Abnormally increased nitric oxide synthesis and increased endothelin-1 in plasma in patients with obstructive sleep apnoea

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 68, Issue 5, 2008, Pages 375-385

  Gjorup P H ^a   Wessels, J ^a   Pedersen, E B ^a,b  

^a HOLSTEBRO HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

Aldosterone; Angiotensin II; Arginine vasopressin; Atrial natriuretic peptide; Blood pressure; Brain natriuretic peptide

Indexed keywords

ALDOSTERONE; ANGIOTENSIN II; ENDOTHELIN 1; N(G) METHYLARGININE; NITRIC OXIDE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIASTOLIC BLOOD PRESSURE; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY BLOOD FLOW; KIDNEY PLASMA FLOW; KIDNEY TUBULE FUNCTION; MAJOR CLINICAL STUDY; MALE; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PULSE RATE; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SLEEP APNEA SYNDROME; SODIUM EXCRETION; SYSTOLIC BLOOD PRESSURE;

ADULT; AGED; BLOOD PRESSURE; ENDOTHELIN-1; FEMALE; HEART RATE; HUMANS; MALE; MIDDLE AGED; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; RENAL CIRCULATION; SLEEP APNEA, OBSTRUCTIVE;

EID: 50449099150     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.1080/00365510701782382     Document Type: Article

References (40)

1. Lavie P, Herer P, Hoffstein V. Obstructive sleep apnea syndrome as a risk factor for hypertension: population study. Br Med J 2000;320:479-82.
2. Peppard PE, Young T, Palta M, Skatrud JB. Prospective study of the association between sleep disordered breathing and hypertension. N Engl J Med 2000;342:1378-84.
3. Marin JM, Carrizo SJ, Vicente E, Agusti AGN. Long-term cardiovascular outcomes in men with obstructive sleep apneahypopnea with or without treatment with continuous positive airway pressure: an observational study. Lancet 2005;365:1046-53.
4. Foster GE, Poulin MJ, Hanly PJ. Intermittent hypoxia and vascular function: implications for obstructive sleep apnoea. Exp Physiol 2006;92:51-65.
5. Sumpio BE, Riley JT, Dardik A. Cells in focus: endothelial cell. Int J Biochem Cell Biol 2002;34:1508-12.
6. Kato M, Roberts-Thomson P, Phillips BG, Haynes WG, Winnicki M, Accurso V, et al. Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea. Circulation 2000;102:2607-10.
7. Lattimore JL, Wilcox I, Skilton M, Langenfeld M, Celermajer DS. Treatment of obstructive sleep apnoea leads to improved microvascular endothelial function in the systemic circulation. Thorax 2006;61:491-5.
8. Thomsen K. Lithium clearance: a new method for determining proximal and distal tubular reabsorption of sodium and water. Nephron 1984;37:217-23.
9. Pedersen EB, Eiskjær H, Madsen B, Danielsen H, Egeblad M, Nielsen CB. Effects of captopril on renal extraction of renin, angiotensin II, atrial natriuretic peptide and vasopressin, and renal vein ratio in patients with arterial hypertension and unilateral renal artery disease. Nephrol Dial Transpl 1993;8:1064-70.
10. Jensen KT, Carstens J, Ivarsen P, Pedersen EB. A new, fast and reliable radioimmunoassay of brain natriuretic peptide in human plasma. Reference values in healthy subjects and in patients with different diseases. Scand J Clin Lab Invest 1997;57:529-40.
11. Na and vasoactive hormones in healthy humans. Am J Physiol 1996;39:F845-51.
12. Haynes WG, Hand MF, Dockrell MEC, Eadington DW, Lee MR, Hussein Z, et al. Physiological role of nitric oxide in regulation of renal function I humans. Am J Physiol 1997;272:F364-71.
13. Delles C, Klingbeil AU, Schneider MP, Handrock R, Schäufele T, Schmeider RE. The role of nitric oxide in the regulation of glomerular hemodynamics in humans. Nephrol Dial Transpl 2004;19:1392-7.
14. Jacobi J, Schneider MP, John S, Schneider RE. Impact of NO-synthase inhibition on renal hemodynamics in normotensive and hypertensive subjects. J Hypertens 2002;20:525-30.
15. Higashi Y, Oshima T, Ozono R, Watanabe M, Matsuura H, Kajiyama G. Effects of L-arginine infusion on renal hemodynamics in patients with mild essential hypertension. Hypertension 1995;25:898-902.
16. Van den Meiracker AH, van der Linde NAJ, Broere A, Derkx FHM, Boomsma F. Effects of L-arginine and L-NAME on the renal function in hypertensive and normotensive subjects. Nephron 2002;91:444-51.
17. Bech JN, Nielsen EH, Pedersen RS, Svendsen KB, Pedersen EB. Enhanced sodium retention after acute nitric oxide blockade in mildly sodium loaded patients with essential hypertension. Am J Hypertens 2007;20:287-95.
18. Krieger J, Imps JL, Schmidt M, Kurtz D. Renal function in patients with obstructive sleep apnea. Effects of nasal continuous positive airway pressure. Arch Intern Med 1988;148:1337-40.
19. Ehlenz K, Firle K, Schneider H, Weber K, Peter JH, Kaffarnik H, et al. Reduction of nocturnal diuresis during treatment of obstructive sleep apnea (OSA) with nasal continuous positive airway pressure (nCPAP) correlates to cGMP secretion. Med Klin 1991;86:294-6.
20. Kourembanas S, Marsden PA, McQuillan LP, Faller DV. Hypoxia induces endothelin gene expression and secretion in cultured human endothelium. J Clin Invest 1991;88:1054-7.
21. Phillips BG, Narkiewicz K, Pesek CA, Haynes WG, Dyken ME, Somers VK. Effects of obstructive sleep apnea on endothelin-1 and blood pressure. J Hypertens 1999;17:61-6.
22. Saarelainen S, Seppälä E, Laasonen K, Hasan J. Circulating endothelin-1 in obstructive sleep apnea. Endothelium 1997;5:115-18.
23. Gjørup PH, Sadauskiene L, Wessels J, Nyvad O, Strunge B, Pedersen EB. Abnormally increased endothelin-1 during the night in obstructive sleep apnea: relation to blood pressure and severity of disease. Am J Hypertens 2007;20:44-52.
24. Møller DC, Lind P, Strunge B, Pedersen EB. Abnormal vasoactive hormones and 24 hour blood pressure in obstructive sleep apnea. Am J hypertens 2003;16:274-80.
25. Grimpen F, Kanne P, Schulz E, Hagenah G, Hasenfuß G, Andreas S. Endothelin-1 plasma levels are not elevated in patients with obstructive sleep apnoea. Eur Respir J 2000;15:320-5.
26. Gess B, Schricker K, Pfeifer M, Kurtz A. Acute hypoxia upregulates NOS gene expression in rats. Am J Physiol 1997;273:R905-10.
27. Phelan MW, Faller DV. Hypoxia decreases constitutive nitric oxide synthase transcript and protein in cultured endothelial cells. J Cell Physiol 1996;167:21-8.
28. Phillips SA, Olson EB, Morgan BJ, Lombard JH. Chronic intermittent hypoxia impairs endothelium-dependent dilation in rat cerebral and skeletal muscle resistance arteries. Am J Physiol 2004;286:H388-93.
29. Lattimore JL, Wilcox I, Adams MR, Kilian JG, Celermajer DS. Treatment of obstructive sleep apnea leads to enhanced pulmonary vascular nitric oxide release. Int J Cardiol 2007;Epub ahead of print.
30. Kraiczi H, Hedner J, Peker Y, Carlson J. Increased vasoconstrictor sensitivity in obstructive sleep apnea. J Appl Physiol 2000;89:493-8.
31. Rubyanyi GM, Polokoff MA. Endothelins: molecular biology, biochemistry, pharmacology, and pathophysiology. Pharm Rev 1994;46:325-415.
32. Kelly LK, Wedgwood S, Steinhorn RH, Black SM. Nitric oxide decreases endothelin-1 secretion through the activation of soluble guanulate cyclase. Am J physiol 2004;286:L984-91.
33. A receptor antagonist in men. Nitric Oxide 2001;5:370-6.
34. Montanari A, Biggi A, Carra N, Fasoli E, Calzolari M, Corsini F, et al. Endothelin-A blockade attenuates systemic and renal hemodynamic effects of L-NAME in humans. Hypertension 2000;35:518-23.
35. Rubens C, Ewert R, Halank M, Wensel R, Orzechowski H-D, Schultheiss H-P, et al. Big endothelin-1 and endothelin-1 plasma levels are correlated with severity of primary pulmonary hypertension. Chest 2001;120:1562-9.
36. Koomans HA, Boer WH, Mees EJD. Evaluation of lithium clearance as a marker of proximal tubule sodium handling. Kidney Int 1989;36:2-12.
37. DeSouza CA, van Guilder GP, Greiner JJ, Smith DT, Hoetzer GL, Stauffer BL. Basal endothelial nitric oxide release is preserved in overweight and obese adults. Obes Res 2005;13:1303-6.
38. Higashi Y, Sasaki S, Nakagawa K, Matsuura H, Chayama K, Oshima T. Effect of obesity on endothelium-dependent nitric oxide-mediated vasodilation in normotensive individuals and patients with essential hypertension. Am J Hypertens 2001;14:1038-45.
39. Rask-Madsen C, King GL. Mechanisms of disease: endothelial dysfunction in insulin resistance and diabetes. Nat Clin Pract Endocrin Metabol 2007;3:46-56.
40. Bech JN, Nielsen CB, Ivasen P, Jenssen KT, Pedersen EB. Dietary sodium affects systemic and renal hemodynamic response to NO inhibition in healthy humans. Am J Physiol 1998;274:F914-23.