Determination of plasma protein binding rate of methyl protodioscin with ultrafiltration

Zhongguo Zhongyao Zazhi

Volumn 33, Issue 11, 2008, Pages 1291-1294

  Yao, Zhi Hong ^a   Cao, Xiu Zhen ^b   Shao, Meng ^c   Pan, Yu Ming ^a   Ye, Wen Cai ^a,c   Yao, Xin Sheng ^a,c  

^a JINAN UNIVERSITY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

HPLC MS MS; Methyl protodioscin; Plasma protein binding rate; Ultrafiltration

Indexed keywords

ANTINEOPLASTIC AGENT; DIOSGENIN; DRUG DERIVATIVE; METHYL PROTODIOSCIN; PLASMA PROTEIN; SAPONIN;

ANIMAL; ARTICLE; CALIBRATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; METABOLISM; PROTEIN BINDING; RAT; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; ULTRAFILTRATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOOD PROTEINS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIOSGENIN; FEMALE; HUMANS; MALE; PROTEIN BINDING; RATS; SAPONINS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; ULTRAFILTRATION;

EID: 50249188731     PISSN: 10015302     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Ju Y ,Jia Z. Steroidal saponins from Smilax lebrunii[J]. Phytochemistry, 1992, 31: 1349.
2. Shao Y, Poobrasert O, Kennelly EJ, et al. Steroidal saponins from Asparagus officinalis and their cytotoxic activity[J]. Planta Med, 1997, 63: 258.
3. Gonzalez A G, Hernandez J C, Leon F, et al. Steroidal saponins from the bark of Dracaena draco and their cytotoxic activities[J]. J Natur Products, 2003, 66: 793.
4. Li M and Yu B. Facile conversion of spirostan saponin into furostan saponin: Synthesis of methyl protodioscin and its 26-thio-analog[J]. Org Lett, 2006, 8: 2679.
5. Hu K, Yao X S. The cytotoxicity of methyl protodioscin against human cancer cell lines in vitro[J]. Cancer Investigat, 2003, 21: 389.
6. Chinese source
7. He X J, Qiao A M, Liu B, et al. Bioconversion of methyl protodioscin by Penicillium melinii cells[J]. Enzyme Microb Technol, 2006, 38: 400.
8. He X J, Qiao A M, Wang XL, et al. Structural identification of methyl protodioscin metabolites in rats' urine and their antiproliferative activities against human tumor cell lines[J]. Steroids, 2006, 71: 828.
9. Cao X Z, Yao Z H, Chen HF, et al. Development and validation of a liquid chromatography/tandem mass spectrometry assay for the quantification of methyl protodioscin in rat plasma : Application to a pharmacokinetic study [DOI]. Biomed Chromatogr, 2007. www.interscience.wiley.com. 10. 1002/bmc. 948.
10. Schwarzwald C C , Sams R A. Determination of plasma protein binding of diltiazem in horses by ultrafiltration[J]. J Vet Pharmacol Ther, 2006, 29(6): 579.
11. Chinese source
12. Chinese source