-
1
-
-
0030038266
-
Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa
-
Hirakawa T, Rokutan K, Nishikawa T, Kishi K. Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa. Gastroenterology 1996; 111: 345-57.
-
(1996)
Gastroenterology
, vol.111
, pp. 345-357
-
-
Hirakawa, T.1
Rokutan, K.2
Nishikawa, T.3
Kishi, K.4
-
2
-
-
0035147216
-
Recent advances in gastrointestinal pathophysiology: Role of heat shock proteins in mucosal defense and ulcer healing
-
Tsukimi Y, Okabe S. Recent advances in gastrointestinal pathophysiology: Role of heat shock proteins in mucosal defense and ulcer healing. Biol Pharm Bull 2001; 24: 1-9.
-
(2001)
Biol Pharm Bull
, vol.24
, pp. 1-9
-
-
Tsukimi, Y.1
Okabe, S.2
-
3
-
-
0041825147
-
Cholesteryl glucoside-induced protection against gastric ulcer
-
Kunimoto S, Murofushi W, Yamatsu I, Hasegawa Y, Sasaki N, Kobayashi S, et al. Cholesteryl glucoside-induced protection against gastric ulcer. Cell Structure and Function 2003; 28: 179-86.
-
(2003)
Cell Structure and Function
, vol.28
, pp. 179-186
-
-
Kunimoto, S.1
Murofushi, W.2
Yamatsu, I.3
Hasegawa, Y.4
Sasaki, N.5
Kobayashi, S.6
-
4
-
-
0034946508
-
A non-toxic heat shock protein 70 inducer, geranylgeranylacetone, suppresses apoptosis of cultured rat hepatocytes caused by hydrogen peroxide and ethanol
-
Ikeyama S, Kusumoto K, Miyake H, Rokutan K, Tashiro S. A non-toxic heat shock protein 70 inducer, geranylgeranylacetone, suppresses apoptosis of cultured rat hepatocytes caused by hydrogen peroxide and ethanol. J Hepatol 2001; 35: 53-61.
-
(2001)
J Hepatol
, vol.35
, pp. 53-61
-
-
Ikeyama, S.1
Kusumoto, K.2
Miyake, H.3
Rokutan, K.4
Tashiro, S.5
-
5
-
-
11144353819
-
2-receptor blocker or sucralfate, suppresses corpus Helicobacter pylori colonization and gastritis in humans: Teprenone inhibition of H. pylori-induced interleukin-8 in MKN28 gastric epithelial cell lines
-
2-receptor blocker or sucralfate, suppresses corpus Helicobacter pylori colonization and gastritis in humans: teprenone inhibition of H. pylori-induced interleukin-8 in MKN28 gastric epithelial cell lines. Helicobacter 2004; 9: 130-7.
-
(2004)
Helicobacter
, vol.9
, pp. 130-137
-
-
Miyake, K.1
Tsukui, T.2
Shinji, Y.3
Shinoki, K.4
Hiratsuka, T.5
Nishigaki, H.6
-
6
-
-
0019508881
-
Antiulcer effect of geranylgeranylacetone, a new acyclic polyisoprenoid on experimentally induced gastric and duodenal ulcers in rats
-
Murakami M, Oketani K, Fujisaki H, Wakabayashi T, Ohgo T. Antiulcer effect of geranylgeranylacetone, a new acyclic polyisoprenoid on experimentally induced gastric and duodenal ulcers in rats. Arzneimittelforschung 1981; 31: 799-804.
-
(1981)
Arzneimittelforschung
, vol.31
, pp. 799-804
-
-
Murakami, M.1
Oketani, K.2
Fujisaki, H.3
Wakabayashi, T.4
Ohgo, T.5
-
7
-
-
0034968582
-
Teprenone promotes the healing of acetic acid-induced chronic gastric ulcers in rats by inhibiting neutrophil infiltration and lipid peroxidation in ulcerated gastric tissues
-
Kobayashi T, Ohta Y, Yoshino J, Nakazawa S. Teprenone promotes the healing of acetic acid-induced chronic gastric ulcers in rats by inhibiting neutrophil infiltration and lipid peroxidation in ulcerated gastric tissues. Pharmacol Res 2001; 43: 23-30.
-
(2001)
Pharmacol Res
, vol.43
, pp. 23-30
-
-
Kobayashi, T.1
Ohta, Y.2
Yoshino, J.3
Nakazawa, S.4
-
8
-
-
0020043538
-
Effects of geranylgeranylacetone on gastrointestinal secretion in rats
-
Fujimoto M, Yamanaka T, Bessho M, Igarashi T. Effects of geranylgeranylacetone on gastrointestinal secretion in rats. Eur J Pharmacol 1982; 77: 113-8.
-
(1982)
Eur J Pharmacol
, vol.77
, pp. 113-118
-
-
Fujimoto, M.1
Yamanaka, T.2
Bessho, M.3
Igarashi, T.4
-
9
-
-
0029377097
-
Role of mucus in gastric mucosal injury induced by local ischemia/reperfusion
-
Seno K, Joh T, Yokoyama Y, Itoh M. Role of mucus in gastric mucosal injury induced by local ischemia/reperfusion. J Lab Clin Med 1995; 126: 287-93.
-
(1995)
J Lab Clin Med
, vol.126
, pp. 287-293
-
-
Seno, K.1
Joh, T.2
Yokoyama, Y.3
Itoh, M.4
-
10
-
-
0022618659
-
Geranylgeranylacetone, a novel anti-ulcer drug, stimulates mucus synthesis and secretion in rat gastric cultured cells
-
Terano A, Hiraishi H, Ota S, Sugimoto T. Geranylgeranylacetone, a novel anti-ulcer drug, stimulates mucus synthesis and secretion in rat gastric cultured cells. Digestion 1986; 33: 206-10.
-
(1986)
Digestion
, vol.33
, pp. 206-210
-
-
Terano, A.1
Hiraishi, H.2
Ota, S.3
Sugimoto, T.4
-
11
-
-
0034899291
-
Geranylgeranylacetone promotes induction and secretion of thioredoxin in gastric mucosal cells and peripheral blood lymphocytes
-
Dekigai H, Nakamura H, Bai J, Tanito M, Masutani H, Hirota K, et al. Geranylgeranylacetone promotes induction and secretion of thioredoxin in gastric mucosal cells and peripheral blood lymphocytes. Free Radic Res 2001; 35: 23-30.
-
(2001)
Free Radic Res
, vol.35
, pp. 23-30
-
-
Dekigai, H.1
Nakamura, H.2
Bai, J.3
Tanito, M.4
Masutani, H.5
Hirota, K.6
-
12
-
-
0036290861
-
Thioredoxin superfamily and thioredoxin-inducing agents
-
Review
-
Hirota K, Nakamura H, Masutani H, Yodoi J. Thioredoxin superfamily and thioredoxin-inducing agents. Ann N Y Acad Sci 2002; 957: 189-99. Review.
-
(2002)
Ann N Y Acad Sci
, vol.957
, pp. 189-99
-
-
Hirota, K.1
Nakamura, H.2
Masutani, H.3
Yodoi, J.4
-
13
-
-
0027413842
-
Role for mucous glycoprotein in protecting cultured rat gastric mucosal cells against toxic oxygen metabolites
-
Hiraishi H, Terano A, Ota S, Mutoh H, Sugimoto T, Harada T, et al. Role for mucous glycoprotein in protecting cultured rat gastric mucosal cells against toxic oxygen metabolites. J Lab Clin Med 1993; 121: 570-8.
-
(1993)
J Lab Clin Med
, vol.121
, pp. 570-578
-
-
Hiraishi, H.1
Terano, A.2
Ota, S.3
Mutoh, H.4
Sugimoto, T.5
Harada, T.6
-
14
-
-
0031661099
-
Protective and preventive effects of teprenone on gastric mucosal lesions in rats
-
Jul 31
-
Nishida K, Ohta Y, Ishiguro I. Protective and preventive effects of teprenone on gastric mucosal lesions in rats. Eur J Pharmacol 1998 Jul 31; 354: 51-8.
-
(1998)
Eur J Pharmacol
, vol.354
, pp. 51-58
-
-
Nishida, K.1
Ohta, Y.2
Ishiguro, I.3
-
15
-
-
0016774453
-
An intestinal disease produced experimentally by a prostaglandin deficiency
-
Robert A. An intestinal disease produced experimentally by a prostaglandin deficiency. Gastroenterology 1975; 69: 1045-7.
-
(1975)
Gastroenterology
, vol.69
, pp. 1045-1047
-
-
Robert, A.1
-
16
-
-
7044256409
-
Role of COX inhibition in pathogenesis of NSAID-induced small intestinal damage
-
Takeuchi K, Tanaka A, Ohno R, Yokota A. Role of COX inhibition in pathogenesis of NSAID-induced small intestinal damage. J Physiol Pharmacol 2003; 54: 165-82.
-
(2003)
J Physiol Pharmacol
, vol.54
, pp. 165-182
-
-
Takeuchi, K.1
Tanaka, A.2
Ohno, R.3
Yokota, A.4
-
17
-
-
0036970711
-
Pathogenic importance of intestinal hypermotility in NSAID-induced small intestinal damage in rats
-
Takeuchi K, Miyazawa T, Tanaka A, Kato S, Kunikata T. Pathogenic importance of intestinal hypermotility in NSAID-induced small intestinal damage in rats. Digestion 2002; 66: 30-41.
-
(2002)
Digestion
, vol.66
, pp. 30-41
-
-
Takeuchi, K.1
Miyazawa, T.2
Tanaka, A.3
Kato, S.4
Kunikata, T.5
-
18
-
-
0036170056
-
Protective effect of thiaton, an antispasmodic drug, against indomethacin-induced intestinal damage in rats
-
Kunikata T, Miyazawa T, Kanatsu K, Kato S, Takeuchi K. Protective effect of thiaton, an antispasmodic drug, against indomethacin-induced intestinal damage in rats. Jpn J Pharmacol 2002; 88: 45-54.
-
(2002)
Jpn J Pharmacol
, vol.88
, pp. 45-54
-
-
Kunikata, T.1
Miyazawa, T.2
Kanatsu, K.3
Kato, S.4
Takeuchi, K.5
-
19
-
-
0027498494
-
Early histological features of small intestinal injury induced by indomethacin
-
Anthony A, Dhillon AP, Nygard G, Hudson M, Piasecki C, Strong P, et al. Early histological features of small intestinal injury induced by indomethacin. Aliment Pharmacol Ther 1993; 7: 29-39.
-
(1993)
Aliment Pharmacol Ther
, vol.7
, pp. 29-39
-
-
Anthony, A.1
Dhillon, A.P.2
Nygard, G.3
Hudson, M.4
Piasecki, C.5
Strong, P.6
-
20
-
-
0036179184
-
Up-regularion of cyclooxygenase-2 by inhibition of cyclooxygenase-1: A key to nonsteroidal anti-inflammatory drug-induced intestinal damage
-
Tanaka A, Hase S, Miyazawa T, Takeuchi K. Up-regularion of cyclooxygenase-2 by inhibition of cyclooxygenase-1: a key to nonsteroidal anti-inflammatory drug-induced intestinal damage. J Pharmacol Exp Ther 2002; 300: 754-61.
-
(2002)
J Pharmacol Exp Ther
, vol.300
, pp. 754-761
-
-
Tanaka, A.1
Hase, S.2
Miyazawa, T.3
Takeuchi, K.4
-
21
-
-
0028089109
-
NS-398, a new antiinflammatory agent, selectively inhibits prostaglandin G/H synthase/ cyclo-oxygenase (COX-2) activity in vitro
-
Futaki N, Takahashi S, Yokoyama M, Arai I, Higuchi S, Otomo S. NS-398, a new antiinflammatory agent, selectively inhibits prostaglandin G/H synthase/ cyclo-oxygenase (COX-2) activity in vitro. Prostaglandins 1994; 47: 55-9.
-
(1994)
Prostaglandins
, vol.47
, pp. 55-59
-
-
Futaki, N.1
Takahashi, S.2
Yokoyama, M.3
Arai, I.4
Higuchi, S.5
Otomo, S.6
-
22
-
-
0018897002
-
Correlation of quantitave changes of gastric mucosal glycoproteins with aspirin-induced gastric damage in rats
-
Azumi Y, Ohara S, Ishihara K, Okabe H, Hotta K. Correlation of quantitave changes of gastric mucosal glycoproteins with aspirin-induced gastric damage in rats. Gut 1981; 21: 533-6.
-
(1981)
Gut
, vol.21
, pp. 533-536
-
-
Azumi, Y.1
Ohara, S.2
Ishihara, K.3
Okabe, H.4
Hotta, K.5
-
23
-
-
0031014088
-
Nonsteroidal antiinflammatory drug enteropathy in rats: Role of permeability, bacteria, and enterohepatic circulation
-
Reuter BK, Davies NM, Wallace JL. Nonsteroidal antiinflammatory drug enteropathy in rats: role of permeability, bacteria, and enterohepatic circulation. Gastroenterology 1997; 112: 109-17.
-
(1997)
Gastroenterology
, vol.112
, pp. 109-117
-
-
Reuter, B.K.1
Davies, N.M.2
Wallace, J.L.3
-
24
-
-
0021742157
-
Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models
-
Krawisz JE, Sharon P, Stenson WF. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models. Gastroenterology 1984; 87: 1344-50.
-
(1984)
Gastroenterology
, vol.87
, pp. 1344-1350
-
-
Krawisz, J.E.1
Sharon, P.2
Stenson, W.F.3
-
25
-
-
0033774810
-
Geranylgeranylacetone stimulates mucin synthesis in cultured guinea pig gastric pit cells by inducing a neuronal nitric oxide synthase
-
Rokutan K, Teshima S, Kawai T, Kawahara T, Kusumoro K, Mizushima T, et al. Geranylgeranylacetone stimulates mucin synthesis in cultured guinea pig gastric pit cells by inducing a neuronal nitric oxide synthase. J Gastroenterol 2000; 35: 673-81.
-
(2000)
J Gastroenterol
, vol.35
, pp. 673-681
-
-
Rokutan, K.1
Teshima, S.2
Kawai, T.3
Kawahara, T.4
Kusumoro, K.5
Mizushima, T.6
-
27
-
-
0020858787
-
Protective effects of prostaglandins against gastric mucosal damage: Current knowledge and proposed mechanisms
-
Miller TA. Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms. Am J Physiol 1983; 245: G601-G623.
-
(1983)
Am J Physiol
, vol.245
-
-
Miller, T.A.1
-
28
-
-
0027364361
-
Nitric oxide generators and cGMP stimulate mucus secretion by rat gastric mucosal cells
-
Brown JF, Keates AC, Hanson PJ, Whittle BJ. Nitric oxide generators and cGMP stimulate mucus secretion by rat gastric mucosal cells. Am J Physiol 1993; 265: G418-G422.
-
(1993)
Am J Physiol
, vol.265
-
-
Brown, J.F.1
Keates, A.C.2
Hanson, P.J.3
Whittle, B.J.4
-
29
-
-
0032422271
-
Teprenone, an anti-ulcer agent, increases gastric mucosal mucus level via nitric oxide in rats
-
Nishida K, Ohta Y, Ishiguro I. Teprenone, an anti-ulcer agent, increases gastric mucosal mucus level via nitric oxide in rats. Jpn J Pharmacol 1998; 78: 519-22.
-
(1998)
Jpn J Pharmacol
, vol.78
, pp. 519-522
-
-
Nishida, K.1
Ohta, Y.2
Ishiguro, I.3
-
30
-
-
0346145826
-
Mechanism in gastrointestinal mucosal injury induced by activated neutrophils
-
Yoshikawa T, Naito J, Yoshida M, Kondo M. Mechanism in gastrointestinal mucosal injury induced by activated neutrophils. Microcirc Annu 1999; 15: 31-2.
-
(1999)
Microcirc Annu
, vol.15
, pp. 31-32
-
-
Yoshikawa, T.1
Naito, J.2
Yoshida, M.3
Kondo, M.4
-
31
-
-
0348136062
-
Protective effect of teprenone against acute gastric mucosal lesions induced by compound 48/80, a mast cell degranulator, in rats
-
Ohta Y, Kobayashi T, Inui K, Yoshino J, Nakazawa S. Protective effect of teprenone against acute gastric mucosal lesions induced by compound 48/80, a mast cell degranulator, in rats. J Pharmacol Sci 2003; 93: 337-46.
-
(2003)
J Pharmacol Sci
, vol.93
, pp. 337-346
-
-
Ohta, Y.1
Kobayashi, T.2
Inui, K.3
Yoshino, J.4
Nakazawa, S.5
-
32
-
-
0028910227
-
Increased gastric production of interleukin-8 and tumour necrosis factor in patients with Helicobacter pylori infection
-
Fan XG, Chua A, Fan XJ, Keeling PW. Increased gastric production of interleukin-8 and tumour necrosis factor in patients with Helicobacter pylori infection. J Clin Pathol 1995; 48: 133-6.
-
(1995)
J Clin Pathol
, vol.48
, pp. 133-136
-
-
Fan, X.G.1
Chua, A.2
Fan, X.J.3
Keeling, P.W.4
-
33
-
-
0036918371
-
Suppression of Helicobacter pylori-induced interleukin-8 production in gastric cancer cell lines by an anti-ulcer drug, geranylgeranylacetone
-
Yoshimura N, Suzuki Y, Saito Y. Suppression of Helicobacter pylori-induced interleukin-8 production in gastric cancer cell lines by an anti-ulcer drug, geranylgeranylacetone. J Gastroenterol Hepatol 2002; 17: 1153-60.
-
(2002)
J Gastroenterol Hepatol
, vol.17
, pp. 1153-1160
-
-
Yoshimura, N.1
Suzuki, Y.2
Saito, Y.3
-
34
-
-
0023901667
-
Gastric cytoprotection by tetraprenylacetone in human subjects
-
Arakawa T, Yamada H, Nakamura A, Nebiki H, Satoh H, Fukuda T, et al. Gastric cytoprotection by tetraprenylacetone in human subjects. Digestion 1988; 39: 111-7.
-
(1988)
Digestion
, vol.39
, pp. 111-117
-
-
Arakawa, T.1
Yamada, H.2
Nakamura, A.3
Nebiki, H.4
Satoh, H.5
Fukuda, T.6
-
35
-
-
0028806023
-
Clinical evaluation of teprenone, a mucosal protective agent, in the treatment of patients with gastric ulcers: A nationwide, multicenter clinical study
-
Shirakabe H, Takemoto T, Kobayashi K, Ogoshi K, Kimura K, Nakamura K, et al. Clinical evaluation of teprenone, a mucosal protective agent, in the treatment of patients with gastric ulcers: a nationwide, multicenter clinical study. Clin Ther 1995; 17: 924-35.
-
(1995)
Clin Ther
, vol.17
, pp. 924-935
-
-
Shirakabe, H.1
Takemoto, T.2
Kobayashi, K.3
Ogoshi, K.4
Kimura, K.5
Nakamura, K.6
|