Two newly synthesized 5-methyltetrahydrofolate-like compounds inhibit methionine synthase activity accompanied by cell cycle arrest in G1/S phase and apoptosis in vitro

Anti-Cancer Drugs

Volumn 19, Issue 7, 2008, Pages 697-704

  Tang, Cai ^a   Zhang, Zhili ^a   Xu, Bo ^a   Li, Min ^a   Liu, Junyi ^a   Cui, Jingrong ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

5 methyltetrahydrofolate; Anticancer; Apoptosis; Cell cycle; HL 60; Methionine synthase

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; CASPASE 3; CASPASE 8; CASPASE 9; CYCLIN DEPENDENT KINASE 2; CYCLIN E; DIETHYL N [4 [[2 [2,4 DIAMINO 5 (2,3 DIBROMOPROPANE) 5,6,7,8 TETRAHYDROPYRIDO[3,2 D]PYRIMIDIN 6 YL]METHYL]AMINO]3 BROMOBENZOYL]GLUTAMATE; ENZYME INHIBITOR; FOLIC ACID; HOMOCYSTEINE; METHIONINE SYNTHASE; N [4 [[2 [2,4 DIAMINO 5 (2,3 DIBROMOPROPANE) 5,6,7,8 TETRAHYDROPYRIDO[3,2 D]PYRIMIDIN 6 YL]METHYL]AMINO] 3 BROMOBENZOYL]GLUTAMIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SULFUR AMINO ACID; UNCLASSIFIED DRUG; ZL 031; ZL 033; 5 METHYLTETRAHYDROFOLATE HOMOCYSTEINE METHYLTRANSFERASE; 5-METHYLTETRAHYDROFOLATE; ANTINEOPLASTIC AGENT; CDK2 PROTEIN, HUMAN; DIETHYL N (4 ((2 (2,4 DIAMINO 5 (2,3 DIBROMOPROPYL) 5,6,7,8 TETRAHYDROPYRIDO(3,2 D)PYRIMIDIN 6 YL)METHYL)AMINO) 3 BROMOBENZOYL)GLUTAMATE; DIETHYL N-(4-((2-(2,4-DIAMINO-5-(2,3-DIBROMOPROPYL)-5,6,7,8-TETRAHYDROPYRIDO(3,2-D)PYRIMIDIN-6-YL)METHYL)AMINO)-3-BROMOBENZOYL)GLUTAMATE; GLUTAMIC ACID DERIVATIVE; N (4 ((2 (2,4 DIAMINO 5 (2,3 DIBROMOPROPYL) 5,6,7,8 TETRAHYDROPYRIDO(3,2 D)PYRIMIDIN 6 YL)METHYL)AMINO) 3 BROMOBENZOYL)GLUTAMIC ACID; N-(4-((2-(2,4-DIAMINO-5-(2,3-DIBROMOPROPYL)-5,6,7,8-TETRAHYDROPYRIDO(3,2-D)PYRIMIDIN-6-YL)METHYL)AMINO)-3-BROMOBENZOYL)GLUTAMIC ACID; PYRIMIDINE DERIVATIVE; TETRAHYDROFOLIC ACID DERIVATIVE;

APOPTOSIS; ARTICLE; CATALYSIS; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; DRUG EFFICACY; DRUG STRUCTURE; ENZYME INACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; BIOSYNTHESIS; CELL STRAIN HL 60; DRUG ANTAGONISM; DRUG EFFECT;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL PROLIFERATION; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; ENZYME INHIBITORS; G1 PHASE; GLUTAMATES; HL-60 CELLS; HUMANS; PYRIMIDINES; S PHASE; TETRAHYDROFOLATES;

EID: 51049093618     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/CAD.0b013e32830317f2     Document Type: Article

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