Bioconversion of methyl protodioscin by Penicillium melinii cells

Enzyme and Microbial Technology

Volumn 38, Issue 3-4, 2006, Pages 400-406

  He, Xiangjiu ^a,b   Qiao, Aimin ^c   Liu, Bo ^d   Wang, Xinluan ^c   Wang, Guanghui ^c   Qu, Gexia ^c   Liu, Rui Hai ^b   Yao, Xinsheng ^a,c  

^a JINAN UNIVERSITY   (China)

^b Department of Obstetrics Gynecology   (United States)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^d UNIVERSITY OF EXETER   (United Kingdom)

Author keywords

Anticancer activities; Glucose conjugation; Methyl protodioscin; Microbial conversion

Indexed keywords

BIOCONVERSION; CELLS; CYTOLOGY; GLUCOSE; TOXIC MATERIALS; TOXICITY; TUMORS;

ANTICANCER ACTIVITIES; GLUCOSE-CONJUGATION; METHYL PROTODIOSCIN; MICROBIAL CONVERSION;

ANTIBIOTICS;

16BETA [4' METHYL 5' O (BETA DEXTRO GLUCOPYRANOSYL (1-6) BETA DEXTRO GLUCOPYRANOSYL)PENTANOXY]PREGN 5 EN 3BETA OL 20 ONE O ALPHA LEVO RHAMPNOPYRANOSYL (1-2) [ALPHA LEVO RHAMNOPYRANOSYL (1-4) BETA DEXTRO GLUCOPYRANOSIDE; 3 O [ALPHA LEVO RHAMNOPYRANOSYL (1-2) (ALPHA LEVO RHAMNOPYRANOSYL (1-4)) BETA DEXTRO GLUCOPYRANOSYL] 26 O (BETA DEXTRO GLUCOPYRANOSYL (1-6) BETA DEXTRO GLUCOPYRANOSYL)FUROST 5 ENE 3BETA,26 TRIOL; 3 O [ALPHA LEVO RHAMNOPYRANOSYL (1-2) (ALPHA LEVO RHAMNOPYRANOSYL (1-4)) BETA DEXTRO GLUCOPYRANOSYL] 26 O (BETA DEXTRO GLUCOPYRANOSYL (1-6) BETA DEXTRO GLUCOPYRANOSYL)FUROST 5,20(22) DIENE 3BETA,26 TRIOL; GLUCOSE DERIVATIVE; GLYCOSIDE; METHYLPROTODIOSCIN; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOSYNTHESIS; BIOTRANSFORMATION; CELL STRAIN HEPG2; CELL STRAIN MCF 7; CYTOTOXICITY; DRUG IDENTIFICATION; DRUG ISOLATION; FUNGUS; FUNGUS ISOLATION; GLYCOSIDATION; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; PENICILLIUM MELINII;

ANIMALIA; FUNGI; MINK CELL FOCUS-FORMING VIRUS; PENICILLIUM MELINII;

EID: 28844486067     PISSN: 01410229     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.enzmictec.2005.06.013     Document Type: Article

References (18)

1. K. Hu, A.J. Dong, X.S. Yao, H. Kobayashi, and S. Iwasaki Antineoplastic agents; I. Three spirostanol glycosides from rhizomes of Dioscorea collettii var. hypoglauca Planta Med 62 1996 573 575
2. K. Hu, and X.S. Yao The cytotoxicity of methyl protoneodioscin (NSC-698791) against human cancer cell lines in vitro Anticancer Res 22 2002 1001 1005
3. K. Hu, X.S. Yao, A.J. Dong, H. Kobayashi, S. Iwasaki, and Y.K. Jing A new pregnane glycoside from Dioscorea collettii var. hypoglauca J Nat Prod 62 1999 299 301
4. K. Hu, and X.S. Yao The cytotoxicity of methyl protodioscin against human cancer cell lines in vitro Cancer Invest 21 2003 389 393
5. Y. Ju, and Z.J. Jia Steroidal saponins from the rhizomes of Smilax menispermoidea Phytochemistry 31 1992 1349 1351
6. Y. Ju, Z.J. Jia, and X.J. Sun Steroidal saponins from Smilax menispermoidea and S Lebrunii Phytochemistry 37 1994 1433 1436
7. S.B. Singh, and R.S. Thakur Saponins From the Seeds of Costus speciosus J Nat Prod 45 1982 667 671
8. M.S. Cheng, Q.L. Wang, Q. Tian, H.Y. Song, Y.X. Liu, and Q. Li Total synthesis of methyl protodioscin: a potent agent with antitumor activity J Org Chem 68 2003 3658 3662
9. J.P.N. Rosazza, and M.W. Duffel Metabolic transformation of alkaloids X. Brossi Alkaloids: Chemistry and Pharmacology vol. 27 1986 Academic Press New York 391 392
10. P. Fernandes, A. Cruz, B. Angelova, H.M. Pinheiro, and J.M.S. Cabral Microbial conversion of steroid compounds: recent developments Enzyme Microbial Technol 32 2003 688 705
11. S. Teshima, T. Kajimoto, K. Nakano, T. Tomimatsu, M. Yamasaki, and T. Nohara From methyl protodioscin to kryptogenin 3-O-β-chacotrioside Chem Pharm Bull 34 1986 3925 3927
12. D. Schlosser, and H.P. Schmauder Catalyst capacity factor in steroid biotransformation Chemie Ingenieur Technik 64 1992 357 360
13. A. Bartmanska, J. Dmochowska-Gładysz, and E. Huszcza Steroids' transformations in Penicillium notatum culture Steroids 70 2005 193 198
14. H.L. Holland, D.H. Nguyen, and N.M. Pearson Biotransformation of corticosteroids by Penicillium decumbens ATCC 10436 Steroids 60 1995 646 649
15. P.K. Agrawal, D.C. Jain, P.K. Gupta, and R.S. Thakur Carbon-13 NMR spectroscopy of steroidal sapogenins and steroidal saponins Phytochemistry 24 1985 2479 2496
16. P.K. Agrawal NMR Spectroscopy in the structural elucidation of oligosaccharides and glycosides Phytochemistry 31 1992 3307 3330
17. M. Dong, X.Z. Feng, B.X. Wang, L.J. Wu, and T. Ikejima Two novel furostanol saponins from the rhizomes of Dioscorea panthaica Prain et Burkill and their cytotoxic activity Tetrahedron 57 2001 501 506
18. G.F. Pauli The cardenolides of Speirantha convallarioides Planta Med 61 1995 162 166