Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity

Toxicology and Applied Pharmacology

Volumn 231, Issue 3, 2008, Pages 364-373

  Tanaka, Yuji ^a   Aleksunes, Lauren M ^a,b   Goedken, Michael J ^b   Chen, Chuan ^a   Reisman, Scott A ^a   Manautou, José E ^b   Klaassen, Curtis D ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

(1 2 cyano 3 ,12 dioxooleana 1,9(11) dien 28 oyl imidazole); 2,6 dichlorophenolindophenol; 4 HNE; 4 hydroxynonenal; bDNA; branched DNA signal amplification; CDDO Im; DCPIP; FeNTA; ferric nitrilotriacetate; GCLC; glutamate cysteine ligase catalytic subunit; glutathione S transferase; GST; heme oxygenase 1; HO 1; Keap1; Kelch like ECH associated protein 1; Kidney; Mrp; Multidrug resistance associated protein; NAD(P)H:quinone oxidoreductase 1; NF E2 related factor 2; NQO1; Nrf2; Oxidative stress; relative light units; RLU

Indexed keywords

4 HYDROXYNONENAL; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE TRANSFERASE P1; GLUTATHIONE TRANSFERASE PI 1; GLUTATHIONE TRANSFERASE PI 2; IRON CHELATE; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 4; NITRILOTRIACETIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ACUTE KIDNEY TUBULE NECROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CELL PROTECTION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ELECTROPHILIC STRESS; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE TARGETING; INCIDENCE; KIDNEY CARCINOMA; KIDNEY INJURY; LIPID PEROXIDATION; LONG TERM EXPOSURE; MALE; MOUSE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RENAL PROTECTION; RODENT; STAINING; TISSUE INJURY; UPREGULATION; UREA NITROGEN BLOOD LEVEL; WILD TYPE;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FERRIC COMPOUNDS; GENE EXPRESSION REGULATION; KIDNEY DISEASES; MALE; MICE; MICE, INBRED C57BL; NF-E2-RELATED FACTOR 2; NITRILOTRIACETIC ACID; OXIDATIVE STRESS;

MUS; RODENTIA;

EID: 50849095765     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.05.022     Document Type: Article

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