rev. Washington, DC: American Psychiatric Association; 2000.
2. Mason JW, Giller EL, Kosten TR, Ostroff RB, Podd L. Urinary-free cortisol levels in post-traumatic stress disorder patients. J Nerv Ment Dis. 1986;174:145-159.
3. Yehuda R, Southwick SM, Nussbaum G, Wahby V, Giller EL Jr, Mason JW. Low urinary cortisol excretion in PTSD J Nerv Ment Dis. 1990;178:366-369.
4. Boscarino JA. Posttraumatic stress disorder, exposure to combat, and lower plasma cortisol among Vietnam veterans: findings and clinical implications. J Consult Clin Psychol. 1996;64:191-201.
5. Yehuda R, Sensitization of the hypothalamic-pituitary-adrenal axis in posttraumatic stress disorder. In: McFarlane AC, Yehuda R, eds. Psychobiology of Posttraumatic Stress Disorder (Annals of the New York Academy of Sciences). vol. 821. New York. NY: New York Academy of Sciences; 1997:57-75.
6. Orr SP, Metzger LJ, Lasko NB, Macklin ML, Peri T, Pitman RK. De novo conditioning in trauma-exposed individuals with and without posttraumatic stress disorder. J Abnorm Psychol. 2000;109:290-298.
7. Wessa M, Flor H. Failure of extinction of fear responses in posttraumatic stress disorder. evidence from second-order conditioning. Am J Psychiatry. 2007;164:1684-1692.
8. Milad MR, Orr SP, Lasko NB, Chang Y, Rauch SL, Pitman RK. Presence and acquired origin of reduced recall for fear extinction in PTSD: results of a twin study. J Psychiatr Res. 2008;42:515-520.
9. Sapolsky RM. Stress and plasticity in the limbic system. Neurochem Res. 2003;28:1735-1742.
10. Miller LA, Taber KH, Gabbard GO, Hurley RA. Neural underpinnings of fear and its modulation: implications for anxiety disorders. J Neuropsychiatry Clin Neurosci. 2005;17:1-6.
11. Davis M, Whalen PJ. The amygdala: vigilance and emotion. Mol Psychiatry. 2001;6:13-34.
12. Hertzberg MA, Butterfield MI, Fledman ME, et al. A preliminary study of lamotrigine for the treatment of posttraumatic stress disorder. Biol Psychiatry. 1999;45:1226-1229.
13. Frye MA, Ketter TA, Kimbrell TA, et al. A placebo-controlled study of lamotrigine and gabapentin monotherapy in refractory mood disorders. J Clin Psychopharmacol. 2000;607-614.
14. Bailey TW, Dimicco JA. Chemical stimulation of the dorsomedial hypothalamus elevates plasma ACTH in conscious rats. Am J Physiol Regul Integr Comp Physiol. 2001;280:R8-R15.
15. Bartanusz V, Muller D, Gaillard RC, Streit P, Vutskits L, Kiss JZ. Local gamma-aminobutyric acid and glutamate circuit control of hypophyseotrophic corticotropin-releasing factor neuron activity in the paraventricular nucleus of the hypothalamus. Eur J Neurosci. 2004;19:777-782.
16. Davidson JR, Stein DJ, Shalev AY, Yehuda R. Post-traumatic stress disorder: acquisition, recognition, course, and treatment. J Neuropsychiatry Clin Neurosci. 2004;16(2):135-141.
17. Hageman I, Andersen HS, Jørgensen MB. Post-traumatic stress disorder: a review of psychobiology and pharmacotherapy. Acta Psychiatr Scand. 2001;104:411-422.
18. Pitman RK, Delahanty DL. Conceptually driven pharmacologic approaches to acute trauma. CNS Spectr. 2005:10:99-106.
19. Ziegler DR, Cullinan WE, Herman JP. Organization and regulation of paraventricular nucleus glutamate signaling systems: N-methyl-D-aspartate receptors. J Comp Neurol. 2005;484:43-56.
20. Herman JP, Eyigor O, Ziegler DR, Jennes L. Expression of ionotropic glutamate receptor subunit mRNAs in the hypothalamic paraventricular nucleus of the rat. J Comp Neurol. 2000;422:352-362.
21. Brann DW, Mahesh VB. Excitatory amino acids: evidence for a role in the control of reproduction and anterior pituitary hormone secretion. Endocr Rev. 1997;18:678-700.
22. Kita I, Seki Y, Nakatani Y, et al. Corticotropin-releasing factor neurons in the hypothalamic paraventricular nucleus are involved in arousal/yawning response of rats. Behav Brain Res. 2006;169:48-56.
23. Mathew SJ, Coplan JD, Schoepp DD, Smith EL, Rosenblum LA, Gorman JM. Glutamate-hypothalamic-pituitary-adrenal axis interactions: implications for mood and anxiety disorders. CRS Spectr. 2001;6:555-556, 561-564.
24. Joanny P, Steinberg J, Oliver C, Grino M. Glutamate and N-methyl-D-aspartate stimulate rat hypothalamic corticotropin-releasing factor secretion in vitro. J Neuroendocrinol. 1997;9:93-97.
25. Fudge JL, Emiliano AB. The extended amygdala and the dopamine system: another piece of the dopamine puzzle. J Neuropsychiatry Clin Neurosci. 2003;15:306-316.
26. Rainnie DG, Bergeron R, Sajdyk TJ, Patil M, Gehlert DR, Shekhar A. Corticotrophin releasing factor-induced synaptic plasticity in the amygdala translates stress into emotional disorders. J Neurosci. 2004;24:3471-3479.
27. Venihaki M, Sakihara S, Subramanian S, et al. Urocortin III, a brain neuropeptide of the corticotropin-releasing hormone family: modulation by stress and attenuation of some anxiety-like behaviours. J Neuroendocrinol. 2004;16:411-422.
28. Gehlert DR, Shekhar A, Morin SM, et al. Stress and central Urocortin increase anxiety-like behavior in the social interaction test via the CRF1 receptor. Eur J Pharmacol. 2005;509:145-153.
29. Valentino RJ, Van Bockstaele E. Opposing regulation of the locus coeruleus by corticotropin-releasing factor and opioids. Potential for reciprocal interactions between stress and opioid sensitivity. Psychopharmacology (Berl). 2001;158:331-342.
30. Curtis AL, Lechner SM, Pavcovich LA, Valentino RJ. Activation of the locus coaruleus noradrenergic system by intracoerulear microinfusion of corticotropin-releasing factor: effects on discharge rate, cortical norepinephrine levels and cortical electroencephalographic activity. J Pharmcol Exp Ther. 1997;281:163-172.
31. Chamey DS, Nagy LM, Bremner JD, Goddard AW, Yehuda R, Southwick SM. Neurobiological mechanisms of human anxiety. In: Fogal BS, Schiffler RB, Rao SM, eds. Neuropsychiatry. Baltimore, Md: Williams & Wilkins; 1996:257-278.
32. Baker DG, Ekhator NN, Kasckow JW, et al. Higher levels of basal serial CSF cortisol in combat veterans with posttraumatic stress disorder. Am J Psychiatry. 2005;162:992-994.
33. Baker DG, West SA, Nicholson WE, et al. Serial CSF corticotropin-releasing hormone levels and adrenocortical activity in combat veterans with posttraumatic stress disorder. Am J Psychiatry. 1999;156:585-588.
34. Arborelius L, Owens MJ, Plotsky PM, Nemeroff CB. The role of corticotropin-releasing factor in depression and anxiety disorders. J Endocrinol. 1999;160:1-12.
35. Mason JW, Wang S, Yehuda R, et al. Marked lability in urinary cortisol levels in subgroups of combat veterans with posttraumatic stress disorder during an intensive exposure treatment program. Psychosom Med. 2002;64:238-246.
36. Mirza NR, Bright JL, Stanhope KJ, Wyatt A, Harrington NR. Lamotrigine has an anxiolytic-like profile in the rat conditioned emotional response test of anxiety: a potential role for sodium channels? Psychopharmacology (Berl). 2005;180:159-168.
37. Höchl C, Hajek T. Hippocampal damage mediated by corticosteroids-a neuropsychiatric research challenge. Eur Arch Psychiatry Clin Neurosci. 2001;251(suppl 2): II81-II88.
38. Kiraly SJ, Ancill RJ, Dimitroua G. The relationship of endogenous cortisol to psychiatric disorder: a review. Can J Psychiatry. 1997;42:415-420.