The catalytic intermediate stabilized by a "down" active site loop for diaminopimelate decarboxylase from Helicobacter pylori: Enzymatic characterization with crystal structure analysis

Journal of Biological Chemistry

Volumn 283, Issue 30, 2008, Pages 21284-21293

  Hu, Tiancen ^a   Wu, Dalei ^a   Chen, Jing ^a   Ding, Jianping ^b   Jiang, Hualiang ^a   Shen, Xu ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITES; ALDIMINE; CATALYTIC EFFICIENCIES; CATALYTIC INTERMEDIATES; CATALYTIC MECHANISMS; COFACTOR; CRYSTAL STRUCTURE ANALYSES; DECARBOXYLASE; ENZYMATIC CHARACTERIZATIONS; EXTERNAL-; HELICOBACTER PYLORUS; LYSINE BIOSYNTHESIS; SCHIFF BASE; SPECIFIC INHIBITORS; STRUCTURAL INSIGHTS; SUBSTRATE SPECIFICITIES;

AMINO ACIDS; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; CONFORMATIONS; STRUCTURAL ANALYSIS;

CRYSTAL STRUCTURE;

CARBOXYLYASE; DIAMINOPIMELATE DECARBOXYLASE; ENZYME INHIBITOR; LIGAND; LYSINE; PHOSPHATE; PYRIDOXAL; SCHIFF BASE; SOLVENT; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT;

ARTICLE; CATALYSIS; CONFORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; HELICOBACTER PYLORI; MUTANT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; BACTERIAL GENOME; BINDING SITE; ENZYMOLOGY; KINETICS; METABOLISM; METHODOLOGY; MOLECULAR CLONING; MOLECULAR GENETICS; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

HELICOBACTER PYLORI;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BINDING SITES; CARBOXY-LYASES; CATALYSIS; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; GENOME, BACTERIAL; HELICOBACTER PYLORI; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 51049107749     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801823200     Document Type: Article

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