Efficient high-performance liquid chromatographic assay for the simultaneous determination of metoprolol and two main metabolites in human urine by solid-phase extraction and fluorescence detection

Journal of Chromatography B: Biomedical Applications

Volumn 696, Issue 1, 1997, Pages 69-74

  Chiu, F C K ^a   Damani, L A ^a   Li, R C ^a   Tomlinson, B ^a  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

Author keywords

Hydroxymetoprolol; Metoprolol

Indexed keywords

ALPHA HYDROXYMETOPROLOL; DRUG METABOLITE; METOPROLOL;

ARTICLE; DRUG DETERMINATION; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY; SOLID PHASE EXTRACTION; URINE;

ADMINISTRATION, ORAL; ADRENERGIC BETA-ANTAGONISTS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCADIAN RHYTHM; HUMANS; LINEAR MODELS; METOPROLOL; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, FLUORESCENCE;

EID: 0030758168     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(97)00059-5     Document Type: Article

References (10)

1. P. Benfield, S.P. Clissold and R.N. Brogden, Drugs, 31 (1986) 376-429.
2. K.O. Borg, E. Carlsson, K.J. Hoffman, T.E. Johnson, H. Thorin and B. Wallin, Acta Pharmacol. Toxicol., 36 (1975) 125-135.
3. F. Li, S.F. Cooper and M. Côté, J. Chromatogr. B, 668 (1995) 67-75.
4. K. Balmér, A. Persson, P.-O. Lagerström, B.-A. Persson and G. Schill, J. Chromatogr., 553 (1991) 391-397.
5. F.M. Gengo, M.A. Ziemniak, W.R. Kinkel and W.B. McHugh, J. Pharm. Sci., 73 (1984) 961-963.
6. G. Tsujimoto and K. Hashimoto, Ther. Drug Monit, 10 (1988) 428-433.
7. J. Moncrieff and D. Simpson, J. Chromatogr., 488 (1989) 498-502.
8. O. Gyllenhaal and K.J. Hoffmann, J. Chromatogr., 309 (1984) 317-328.
9. K. Balmer, Y. Zhang, P.O. Largerstrom and B.A. Persson, J. Chromatogr., 417 (1987) 357-365.
10. F.C.K. Chiu, L.A. Damani, R.C. Li and B. Tomlinson, unpublished data.