Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease

PLoS ONE

Volumn 3, Issue 7, 2008, Pages

  Li, Yonghong ^a   Rowland, Charles ^a   Xiromerisiou, Georgia ^b   Lagier, Robert J ^a   Schrodi, Steven J ^a   Dradiotis, Efthimios ^b   Ross, David ^a   Bui, Nam ^a   Catanese, Joseph ^a   Aggelakis, Konstantinos ^b   Grupe, Andrew ^a   Hadjigeorgiou, Georgios ^b,c  

^a CELERA   (United States)

^b UNIVERSITY OF THESSALY   (Greece)

^c INSTITUTE OF HUMAN PERFORMANCE AND REHABILITATION   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOME PROTEIN; GENE PRODUCT;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC RISK; HUMAN; MAJOR CLINICAL STUDY; MALE; NERVE FIBER; PARKINSON DISEASE; PREDICTION; PROCESS MODEL; RANDOM SAMPLE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE; BIOLOGICAL MODEL; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MIDDLE AGED; ONSET AGE; PATHOLOGY; RISK; STATISTICAL MODEL;

ADULT; AGE OF ONSET; AGED; AGED, 80 AND OVER; AXONS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; MODELS, GENETIC; MODELS, STATISTICAL; PARKINSON DISEASE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK;

EID: 50549104769     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0002707     Document Type: Article

References (33)

1. Thomas B, Beal MF (2007) Parkinson's disease. Hum Mol Genet, 16 Spec No. 2, R183-94.
2. Gilks WP, Abou-Sleiman PM, Gandhi S, Jain S, Singleton A, et al. (2005) A common LRRK2 mutation in idiopathic Parkinson's disease. Lancet 365: 415-6.
3. Lesage S, Durr A, Tazir M, Lohmann E, Leutenegger AL, et al. (2006) LRRK2 G2019S as a cause of Parkinson's disease in North African Arabs. N Engl J Med 354: 422-3.
4. Ozelius LJ, Senthil G, Saunders-Pullman R, Ohmann E, Deligtisch A, et al. (2006) LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews. N Engl J Med 354: 424-5.
5. Maraganore DM, de Andrade M, Elbaz A, Farrer MJ, Ioannidis JP, et al. (2006) Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease. Jama 296: 661-70.
6. Zhang J, Song Y, Chen H, Fan D (2005) The tau gene haplotype h1 confers a susceptibility to Parkinson's disease. Eur Neurol 53: 15-21.
7. Maraganore DM, de Andrade M, Lesnick TG, Strain KJ, Farrer MJ, et al. (2005) High-Resolution Whole-Genome Association Study of Parkinson Disease. Am J Hum Genet 77: 685-693.
8. Fung HC, Scholz S, Matarin M, Simon-Sanchez J, Hernandez D, et al. (2006) Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data. Lancet Neurol 5: 911-6.
9. Clarimon J, Scholz S, Fung H-C, Hardy J, Eerola J, et al. (2006) Conflicting results regarding the semaphorin gene (SEMA5A) and the risk for Parkinson disease. Am J Hum Genet 78: 1082-1084.
10. Elbaz A, Nelson LM, Payami H, Ioannidis JP, Fiske BK, et al. (2006) Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study. Lancet Neurol 5: 917-23.
11. Farrer MJ, Haugarvoll K, Ross WA, Stone JT, Milkovic NM, et al. (2006) Genome-wide association, Parkinson's disease and PARK10. Am J Hum Genet 78: 1084-1088.
12. Goris A, Williams-Gray CH, Foltynie T, Compston DAS, Barker RA, et al. (2006) No evidence for association with Parkinson disease for 13 SNPs identified by whole genome association screening. Am J Hum Genet 78: 1088-1090.
13. Li Y, Rowland C, Schrodi S, Laird W, Tacey K, et al. (2006) A case-control association study of the 12 single nucleotide polymorphisms implicated in Parkinson's disease by a recent genome scan. Am J Hum Genet 78: 1090-1092.
14. Bialecka M, Kurzawski M, Klodowska-Duda G, Opala G, Tan EK, et al. (2006) Polymorphism in semaphorin 5A (Sema5A) gene is not a marker of Parkinson's disease risk. Neurosci Lett 399: 121-3.
15. Shiffman D, Rowland CM, Sninsky JJ, Devlin JJ (2006) Polymorphisms associated with coronary heart disease: better by the score. Curr Opin Mol Ther 8: 493-9.
16. Lesnick TG, Papapetropoulos S, Mash DC, Ffrench-Mullen J, Shehadeh L, et al. (2007) A genomic pathway approach to a complex disease: axon guidance and Parkinson disease. PLoS Genet 3: e98.
17. Lesnick TG, Sorenson EJ, Ahlskog JE, Henley JR, Shehadeh L, et al. (2008) Beyond Parkinson disease: amyotrophic lateral sclerosis and the axon guidance pathway. PLoS ONE 3: e1449.
18. Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, et al. (2007) Relication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316: 1336-41.
19. Cargill M, Schrodi SJ, Chang M, Garcia VE, Brandon R, et al. (2007) A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet 80: 273-390.
20. Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14,000 cases or seven common diseases and 3,000 shared controls. Nature 447: 661-78.
21. Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn (2003) Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 33: 177-82.
22. Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297: 353-6.
23. Dawson TM, Dawson VL (2003) Molecular pathways of neurodegeneration in Parkinson's disease. Science 302: 819-22.
24. Wood-Kaczmar A, Gandhi S, Wood NW (2006) Understanding the molecular causes of Parkinson's disease. Trends Mol Med 12: 521-8.
25. Wang K, Li M, Bucan M (2007) Pathway-based approaches for analysis of genome-wide association studies. Am J Hum Genet, early-online publication..
26. Chanock SJ, Manolio T, Boehnke M, Boerwinkle E, Hunter DJ, et al. (2007) Replicating genotype-phenotype associations. Nature 447: 655-60.
27. Williams SM, Canter JA, Crawford DC, Moore JH, Ritchie MD, et al. (2007) Problems with genome-wide association studies. Science 316: 1840-2.
28. Xiromerisiou G, Hadjigeorgiou GM, Eerola J, Fernandez HH, Tsimourtou V, et al. (2007) BDNF tagging polymorphisms and haplotype analysis in sporadic Parkinson's disease in diverse ethnic groups. Neurosci Lett 415: 59-63.
29. Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55: 181-4.
30. Xiromerisiou G, Hadjigeorgiou GM, Gourbali V, Johnson J, Papakonstantinou I, et al. (2007) Screening for SNCA and LRRK2 mutations in Greek sporadic and autosomal dominant Parkinson's disease: identification of two novel LRRK2 variants. Eur J Neurol 14: 7-11.
31. Li Y, Schrodi S, Rowland C, Tacey K, Catanese J, et al. (2006) Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease. Hum Mutat 27: 1017-1023.
32. Germer S, Holland MJ, Higuchi R (2000) High-throughput SNP allele-frequency determination in pooled DNA samples by kinetic PCR. Genome Res 10: 258-66.
33. Li Y, Rowland C, Catanese J, Morris JC, Lovestone S, et al. (2007) SORL1 variants and risk of late-onset Alzheimer's disease. Neurobiol Dis 209: 293-296.