Simultaneous determination of metoprolol succinate and amlodipine besylate in human plasma by liquid chromatography-tandem mass spectrometry method and its application in bioequivalence study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 873, Issue 1, 2008, Pages 77-85

  Sarkar, Amlan Kanti ^a   Ghosh, Debotri ^a   Das, Ayan ^a   Selvan, P Senthamil ^a   Gowda, K Veeran ^a   Mandal, Uttam ^a   Bose, Anirbandeep ^a   Agarwal, Sangeeta ^a   Bhaumik, Uttam ^a   Pal, Tapan Kumar ^a  

^a JADAVPUR UNIVERSITY   (India)

Author keywords

Amlodipine besylate; Hydrochlorothiazide; LC MS MS; Metoprolol succinate; Validation

Indexed keywords

AMPLITUDE MODULATION; BODY FLUIDS; CHEMOTHERAPY; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; CONCENTRATION (PROCESS); DRUG DELIVERY; DRUG DOSAGE; ELECTRIC NETWORK TOPOLOGY; EXTRACTION; FORMIC ACID; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; IONIZATION OF LIQUIDS; MAGNETOPLASMA; MASS SPECTROMETERS; MASS SPECTROMETRY; METHANOL; ORGANIC ACIDS; PHASE SEPARATION; PLASMA (HUMAN); PLASMAS; SEPARATION; SOLVENT EXTRACTION; SPECTROMETERS; SPECTROMETRY; SPECTRUM ANALYSIS;

AMLODIPINE; AMLODIPINE BESYLATE; ANALYTE; BIOEQUIVALENCE STUDY; C18 COLUMN; CHROMATOGRAPHIC SEPARATIONS; CONCENTRATION RANGES; FIXED-DOSE COMBINATION; HUMAN PLASMAS; HUMAN VOLUNTEERS; HYDROCHLOROTHIAZIDE; LC-MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID-LIQUID EXTRACTION; METHANOL-WATER; METOPROLOL; METOPROLOL SUCCINATE; MOBILE PHASE; MULTIPLE-REACTION MONITORING; ORAL ADMINISTRATION; PHARMACOKINETIC STUDIES; PROTONATED; REVERSED-PHASE; SIMULTANEOUS DETERMINATIONS; VALIDATION;

LIQUID CHROMATOGRAPHY;

AMLODIPINE BESYLATE; CHLOROFORM; FORMIC ACID; HYDROCHLOROTHIAZIDE; METHANOL; METOPROLOL SUCCINATE;

AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; DRUG CLEARANCE; EXTRACTION; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; NORMAL HUMAN; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

AMLODIPINE; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; METOPROLOL; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; THERAPEUTIC EQUIVALENCY; UNCERTAINTY;

EID: 50849141907     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.07.040     Document Type: Article

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