Fibroblast growth factor 2 restrains Ras-driven proliferation of malignant cells by triggering RhoA-mediated senescence

Cancer Research

Volumn 68, Issue 15, 2008, Pages 6215-6223

  Costa, Érico T ^a   Forti, Fábio L ^a   Matos, Tatiana G F ^a   Dermargos, Alexandre ^a   Nakano, Fábio ^a   Salotti, Jacqueline ^a   Rocha, Kátia M ^a   Asprino, Paula F ^a   Yoshihara, Celina K ^a   Koga, Marianna M ^a   Armelin, Hugo A ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; FIBROBLAST GROWTH FACTOR 2; K RAS PROTEIN; PROTEIN TYROSINE KINASE INHIBITOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN P21;

ADRENAL CORTEX CELL; ANIMAL CELL; APOPTOSIS; ARTICLE; BAGG ALBINO MOUSE; CANCER CELL; CANCER CELL CULTURE; CELL CYCLE; CELL PROLIFERATION; CYTOTOXICITY; IMMUNOCOMPETENCE; MOLECULAR CLONING; MOUSE; NECROSIS; NONHUMAN; NUDE MOUSE; ONCOGENE RAS; PRIORITY JOURNAL; SENESCENCE; STRESS; ANIMAL; CELL AGING; CELL LINE; CELL STRAIN 3T3; FLOW CYTOMETRY; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS;

3T3 CELLS; ANIMALS; CELL AGING; CELL LINE; CELL PROLIFERATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FIBROBLAST GROWTH FACTOR 2; FLOW CYTOMETRY; MICE; MICE, INBRED BALB C; ONCOGENE PROTEIN P21(RAS); RHOA GTP-BINDING PROTEIN;

EID: 51049102785     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-0342     Document Type: Article

References (33)

1. Böttcher RT, Niehrs C. FGF signalling during early vertebrate development. Endocr Rev 2005;26:63-77.
2. Şrensen V, Nilsen T, Wiedùocha A. Functional diversity of FGF-2 isoforms by intracellular sorting. Bioessays 2006;28:504-14.
3. Itoh N, Ornitz DM. Functional evolutionary history of the mouse Fgf gene family. Dev Dyn 2008;237:18-27.
4. Sasada R, Kurokawa T, Iwane M, Igarashi K. Transformation of mouse BALB/c 3T3 cells with human basic fibroblast growth factor cDNA. Mol Cell Biol 1988;8:588-94.
5. Grose R, Dickson C. Fibroblast growth factor signaling in tumorigenesis. Cytokine Growth Factor Rev 2005;16:179-86.
6. Bremnes RM, Camps C, Sirera R. Angiogenesis in non-small cell lung cancer: the prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood. Lung Cancer 2006;51:143-58.
7. Gan Y, Wientjes MG, Au JL. Expression of basic fibroblast growth factor correlates with resistance to paclitaxel in human patient tumors. Pharm Res 2006;23:1324-31.
8. Pardo OE, Wellbrock C, Khanzada UK, et al. FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCq, B-Raf and S6K2. EMBO J 2006;25:3078-88.
9. Wang JK, Goldfarb M. Amino acid residues which distinguish the mitogenic potentials of two FGF receptors. Oncogene 1997;14:1767-78.
10. Wang Q, Maloof P, Wang H, et al. Basic fibroblast growth factor downregulates Bcl-2 and promotes apoptosis in MCF-7 human breast cancer cells. Exp Cell Res 1998;238:177-87.
11. Burchill SA, Westwood G. Mechanism of basic fibroblast growth factor-induced cell death. Apoptosis 2002;7:5-12.
12. Coleman AB, Metz MZ, Donohue CA, Schwarz RE, Kane SE. Chemosensitization by fibroblast growth factor-2 is not dependent upon proliferation, S-phase accumulation, or p53 status. Biochem Pharmacol 2002;64:1111-23.
13. Costa ET, Forti FL, Rocha KM, Moraes MS, Armelin HA. Molecular mechanisms of cell cycle control in the mouse Y1 adrenal cell line. Endocr Res 2004;30:503-9.
14. Yasumura Y, Buonassisi V, Sato G. Clonal analysis of differentiated function in animal cell cultures. I. Possible correlated maintenance of differentiated function and the diploid karyotype. Cancer Res 1966;26:529-35.
15. Schwab M, Alitalo K, Varmus HE, Bishop JM, George D. A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells. Nature 1983;303:497-501.
16. Kovary K, Armelin MC, Armelin HA. Ha-Ras-1 oncogene dosage differentially affects Balb/3T3 cells growth factor requirement and tumorigenicity. Oncogene Res 1989;4:55-64.
17. Barbacid M. ras genes. Annu Rev Biochem 1987;56:779-827.
18. Bos JL. ras oncogenes in human cancer: a review. Cancer Res 1989;49:4682-9. Erratum in: Cancer Res 1990;50:1352.
19. Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW, Weinberg RA. Creation of human tumour cells with defined genetic elements. Nature 1999;400:464-8.
20. Lim KH, Counter CM. Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance. Cancer Cell 2005;8:381-92.
21. Lin AW, Barradas M, Stone JC, van Aelst L, Serrano M, Lowe SW. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev 1998;12:3008-19.
22. Lowe SW, Cepero E, Evan G. Intrinsic tumour suppression. Nature 2004;432:307-15.
23. George DL, Francke U. Homogeneously staining chromosome regions and double minutes in a mouse adrenocortical tumor cell line. Cytogenet Cell Genet 1980;28:217-26.
24. Reid T, Furuyashiki T, Ishizaki T, et al. Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rhobinding domain. J Biol Chem 1996;271:13556-60.
25. Lotfi CF, Armelin HA. cfos and cjun antisense oligonucleotides block mitogenesis triggered by fibroblast growth factor-2and ACTH in mouse Y1 adrenocortical cells. J Endocrinol 2001;168:381-9.
26. Forti FL, Schwindt TT, Moraes MS, Eichler CB, Armelin HA. ACTH promotion of p27(Kip1) induction in mouse Y1 adrenocortical tumor cells is dependent on both PKA activation and Akt/PKB inactivation. Biochemistry 2002;41:10133-40.
27. Feig LA, Cooper GM. Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol Cell Biol 1988;8:3235-43.
28. Jaffe AB, Hall A. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 2005;21:247-69.
29. Forti FL, Costa ET, Rocha KM, Moraes MS, Armelin HA. c-K-ras oncogene and FGF2 signaling pathways in the mouse Y1 adrenocortical cell line. An Acad Bras Cienc 2006;78:231-9.
30. Forti FL, Armelin HA. Vasopressin triggers senescence in K-ras transformed cells via RhoA-dependent downregulation of cyclin D1. Endocr Relat Cancer 2007;14:1117-25.
31. Mechta F, Lallemand D, Pfarr CM, Yaniv M. Transformation by ras modifies AP1 composition and activity. Oncogene 1997;14:837-47.
32. Vakifahmetoglu H, Olson M, Tamm C, Heldari N, Orrenius S, Zhivotovisky B. DNA damage induces distinct modes of cell death in ovarian carcinomas. Cell Death Differ 2008;15:555-66.
33. Campisi J, d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 2007;8:729-40.