Disorders of adhesions or adhesion-related disorder: Monolithic entities or part of something bigger - CAPPS?

Seminars in Reproductive Medicine

Volumn 26, Issue 4, 2008, Pages 356-368

  Wiseman, David M ^a,b  

^a Synechion Inc   (United States)

^b International Adhesions Society   (United States)

Author keywords

Adhesion related disorder; Adhesions; Chronic pelvic pain; Complex abdominopelvic and pain syndrome; Hemochromatosis; Hysterectomy; Iron overload

Indexed keywords

CARBOXYMETHYLCELLULOSE; FERRIC HYALURONATE; HYALURONIC ACID; HYALURONIC ACID DERIVATIVE; OXIDIZED REGENERATED CELLULOSE; UNCLASSIFIED DRUG;

ABDOMINAL DISEASE; ABDOMINAL PAIN; ABDOMINAL SURGERY; ADHESION RELATED DISORDER; CESAREAN SECTION; COMPLEX ABDOMINOPELVIC AND PAIN SYNDROME; COST OF ILLNESS; DEVICE THERAPY; ENDOMETRIOSIS; FAMILY INTERACTION; FEMALE INFERTILITY; GASTROINTESTINAL SYMPTOM; GENETIC RISK; HEALTH CARE COST; HEALTH SURVEY; HEMOCHROMATOSIS; HOSPITAL DISCHARGE; HUMAN; HYSTERECTOMY; INTERNET; INTERSTITIAL CYSTITIS; INTESTINE OBSTRUCTION; IRON OVERLOAD; IRRITABLE COLON; OXIDATIVE STRESS; PAIN; PELVIC DISEASE; PELVIS PAIN SYNDROME; PERITONEUM ADHESION; PHYSICIAN; POSTOPERATIVE COMPLICATION; PREVALENCE; RECURRENT DISEASE; REVIEW; RISK ASSESSMENT; RISK FACTOR; SOCIAL INTERACTION; SYMPTOM; VALIDATION STUDY; VALIDITY; WORK DISABILITY;

ADHESIONS; AWARENESS; DISEASE PROGRESSION; FEMALE; GYNECOLOGIC SURGICAL PROCEDURES; HUMANS; PATIENT EDUCATION AS TOPIC; PELVIC PAIN; PERITONEAL DISEASES; POSTOPERATIVE COMPLICATIONS; RISK FACTORS; SYNDROME; TREATMENT OUTCOME; UTERINE DISEASES;

EID: 50249157050     PISSN: 15268004     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0028-1082394     Document Type: Review

References (130)

1. Wiseman DM. Adhesion prevention: past the future. In: diZerega G, DeCherney A, Diamond M, et al, eds. Peritoneal Surgery. New York, NY: Springer-Verlag; 2000: 401-418
2. Wiseman DM, Trout JR, Franklin RR, Diamond MP. Metaanalysis of the safety and efficacy of an adhesion barrier (Interceed TC7) in laparotomy. J Reprod Med 1999;44:325-331
3. Beck DE, Cohen Z, Fleshman JW, Kaufman HS, van Goor H, Wolff BG. A prospective, randomized, multicenter, controlled study of the safety of Seprafilm adhesion barrier in abdominopelvic surgery of the intestine. Dis Colon Rectum 2003;46:1310-1319
4. Diamond MP. Reduction of adhesions after uterine myomectomy by Seprafilm membrane (HAL-F): a blinded, prospective, randomized, multicenter clinical study. Seprafilm Adhesion Study Group. Fertil Steril 1996;66:904-910
5. Haney AF, Hesla J, Hurst BS, et al. Expanded polytetrafluoroethylene (Gore-Tex Surgical Membrane) is superior to oxidized regenerated cellulose (Interceed TC7) in preventing adhesions. Fertil Steril 1995;63:1021-1026
6. Diamond MP and the Sepracoat Adhesion Study Group. Reduction of de novo postsurgical adhesions by intraoperative precoating with Sepracoat (HAL-C) solution: a prospective, randomized, blinded, placebo-controlled multicenter study. The Sepracoat Adhesion Study Group. Fertil Steril 1998;69:1067-1074
7. Johns DB, Keyport GM, Hoehler F, diZerega GS. Reduction of postsurgical adhesions with Intergel adhesion prevention solution: a multicenter study of safety and efficacy after conservative gynecologic surgery. Fertil Steril 2001;76:595-604
8. Wiseman DM. Possible Intergel reaction syndrome (pIRS). Ann Surg 2006;244:630-632
9. Holmdahl L. Mechanisms of adhesion development and effects on wound healing. Eur J Surg Suppl 1997;579:7-9
10. Practice Committee of the American Society for Reproductive Medicine. Pathogenesis, consequences, and control of peritoneal adhesions in gynecologic surgery. Fertil Steril 2007;88:21-26
11. Liakakos T, Thomakos N, Fine PM, Dervenis C, Young RL. Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Recent advances in prevention and management. Dig Surg 2001;18:260-273
12. Lower AM, Hawthorn RJ, Clark D, et al. Adhesion-related readmissions following gynaecological laparoscopy or laparotomy in Scotland: an epidemiological study of 24 046 patients. Hum Reprod 2004;19:1877-1885
13. Lower AM, Hawthorn RJ, Ellis H, O'Brien F, Buchan S, Crowe AM. The impact of adhesions on hospital readmissions over ten years after 8849 open gynaecological operations: an assessment from the Surgical and Clinical Adhesions Research Study. BJOG 2000;107:855-862
14. Ivarsson ML, Holmdahl L, Franzen G, Risberg B. Cost of bowel obstruction resulting from adhesions. Eur J Surg 1997;163:679-684
15. Jeekel H. Cost implications of adhesions as highlighted in a European study. Eur J Surg Suppl 1997;579:43-45
16. Ray NF, Denton WG, Thamer M, Henderson SC, Perry S. Abdominal adhesiolysis: inpatient care and expenditures in the United States in 1994. J Am Coll Surg 1998;186:1-9
17. Farquhar C, Vandekerckhove P, Watson A, Vail A, Wiseman D. Barrier agents for preventing adhesions after surgery for subfertility. Cochrane Database Syst Rev 2000:CD000475
18. Wiseman DM. Correlations between animal and human models of adhesions. Diamond MP, DeCherney AH, eds. Infertility and Reproductive, Medical Clinics of North America; 2003:391-401
19. Attard JA, MacLean AR. Adhesive small bowel obstruction: epidemiology, biology and prevention. Can J Surg 2007;50:291-300
20. Al-Jaroudi D, Tulandi T. Adhesion prevention in gynecologic surgery. Obstet Gynecol Surv 2004;59:360-367
21. Diamond MP, Freeman ML. Clinical implications of postsurgical adhesions. Hum Reprod Update 2001;7:567-576
22. Food and Drug Administration. Guidance for resorbable adhesion barrier devices for use in abdominal and/or pelvic surgery; Guidance for Industry. 2002. Available at: www.fda.gov/cdrh/ode/guidance/1356.pdf. Accessed November 23, 2006
23. Ellis H, Moran BJ, Thompson JN, et al. Adhesion-related hospital readmissions after abdominal and pelvic surgery: a retrospective cohort study. Lancet 1999;353:1476-1480
24. Fushiki H, Ikoma T, Kobayashi H, Yoshimoto H. Efficacy of Seprafilm as an adhesion barrier in cesarean sections. Obstet Gynecol Treatment 2005;91:557-561
25. Inoue M, Uchida K, Miki C, Kusunoki M. Efficacy of Seprafilm for reducing reoperative risk in pediatric surgical patients undergoing abdominal surgery. J Pediatr Surg 2005;40:1301-1306
26. Salum M, Wexner SD, Nogueras JJ, et al. Does sodium hyaluronate- and carboxymethylcellulose-based bioresorbable membrane (Seprafilm) decrease operative time for loop ileostomy closure? Tech Coloproctol 2006;10:187-190
27. American Fertility Society. The American Fertility Society classifications of adnexal adhesions, distal tubal occlusion, tubal occlusion secondary to tubal ligation, tubal pregnancies, mullerian anomalies and intrauterine adhesions. Fertil Steril 1988;49:944-955
28. Bronson RA, Wallach EE. Lysis of periadnexal adhesions for correction of infertility. Fertil Steril 1977;28:613-619
29. Marana R, Rizzi M, Muzii L, Catalano GF, Caruana P, Mancuso S. Correlation between the American Fertility Society classifications of adnexal adhesions and distal tubal occlusion, salpingoscopy, and reproductive outcome in tubal surgery. Fertil Steril 1995;64:924-929
30. Marana R, Catalano GF, Muzii L, Caruana P, Margutti F, Mancuso S. The prognostic role of salpingoscopy in laparoscopic tubal surgery. Hum Reprod 1999;14:2991-2995
31. Tulandi T, Collins JA, Burrows E, et al. Treatment-dependent and treatment-independent pregnancy among women with periadnexal adhesions. Am J Obstet Gynecol 1990;162:354-357
32. Sawada T, Nishizawa H, Nishio E, Kadowaki M. Post-operative adhesion prevention with an oxidized regenerated cellulose adhesion barrier in infertile women. J Reprod Med 2000;45:387-389
33. Ellis H. The clinical significance of adhesions: focus on intestinal obstruction. Eur J Surg Suppl 1997;579:5-9
34. Wilson MS, Ellis H, Menzies D, Moran BJ, Parker MC, Thompson JN. A review of the management of small bowel obstruction. Members of the Surgical and Clinical Adhesions Research Study (SCAR). Ann R Coll Surg Engl 1999;81:320-328
35. Nagle A, Ujiki M, Denham W, Murayama K. Laparoscopic adhesiolysis for small bowel obstruction. Am J Surg 2004;187:464-470
36. Fazio VW, Cohen Z, Fleshman JW, et al. Reduction in adhesive small-bowel obstruction by Seprafilm adhesion barrier after intestinal resection. Dis Colon Rectum 2006;49:1-11
37. Mohri Y, Uchida K, Araki T, et al. Hyaluronic acid-carboxycellulose membrane (Seprafilm) reduces early post-operative small bowel obstruction in gastrointestinal surgery. Am Surg 2005;71:861-863
38. Kudo FA, Nishibe T, Miyazaki K, Murashita T, Nishibe M, Yasuda K. Use of bioresorbable membrane to prevent postoperative small bowel obstruction in transabdominal aortic aneurysm surgery. Surg Today 2004;34:648-651
39. Zeng Q, Yu Z, You J, Zhang Q. Efficacy and safety of Seprafilm for preventing postoperative abdominal adhesion: systematic review and meta-analysis. World J Surg 2007;31:2125-2131
40. Alexander-Williams J. Do adhesions cause pain? Br Med J (Clin Res Ed) 1987;294:659-660
41. Hammoud A, Gago LA, Diamond MP. Adhesions in patients with chronic pelvic pain: a role for adhesiolysis? Fertil Steril 2004;82:1483-1491
42. Herrick SE, Mutsaers SE, Ozua P, et al. Human peritoneal adhesions are highly cellular, innervated, and vascularized. J Pathol 2000;192:67-72
43. Demco L. Pain mapping of adhesions. J Am Assoc Gynecol Laparosc 2004;11:181-183
44. Howard FM. The role of laparoscopy in chronic pelvic pain: promise and pitfalls. Obstet Gynecol Surv 1993;48:357-387
45. Freys SM, Fuchs KH, Heimbucher J, Thiede A. Laparoscopic adhesiolysis. Surg Endosc 1994;8:1202-1207
46. Steege JF, Stout AL. Resolution of chronic pelvic pain after laparoscopic lysis of adhesions. Am J Obstet Gynecol 1991;165:278-281
47. Daniell JF. Laparoscopic enterolysis for chronic abdominal pain. J Gynecol Surg 1989;5:61-66
48. Peters AA, Trimbos-Kemper GC, Admiraal C, Trimbos JB, Hermans J. A randomized clinical trial on the benefit of adhesiolysis in patients with intraperitoneal adhesions and chronic pelvic pain. Br J Obstet Gynaecol 1992;99:59-62
49. Baker PN, Symonds EM. The resolution of chronic pelvic pain after normal laparoscopy findings. Am J Obstet Gynecol 1992;166:835-836
50. Swank DJ, Swank-Bordewijk SC, Hop WC, et al. Laparoscopic adhesiolysis in patients with chronic abdominal pain: a blinded randomised controlled multi-centre trial. Lancet 2003;361:1247-1251
51. Moseley JB, O'Malley K, Petersen NJ, et al. A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med 2002;347:81-88
52. Jarrell J, Mohindra R, Ross S, Taenzer P, Brant R. Laparoscopy and reported pain among patients with endometriosis. J Obstet Gynaecol Can 2005;27:477-485
53. Wiseman DM; Trout JR, Diamond MP. The rates of adhesion development and the effects of crystalloid solutions on adhesion development in pelvic surgery. Fertil Steril 1998;70(4):702-711
54. Khaitan L, Scholz S, Houston HL, Richards WO. Results after laparoscopic lysis of adhesions and placement of Seprafilm for intractable abdominal pain. Surg Endosc 2003;17:247-253
55. Menzies D, Ellis H. Intestinal obstruction from adhesions-how big is the problem? Ann R Coll Surg Engl 1990;72:60-63
56. Wiseman DM. Polymers for the prevention of surgical adhesions. In: Domb AJ, ed. Polymeric Site-Specific Pharmacotherapy. Chichester, England: John Wiley, 1994:369-421
57. Wiseman D. Information and consent regarding adhesions: an internet survey. J Minim Invasive Gynecol 2006;13:S73
58. Ellis H. Medicolegal consequences of adhesions. Hosp Med 2004;65:348-350
59. Courtney MJ. Information about surgery: what does the public want to know? Aust N Z J Surg 2001;71:24-26
60. Lloyd A, Hayes P, Bell PR, Naylor AR. The role of risk and benefit perception in informed consent for surgery. Med Decis Making 2001;21:141-149
61. Wiseman D. Severe adhesion related disorder (ARD); pattern of bowel dysfunction and obstruction, social and physician issues: an Internet survey. J Minim Invasive Gynecol 2006;13:S65-S66
62. Kotarinos RK. Pelvic floor physical therapy in urogynecologic disorders. Curr Womens Health Rep 2003;3:334-339
63. Vizzard MA. Alterations in spinal cord Fos protein expression induced by bladder stimulation following cystitis. Am J Physiol Regul Integr Comp Physiol 2000;278:R1027-R1039
64. LaBerge J, Malley SE, Zvarova K, Vizzard MA. Expression of corticotropin-releasing factor and CRF receptors in micturition pathways after cyclophosphamide-induced cystitis. Am J Physiol Regul Integr Comp Physiol 2006;291:R692-R703
65. Qiao LY, Vizzard MA. Cystitis-induced upregulation of tyrosine kinase (TrkA, TrkB) receptor expression and phosphorylation in rat micturition pathways. J Comp Neurol 2002;454:200-211
66. Melzack R. Phantom limb pain. Patol Fiziol Eksp Ter 1992;4:52-54
67. Brena SF, Sammons EE. Phantom urinary bladder pain-case report. Pain 1979;7:197-201
68. Biley FC. Phantom bladder sensations: a new concern for stoma care workers. Br J Nurs 2001;10:1290-1296
69. Rogers RM. Basic pelvic neuroanatomy. In: Steege JF, Metzger DA, Levy BS, eds. Chronic Pelvic Pain. Philadelphia, PA: W.B. Saunders; 1998:31-58
70. Wesselmann U, Burnett AL, Heinberg LJ. The urogenital and rectal pain syndromes. Pain 1997;73:269-294
71. Pezzone MA, Liang R, Fraser MO. A model of neural cross-talk and irritation in the pelvis: implications for the overlap of chronic pelvic pain disorders. Gastroenterology 2005;128:1953-1964
72. Giamberardino MA, Berkley KJ, Affaitati G, et al. Influence of endometriosis on pain behaviors and muscle hyperalgesia induced by a ureteral calculosis in female rats. Pain 2002;95:247-257
73. Bielefeldt K, Lamb K, Gebhart GF. Convergence of sensory pathways in the development of somatic and visceral hypersensitivity. Am J Physiol Gastrointest Liver Physiol 2006;291:G658-G665
74. Ustinova EE, Fraser MO, Pezzone MA. Colonic irritation in the rat sensitizes urinary bladder afferents to mechanical and chemical stimuli: an afferent origin of pelvic organ cross-sensitization. Am J Physiol Renal Physiol 2006;290:F1478-F1487
75. Winnard KP, Dmitrieva N, Berkley KJ. Cross-organ interactions between reproductive, gastrointestinal, and urinary tracts: modulation by estrous stage and involvement of the hypogastric nerve. Am J Physiol Regul Integr Comp Physiol 2006;291:R1592-R1601
76. Gomel V. Chronic pelvic pain: a challenge. J Minim Invasive Gynecol 2007;14:521-526
77. Zondervan KT, Yudkin PL, Vessey MP, et al. Chronic pelvic pain in the community-symptoms, investigations, and diagnoses. Am J Obstet Gynecol 2001;184:1149-1155
78. Stanford EJ, Koziol J, Feng A. The prevalence of interstitial cystitis, endometriosis, adhesions, and vulvar pain in women with chronic pelvic pain. J Minim Invasive Gynecol 2005;12:43-49
79. Engel GL. The need for a new medical model: a challenge for biomedicine. Science 1977;196:129-136
80. Wesselmann U, Czakanski PP. Pelvic pain: a chronic visceral pain syndrome. Curr Pain Headache Rep 2001;5:13-19
81. Peters AA, Van den Tillaart SA. The difficult patient in gastroenterology: chronic pelvic pain, adhesions, and sub occlusive episodes. Best Pract Res Clin Gastroenterol 2007;21:445-463
82. Stanford EJ, Dell JR, Parsons CL. The emerging presence of interstitial cystitis in gynecologic patients with chronic pelvic pain. Urology 2007;69:53-59
83. Levey KA. Chronic pelvic pain. J Minim Invasive Gynecol 2004;11:546
84. Peters AA, van Dorst E, Jellis B, van Zuuren E, Hermans J, Trimbos JB. A randomized clinical trial to compare two different approaches in women with chronic pelvic pain. Obstet Gynecol 1991;77:740-744
85. Reiter RC. Evidence-based management of chronic pelvic pain. Clin Obstet Gynecol 1998;41:422-435
86. Steege JF, Stout AL, Somkuti SG. Chronic pelvic pain in women: toward an integrative model. Obstet Gynecol Surv 1993;48:95-110
87. Peters KM. Neuromodulation for the treatment of refractory interstitial cystitis. Rev Urol 2002;4(Suppl 1):S36-S43
88. Kapural L, Narouze SN, Janicki TI, Mekhail N. Spinal cord stimulation is an effective treatment for the chronic intractable visceral pelvic pain. Pain Med 2006;7:440-443
89. Bedaiwy MA, Falcone T, Mascha EJ, Casper RF. Genetic polymorphism in the fibrinolytic system and endometriosis. Obstet Gynecol 2006;108:162-168
90. Wieser F, Tempfer C, Schneeberger C, van Trotsenburg M, Huber J, Wenzl R. Interleukin-1 receptor antagonist polymorphism in women with peritoneal adhesions. BJOG 2002;109:1298-1300
91. Duron JJ, Silva NJ, du Montcel ST, et al. Adhesive postoperative small bowel obstruction: incidence and risk factors of recurrence after surgical treatment: a multicenter prospective study. Ann Surg 2006;244:750-757
92. Fevang BT, Fevang J, Lie SA, Soreide O, Svanes K, Viste A. Long-term prognosis after operation for adhesive small bowel obstruction. Ann Surg 2004;240:193-201
93. Ingber MS, Peters KM, Killinger KA, Carrico DJ, Ibrahim IA, Diokno AC. Dilemmas in diagnosing pelvic pain: multiple pelvic surgeries common in women with interstitial cystitis. Int Urogynecol J Pelvic Floor Dysfunct 2008;19:341-345
94. Saed GM, Diamond MP. Molecular characterization of postoperative adhesions: the adhesion phenotype. J Am Assoc Gynecol Laparosc 2004;11:307-314
95. Kluivers KB, Mol BW, Bremer GL, Brolmann HA, Vierhout ME, Bongers MY. Pelvic organ function in randomized patients undergoing laparoscopic or abdominal hysterectomy. J Minim Invasive Gynecol 2007;14:442-448
96. Stricker B, Blanco J, Fox HE. The gynecologic contribution to intestinal obstruction in females. J Am Coll Surg 1994;178:617-620
97. Ratcliff JB, Kapernick P, Brooks GG, Dunnihoo DR. Small bowel obstruction and previous gynecologic surgery. South Med J 1983;76:1349-1350
98. Monk BJ, Berman ML, Montz FJ. Adhesions after extensive gynecologic surgery: clinical significance, etiology, and prevention. Am J Obstet Gynecol 1994;170:1396-1403
99. Brett KM, Higgins JA. Hysterectomy prevalence by Hispanic ethnicity: evidence from a national survey. Am J Public Health 2003;93:307-312
100. Centers for Disease Control and Prevention. Hysterectomy prevalence and death rates for cervical cancer-United States, 1965-1988. MMWR Morb Mortal Wkly Rep 1992;41:17-20
101. Moirand R, Adams PC, Bicheler V, Brissot P, Deugnier Y. Clinical features of genetic hemochromatosis in women compared with men. Ann Intern Med 1997;127:105-110
102. Cade JE, Moreton JA, O'Hara B, et al. Diet and genetic factors associated with iron status in middle-aged women. Am J Clin Nutr 2005;82:813-820
103. Bureau I, Gueux E, Mazur A, Rock E, Roussel AM, Rayssiguier Y. Female rats are protected against oxidative stress during copper deficiency. J Am Coll Nutr 2003;22:239-246
104. Persky AM, Green PS, Stubley L, et al. Protective effect of estrogens against oxidative damage to heart and skeletal muscle in vivo and in vitro. Proc Soc Exp Biol Med 2000;223:59-66
105. Binda MM, Molinas CR, Koninckx PR. Reactive oxygen species and adhesion formation: clinical implications in adhesion prevention. Hum Reprod 2003;18:2503-2507
106. Alpay Z, Saed GM, Diamond MP. Female infertility and free radicals: potential role in adhesions and endometriosis. J Soc Gynecol Investig 2006;13:390-398
107. Gupta S, Agarwal A, Krajcir N, Alvarez JG. Role of oxidative stress in endometriosis. Reprod Biomed Online 2006;13:126-134
108. McDonnell SM, Preston BL, Jewell SA, et al. A survey of 2,851 patients with hemochromatosis: symptoms and response to treatment. Am J Med 1999;106:619-624
109. Burke W, Reyes M, Imperatore G. Hereditary haemochromatosis: a realistic approach to prevention of iron overload disease in the population. Best Pract Res Clin Haematol 2002;15:315-328
110. Tweed MJ, Roland JM. Haemochromatosis as an endocrine cause of subfertility. BMJ 1998;316:915-916
111. Britton RS, Ramm GA, Olynyk J, Singh R, O'Neill R, Bacon BR. Pathophysiology of iron toxicity. Adv Exp Med Biol 1994;356:239-253
112. Goswami T, Rolfs A, Hediger MA. Iron transport: emerging roles in health and disease. Biochem Cell Biol 2002;80:679-689
113. Arumugam K, Yip YC. De novo formation of adhesions in endometriosis: the role of iron and free radical reactions. Fertil Steril 1995;64:62-64
114. Van Langendonckt A, Casanas-Roux F, Donnez J. Iron overload in the peritoneal cavity of women with pelvic endometriosis. Fertil Steril 2002;78:712-718
115. Defrere S, Van Langendonckt A, Vaesen S, et al. Iron overload enhances epithelial cell proliferation in endometriotic lesions induced in a murine model. Hum Reprod 2006;21:2810-2816
116. Sullivan JL. Iron and the genetics of cardiovascular disease. Circulation 1999;100:1260-1263
117. Weinberg ED. Do some carriers of hemochromatosis gene mutations have higher than normal rates of disease and death? Biometals 2002;15:347-350
118. Holmstrom P, Marmur J, Eggertsen G, Gafvels M, Stal P. Mild iron overload in patients carrying the HFE S65C gene mutation: a retrospective study in patients with suspected iron overload and healthy controls. Gut 2002;51:723-730
119. Adams PC. Hemochromatosis. Clin Liver Dis 2004;8:735-753 vii
120. Eisenbach C, Gehrke SG, Stremmel W. Iron, the HFE gene, and hepatitis C. Clin Liver Dis 2004;8:775-785vii-viii
121. Geier A, Reugels M, Weiskirchen R, et al. Common heterozygous hemochromatosis gene mutations are risk factors for inflammation and fibrosis in chronic hepatitis C. Liver Int 2004;24:285-294
122. Andrews NC. Anemia of inflammation: the cytokinehepcidin link. J Clin Invest 2004;113:1251-1253
123. Weiss G. Iron and anemia of chronic disease. Kidney Int Suppl 1999;69:S12-S17
124. Wiseman D. Possible Intergel reaction syndrome (pIRS): mechanisms and general consequences for patients undergoing surgery. J Minim Invasive Gynecol 2006;13:S67
125. Wiseman DM. Registries for anti-adhesion products? Fertil Steril 2006;86:771
126. Lifecore Biomedical, Inc. Major Amendment to INTERGEL PMA P99015/A010 Appendix C: Summary of Safety and Effectiveness (Revised). June 2, 2000Available at: www.fda.gov/ohrms/dockets/ac/01/briefing/ 3789b1_12_08_summary%20of%20S&E.pdf. Accessed March 24, 2005
127. Courselaud B, Pigeon C, Inoue Y, et al. C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism. J Biol Chem 2002;277:41163-41170
128. Horbowyj R. INTERGEL Adhesion Prevention Solution. Clinical study of use during laparotomy for gynecologic interventions - FDA Clinical Perspective. September 6, 2001. Available at: www.fda.gov/ohrms/dockets/ac/01/briefing/ 3789b1_08.ppt. Accessed March 28, 2005
129. Diatchenko L, Nackley AG, Slade GD, et al. Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain 2006;125:216-224
130. Tegeder I, Costigan M, Griffin RS, et al. GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med 2006;12:1269-1277