Aqueous solution behaviour and membrane disruptive activity of pH-responsive PEGylated pseudo-peptides and their intracellular distribution

Biomaterials

Volumn 29, Issue 32, 2008, Pages 4333-4340

  Chen, Rongjun ^a   Yue, Zhilian ^b   Eccleston, Mark E ^c   Slater, Nigel K H ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

^c Vivamer Ltd   (United Kingdom)

Author keywords

Drug delivery; Haemolysis; Hydrophilicity; Micelle; Peptide; Polyethylene oxide

Indexed keywords

AMINES; AMINO ACIDS; CELL MEMBRANES; CELLS; CHEMOTHERAPY; CYTOLOGY; DRUG DELIVERY; DRUG DOSAGE; FLUID DYNAMICS; FLUID MECHANICS; FLUORESCENCE MICROSCOPY; IMAGING TECHNIQUES; MEMBRANES; MICROSCOPIC EXAMINATION; POLYMERS; POLYSTYRENES; SOLUTIONS;

AQUEOUS SOLUTIONS; COMPACT STRUCTURES; DESTABILISATION; DYNAMIC LIGHT-SCATTERING; HAEMOLYSIS; HELA CELLS; HYDRODYNAMIC DIAMETERS; HYDROPHILICITY; IN-CELL; INTRACELLULAR DISTRIBUTION; INTRACELLULAR TRAFFICKING; L-LYSINE; LACTATE DEHYDROGENASE; LOW DEGREE; MICELLE; MODIFIED POLYMERS; PEGYLATION; PEPTIDE; PH-DEPENDENT; PH-RESPONSIVE; PHTHALAMIDE; POLYETHYLENE OXIDE; POTENTIAL APPLICATIONS; PSEUDO-PEPTIDE; SINGLE PARTICLES;

PH EFFECTS;

LACTATE DEHYDROGENASE; POLY(LYSINE ISO PHTHALAMIDE); POLYLYSINE; POLYMER; PSEUDOPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; CELL MEMBRANE; CELL MIGRATION; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CYTOPLASM; ENDOCYTOSIS; ENZYME ASSAY; FEMALE; FLUORESCENCE MICROSCOPY; HELA CELL; HEMOLYSIS; HUMAN; HUMAN CELL; HYDRODYNAMICS; KINETICS; LIGHT SCATTERING; MEMBRANE DAMAGE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL;

ANIMALS; CELL LINE; CELL MEMBRANE; CRICETINAE; HEMOLYSIS; HUMANS; HYDROGEN-ION CONCENTRATION; PARTICLE SIZE; PEPTIDES; POLYETHYLENE GLYCOLS; SHEEP; SOLUTIONS;

EID: 50649083032     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2008.07.040     Document Type: Article

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