Basal endothelial nitric oxide release is preserved in overweight and obese adults

Obesity Research

Volumn 13, Issue 8, 2005, Pages 1303-1306

  Desouza, Christopher A ^a,b   Van Guilder, Gary P ^a   Greiner, Jared J ^a   Smith, Derek T ^a   Hoetzer, Greta L ^a   Stauffer, Brian L ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Endothelium; Nitric oxide; Overweight

Indexed keywords

AUTACOID; N(G) METHYLARGININE; NITRIC OXIDE;

ADULT; AGED; ARTICLE; BLOOD FLOW VELOCITY; DRUG EFFECT; FEMALE; HUMAN; MALE; METABOLISM; MIDDLE AGED; OBESITY; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

ADULT; AGED; BLOOD FLOW VELOCITY; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; INFLAMMATION MEDIATORS; MALE; MIDDLE AGED; NITRIC OXIDE; OBESITY; OMEGA-N-METHYLARGININE; OVERWEIGHT; OXIDATIVE STRESS;

EID: 32944467476     PISSN: 10717323     EISSN: None     Source Type: Journal    
DOI: 10.1038/oby.2005.157     Document Type: Article

References (14)

1. Cooke JP, Dzau VJ. Nitric oxide synthase: role in the genesis of vascular disease. Ann Rev Med. 1997:48:489-509.
2. Eberhardt RT, Loscalzo J. Nitric oxide in atherosclerosis. In: Loscalzo J, Vita J. eds. Contemporary Cardiology: Nitric Oxide and the Cardiovascular System. Totowa, NJ: Humana Press Inc.; 2000, pp. 273-95.
3. Luscher TF, Tanner FC, Tschudi MR, Noll G. Endothelial dysfunction in coronary artery disease. Ann Rev Med. 1993;44:395-418.
4. Higashi Y, Saski S, Nakagawa K, Matsuura H, Chayama K, Oshima T. Effect of obesity on endothelium-dependent, nitric oxide-mediated vasodilation in normotensive individuals and patients with essential hypertension. Am J Hypertens. 2001;14:1038-45.
5. Perticone F, Ceravolo R, Candigliota M, et al. Obesity and body fat distribution induce endothelial dysfunction by oxidative stress. Diabetes. 2001;50:159-165.
6. Casino PR, Kilcoyne CM, Quyyumi A A, Hoeg JM, Panza JA. The role of nitric oxide in endothelium-dependent vasodilation of hypercholesterolemic patients. Circulation. 1993;88:2541-7.
7. Sobrevia L, Mann GE. Dysfunction of the endothelial nitric oxide signalling pathway in diabetes and hyperglycemia. Exp Physiol. 1997;82:423-52.
8. Lohman TG, Roche AF, Mortorell R. Athropometric Standardization Reference Manual. Champaign, IL: Human Kinetics; 1988.
9. Mathews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and B-cell function from plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412-9.
10. Smith DT, Hoetzer GL, Greiner JJ, Stauffer BL, DeSouza CA. Endothelial release of tissue-type plasminogen activator in the human forearm: role of nitric oxide. J Cardiovasc Pharmacol. 2003;42:311-4.
11. Expert Panel on Detection Evaluation, and Treatment of High Blood Cholesterol In Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection. Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). J Am Med Assoc. 2001;285:2486-97.
12. Dinerman JL, Lowenstein CJ, Synder SH. Molecular mechanisms of nitric oxide regulation: potential relevance to cardiovascular disease. Circ Rex. 1993;73:217-22.
13. Joyner MJ, Dietz NM. Nitric oxide and vasodilation in human limbs. J Appl Physiol. 1997;83:1785-96.
14. Williams IL, SB Wheatcroft, AM Shah, MT Kearney. Obesity, atherosclerosis and vascular endothelium: mechanisms of reduced nitric oxide bioavailability in obese humans. Int J Obes. 2002;26:754-64.