메뉴 건너뛰기




Volumn 90, Issue 10, 2008, Pages 1523-1529

In silico analysis of structural and functional consequences in p16INK4A by deleterious nsSNPs associated CDKN2A gene in malignant melanoma

Author keywords

cdk6; CDKN2A gene; Malignant melanoma; p16INK4A; Single nucleotide polymorphism

Indexed keywords

CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 2A;

EID: 50949106676     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2008.05.017     Document Type: Article
Times cited : (15)

References (52)
  • 1
    • 17044437374 scopus 로고    scopus 로고
    • Gene SNPs and mutations in clinical genetic testing: haplotype-based testing and analysis
    • Lee J.E., Choi J.H., Lee J.H., and Lee M.G. Gene SNPs and mutations in clinical genetic testing: haplotype-based testing and analysis. Mutat. Res. 573 (2005) 195-204
    • (2005) Mutat. Res. , vol.573 , pp. 195-204
    • Lee, J.E.1    Choi, J.H.2    Lee, J.H.3    Lee, M.G.4
  • 2
    • 0032429154 scopus 로고    scopus 로고
    • A DNA polymorphism discovery resource for research on human genetic variation
    • Collins F.S., Brooks L.D., and Chakravarti A. A DNA polymorphism discovery resource for research on human genetic variation. Genome Res. 8 (1998) 1229-1231
    • (1998) Genome Res. , vol.8 , pp. 1229-1231
    • Collins, F.S.1    Brooks, L.D.2    Chakravarti, A.3
  • 3
    • 0029805706 scopus 로고    scopus 로고
    • The new genomics: global views of biology
    • Lander E.S. The new genomics: global views of biology. Science 274 (1996) 536-539
    • (1996) Science , vol.274 , pp. 536-539
    • Lander, E.S.1
  • 5
    • 0034026082 scopus 로고    scopus 로고
    • Cytokine and cytokine receptor polymorphisms in infectious disease
    • Van Deventer S.J. Cytokine and cytokine receptor polymorphisms in infectious disease. Intensive Care Med. 26 (2000) S98-S102
    • (2000) Intensive Care Med. , vol.26
    • Van Deventer, S.J.1
  • 6
    • 0038795172 scopus 로고    scopus 로고
    • Genetics of melanoma predisposition
    • Hayward N.K. Genetics of melanoma predisposition. Oncogene 22 (2003) 3053-3062
    • (2003) Oncogene , vol.22 , pp. 3053-3062
    • Hayward, N.K.1
  • 7
    • 0031894534 scopus 로고    scopus 로고
    • Molecular genetics of familial cutaneous melanoma
    • Haluska F.G., and Hodi F.S. Molecular genetics of familial cutaneous melanoma. J. Clin. Oncol. 16 (1998) 670-682
    • (1998) J. Clin. Oncol. , vol.16 , pp. 670-682
    • Haluska, F.G.1    Hodi, F.S.2
  • 8
    • 0030040533 scopus 로고    scopus 로고
    • Immunohistochemical detection of CDK4 and p16INK4 proteins in cutaneous malignant melanoma
    • Wang Y.L., Uhara H., Yamazaki Y., Nikaido T., and Saida T. Immunohistochemical detection of CDK4 and p16INK4 proteins in cutaneous malignant melanoma. Br. J. Dermatol. 134 (1996) 269-275
    • (1996) Br. J. Dermatol. , vol.134 , pp. 269-275
    • Wang, Y.L.1    Uhara, H.2    Yamazaki, Y.3    Nikaido, T.4    Saida, T.5
  • 9
    • 0038819652 scopus 로고    scopus 로고
    • The INK4a/ARF locus and melanoma
    • Sharpless E., and Chin L. The INK4a/ARF locus and melanoma. Oncogene 22 (2003) 3092-3098
    • (2003) Oncogene , vol.22 , pp. 3092-3098
    • Sharpless, E.1    Chin, L.2
  • 10
    • 0038457477 scopus 로고    scopus 로고
    • Human melanocyte senescence and melanoma susceptibility genes
    • Bennett D.C. Human melanocyte senescence and melanoma susceptibility genes. Oncogene 22 (2003) 3063-3069
    • (2003) Oncogene , vol.22 , pp. 3063-3069
    • Bennett, D.C.1
  • 11
    • 0029094704 scopus 로고
    • Cell cycle arrest and inhibition of tumor cell proliferation by the p16INK4 gene mediated by an adenovirus vector
    • Jin X., Nguyen D., Zhang W.W., Kyritsis A.P., and Roth J.A. Cell cycle arrest and inhibition of tumor cell proliferation by the p16INK4 gene mediated by an adenovirus vector. Cancer Res. 55 (1995) 3250-3253
    • (1995) Cancer Res. , vol.55 , pp. 3250-3253
    • Jin, X.1    Nguyen, D.2    Zhang, W.W.3    Kyritsis, A.P.4    Roth, J.A.5
  • 12
    • 0030033729 scopus 로고    scopus 로고
    • Adenovirus-mediated p16/CDKN2 gene transfer induces growth arrest and modifies the transformed phenotype of glioma cells
    • Fueyo J., Gomez-Manzano C., Yung W.K.A., Clayman G.L., Liu T.J., Bruner J., Levin V.A., and Kyritsis A.P. Adenovirus-mediated p16/CDKN2 gene transfer induces growth arrest and modifies the transformed phenotype of glioma cells. Oncogene 12 (1996) 103-110
    • (1996) Oncogene , vol.12 , pp. 103-110
    • Fueyo, J.1    Gomez-Manzano, C.2    Yung, W.K.A.3    Clayman, G.L.4    Liu, T.J.5    Bruner, J.6    Levin, V.A.7    Kyritsis, A.P.8
  • 13
    • 0031991891 scopus 로고    scopus 로고
    • Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4
    • Byeon I.J., Li J., Ericson K., Selby T.L., Tevelev A., Kim H.J., O'Maille P., and Tsai M.D. Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4. Mol. Cell 1 3 (1998) 421-431
    • (1998) Mol. Cell , vol.1 , Issue.3 , pp. 421-431
    • Byeon, I.J.1    Li, J.2    Ericson, K.3    Selby, T.L.4    Tevelev, A.5    Kim, H.J.6    O'Maille, P.7    Tsai, M.D.8
  • 14
    • 0032541623 scopus 로고    scopus 로고
    • Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a
    • Russo A.A., Tong L., Lee J.O., Jeffrey P.D., and Pavletich N.P. Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. Nature 395 6699 (1998) 237-243
    • (1998) Nature , vol.395 , Issue.6699 , pp. 237-243
    • Russo, A.A.1    Tong, L.2    Lee, J.O.3    Jeffrey, P.D.4    Pavletich, N.P.5
  • 15
    • 0025117790 scopus 로고
    • Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins
    • Lux S.E., John K.M., and Bennett V. Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins. Nature 344 (1990) 36-42
    • (1990) Nature , vol.344 , pp. 36-42
    • Lux, S.E.1    John, K.M.2    Bennett, V.3
  • 16
    • 0026601245 scopus 로고
    • Making a difference: the role of cell-cell interactions in establishing separate identities for equivalent cells
    • Greenwald I., and Rubin G.M. Making a difference: the role of cell-cell interactions in establishing separate identities for equivalent cells. Cell 68 (1992) 271-281
    • (1992) Cell , vol.68 , pp. 271-281
    • Greenwald, I.1    Rubin, G.M.2
  • 17
    • 0027333330 scopus 로고
    • Hundreds of ankyrin-like repeats in functionally diverse proteins: mobile modules that cross phyla horizontally
    • Bork P. Hundreds of ankyrin-like repeats in functionally diverse proteins: mobile modules that cross phyla horizontally. Proteins 17 4 (1993) 363-374
    • (1993) Proteins , vol.17 , Issue.4 , pp. 363-374
    • Bork, P.1
  • 18
    • 0029617851 scopus 로고
    • Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53
    • Helps N.R., Barker H.M., Elledge S.J., and Cohen P.T. Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53. FEBS Lett. 377 (1995) 295-300
    • (1995) FEBS Lett. , vol.377 , pp. 295-300
    • Helps, N.R.1    Barker, H.M.2    Elledge, S.J.3    Cohen, P.T.4
  • 20
    • 0036713510 scopus 로고    scopus 로고
    • Human non-synonymous SNPs: server and survey
    • Ramensky V., Bork P., and Sunyaev S. Human non-synonymous SNPs: server and survey. Nucleic Acids Res. 30 17 (2002) 3894-3900
    • (2002) Nucleic Acids Res. , vol.30 , Issue.17 , pp. 3894-3900
    • Ramensky, V.1    Bork, P.2    Sunyaev, S.3
  • 21
    • 18844366475 scopus 로고    scopus 로고
    • Regulatory SNPs in complex diseases: their identification and functional validation
    • Prokunina L., and Alarcn-Riquelme M.E. Regulatory SNPs in complex diseases: their identification and functional validation. Expert Rev. Mol. Med. 6 10 (2004) 1-15
    • (2004) Expert Rev. Mol. Med. , vol.6 , Issue.10 , pp. 1-15
    • Prokunina, L.1    Alarcn-Riquelme, M.E.2
  • 24
    • 17444419765 scopus 로고    scopus 로고
    • Mapping SNPs to protein sequence and structure data
    • Cavallo A., and Martin A.C. Mapping SNPs to protein sequence and structure data. Bioinformatics 21 8 (2005) 1443-1450
    • (2005) Bioinformatics , vol.21 , Issue.8 , pp. 1443-1450
    • Cavallo, A.1    Martin, A.C.2
  • 26
    • 2342518038 scopus 로고    scopus 로고
    • On the use of low-frequency normal modes to enforce collective movements in refining macromolecular structural models
    • Delarue M., and Dumas P. On the use of low-frequency normal modes to enforce collective movements in refining macromolecular structural models. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 6957-6962
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 6957-6962
    • Delarue, M.1    Dumas, P.2
  • 27
    • 33646475098 scopus 로고    scopus 로고
    • Divergence of interdomain geometry in two-domain proteins
    • Han J.H., Kerrison N., Chothia C., and Teichmann S.A. Divergence of interdomain geometry in two-domain proteins. Structure 14 5 (2006) 935-945
    • (2006) Structure , vol.14 , Issue.5 , pp. 935-945
    • Han, J.H.1    Kerrison, N.2    Chothia, C.3    Teichmann, S.A.4
  • 29
    • 34547572513 scopus 로고    scopus 로고
    • FastContact: a free energy scoring tool for protein-protein complex structures
    • Champ P.C., and Camacho C.J. FastContact: a free energy scoring tool for protein-protein complex structures. Nucleic Acids Res. 35 (2007) W556-W560
    • (2007) Nucleic Acids Res. , vol.35
    • Champ, P.C.1    Camacho, C.J.2
  • 31
    • 3242879177 scopus 로고    scopus 로고
    • iMolTalk: an interactive, internet-based protein structure analysis server
    • Diemand A.V., and Scheib H. iMolTalk: an interactive, internet-based protein structure analysis server. Nucleic Acids Res. 32 (2004) W512-W516
    • (2004) Nucleic Acids Res. , vol.32
    • Diemand, A.V.1    Scheib, H.2
  • 33
    • 0029715628 scopus 로고    scopus 로고
    • CDKN2A (p16INK4A) somatic and germline mutations
    • Smith-Soerensen B., and Hovig E. CDKN2A (p16INK4A) somatic and germline mutations. Hum. Mutat. 7 (1996) 294-303
    • (1996) Hum. Mutat. , vol.7 , pp. 294-303
    • Smith-Soerensen, B.1    Hovig, E.2
  • 34
    • 0028024945 scopus 로고
    • Somatic mutations of the MTS (multiple tumor suppressor) 1/CDK4l (cyclin-dependent kinase-4 inhibitor) gene in human primary non-small cell lung carcinomas
    • Hayashi N., Sugimoto Y., Tsuchiya E., Ogawa M., and Nakamura Y. Somatic mutations of the MTS (multiple tumor suppressor) 1/CDK4l (cyclin-dependent kinase-4 inhibitor) gene in human primary non-small cell lung carcinomas. Biochem. Biophys. Res. Commun. 202 (1994) 1426-1430
    • (1994) Biochem. Biophys. Res. Commun. , vol.202 , pp. 1426-1430
    • Hayashi, N.1    Sugimoto, Y.2    Tsuchiya, E.3    Ogawa, M.4    Nakamura, Y.5
  • 44
    • 18844478280 scopus 로고    scopus 로고
    • Five novel somatic CDKN2/p16 mutations identified in melanoma, glioma and carcinoma of the pancreas
    • 212-212
    • Gretarsdottir S., Olafsdottir G.H., and Borg A. Five novel somatic CDKN2/p16 mutations identified in melanoma, glioma and carcinoma of the pancreas. Hum. Mutat. 12 (1998) 212-212
    • (1998) Hum. Mutat. , vol.12
    • Gretarsdottir, S.1    Olafsdottir, G.H.2    Borg, A.3
  • 45
    • 0344993959 scopus 로고    scopus 로고
    • Hereditary TP53 codon 292 and somatic P16INK4A codon 94 mutations in a Li-Fraumeni syndrome family
    • Gueran S., Tunca Y., and Imirzalioglu N. Hereditary TP53 codon 292 and somatic P16INK4A codon 94 mutations in a Li-Fraumeni syndrome family. Cancer Genet. Cytogenet. 113 (1999) 145-151
    • (1999) Cancer Genet. Cytogenet. , vol.113 , pp. 145-151
    • Gueran, S.1    Tunca, Y.2    Imirzalioglu, N.3
  • 46
    • 0035902848 scopus 로고    scopus 로고
    • A common founder for the V126D CDKN2A mutation in seven North American melanoma-prone families
    • Goldstein A.M., Liu L., Shennan M.G., Hogg D., Tucker M.A., and Struewing J.P. A common founder for the V126D CDKN2A mutation in seven North American melanoma-prone families. Br. J. Cancer 85 (2001) 527-530
    • (2001) Br. J. Cancer , vol.85 , pp. 527-530
    • Goldstein, A.M.1    Liu, L.2    Shennan, M.G.3    Hogg, D.4    Tucker, M.A.5    Struewing, J.P.6
  • 52
    • 0033598382 scopus 로고    scopus 로고
    • Functional evaluation of tumour-specific variants of p16INK4a/CDKN2A: correlation with protein structure information
    • Ruas M., Brookes S., McDonald N.Q., and Peters G. Functional evaluation of tumour-specific variants of p16INK4a/CDKN2A: correlation with protein structure information. Oncogene 18 39 (1999) 5423-5434
    • (1999) Oncogene , vol.18 , Issue.39 , pp. 5423-5434
    • Ruas, M.1    Brookes, S.2    McDonald, N.Q.3    Peters, G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.