Determination of plasma protein binding of diltiazem in horses by ultrafiltration

Journal of Veterinary Pharmacology and Therapeutics

Volumn 29, Issue 6, 2006, Pages 579-580

  Schwarzwald, C C ^a   Sams, R A ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; DEACETYLDILTIAZEM; DILTIAZEM; DRUG METABOLITE; FIBRINOGEN; GLOBULIN; PLASMA PROTEIN;

ARTICLE; BINDING AFFINITY; BLOOD LEVEL; CONTROLLED STUDY; DRUG PROTEIN BINDING; FEMALE; HORSE; MALE; NONHUMAN; PRIORITY JOURNAL; ULTRAFILTRATION;

ANIMALS; BLOOD PROTEINS; CALCIUM CHANNEL BLOCKERS; DILTIAZEM; FEMALE; HORSES; MALE; PROTEIN BINDING; ULTRAFILTRATION;

EQUIDAE;

EID: 33750602627     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2006.00790.x     Document Type: Article

References (10)

1. Bloedow, D.C., Piepho, R.W., Nies, A.S. & Gal, J. (1982) Serum binding of diltiazem in humans. Journal of Clinical Pharmacology, 22, 201-205.
2. Cooke, K.L. & Snyder, P.S. (1998) Calcium channel blockers in veterinary medicine. Journal of Veterinary Internal Medicine, 12, 123-131.
3. Hermann, P. & Morselli, P.L. (1985) Pharmacokinetics of diltiazem and other calcium entry blockers. Acta Pharmacologica et Toxicologica (Copenhagen), 57 (Suppl 2), 10-20.
4. Johnson, L.M., Atkins, C.E., Keene, B.W. & Bai, S.A. (1996) Pharmacokinetic and pharmacodynamic properties of conventional and CD-formulated diltiazem in cats. Journal of Veterinary Internal Medicine, 10, 316-320.
5. Opie, L.H. (2001) Calcium channel blockers (calcium antagonists). In Drugs for the Heart, 5th edn., Eds Opie, L.H. & Gersh, B.J. pp. 53-83. W.B. Saunders, Philadelphia.
6. Piepho, R.W., Bloedow, D.C., Lacz, J.P., Runser, D.J., Dimmit, D.C. & Browne, R.K. (1982) Pharmacokinetics of diltiazem in selected animal species and human beings. American Journal of Cardiology, 49, 525-528.
7. Pool, P.E. (1996) Diltiazem. In Cardiovascular Drug Therapy, 2nd edn., Ed Messerli, F.H. pp. 931-971. W.B. Saunders, Philadelphia.
8. Schwarzwald, C.C., Bonagura, J.D. & Luis-Fuentes, V. (2005) Effects of diltiazem on hemodynamic variables and ventricular function in healthy horses. Journal of Veterinary Internal Medicine, 19, 703-711.
9. Schwarzwald, C.C., Sams, R.A. & Bonagura, J.D. (2006) Pharmacokinetics of the calcium channel blocker diltiazem after a single intravenous dose in horses. Journal of Veterinary Pharmacology & Therapeutics, 29, 165-171.
10. Sebille, B., Zini, R., Madjar, C.V., Thuaud, N. & Tillement, J.P. (1990) Separation procedures used to reveal and follow drug-protein binding. Journal of Chromatography, 531, 51-77.