Effect of the 21-aminosteroid U-74006F on antigen-induced bronchoconstriction and bronchoalveolar eosinophilia in allergic sheep

European Respiratory Journal

Volumn 9, Issue 10, 1996, Pages 2044-2049

  Fujimoto, K ^a   Kubo, K ^a   Okada, K ^a   Kobayashi, T ^a   Sekiguchi, M ^a   Sakai, A ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

21 aminosteroid; airway hyperreactivity; Ascaris sensitive allergic sheep model; eosinophil; immediate asthmatic response; late asthmatic response

Indexed keywords

21 AMINOSTEROID; TIRILAZAD;

ALLERGY; ANIMAL MODEL; ARTICLE; BRONCHOSPASM; CONTROLLED STUDY; EOSINOPHILIA; INTRAVENOUS DRUG ADMINISTRATION; LUNG LAVAGE; NONHUMAN; PRIORITY JOURNAL; SHEEP;

EID: 0029780723     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.96.09102044     Document Type: Article

References (30)

1. Djukanovic R, Roche WR, Wilson JW, et al. Mucosal inflammation in asthma. Am Rev Respir Dis 1990; 142: 434-457.
2. Booij-Noord H, Orie NGM, de Vries K. Immediate and late bronchial obstructive reactions to inhalation of house dust and protective effects of disodium cromoglycate and prednisolone. J Allergy Clin Immunol 1971; 48: 344-354.
3. Barnes PJ. Effect of corticosteroids on airway hyperresponsiveness. Am Rev Respir Dis 1990; 141: S70-S76.
4. Horn BR, Robin ED, Theodore J, Van Kessel A. Total eosinophil counts in the management of bronchial asthma. N Engl J Med 1975; 292: 1152-1155.
5. National Heart, Lung and Blood Institute, National Institute of Health, USA. International consensus report on diagnosis and management of asthma, US Department of Health and Human Services, Public Health Service, A.L. Clin Exp Allergy 1992; 22 (Suppl. 1): 1-72.
6. Barnes PJ. Reactive oxygen species and airway inflammation. Free Rad Biol Med 1990; 9: 235-243.
7. Braughler JM, Pregenzer JF, Chase RL, Duncan LA, Jacobsen EJ, McCall JM. Novel 21-aminosteroids as potent inhibitors of iron-dependent lipid peroxidation. J Biol Chem 1987; 262: 10438-10440.
8. Braughler JM, Pregenzer JF, Chase RL. A new 21-aminosteroid antioxidant lacking glucocorticoid activity stimulates ACTH secretion and blocks arachidonic release from mouse pituitary tumor (AtT-20) cells. J Pharmacol Exp Ther 1988; 244: 423-427.
9. Hall ED, McCall JM, Means ED. Therapeutic potential of the lazaroids (21-aminosteroids) in acute central nervous system trauma, ischemia and subarachnoid hemorrhage. Adv Pharmacol 1994; 28: 221-268.
10. Richards IM, Shields SK, Griffin RL, Dunn CJ. A novel model of antigen-induced lung eosinophilia in Brown-Norway rats: effects of methylprednisolone. Eur J Pharmacol 1990; 183: 1191-1192.
11. Richards IM, Shields SK, Bienkowski M, Dunn CJ, Jacobsen EJ. Novel inhibitors of pulmonary eosinophil accumulation. Agents Actions 1991; 34: 359-368.
12. Richards IM, Shields SK, Griffin RL, Fidler SF, Dunn CJ. Novel steroid-based inhibitors of lung inflammation. Clin Exp Allergy 1992; 22: 432-439.
13. De Monchy JGR, Kauffinan HP, Venge P, et al. Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions. Am Rev Respir Dis 1985; 131: 373-376.
14. Durham SR, Kay AB. Eosinophils, bronchial hyperreactivity and late-phase asthmatic reactions. Clin Allergy 1985; 15: 411-418.
15. Wardlaw AJ, Dunnette S, Gleich GJ, Collins JV, Kay AB. Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma: relationship to bronchial hyperreactivity. Am Rev Respir Dis 1988; 137: 62-69.
16. Soler M, Sielczak M, Abraham WM. Separation of late bronchial responses from airway hyperresponsiveness in allergic sheep. J Appl Physiol 1991; 70: 617-623.
17. Friedman BS, Bel EH, Buntinx A, et al. Oral leukotriene inhibitor (MK-886) blocks allergen-induced airway responses. Am Rev Respir Dis 1993; 147: 839-844.
18. Abraham WM. The importance of lipoxygenase products of arachidonic acid in allergen-induced late responses. Am Rev Respir Dis 1987; 135: S49-S53.
19. Coyle AJ, Urwin SC, Page CP, Touvay C, Villain B, Braquet P. The effect of the selective PAP antagonist BN 52021 on PAF- and antigen-induced bronchial hyperreactivity and eosinophil accumulation. Eur J Pharmacol 1988; 148: 51-58.
20. Chabot-Fletcher MC, Underwood DC, Breton JJ, et al. Pharmacological characterization of SB 202235, a potent and selective 5-lipoxygenase inhibitor: effects in models of allergic asthma. J Pharmacol Exp Ther 1955; 273: 1147-1155.
21. Matsumoto T, Ashida Y, Tsukuda R. Pharmacological modulation of immediate and late airway response and leukocyte infiltration in guinea-pig. J Pharmacol Exp Ther 1994; 269: 1236-1244.
22. Abraham WM. The role of leukotrienes in allergen-induced late responses in allergic sheep. Ann NY Acad Sci 1988; 524: 260-270.
23. Owen S, Pearson D, O'Driscoll R, Woodcock A. Evidence of free radical activity in asthma. N Engl J Med 1991; 325: 586-587.
24. Abraham WM. The interaction among granulocyte lipid mediators and the generation of oxygen radicals in antigen-induced airway hyperresponsiveness. Adv Prostaglandin Thromboxane Leukotriene Res 1994; 22: 131-140.
25. Ikuta N, Sugiyama S, Takagi K, Satake T, Ozawa T. Implication of oxygen radicals on airway hyperresponsiveness after ovalbumin challenge in guinea-pigs. Am Rev Respir Dis 1992; 145: 561-565.
26. Matsuyama T, Ihaku D, Tanimukai T, Uyama O, Kitada O. Superoxide dismutase suppressed asthmatic response with inhibition of manganese superoxide induction in rat lung. Nippon Kyobu Shikkan Gakkai Zasshi 1993; 31: 139-145.
27. Reid LM, Gleich GJ, Hogg J, Kleinerman J, Laitinen LA. Pathology. In: Holgate ST, ed. The Role of Inflammatory Processes in Airway Hyperresponsiveness. Oxford, Blackwell Scientific Publications, 1989; pp. 36-79.
28. Durham SR, Graneek BJ, Hawkins R, Taylor AJN. The temporal relationship between increases in airway responsiveness to histamine and late asthmatic responses induced by occupational agents. J Allergy Clin Immunol 1987; 79: 398-406.
29. Lanes S, Stevenson JS, Codias E, et al. Indomethacin and FPL-57231 inhibit antigen-induced airway hyperresponsiveness in sheep. J Appl Physiol 1986; 61: 864-872.
30. Fujimoto K, Kubo K, Shinozaki S, et al. Neutrophil elastase inhibitor reduces asthmatic responses in allergic sheep. Respir Physiol 1995; 100: 91-100.