Specific increase of human kallikrein 4 mRNA and protein levels in breast cancer stromal cells

Biochemical and Biophysical Research Communications

Volumn 375, Issue 1, 2008, Pages 107-112

  Mangé, Alain ^a,b,c   Desmetz, Caroline ^a,b,c   Berthes, Marie Laurence ^b   Maudelonde, Thierry ^a,b,c   Solassol, Jérôme ^a,b,c  

^a UNIV MONTPELLIER   (France)

^b HÔPITAL ARNAUD DE VILLENEUVE   (France)

^c CENTRE VAL D AURELLE   (France)

Author keywords

Breast cancer; Gene expression; Kallikrein; Serine protease; Stromal cells

Indexed keywords

KALLIKREIN; KALLIKREIN 4; MESSENGER RNA; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BREAST; BREAST CANCER; CANCER GRADING; CANCER GROWTH; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE FUNCTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KALLIKREIN 4 GENE; MICRODISSECTION; PRIORITY JOURNAL; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; STROMA CELL; TUMOR GENE; UPREGULATION;

ADULT; AGED; BREAST NEOPLASMS; CELLS, CULTURED; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KALLIKREINS; MIDDLE AGED; RNA, MESSENGER; STROMAL CELLS;

EID: 50149114508     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.07.138     Document Type: Article

References (36)

1. Balk S.P., Ko Y.J., and Bubley G.J. Biology of prostate-specific antigen. J. Clin. Oncol. 21 (2003) 383-391
2. Clements J., Hooper J., Dong Y., and Harvey T. The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions. Biol. Chem. 382 (2001) 5-14
3. Yousef G.M., and Diamandis E.P. The new human tissue kallikrein gene family: structure, function, and association to disease. Endocr. Rev. 22 (2001) 184-204
4. Borgono C.A., Michael I.P., and Diamandis E.P. Human tissue kallikreins: physiologic roles and applications in cancer. Mol. Cancer Res. 2 (2004) 257-280
5. Clements J.A., Willemsen N.M., Myers S.A., and Dong Y. The tissue kallikrein family of serine proteases: functional roles in human disease and potential as clinical biomarkers. Crit. Rev. Clin. Lab. Sci. 41 (2004) 265-312
6. Magklara A., Scorilas A., Catalona W.J., and Diamandis E.P. The combination of human glandular kallikrein and free prostate-specific antigen (PSA) enhances discrimination between prostate cancer and benign prostatic hyperplasia in patients with moderately increased total PSA. Clin. Chem. 45 (1999) 1960-1966
7. Luo L.Y., Katsaros D., Scorilas A., Fracchioli S., Piccinno R., Rigault de la Longrais I.A., Howarth D.J., and Diamandis E.P. Prognostic value of human kallikrein 10 expression in epithelial ovarian carcinoma. Clin. Cancer Res. 7 (2001) 2372-2379
8. Diamandis E.P., Okui A., Mitsui S., Luo L.Y., Soosaipillai A., Grass L., Nakamura T., Howarth D.J., and Yamaguchi N. Human kallikrein 11: a new biomarker of prostate and ovarian carcinoma. Cancer Res. 62 (2002) 295-300
9. Borgono C.A., and Diamandis E.P. The emerging roles of human tissue kallikreins in cancer. Nat. Rev. Cancer 4 (2004) 876-890
10. Sano A., Sangai T., Maeda H., Nakamura M., Hasebe T., and Ochiai A. Kallikrein 11 expressed in human breast cancer cells releases insulin-like growth factor through degradation of IGFBP-3. Int. J. Oncol. 30 (2007) 1493-1498
11. Liu X.L., Wazer D.E., Watanabe K., and Band V. Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression. Cancer Res. 56 (1996) 3371-3379
12. Yousef G.M., Chang A., and Diamandis E.P. Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues. J. Biol. Chem. 275 (2000) 11891-11898
13. Yousef G.M., Magklara A., Chang A., Jung K., Katsaros D., and Diamandis E.P. Cloning of a new member of the human kallikrein gene family, KLK14, which is down-regulated in different malignancies. Cancer Res. 61 (2001) 3425-3431
14. Fortier A.H., Nelson B.J., Grella D.K., and Holaday J.W. Antiangiogenic activity of prostate-specific antigen. J. Natl. Cancer Inst. 91 (1999) 1635-1640
15. Goyal J., Smith K.M., Cowan J.M., Wazer D.E., Lee S.W., and Band V. The role for NES1 serine protease as a novel tumor suppressor. Cancer Res. 58 (1998) 4782-4786
16. Lai L.C., Erbas H., Lennard T.W., and Peaston R.T. Prostate-specific antigen in breast cyst fluid: possible role of prostate-specific antigen in hormone-dependent breast cancer. Int. J. Cancer 66 (1996) 743-746
17. Veveris-Lowe T.L., Lawrence M.G., Collard R.L., Bui L., Herington A.C., Nicol D.L., and Clements J.A. Kallikrein 4 (hK4) and prostate-specific antigen (PSA) are associated with the loss of E-cadherin and an epithelial-mesenchymal transition (EMT)-like effect in prostate cancer cells. Endocr. Relat. Cancer 12 (2005) 631-643
18. Klokk T.I., Kilander A., Xi Z., Waehre H., Risberg B., Danielsen H.E., and Saatcioglu F. Kallikrein 4 is a proliferative factor that is overexpressed in prostate cancer. Cancer Res. 67 (2007) 5221-5230
19. Nielsen B.S., Rank F., Illemann M., Lund L.R., and Dano K. Stromal cells associated with early invasive foci in human mammary ductal carcinoma in situ coexpress urokinase and urokinase receptor. Int. J. Cancer 120 (2007) 2086-2095
20. Spyratos F., Maudelonde T., Brouillet J.P., Brunet M., Defrenne A., Andrieu C., Hacene K., Desplaces A., Rouesse J., and Rochefort H. Cathepsin D: an independent prognostic factor for metastasis of breast cancer. Lancet 2 (1989) 1115-1118
21. Tetu B., Brisson J., Wang C.S., Lapointe H., Beaudry G., and Blanchette C. Expression of cathepsin D, stromelysin-3, and urokinase by reactive stromal cells on breast carcinoma prognosis. Cancer 92 (2001) 2957-2964
22. Beaufort N., Debela M., Creutzburg S., Kellermann J., Bode W., Schmitt M., Pidard D., and Magdolen V. Interplay of human tissue kallikrein 4 (hK4) with the plasminogen activation system: hK4 regulates the structure and functions of the urokinase-type plasminogen activator receptor (uPAR). Biol. Chem. 387 (2006) 217-222
23. Takayama T.K., McMullen B.A., Nelson P.S., Matsumura M., and Fujikawa K. Characterization of hK4 (prostase), a prostate-specific serine protease: activation of the precursor of prostate specific antigen (pro-PSA) and single-chain urokinase-type plasminogen activator and degradation of prostatic acid phosphatase. Biochemistry 40 (2001) 15341-15348
24. Ramsay A.J., Dong Y., Hunt M.L., Linn M., Samaratunga H., Clements J.A., and Hooper J.D. Kallikrein-related peptidase 4 (KLK4) initiates intracellular signaling via protease-activated receptors (PARs): KLK4 AND PAR-2 are co-expressed during prostate cancer progression. J. Biol. Chem. 283 (2008) 12293-12304
25. Coughlin S.R. How the protease thrombin talks to cells. Proc. Natl. Acad. Sci. USA 96 (1999) 11023-11027
26. Macfarlane S.R., Seatter M.J., Kanke T., Hunter G.D., and Plevin R. Proteinase-activated receptors. Pharmacol. Rev. 53 (2001) 245-282
27. Kamath L., Meydani A., Foss F., and Kuliopulos A. Signaling from protease-activated receptor-1 inhibits migration and invasion of breast cancer cells. Cancer Res. 61 (2001) 5933-5940
28. Liu Y., and Mueller B.M. Protease-activated receptor-2 regulates vascular endothelial growth factor expression in MDA-MB-231 cells via MAPK pathways. Biochem. Biophys. Res. Commun. 344 (2006) 1263-1270
29. Morris D.R., Ding Y., Ricks T.K., Gullapalli A., Wolfe B.L., and Trejo J. Protease-activated receptor-2 is essential for factor VIIa and Xa-induced signaling, migration, and invasion of breast cancer cells. Cancer Res. 66 (2006) 307-314
30. Oikonomopoulou K., Hansen K.K., Saifeddine M., Tea I., Blaber M., Blaber S.I., Scarisbrick I., Andrade-Gordon P., Cottrell G.S., Bunnett N.W., Diamandis E.P., and Hollenberg M.D. Proteinase-activated receptors, targets for kallikrein signaling. J. Biol. Chem. 281 (2006) 32095-32112
31. Angelo P.F., Lima A.R., Alves F.M., Blaber S.I., Scarisbrick I.A., Blaber M., Juliano L., and Juliano M.A. Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects. J. Biol. Chem. 281 (2006) 3116-3126
32. Stefansson K., Brattsand M., Roosterman D., Kempkes C., Bocheva G., Steinhoff M., and Egelrud T. Activation of proteinase-activated receptor-2 by human kallikrein-related peptidases. J. Invest. Dermatol. 128 (2008) 18-25
33. Xi Z., Klokk T.I., Korkmaz K., Kurys P., Elbi C., Risberg B., Danielsen H., Loda M., and Saatcioglu F. Kallikrein 4 is a predominantly nuclear protein and is overexpressed in prostate cancer. Cancer Res. 64 (2004) 2365-2370
34. Dong Y., Bui L.T., Odorico D.M., Tan O.L., Myers S.A., Samaratunga H., Gardiner R.A., and Clements J.A. Compartmentalized expression of kallikrein 4 (KLK4/hK4) isoforms in prostate cancer: nuclear, cytoplasmic and secreted forms. Endocr. Relat. Cancer 12 (2005) 875-889
35. Obiezu C.V., Shan S.J., Soosaipillai A., Luo L.Y., Grass L., Sotiropoulou G., Petraki C.D., Papanastasiou P.A., Levesque M.A., and Diamandis E.P. Human kallikrein 4: quantitative study in tissues and evidence for its secretion into biological fluids. Clin. Chem. 51 (2005) 1432-1442
36. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 (2001) 402-408