Mild folate deficiency induces a proatherosclerotic phenotype in endothelial cells

Atherosclerosis

Volumn 189, Issue 1, 2006, Pages 133-141

  Brown, Karen S ^a   Huang, Yuehua ^a   Lu, Zhi Yong ^a   Jian, Wenying ^a   Blair, Ian A ^a   Whitehead, Alexander S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Atherosclerosis; Endothelial cells; Folate; Homocysteine; Monocyte chemoattractant protein 1

Indexed keywords

FOLIC ACID; FOLIC ACID DERIVATIVE; HOMOCYSTEINE; HYPOXANTHINE; MONOCYTE CHEMOTACTIC PROTEIN 1; RHO KINASE INHIBITOR; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; THYMIDINE;

ARTICLE; ATHEROSCLEROTIC PLAQUE; CELL CYCLE; CELL CYCLE S PHASE; CELL FUNCTION; CONTROLLED STUDY; DNA METHYLATION; ENDOTHELIUM CELL; FOLIC ACID DEFICIENCY; HUMAN; HUMAN CELL; MONOLAYER CULTURE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRESS FIBER;

ATHEROSCLEROSIS; CELL DIVISION; CELL LINE; CHEMOKINE CCL2; DNA METHYLATION; ENDOTHELIUM, VASCULAR; FOLIC ACID DEFICIENCY; GENE EXPRESSION; HUMANS; PHENOTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK FACTORS; RNA; S-ADENOSYLHOMOCYSTEINE; S-ADENOSYLMETHIONINE;

EID: 33646243998     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2005.12.018     Document Type: Article

References (29)

1. Lucock M. Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol Genet Metab 71 (2000) 121-138
2. Durand P., Prost M., Loreau N., Lussier-Cacan S., and Blache D. Impaired homocysteine metabolism and atherothrombotic disease. Lab Invest 81 (2001) 645-672
3. Hanratty C.G., McGrath L.T., McAuley D.F., Young I.S., and Johnston G.D. The effects of oral methionine and homocysteine on endothelial function. Heart 85 (2001) 326-330
4. Bellamy M.F., McDowell I.F., Ramsey M.W., Brownlee M., Bones C., Newcombe R.G., and Lewis M.J. Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults. Circulation 98 (1998) 1848-1852
5. Doshi S.N., McDowell I.F., Moat S.J., et al. Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering. Circulation 105 (2002) 22-26
6. Verhaar M.C., Wever R.M.F., Kastelein J.J.P., et al. 5-Methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia. Circulation 97 (1998) 237-241
7. Poddar R., Sivasubramanian N., DiBello P.M., Robinson K., and Jacobsen D.W. Homocysteine induces expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human aortic endothelial cells: implications for vascular disease. Circulation 103 (2001) 2717-2723
8. Au-Yeung KK, Woo CW, Sung FL, Yip JC, Siow YL, O K. Hyperhomocysteinemia activates nuclear factor-kappaB in endothelial cells via oxidative stress. Circ Res 2004;94:28-36.
9. Outinen P.A., Sood S.K., Pfeifer S.I., et al. Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells. Blood 94 (1999) 959-967
10. Upchurch Jr. G.R., Welch G.N., Fabian A.J., et al. Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J Biol Chem 272 (1997) 17012-17017
11. Dardik R., Savion N., Gal N., and Varon D. Flow conditions modulate homocysteine induced changes in the expression of endothelial cell genes associated with cell-cell interaction and cytoskeletal rearrangement. Thromb Haemost 88 (2002) 1047-1053
12. Hajjar K.A., Mauri L., Jacovina A.T., et al. Tissue plasminogen activator binding to the annexin II tail domain. Direct modulation by homocysteine. J Biol Chem 273 (1998) 9987-9993
13. Zhou J., Werstuck G.H., Lhotak S., et al. Association of multiple cellular stress pathways with accelerated atherosclerosis in hyperhomocysteinemic apolipoprotein E-deficient mice. Circulation 110 (2004) 207-213
14. Zhang R., Jing M., Xia M., Zhu H., and Ling W. Mild hyperhomocysteinemia induced by feeding rats diets rich in methionine or deficient in folate promotes early atherosclerotic inflammatory processes. J Nutr 134 (2004) 825-830
15. Coppola A., Astarita C., Liguori C., et al. Impairment of coronary circulation by acute hyperhomocysteinemia and reversal by antioxidant vitamins. J Intern Med 256 (2004) 398-405
16. Zeng X.K., Remick D.G., and Wang X. Homocysteine induces production of monocyte chemoattractant protein-1 and interleukin-8 in cultured human whole blood. Acta Pharmacol Sin 25 (2004) 1419-1425
17. Libbus B.L., Borman L.S., Ventrone C.H., and Branda R.F. Nutritional folate-deficiency in Chinese hamster ovary cells. Chromosomal abnormalities associated with perturbations in nucleic acid precursors. Cancer Genet Cytogenet 46 (1990) 231-242
18. Duthie S.J., Narayanan S., Blum S., Pirie L., and Brand G.M. Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells. Nutr Cancer 37 (2000) 245-251
19. Fenech M., and Crott J.W. Micronuclei, nucleoplasmic bridges and nuclear buds induced in folic acid deficient human lymphocytes-evidence for breakage-fusion-bridge cycles in the cytokinesis-block micronucleus assay. Mutat Res 504 (2002) 131-136
20. Zijno A., Andreoli C., Leopardi P., et al. Folate status, metabolic genotype, and biomarkers of genotoxicity in healthy subjects. Carcinogenesis 24 (2003) 1097-1103
21. Wang X., and Fenech M. A comparison of folic acid and 5-methyltetrahydrofolate for prevention of DNA damage and cell death in human lymphocytes in vitro. Mutagenesis 18 (2003) 81-86
22. Branda R.F., and Tracy P.B. Effects of nutritional folate deficiency on the adhesive properties of murine melanoma cells. Cancer Lett 55 (1990) 95-102
23. Huang R.-F.S., Ho Y.-H., Lin H.-L., Wei J.-S., and Liu T.-Z. Folate deficiency induces a cell cycle-specific apoptosis in HepG2 cells. J Nutr 129 (1999) 25-31
24. Jhaveri M.S., Wagner C., and Trepel J.B. Impact of extracellular folate levels on global gene expression. Mol Pharmacol 60 (2001) 1288-1295
25. Pogribny I., Yi P., and James S.J. A sensitive new method for rapid detection of abnormal methylation patterns in global DNA and within CpG islands. Biochem Biophys Res Commun 262 (1999) 624-628
26. Stamatovic S.M., Keep R.F., Kunkel S.L., and Andelkovic A.V. Potential role of MCP-1 in endothelial cell tight junction 'opening': signaling via rho and rho kinase. J Cell Sci 116 (2003) 4615-4628
27. Pogribny I.P., James S.J., Jernigan S., and Pogribna M. Genomic hypomethylation is specific for preneoplastic liver in folate/methyl deficient rats and does not occur in non-target tissues. Mutat Res 548 (2004) 53-59
28. Borman L.S., and Branda R.F. Nutritional folate deficiency in Chinese hamster ovary cells. I. Characterization of the pleiotropic response and its modulation by nucleic acid precursors. J Cell Physiol 140 (1989) 336-343
29. Czeizel A., and Dudas I. Prevention of the first occurrence of neural tube defects by periconceptional vitamin supplementation. N Engl J Med 327 (1992) 1832-1835