Hypoxia decreases constitutive nitric oxide synthase transcript and protein in cultured endothelial cells

Journal of Cellular Physiology

Volumn 167, Issue 3, 1996, Pages 469-476

  Phelan, Michael W ^a   Faller, Douglas V ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; BRADYKININ; COBALT; DACTINOMYCIN; ENDOTHELIN 1; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PLATELET DERIVED GROWTH FACTOR B; PYRROLIDINE DERIVATIVE;

ARTICLE; ENDOTHELIUM CELL; GENE EXPRESSION; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYPOXIA; OXYGEN TENSION; PRIORITY JOURNAL; UMBILICAL VEIN;

BOVINAE;

EID: 0029948575     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-4652(199606)167:3<469::aid-jcp11>3.0.co;2-%23     Document Type: Article

References (57)

1. Abate, C., Patel, L., Rauscher, F.J., and Curran, T. (1990) Redox regulation of fos and jun DNA-binding activity in vitro. Science, 249:1157-1161.
2. Adnot, S., Rajjestin, B., Eddahibi, S., Braquet, P., and Chabrier, P.-E. (1991) Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia. J. Clin. Invest., 87:155-162.
3. Ausserer, W.A., Bourratfloeck, B., Green, C.J., Laderoute, K.R., and Sutherland, R.M. (1994) Regulation of c-jun expression during hypoxic and low-glucose stress. Mol. Cell Biol., 14:5032-5042.
4. Bandyopadhyay, R.S., Phelan, M., and Faller, D.V. (1995) Hypoxia induces AP-1-regulated genes and AP-1 transcription factor binding in human endothelial and other cell types. Bba-Gene. Struct. Express., 1264:72-78.
5. 2 sensor in the pulmonary artery. J. Appl. Physiol., 66:167-170.
6. 2 by ethanol. Am. J. Physiol., 258:H1267-H1273.
7. Carville, C., Raffestin, B., Eddahibi, S., Blouquit, Y., and Adnot, S. (1993) Loss of endothelium-dependent relaxation in proximal pulmonary arteries from rats exposed to chronic hypoxia - effects of in vivo and in vitro supplementation with L-arginine. J. Cardiovasc. Pharmacol., 22:889-896.
8. Crawley, D.E., Zhao, L., Giembycz, M.A., Liu, S., Barnes, P.J., Winter, R.J.P., and Evans, T.W. (1992) Chronic hypoxia impairs soluble guanylyl cyclase mediated pulmonary arterial relaxation in the rat. Am. J. Physiol., 263:L325-L332.
9. De Mey, J.G., and Vanhoutte, P.M. (1983) Anoxia and endothelium-dependent reactivity of the canine femoral artery. J. Physiol., 335:65-74.
10. Demiryurek, A.T., Wadsworth, R.M., Kane, K.A., and Peacock, A.J. (1993) The role of endothelium in hypoxic constriction of human pulmonary artery rings. Am. Rev. Respir. Dis., 147:283-290.
11. Dinh-Xuan, A.T., Higenbottam, T.W., Clelland, C.A., Pepke-Zaba, J., Cremona, G., Butt, A.Y., Large, S.R., Wells, F.C., and Wallwork, J. (1991) Impairment of endothelium-dependent pulmonary-artery relaxation in chronic obstructive lung disease. N. Engl. J. Med., 324:1539-1547.
12. Faller, D.V. (1994) Vascular modulation in sickle cell anemia. In: Sickle Cell Disease: Basic Principles and Clinical Practice. S.H. Embury, R.P. Hebbel, N. Mohandas, and M.H. Steinberg, eds. Raven Press, Ltd., New York, Vol. 1, pp. 235-246.
13. Faller, D.V., Barnett, H., Weisbrod, R., and Cohen, R.A. (in press) Regulation of nitric oxide synthase induction in cultured vascular smooth muscle cells by lipopolysaccharide and interferon. Endothelium.
14. Feinberg, A.P., and Vogelstein, B. (1983) A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem., 132:6-13.
15. Fineman, J.R., Wong, J., Morin, I., Wild, L.M., and Soifer, S.J. (1994) Chronic nitric oxide inhibition in utero produces persistent pulmonary hypertension in newborn lambs. J. Clin. Invest., 93:2675-2683.
16. Fiscus, R.R. (1988) Molecular mechanisms of endothelium-mediated vasodilation. Semin. Thromb. Hemost., 14:12-22.
17. Fishman, A.P. (1976) Hypoxia on the pulmonary circulation. Circ. Res., 38:221-231.
18. Furchgott, R.F., and Zawadzki, J.V. (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature, 288:373-376.
19. Garg, U.C., and Hassid, A. (1989) Nitric-oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of culture rat smooth muscle cells. J. Clin. Invest., 83:1774-1777.
20. Giaid, A., and Saleh, D. (1995) Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N. Engl. J. Med., 333:214-221.
21. Graser, J., and Vanhoutte, P.M. (1991) Hypoxic contraction of canine coronary arteries: Role of endothelium and cGMP. Am. J. Physiol., 261:H1769-H1777.
22. Hannan, R., Kourembanas, S., Flanders, K., Rogelj, S., Roberts, A., Faller, D.V., and Klagsbrun, M. (1988) Endothelial cells synthesize basic fibroblast growth factor and transforming growth factor beta. Growth Factors, 1:7-17.
23. Ignarro, L.J., Burke, T.M., Wood, K.S., Wolin, M.S., and Kadowitz, P.J. (1984) Association between cyclic GMP accumulation and acetylcholine-elicited relaxation of bovine intrapulmonary artery. J. Pharmacol. Exp. Ther., 228:682-690.
24. Ignarro, L.J., Byrns, R.E., Buga, G.M., and Woods, K.S. (1987) Endothelium-derived relaxing factor from pulmonary artery and vein possessed pharmacologic and chemical properties identical to those of nitric oxide radical. Circ. Res., 67:866-879.
25. Ishii, K., Sheng, H., Warner, T.D., Forstermann, U., and Murad, F. (1991) A simple and sensitive bioassay method for detection of EDRF with RFL-6 rat lung fibroblasts. Am. J. Physiol, 261:H598-H603.
26. Itoh, Y., Yanagisawa, M., Ohkubo, S., Kimura, C., Kosaka, T., Inoue, A., Ishida, N., Mitsui, Y., Onda, H., Fujino, M., and Masaki, T. (1988) Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: Identitity of human and porcine endothelin. FEBS Lett., 231:L440-L444.
27. Johns, R.A., Linden, J., and Peach, M.J. (1989) Endothelium-dependent relaxation and cyclic GMP accumulation in rabbit pulmonary artery are selectively impaired by moderate hypoxia. Circ. Res., 65:1508-1515.
28. Kourembanas, S., Hannan, R., and Faller, D.V. (1990) Oxygen tension regulates the expression of platelet-derived growth factor-B chain gene in human endothelial cells. J. Clin. Invest., 86:670-674.
29. Kourembanas, S., Marsden, P.A., Mcquillan, L.P., and Faller, D.V. (1991) Hypoxia induces endothelin gene expression and secretion in cultured human endothelium. J. Clin. Invest., 88:1054-1057.
30. Kourembanas, S., Mcquillan, L.P., Leung, G.K., and Faller, D.V. (1993) Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxic and hypoxic conditions. J. Clin. Invest., 92:99-104.
31. Lamas, S., Marsden, P.A., Li, G.K., Tempst, P., and Michel, T. (1992) Endothelial nitric oxide synthase - molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc. Natl. Acad. Sci. U.S.A., 89:6348-6352.
32. Leeman, M., and Naeije, R. (1995) Nitric oxide and hypoxic pulmonary hypertension. Eur. Respir. J., 8:513-514.
33. Madden, J.A., Vadula, M.S., and Kurup, V.P. (1992) Effects of hypoxia and other vasoactive agents on pulmonary and cerebral artery smooth muscle cells. Am. J. Physiol., 263:L384-L393.
34. Marsden, P.A., Schappert, K.T., Chen, H.S., Flowers, M., Sundell, C.L., Wilcox, J.N., Lamas, S., and Michel, T. (1992) Molecular cloning and characterization of human endothelial nitric oxide synthase. FEBS Lett., 307:287-293.
35. Mayer, B., Brunner, F., and Schmidt, K. (1993) Inhibition of nitric oxide synthesis by methylene blue. Biochem. Pharmacol., 45:367-374.
36. Misko, T.P., Schilling, R.J., Salvemini, D., Moore, W.M., and Currie, M.G. (1993) A fluorometric assay for the measurement of nitrite in biological samples. Anal. Biochem., 214:11-16.
37. Nathan, C. (1992) Nitric oxide as a secretory product of mammalian cells. FASEB J., 6:3051-3064.
38. Nathan, C., and Xie, Q. (1994) Regulation of biosynthesis of nitric oxide. J. Biol. Chem., 269:13725-13728.
39. Nishida, K., Harrison, D.G., Navas, J.P., Fisher, A.A., Dockery, S.P., Uematsu, M., Nerem, R.M., Alexander, R.W., and Murphy, T.J. (1992) Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase. J. Clin. Invest., 90:2092-2096.
40. Palmer, R.M.J., Ferrige, A.G., and Moncada, S. (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature, 327:524-526.
41. Peach, M.J., Johns, R.A., and Rose, C.E. (1989) The potential role of interactions between endothelium and smooth muscle in pulmonary vascular physiology and pathophysiology. In: Pulmonary Vascular Physiology and Pathophysiology. E.K. Weir and J.T. Reeves, eds. Marcel Dekker, Inc. New York, Vol. 38, pp. 643-697.
42. Rengasamy, A., and Johns, R.A. (1991) Characterization of endothelium-derived relaxing factor/nitric oxide synthase from bovine cerebellum and mechanism of modulation by high and low oxygen tensions. J. Pharmacol. Exp. Ther., 259:310-316.
43. Rodman, D.M., Yamaguchi, T., O'Brien, R.F., and Mcmurtry, I.F. (1989) Hypoxic contraction of isolated rat pulmonary artery. J. Pharmacol. Exp. Ther., 24:952-959.
44. Rodman, D.M., Yamaguchi, T., Hasunuma, K., O'Brien, R.F., and Mcmurtry, I.F. (1990) Effects of hypoxia on endothelium-dependent relaxation, cyclic nucleotide content, and tone of rat pulmonary artery. Am. J. Physiol., 258:L207-L214.
45. Rubanyi, G.M., and Vanhoutte, P.M. (1985) Hypoxia releases a vasoconstrictor substance from the canine vascular endothelium. J. Physiol. (Lond.), 364:45-56.
46. Shaul, P.W., Wells, L.B., and Horning, K.M. (1993) Acute and prolonged hypoxia attenuate endothelial nitric oxide production in rat pulmonary arteries by different mechanisms. J. Cardiovasc. Pharmacol., 22:819-827.
47. Shimizu, S., Yamamoto, T., and Momose, K. (1993) Inhibition by methylene blue of the L-arginine metabolism to L-citrulline coupled with nitric oxide synthesis in cultured endothelial cells. Res. Commun. Chem. Pathol. Pharmacol., 82:35-48.
48. Smith, P. (1994) Ultrastructure of the lung in chronic hypoxia. Thorax, 49:S27-S32.
49. Spiegelman, B., Frank, M., and Green, H. (1983) Molecular cloning of mRNA from 3T3 adipocytes. J. Biol. Chem., 258:10083-10089.
50. Tiktinsky, M.H., and Morin, F.C., III (1993) Increasing oxygen tension dilates fetal pulmonary circulation via endothelium-derived relaxing factor. Am. J. Physiol., 265:H376-H380.
51. Warren, J.B., Maltby, N.H., MacCormack, D., and Barnes, P.J. (1989) Pulmonary endothelium-derived relaxing factor is impaired in hypoxia. Clin. Sci., 77:671-676.
52. Webster, K.A., Discher, D.J., and Bishopric, N.H. (1994) Regulation of fos and jun immediate-early genes by redox or metabolic stress in cardiac myocytes. Circ. Res., 74:679-686.
53. Yang, B.C., and Mehta, J.L. (1994) Prior episode of anoxia attenuates vasorelaxation in response to subsequent episode of anoxia. Am. J. Physiol., 266:H974-H979.
54. Yao, K.S., Xanthoudakis, S., Curran, T., and Odwyer, P.J. (1994) Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia. Mol. Cell Biol., 14:5997-6003.
55. Yonetani, T., Yamamoto, H., and Woodrow, G.V. (1974) Studies on cobalt myoglobins and hemoglobins. I. Preparation and optical properties of myoglobins and hemoglobins containing cobalt proto-meso-and deuteroporphyrins and thermodynamic characterization of their reversible oxygenation. J. Biol. Chem., 249:682-690.
56. Yoshizumi, M., Perrella, M.A., Burnett, J.C., and Lee, M.E. (1993) Tumor necrosis factor downregulates an endothelial nitric oxide synthase messenger RNA by shortening its half-life. Circ. Res., 73:205-209.
57. Zelenkov, P., Mcloughlin, T., and Johns, R.A. (1993) Endotoxin enhances hypoxic constriction of rat aorta and pulmonary artery through induction of EDRF/NO synthase. Am. J. Physiol., 265:L346-L354.