Effects of systemic NO synthesis inhibition on RPF, GFR, UNa, and vasoactive hormones in healthy humans

American Journal of Physiology

Volumn 270, Issue 5 PART 2, 1996, Pages

  Bech, J N ^a   Nielsen, C B ^a   Pedersen, E B ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

N(G) METHYLARGININE; NITRIC OXIDE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GLOMERULUS FILTRATION RATE; HORMONE BLOOD LEVEL; HUMAN; KIDNEY BLOOD FLOW; KIDNEY PLASMA FLOW; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SODIUM URINE LEVEL; VASODILATATION;

ADULT; BLOOD PRESSURE; CYCLIC GMP; DIURESIS; FEMALE; GLOMERULAR FILTRATION RATE; HEART RATE; HEMODYNAMIC PROCESSES; HORMONES; HUMANS; LITHIUM; MALE; NATRIURESIS; NITRIC OXIDE; OMEGA-N-METHYLARGININE; POTASSIUM; RENAL CIRCULATION;

EID: 0029893249     PISSN: 00029513     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajprenal.1996.270.5.f845     Document Type: Article

References (38)

1. G-methylarginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent presser agent in the guinea pig: does nitric oxide regulate blood pressure in vivo? Biochem Biophys. Res. Commun. 160: 881-886, 1989.
2. Baumann, J. E., P. B. Persson, H. Ebmke, B. Nafz, and H. R. Kirchheim. Role of endothelium-derived relaxing factor in renal autoregulation in conscious dogs. Am. J. Physiol. 263 (Renal Fluid Electrolyte Physiol. 32): F208-F213, 1992.
3. Baylis, C., P. Harton, and K. Engels. Endothelial derived relaxing factor controls renal hemodynamics in the normal rat kidney. J. Am. Soc. Nephrol. 1: 875-881, 1990.
4. Boer, W. H., H. A. Koomans, E. J. Dorhout Mees, G. A. Gaillard, and A. J. Rabelink. Lithium clearance during varia-tions in sodium intake in man: effects of sodium restriction and amiloride. Ear. J. Clin. Invest. 18: 279-283, 1988.
5. Bolotina, V. M., S. Najibi, J. J. Palacino, P. J. Pagano, and R. A. Cohen. Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature Land. 368: 850-853, 1994.
6. Dembinska, Kiec, A., I. Goscinski, and A. Szczudlik. Labile products of vascular endothelium as mediators and modulators of the functions of the central nervous system. J. Physiol. Pharmacol. 45: 191-221, 1994.
7. Deng, A., and C. Baylis. Locally produced EDRF controls preglomerular resistance and ultrafiltration coefficient. Am. J. Physiol. 264 (Renal Fluid Electrolyte Physiol. 33): F212-F215, 1993.
8. Fenoy, F. J., P. Ferrer, L. Carbonell, and M. Garcia Salom. Role of nitric oxide on papillary blood flow and pressure natriuresis. Hypertension Dallas 25: 408-414, 1995.
9. +-ATPase by nitric oxide in mouse proximal tubule epithelial cells. J. Clin. Invest. 95: 2083-2088,1995.
10. Haas, J. A., A. A. Khraibi, M. A. Perrella, and F. G. Knox. Role of renal interstitial hydrostatic pressure in natriuresis of systemic nitric oxide inhibition. Am. J. Physiol. 264 (Renal Fluid Electrolyte Physiol. 33): F411-F414,1993.
11. Hansen, J., T. N. Jacobsen, and R. G. Victor. Is nitric oxide involved in the tonic inhibition of central sympathetic outflow in humans? Hypertension Dallas 24: 439-444,1994.
12. Haynes, W. G., J. P. Noon, B. R. Walker, and D. J. Webb. L-NMMA increases blood pressure in man. Lancet 342: 931-932, 1993.
13. Ito, S. Nitric oxide in the kidney. Curr. Opin. Nephrol. Hypertens. 4: 23-30,1995.
14. Ito, S., S. Arima, Y. L. Ren, L. A. Juncos, and O. A. Carretero. Endothelium-derived relaxing factor/nitric oxide modulates angiotensin action in the isolated microperfused rabbit afferent but not efferent arteriole. J. Clin. Invest. 91: 2012-2019,1993.
15. Johnson, R. A., and R. H. Freeman. Pressure natriuresis in rats during blockade of the L-arginine/nitric oxide pathway. Hypertension Dallas 19: 333-338, 1992.
16. Kappelgaard, A. M., M. Damkjaer-Nielsen, and J. Giese. Measurement of angiotensin in human plasma: technical modification and practical experience. Clin. Chim. Acta 67: 299-306,1976.
17. Kirchner, K. A. Lithium as a marker for proximal tubular delivery during low salt intake and diuretic infusion. Am. J. Physiol. 253 (Renal Fluid Electrolyte Physiol. 22): F188-F196, 1987.
18. Lahera, V., M. G. Salom, M. J. Fiksen Olsen, and J. C. Romero. Mediatory role of endothelium-derived nitric oxide in renal vasodilatory and excretory effects of bradykinin. Am. J. Hypertens. 4: 260-262,1991.
19. G-nitro-L-arginine methyl ester on renal function and blood pressure. Am. J. Physiol. 261 (Renal Fluid Electrolyte Physiol. 30): F1033-F1037,1991.
20. G-nitro-L-arginine methyl ester on atrial natriuretic peptide and brain natriuretic peptide release. Endocrinology 136: 1241-1249, 1995.
21. Loeb, A. L., and D. E. Longnecker. Inhibition of endothelium-derived relaxing factor-dependent circulatory control in intact rats. Am. J. Physiol. 262 (Heart Circ. Physiol. 31): H1494-H1500, 1992.
22. Majid, D. S., M. Godfrey, M. B. Grisham, and L. G. Navar. Relation between pressure natriuresis and urinary excretion of nitrate/nitrite in anesthetized dogs. Hypertension Dallas 25: 860-865,1995.
23. Mattson, D. L., R. J. Roman, and A. W. J. Cowley. Role of nitric oxide in renal papillary blood flow and sodium excretion. Hypertension Dallas 19: 766-769, 1992.
24. Moncada, S., and A. Higgs. The L-arginine-nitric oxide pathway. N. Engl. J. Med. 329: 2002-2012, 1993.
25. Murad, F., W. F. Arnold, C. K. Mittal, and J. M. Braughler. Properties and regulation of guanylate cyclase and some proposed functions for cyclic CMP. Adv. Cyd. Nucleotide Res. 11: 175-204,1979.
26. Pedersen, E. B., H. Danielsen, and E. S. Spencer. Effect of indapamid on renal plasma flow, glomerular filtration rate, and arginine vasopressin in plasma in essential hypertension. Ear. J. Clin. Pharmacol. 26: 543-547, 1984.
27. Rask-Madsen, J.,A. Bruunsgaard, O. Munck, M. D. Nielsen, and H. Worming. The significance of the bile acids and aldosterone for the electrical hyperpolarization of human rectum in obese patients treated with intestinal by-pass operation. J. Gastroenterol. 9: 417-426, 1974.
28. Rees, D. D., R. M. Palmer, R. Schulz, H. F. Hodson, and S. Moncada. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br. J. Pharmacol. 101: 746-752, 1990.
29. Salom, M. G., V. Lahera, and J. C. Romero. Role of prostaglandins and endothelium-derived relaxing factor on the renal response to acetylcholine. Am. J. Physiol. 260 (Renal Fluid Electrolyte Physiol. 29): F145-F149, 1991.
30. Shultz, P. J., A. E. Schorer, and L. Raij. Effects of endothelium-derived relaxing factor and nitric oxide on rat mesangial cells. Am. J Physiol. 258 (Renal Fluid Electrolyte Physiol. 27): F162-F167, 1990.
31. Siegel, S., and N. J. Castellan. Nonparametric Statistics for the Behavioral Sciences. New York: McGraw-Hill, 1988, p. 174-184.
32. Siragy, H. M., R. A. Johns, M. J. Peach, and R. M. Carey. Nitric oxide alters renal function and guanosine 3′,5′-cyclic monophosphate. Hypertension Dallas 19: 775-779, 1992.
33. Stamler, J. S., E. Loh, M. A. Roddy, K. E. Currie, and M. A. Creager. Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. Circulation 89: 2035-2040, 1994.
34. Stoos, B. A., O. A. Carretero, R. D. Farhy, G. Scicli, and J. L. Garvin. Endothelium-derived relaxing factor inhibits transport and increases cGMP content in cultured mouse cortical collecting duct cells. J. Clin. Invest. 89: 761-765, 1992.
35. Tagami, M., K. Ikeda, Y. Nara, H. Fujino, A. Kubota, F. Numano, and Y. Yamori. Detailed examination of vascular lesions triggered by an inhibitor of endothelium-derived relaxing factor. Lab. Invest. 72: 174-182,1995.
36. Thomassen, A. R., J. P. Bagger, T. T. Nielsen, and E. B. Pedersen. Atrial natriuretic peptide during pacing in controls and patients with coronary aterial disease. Int. J. Cardiol. 17: 267-276, 1987.
37. Vallance, P.,A. Leone,A. Calver, J. Collier, and S. Moncada. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 339: 572-575, 1992.
38. Zatz, R., and G. de Nucci. Effects of acute nitric oxide inhibition on rat glomerular microcirculation. Am. J. Physiol. 261 (Renal Fluid Electrolyte Physiol. 30): F360-F363, 1991.